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Large cell lung carcinoma

MedGen UID:
91060
•Concept ID:
C0345958
•
Neoplastic Process
Synonyms: Anaplastic Lung Carcinoma; anaplastic lung carcinoma; Large cell carcinoma of lung; Large Cell Carcinoma of Lung; large cell carcinoma of lung; Large Cell Carcinoma of the Lung; large cell carcinoma of the lung; large cell lung cancer; Large Cell Lung Carcinoma; large cell lung carcinoma; Large Cell Undifferentiated Lung Carcinoma; large cell undifferentiated lung carcinoma; LCLC; Lung Large Cell Carcinoma; lung large cell carcinoma
SNOMED CT: Large cell carcinoma of lung (254629004)
 
HPO: HP:0030360
Monarch Initiative: MONDO:0003050

Definition

A type of non-small cell lung carcinoma that is derived from undifferentiated malignant neoplasms originating from transformed epithelial cells in the lung, and which is differentiate from small-cell lung carcinoma by the larger size of the anaplastic cells, a higher cytoplasmic-to-nuclear size ratio, and a lack of salt-and-pepper appearance of the chromatin. [from HPO]

Professional guidelines

PubMed

Epigenetic Alterations and Inflammation as Emerging Use for the Advancement of Treatment in Non-Small Cell Lung Cancer.
Yang S, Huang Y, Zhao Q
Front Immunol 2022;13:878740. Epub 2022 Apr 20 doi: 10.3389/fimmu.2022.878740. PMID: 35514980Free PMC Article
Treatment of lung large cell neuroendocrine carcinoma.
Lo Russo G, Pusceddu S, Proto C, Macerelli M, Signorelli D, Vitali M, Ganzinelli M, Gallucci R, Zilembo N, Platania M, Buzzoni R, de Braud F, Garassino MC
Tumour Biol 2016 Jun;37(6):7047-57. Epub 2016 Mar 4 doi: 10.1007/s13277-016-5003-4. PMID: 26943800
Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship.
Molina JR, Yang P, Cassivi SD, Schild SE, Adjei AA
Mayo Clin Proc 2008 May;83(5):584-94. doi: 10.4065/83.5.584. PMID: 18452692Free PMC Article

Recent clinical studies

Etiology

Five-year survival of resectable stage IIIA non-small cell lung cancer in Brazil.
de Barros MLGP, Silva VG, Moreira FR, Perez SV, Younes RN, Abrão FC
J Surg Oncol 2023 Dec;128(7):1195-1204. Epub 2023 Jul 13 doi: 10.1002/jso.27394. PMID: 37448240
RAI3 expression is not associated with clinical outcomes of patients with non-small cell lung cancer.
Melling N, Reeh M, Ghadban T, Tachezy M, Hajek A, Izbicki JR, Grupp K
J Cancer Res Clin Oncol 2023 Aug;149(9):6549-6555. Epub 2023 Feb 13 doi: 10.1007/s00432-023-04631-3. PMID: 36781501Free PMC Article
Effect of Chemotherapy in Stage II-IV Large-Cell Lung Carcinoma and Construction of Its Predictive Nomograms: A SEER Analysis.
Hu G, Liu Y, Li X, Jin M, Liu X, Yu Q
Med Princ Pract 2023;32(1):49-60. Epub 2023 Jan 18 doi: 10.1159/000529202. PMID: 36652925Free PMC Article
Treatment of lung large cell neuroendocrine carcinoma.
Lo Russo G, Pusceddu S, Proto C, Macerelli M, Signorelli D, Vitali M, Ganzinelli M, Gallucci R, Zilembo N, Platania M, Buzzoni R, de Braud F, Garassino MC
Tumour Biol 2016 Jun;37(6):7047-57. Epub 2016 Mar 4 doi: 10.1007/s13277-016-5003-4. PMID: 26943800
Animal models of lung cancer characterization and use for chemoprevention research.
Wang Y, Rouggly L, You M, Lubet R
Prog Mol Biol Transl Sci 2012;105:211-26. doi: 10.1016/B978-0-12-394596-9.00007-X. PMID: 22137433

Diagnosis

SMARCA4 deficiency and mutations are frequent in large cell lung carcinoma and are prognostically significant.
Cheung AH, Wong KY, Chau SL, Xie F, Mui Z, Li GY, Li MSC, Tong J, Ng CS, Mok TS, Kang W, To KF
Pathology 2024 Jun;56(4):504-515. Epub 2024 Feb 15 doi: 10.1016/j.pathol.2023.12.414. PMID: 38413251
Epigenetic Alterations and Inflammation as Emerging Use for the Advancement of Treatment in Non-Small Cell Lung Cancer.
Yang S, Huang Y, Zhao Q
Front Immunol 2022;13:878740. Epub 2022 Apr 20 doi: 10.3389/fimmu.2022.878740. PMID: 35514980Free PMC Article
Histone Modification in NSCLC: Molecular Mechanisms and Therapeutic Targets.
Bajbouj K, Al-Ali A, Ramakrishnan RK, Saber-Ayad M, Hamid Q
Int J Mol Sci 2021 Oct 28;22(21) doi: 10.3390/ijms222111701. PMID: 34769131Free PMC Article
Epigenetic Regulation of EMT in Non-Small Cell Lung Cancer.
O'Leary K, Shia A, Schmid P
Curr Cancer Drug Targets 2018;18(1):89-96. doi: 10.2174/1568009617666170203162556. PMID: 28176646
Animal models of lung cancer characterization and use for chemoprevention research.
Wang Y, Rouggly L, You M, Lubet R
Prog Mol Biol Transl Sci 2012;105:211-26. doi: 10.1016/B978-0-12-394596-9.00007-X. PMID: 22137433

Therapy

Effect of Chemotherapy in Stage II-IV Large-Cell Lung Carcinoma and Construction of Its Predictive Nomograms: A SEER Analysis.
Hu G, Liu Y, Li X, Jin M, Liu X, Yu Q
Med Princ Pract 2023;32(1):49-60. Epub 2023 Jan 18 doi: 10.1159/000529202. PMID: 36652925Free PMC Article
Case Report: Therapeutic Response to Chemo-Immunotherapy in an Advanced Large Cell Lung Carcinoma Patient With Low Values of Multiple Predictive Biomarkers.
Wang G, Chai Q, Xiao Y, Peng W, Teng M, Wang J, Lin H, Su X, Wu L
Front Immunol 2020;11:607416. Epub 2021 Jan 28 doi: 10.3389/fimmu.2020.607416. PMID: 33584678Free PMC Article
Doxycycline inhibits electric field-induced migration of non-small cell lung cancer (NSCLC) cells.
Chang HF, Cheng HT, Chen HY, Yeung WK, Cheng JY
Sci Rep 2019 May 30;9(1):8094. doi: 10.1038/s41598-019-44505-8. PMID: 31147570Free PMC Article
Treatment of lung large cell neuroendocrine carcinoma.
Lo Russo G, Pusceddu S, Proto C, Macerelli M, Signorelli D, Vitali M, Ganzinelli M, Gallucci R, Zilembo N, Platania M, Buzzoni R, de Braud F, Garassino MC
Tumour Biol 2016 Jun;37(6):7047-57. Epub 2016 Mar 4 doi: 10.1007/s13277-016-5003-4. PMID: 26943800
Drug localization in different lung cancer phenotypes by MALDI mass spectrometry imaging.
Marko-Varga G, Fehniger TE, Rezeli M, Döme B, Laurell T, Végvári A
J Proteomics 2011 Jun 10;74(7):982-92. Epub 2011 Apr 1 doi: 10.1016/j.jprot.2011.03.019. PMID: 21440690

Prognosis

SMARCA4 deficiency and mutations are frequent in large cell lung carcinoma and are prognostically significant.
Cheung AH, Wong KY, Chau SL, Xie F, Mui Z, Li GY, Li MSC, Tong J, Ng CS, Mok TS, Kang W, To KF
Pathology 2024 Jun;56(4):504-515. Epub 2024 Feb 15 doi: 10.1016/j.pathol.2023.12.414. PMID: 38413251
Whole-exome and targeted gene sequencing of large-cell lung carcinoma reveals recurrent mutations in the PI3K pathway.
Guo JH, Ma YS, Lin JW, Jiang GX, He J, Lu HM, Wu W, Diao X, Fan QY, Wu CY, Liu JB, Fu D, Hou LK
Br J Cancer 2023 Aug;129(2):366-373. Epub 2023 May 13 doi: 10.1038/s41416-023-02301-2. PMID: 37179440Free PMC Article
Effect of Chemotherapy in Stage II-IV Large-Cell Lung Carcinoma and Construction of Its Predictive Nomograms: A SEER Analysis.
Hu G, Liu Y, Li X, Jin M, Liu X, Yu Q
Med Princ Pract 2023;32(1):49-60. Epub 2023 Jan 18 doi: 10.1159/000529202. PMID: 36652925Free PMC Article
Prevalence and clinical significance of RBM3 immunostaining in non-small cell lung cancers.
Melling N, Bachmann K, Hofmann B, El Gammal AT, Reeh M, Mann O, Moebius C, Blessmann M, Izbicki JR, Grupp K
J Cancer Res Clin Oncol 2019 Apr;145(4):873-879. Epub 2019 Feb 13 doi: 10.1007/s00432-019-02850-1. PMID: 30758670
Treatment of lung large cell neuroendocrine carcinoma.
Lo Russo G, Pusceddu S, Proto C, Macerelli M, Signorelli D, Vitali M, Ganzinelli M, Gallucci R, Zilembo N, Platania M, Buzzoni R, de Braud F, Garassino MC
Tumour Biol 2016 Jun;37(6):7047-57. Epub 2016 Mar 4 doi: 10.1007/s13277-016-5003-4. PMID: 26943800

Clinical prediction guides

SMARCA4 deficiency and mutations are frequent in large cell lung carcinoma and are prognostically significant.
Cheung AH, Wong KY, Chau SL, Xie F, Mui Z, Li GY, Li MSC, Tong J, Ng CS, Mok TS, Kang W, To KF
Pathology 2024 Jun;56(4):504-515. Epub 2024 Feb 15 doi: 10.1016/j.pathol.2023.12.414. PMID: 38413251
Effect of Chemotherapy in Stage II-IV Large-Cell Lung Carcinoma and Construction of Its Predictive Nomograms: A SEER Analysis.
Hu G, Liu Y, Li X, Jin M, Liu X, Yu Q
Med Princ Pract 2023;32(1):49-60. Epub 2023 Jan 18 doi: 10.1159/000529202. PMID: 36652925Free PMC Article
Prevalence and clinical significance of RBM3 immunostaining in non-small cell lung cancers.
Melling N, Bachmann K, Hofmann B, El Gammal AT, Reeh M, Mann O, Moebius C, Blessmann M, Izbicki JR, Grupp K
J Cancer Res Clin Oncol 2019 Apr;145(4):873-879. Epub 2019 Feb 13 doi: 10.1007/s00432-019-02850-1. PMID: 30758670
Comparison of human lung cancer cell radiosensitivity after irradiations with therapeutic protons and carbon ions.
Keta OD, Todorović DV, Bulat TM, Cirrone PG, Romano F, Cuttone G, Petrović IM, Ristić Fira AM
Exp Biol Med (Maywood) 2017 May;242(10):1015-1024. Epub 2016 Sep 15 doi: 10.1177/1535370216669611. PMID: 27633574Free PMC Article
Mixed squamous and large-cell carcinoma of the lung: a case study and literature review.
Katsenos S, Karachaliou I, Archondakis S
J Cancer Res Ther 2012 Jul-Sep;8(3):445-7. doi: 10.4103/0973-1482.103531. PMID: 23174733

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