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Sarcomatoid renal cell carcinoma

MedGen UID:
220411
Concept ID:
C1266043
Neoplastic Process
Synonym: Sarcomatoid Renal Cell Carcinoma
SNOMED CT: Renal cell carcinoma, spindle cell (128668003); Renal cell carcinoma, sarcomatoid (128668003)
 
Monarch Initiative: MONDO:0003012

Definition

A high grade carcinoma of the kidney. It is not a distinct clinicopathological entity and includes a diverse group of renal cell carcinomas which have been transformed from a lower to a higher grade. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Tannir NM, Signoretti S, Choueiri TK, McDermott DF, Motzer RJ, Flaifel A, Pignon JC, Ficial M, Frontera OA, George S, Powles T, Donskov F, Harrison MR, Barthélémy P, Tykodi SS, Kocsis J, Ravaud A, Rodriguez-Cid JR, Pal SK, Murad AM, Ishii Y, Saggi SS, McHenry MB, Rini BI
Clin Cancer Res 2021 Jan 1;27(1):78-86. Epub 2020 Sep 1 doi: 10.1158/1078-0432.CCR-20-2063. PMID: 32873572Free PMC Article
Blum KA, Gupta S, Tickoo SK, Chan TA, Russo P, Motzer RJ, Karam JA, Hakimi AA
Nat Rev Urol 2020 Dec;17(12):659-678. Epub 2020 Oct 13 doi: 10.1038/s41585-020-00382-9. PMID: 33051619Free PMC Article
Mouallem NE, Smith SC, Paul AK
Urol Oncol 2018 Jun;36(6):265-271. Epub 2018 Jan 3 doi: 10.1016/j.urolonc.2017.12.012. PMID: 29306556

Recent clinical studies

Etiology

Saliby RM, El Zarif T, Bakouny Z, Shah V, Xie W, Flippot R, Denize T, Kane MH, Madsen KN, Ficial M, Hirsch L, Wei XX, Steinharter JA, Harshman LC, Vaishampayan UN, Severgnini M, McDermott DF, Lee GM, Xu W, Van Allen EM, McGregor BA, Signoretti S, Choueiri TK, McKay RR, Braun DA
Cancer Immunol Res 2023 Aug 3;11(8):1114-1124. doi: 10.1158/2326-6066.CIR-22-0996. PMID: 37279009Free PMC Article
Cheng M, Duzgol C, Kim TH, Ghafoor S, Becker AS, Causa Andrieu PI, Gangai N, Jiang H, Hakimi AA, Vargas HA, Woo S
Cancer Imaging 2023 Feb 15;23(1):16. doi: 10.1186/s40644-023-00535-0. PMID: 36793052Free PMC Article
Rini BI, Signoretti S, Choueiri TK, McDermott DF, Motzer RJ, George S, Powles T, Donskov F, Tykodi SS, Pal SK, Gupta S, Lee CW, Jiang R, Tannir NM
J Immunother Cancer 2022 Dec;10(12) doi: 10.1136/jitc-2022-005445. PMID: 36549781Free PMC Article
Lee E, Guan P, Lim AH, Loh JW, Tan GF, Loh T, Ng DYX, Lee JY, Goh S, Liu W, Ng CC, Teh BT, Chan JY
Mol Genet Genomic Med 2022 Mar;10(3):e1853. Epub 2022 Feb 5 doi: 10.1002/mgg3.1853. PMID: 35122417Free PMC Article
Park JJ, Kellezi O, Hamasha R, Ali A, Alva AS
Cancer Treat Res Commun 2020;25:100251. Epub 2020 Nov 23 doi: 10.1016/j.ctarc.2020.100251. PMID: 33310369

Diagnosis

Blum KA, Gupta S, Tickoo SK, Chan TA, Russo P, Motzer RJ, Karam JA, Hakimi AA
Nat Rev Urol 2020 Dec;17(12):659-678. Epub 2020 Oct 13 doi: 10.1038/s41585-020-00382-9. PMID: 33051619Free PMC Article
Alevizakos M, Gaitanidis A, Nasioudis D, Msaouel P, Appleman LJ
Clin Genitourin Cancer 2019 Jun;17(3):e447-e453. Epub 2019 Jan 17 doi: 10.1016/j.clgc.2019.01.005. PMID: 30799129
Liang X, Liu Y, Ran P, Tang M, Xu C, Zhu Y
BMC Nephrol 2018 Apr 10;19(1):84. doi: 10.1186/s12882-018-0884-7. PMID: 29636020Free PMC Article
Shuch B, Bratslavsky G, Linehan WM, Srinivasan R
Oncologist 2012;17(1):46-54. Epub 2012 Jan 10 doi: 10.1634/theoncologist.2011-0227. PMID: 22234634Free PMC Article
Li L, Parwani AV
Arch Pathol Lab Med 2011 May;135(5):671-4. doi: 10.5858/2009-0769-RSR.1. PMID: 21526966

Therapy

Adler C, Menias C
Radiology 2024 Aug;312(2):e232149. doi: 10.1148/radiol.232149. PMID: 39189900
Saliby RM, El Zarif T, Bakouny Z, Shah V, Xie W, Flippot R, Denize T, Kane MH, Madsen KN, Ficial M, Hirsch L, Wei XX, Steinharter JA, Harshman LC, Vaishampayan UN, Severgnini M, McDermott DF, Lee GM, Xu W, Van Allen EM, McGregor BA, Signoretti S, Choueiri TK, McKay RR, Braun DA
Cancer Immunol Res 2023 Aug 3;11(8):1114-1124. doi: 10.1158/2326-6066.CIR-22-0996. PMID: 37279009Free PMC Article
Rini BI, Signoretti S, Choueiri TK, McDermott DF, Motzer RJ, George S, Powles T, Donskov F, Tykodi SS, Pal SK, Gupta S, Lee CW, Jiang R, Tannir NM
J Immunother Cancer 2022 Dec;10(12) doi: 10.1136/jitc-2022-005445. PMID: 36549781Free PMC Article
Blum KA, Gupta S, Tickoo SK, Chan TA, Russo P, Motzer RJ, Karam JA, Hakimi AA
Nat Rev Urol 2020 Dec;17(12):659-678. Epub 2020 Oct 13 doi: 10.1038/s41585-020-00382-9. PMID: 33051619Free PMC Article
Li L, Parwani AV
Arch Pathol Lab Med 2011 May;135(5):671-4. doi: 10.5858/2009-0769-RSR.1. PMID: 21526966

Prognosis

Cheng M, Duzgol C, Kim TH, Ghafoor S, Becker AS, Causa Andrieu PI, Gangai N, Jiang H, Hakimi AA, Vargas HA, Woo S
Cancer Imaging 2023 Feb 15;23(1):16. doi: 10.1186/s40644-023-00535-0. PMID: 36793052Free PMC Article
Rini BI, Signoretti S, Choueiri TK, McDermott DF, Motzer RJ, George S, Powles T, Donskov F, Tykodi SS, Pal SK, Gupta S, Lee CW, Jiang R, Tannir NM
J Immunother Cancer 2022 Dec;10(12) doi: 10.1136/jitc-2022-005445. PMID: 36549781Free PMC Article
Blum KA, Gupta S, Tickoo SK, Chan TA, Russo P, Motzer RJ, Karam JA, Hakimi AA
Nat Rev Urol 2020 Dec;17(12):659-678. Epub 2020 Oct 13 doi: 10.1038/s41585-020-00382-9. PMID: 33051619Free PMC Article
Mouallem NE, Smith SC, Paul AK
Urol Oncol 2018 Jun;36(6):265-271. Epub 2018 Jan 3 doi: 10.1016/j.urolonc.2017.12.012. PMID: 29306556
Shuch B, Bratslavsky G, Linehan WM, Srinivasan R
Oncologist 2012;17(1):46-54. Epub 2012 Jan 10 doi: 10.1634/theoncologist.2011-0227. PMID: 22234634Free PMC Article

Clinical prediction guides

Blum KA, Silagy AW, Knezevic A, Weng S, Wang A, Mano R, Marcon J, DiNatale RG, Sanchez A, Tickoo S, Gupta S, Motzer R, Haas NB, Kim SE, Uzzo RG, Coleman JA, Hakimi AA, Russo P
BJU Int 2024 Feb;133(2):169-178. Epub 2023 Sep 9 doi: 10.1111/bju.16125. PMID: 37589200Free PMC Article
Almuradova E, Basoglu T, Nayir E, Bayram E, Paydas S, Gokmen I, Karakaya S, Oksuzoglu B, Erdem D, Sakin A, Atcı M, Belen Gulbagcı B, Hacibekiroglu I, Onder AH, Karaarslan S, Karakurt Eryılmaz M, Korkmaz M, Yazıcı O, Sutcuoglu O, Akagunduz B, Arak H, Sakalar T, Aydin D, Iriagac Y, Alan O, Midik M, Cetin D, Kip AD, Turhal S, Kacan T, Koseci T
Neoplasma 2023 Feb;70(1):158-165. Epub 2023 Jan 9 doi: 10.4149/neo_2022_221004N984. PMID: 36620878
Lee E, Guan P, Lim AH, Loh JW, Tan GF, Loh T, Ng DYX, Lee JY, Goh S, Liu W, Ng CC, Teh BT, Chan JY
Mol Genet Genomic Med 2022 Mar;10(3):e1853. Epub 2022 Feb 5 doi: 10.1002/mgg3.1853. PMID: 35122417Free PMC Article
Weng WH, Yu KJ, Jhan JW, Pang SN, Chiou YE, Pang ST
Anticancer Res 2022 Feb;42(2):811-825. doi: 10.21873/anticanres.15539. PMID: 35093879
Kunene V, Miscoria M, Pirrie S, Islam MR, Afshar M, Porfiri E
Clin Genitourin Cancer 2014 Aug;12(4):251-5. Epub 2013 Dec 27 doi: 10.1016/j.clgc.2013.12.001. PMID: 24560086

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