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Malignant Pericytic Neoplasm

MedGen UID:
233158
•Concept ID:
C1334611
•
Neoplastic Process
Synonyms: Malignant Pericytic Tumor; Malignant Perivascular Neoplasm; Malignant Perivascular Tumor

Definition

A malignant mesenchymal neoplasm arising from the perivascular cells of the connective and soft tissues. It is characterized by the presence of pericytes that grow in a circumferential pattern around vessels, and cytologic atypia. [from NCI]

Professional guidelines

PubMed

Hemangiopericytoma: Incidence, Treatment, and Prognosis Analysis Based on SEER Database.
Wang K, Mei F, Wu S, Tan Z
Biomed Res Int 2020;2020:2468320. Epub 2020 Nov 2 doi: 10.1155/2020/2468320. PMID: 33204688Free PMC Article
PDGF receptors in tumor stroma: Biological effects and associations with prognosis and response to treatment.
Östman A
Adv Drug Deliv Rev 2017 Nov 1;121:117-123. Epub 2017 Sep 29 doi: 10.1016/j.addr.2017.09.022. PMID: 28970051
Normalization of the vasculature for treatment of cancer and other diseases.
Goel S, Duda DG, Xu L, Munn LL, Boucher Y, Fukumura D, Jain RK
Physiol Rev 2011 Jul;91(3):1071-121. doi: 10.1152/physrev.00038.2010. PMID: 21742796Free PMC Article

Recent clinical studies

Etiology

Targeting vascular normalization: a promising strategy to improve immune-vascular crosstalk in cancer immunotherapy.
Qian C, Liu C, Liu W, Zhou R, Zhao L
Front Immunol 2023;14:1291530. Epub 2023 Dec 15 doi: 10.3389/fimmu.2023.1291530. PMID: 38193080Free PMC Article
Cytokines in CAR T Cell-Associated Neurotoxicity.
Gust J, Ponce R, Liles WC, Garden GA, Turtle CJ
Front Immunol 2020;11:577027. Epub 2020 Dec 16 doi: 10.3389/fimmu.2020.577027. PMID: 33391257Free PMC Article
Spinal Cord Tumor Microenvironment.
Rauschenbach L
Adv Exp Med Biol 2020;1226:97-109. doi: 10.1007/978-3-030-36214-0_8. PMID: 32030679
A Distinct Malignant Epithelioid Neoplasm With GLI1 Gene Rearrangements, Frequent S100 Protein Expression, and Metastatic Potential: Expanding the Spectrum of Pathologic Entities With ACTB/MALAT1/PTCH1-GLI1 Fusions.
Antonescu CR, Agaram NP, Sung YS, Zhang L, Swanson D, Dickson BC
Am J Surg Pathol 2018 Apr;42(4):553-560. doi: 10.1097/PAS.0000000000001010. PMID: 29309307Free PMC Article
Haemangiopericytoma of the jaw.
Wushou A, Bai XF, Qi H, Xu Z, Zheng J, Li G
J Craniomaxillofac Surg 2014 Jul;42(5):689-94. Epub 2013 Oct 16 doi: 10.1016/j.jcms.2013.09.016. PMID: 24252622

Diagnosis

Methionine secreted by tumor-associated pericytes supports cancer stem cells in clear cell renal carcinoma.
Zhang C, Du Z, Gao Y, Lim KS, Zhou W, Huang H, He H, Xiao J, Xu D, Li Q
Cell Metab 2024 Apr 2;36(4):778-792.e10. Epub 2024 Feb 19 doi: 10.1016/j.cmet.2024.01.018. PMID: 38378000
TCAF2 in Pericytes Promotes Colorectal Cancer Liver Metastasis via Inhibiting Cold-Sensing TRPM8 Channel.
Li X, Qi Q, Li Y, Miao Q, Yin W, Pan J, Zhao Z, Chen X, Yang F, Zhou X, Huang M, Wang C, Deng L, Huang D, Qi M, Fan S, Zhang Y, Qiu S, Deng W, Liu T, Chen M, Ye W, Zhang D
Adv Sci (Weinh) 2023 Oct;10(30):e2302717. Epub 2023 Aug 27 doi: 10.1002/advs.202302717. PMID: 37635201Free PMC Article
Hand Masses.
Teh J, Shahabpour M, Drape JL, Feydy A, Sudoł-Szopińska I, Vanhoenacker FM
Semin Musculoskelet Radiol 2021 Apr;25(2):216-231. Epub 2021 Jun 3 doi: 10.1055/s-0041-1724017. PMID: 34082448
A Distinct Malignant Epithelioid Neoplasm With GLI1 Gene Rearrangements, Frequent S100 Protein Expression, and Metastatic Potential: Expanding the Spectrum of Pathologic Entities With ACTB/MALAT1/PTCH1-GLI1 Fusions.
Antonescu CR, Agaram NP, Sung YS, Zhang L, Swanson D, Dickson BC
Am J Surg Pathol 2018 Apr;42(4):553-560. doi: 10.1097/PAS.0000000000001010. PMID: 29309307Free PMC Article
The Role of Neutrophilic Inflammation, Angiotropism, and Pericytic Mimicry in Melanoma Progression and Metastasis.
Landsberg J, Tüting T, Barnhill RL, Lugassy C
J Invest Dermatol 2016 Feb;136(2):372-377. doi: 10.1016/j.jid.2015.11.013. PMID: 26802235

Therapy

Targeting vascular normalization: a promising strategy to improve immune-vascular crosstalk in cancer immunotherapy.
Qian C, Liu C, Liu W, Zhou R, Zhao L
Front Immunol 2023;14:1291530. Epub 2023 Dec 15 doi: 10.3389/fimmu.2023.1291530. PMID: 38193080Free PMC Article
Targeting the tumor stroma for cancer therapy.
Xu M, Zhang T, Xia R, Wei Y, Wei X
Mol Cancer 2022 Nov 2;21(1):208. doi: 10.1186/s12943-022-01670-1. PMID: 36324128Free PMC Article
Exercise Training Improves Tumor Control by Increasing CD8(+) T-cell Infiltration via CXCR3 Signaling and Sensitizes Breast Cancer to Immune Checkpoint Blockade.
Gomes-Santos IL, Amoozgar Z, Kumar AS, Ho WW, Roh K, Talele NP, Curtis H, Kawaguchi K, Jain RK, Fukumura D
Cancer Immunol Res 2021 Jul;9(7):765-778. Epub 2021 Apr 10 doi: 10.1158/2326-6066.CIR-20-0499. PMID: 33839688Free PMC Article
Targeting the microenvironment in solid tumors.
Belli C, Trapani D, Viale G, D'Amico P, Duso BA, Della Vigna P, Orsi F, Curigliano G
Cancer Treat Rev 2018 Apr;65:22-32. Epub 2018 Feb 22 doi: 10.1016/j.ctrv.2018.02.004. PMID: 29502037
Normalization of the vasculature for treatment of cancer and other diseases.
Goel S, Duda DG, Xu L, Munn LL, Boucher Y, Fukumura D, Jain RK
Physiol Rev 2011 Jul;91(3):1071-121. doi: 10.1152/physrev.00038.2010. PMID: 21742796Free PMC Article

Prognosis

Tumour vasculature at single-cell resolution.
Pan X, Li X, Dong L, Liu T, Zhang M, Zhang L, Zhang X, Huang L, Shi W, Sun H, Fang Z, Sun J, Huang Y, Shao H, Wang Y, Yin M
Nature 2024 Aug;632(8024):429-436. Epub 2024 Jul 10 doi: 10.1038/s41586-024-07698-1. PMID: 38987599
Integration of Pan-Cancer Single-Cell and Spatial Transcriptomics Reveals Stromal Cell Features and Therapeutic Targets in Tumor Microenvironment.
Du Y, Shi J, Wang J, Xun Z, Yu Z, Sun H, Bao R, Zheng J, Li Z, Ye Y
Cancer Res 2024 Jan 16;84(2):192-210. doi: 10.1158/0008-5472.CAN-23-1418. PMID: 38225927
The single-cell transcriptional landscape of lung carcinoid tumors.
Bischoff P, Trinks A, Wiederspahn J, Obermayer B, Pett JP, Jurmeister P, Elsner A, Dziodzio T, Rückert JC, Neudecker J, Falk C, Beule D, Sers C, Morkel M, Horst D, Klauschen F, Blüthgen N
Int J Cancer 2022 Jun 15;150(12):2058-2071. Epub 2022 Mar 16 doi: 10.1002/ijc.33995. PMID: 35262195
Single-cell RNA sequencing reveals the multi-cellular ecosystem in different radiological components of pulmonary part-solid nodules.
Li Y, Li X, Chen H, Sun K, Li H, Zhou Y, Wang J, Bai F, Yang F
Clin Transl Med 2022 Feb;12(2):e723. doi: 10.1002/ctm2.723. PMID: 35184398Free PMC Article
Investigating immune and non-immune cell interactions in head and neck tumors by single-cell RNA sequencing.
Kürten CHL, Kulkarni A, Cillo AR, Santos PM, Roble AK, Onkar S, Reeder C, Lang S, Chen X, Duvvuri U, Kim S, Liu A, Tabib T, Lafyatis R, Feng J, Gao SJ, Bruno TC, Vignali DAA, Lu X, Bao R, Vujanovic L, Ferris RL
Nat Commun 2021 Dec 17;12(1):7338. doi: 10.1038/s41467-021-27619-4. PMID: 34921143Free PMC Article

Clinical prediction guides

Tumour vasculature at single-cell resolution.
Pan X, Li X, Dong L, Liu T, Zhang M, Zhang L, Zhang X, Huang L, Shi W, Sun H, Fang Z, Sun J, Huang Y, Shao H, Wang Y, Yin M
Nature 2024 Aug;632(8024):429-436. Epub 2024 Jul 10 doi: 10.1038/s41586-024-07698-1. PMID: 38987599
Metastasis-associated fibroblasts in peritoneal surface malignancies.
Ramos C, Gerakopoulos V, Oehler R
Br J Cancer 2024 Aug;131(3):407-419. Epub 2024 May 23 doi: 10.1038/s41416-024-02717-4. PMID: 38783165Free PMC Article
Thrombospondins in the tumor microenvironment.
Petrik J, Lauks S, Garlisi B, Lawler J
Semin Cell Dev Biol 2024 Mar 1;155(Pt B):3-11. Epub 2023 Jun 5 doi: 10.1016/j.semcdb.2023.05.010. PMID: 37286406
Transcriptome analysis reveals tumor microenvironment changes in glioblastoma.
Hoogstrate Y, Draaisma K, Ghisai SA, van Hijfte L, Barin N, de Heer I, Coppieters W, van den Bosch TPP, Bolleboom A, Gao Z, Vincent AJPE, Karim L, Deckers M, Taphoorn MJB, Kerkhof M, Weyerbrock A, Sanson M, Hoeben A, Lukacova S, Lombardi G, Leenstra S, Hanse M, Fleischeuer REM, Watts C, Angelopoulos N, Gorlia T, Golfinopoulos V, Bours V, van den Bent MJ, Robe PA, French PJ
Cancer Cell 2023 Apr 10;41(4):678-692.e7. Epub 2023 Mar 9 doi: 10.1016/j.ccell.2023.02.019. PMID: 36898379
Investigating immune and non-immune cell interactions in head and neck tumors by single-cell RNA sequencing.
Kürten CHL, Kulkarni A, Cillo AR, Santos PM, Roble AK, Onkar S, Reeder C, Lang S, Chen X, Duvvuri U, Kim S, Liu A, Tabib T, Lafyatis R, Feng J, Gao SJ, Bruno TC, Vignali DAA, Lu X, Bao R, Vujanovic L, Ferris RL
Nat Commun 2021 Dec 17;12(1):7338. doi: 10.1038/s41467-021-27619-4. PMID: 34921143Free PMC Article

Recent systematic reviews

Pericyte in Oral Squamous Cell Carcinoma: A Systematic Review.
Valle IB, Schuch LF, da Silva JM, Gala-García A, Diniz IMA, Birbrair A, Abreu LG, Silva TA
Head Neck Pathol 2020 Dec;14(4):1080-1091. Epub 2020 Jun 6 doi: 10.1007/s12105-020-01188-2. PMID: 32506378Free PMC Article

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