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Prostate phyllodes tumor

MedGen UID:
233326
Concept ID:
C1335409
Neoplastic Process
Synonym: Phyllodes tumor of the prostate
SNOMED CT: Phyllodes tumor of prostate (1260182007); Cystic epithelial stromal tumor of prostate (1260182007); Phyllodes type of atypical prostatic hyperplasia (1260182007); Cystosarcoma phyllodes of prostate (1260182007)
 
Monarch Initiative: MONDO:0021102
Orphanet: ORPHA498228

Definition

A rare urogenital tumor characterized by stromal and epithelial components forming cysts lined by hyperplastic epithelium in a cellular or sarcomatoid stroma. The tumors may be clinically benign or malignant and tend to recur after transurethral resection. Metastatic spread is to lungs, bone and liver. Patients may present with obstructive voiding symptoms, dysuria, hematuria, urinary retention or a palpable abdominal mass. The prostate is palpably enlarged but feels soft and spongy. [from SNOMEDCT_US]

Recent clinical studies

Etiology

Acosta AM, Sholl LM, Dickson BC, McKenney JK, Gordetsky JB, Pins MR, Marino-Enriquez A, Dong F, Dubuc AM, Cin PD, Fletcher CDM
Mod Pathol 2021 Sep;34(9):1763-1779. Epub 2021 May 13 doi: 10.1038/s41379-021-00818-6. PMID: 33986460
Hossain D, Meiers I, Qian J, MacLennan GT, Bostwick DG
Arch Pathol Lab Med 2008 Nov;132(11):1729-33. doi: 10.5858/132.11.1729. PMID: 18976007
Bhat DM, Poflee SV, Kotwal MN, Pangarkar MA, Gadkari RU, Bobhate SK
Indian J Cancer 2004 Jul-Sep;41(3):129-32. PMID: 15472412
Bostwick DG, Hossain D, Qian J, Neumann RM, Yang P, Young RH, di Sant'agnese PA, Jones EC
J Urol 2004 Sep;172(3):894-9. doi: 10.1097/01.ju.0000134580.71261.57. PMID: 15310992
Birch JM, Alston RD, McNally RJ, Evans DG, Kelsey AM, Harris M, Eden OB, Varley JM
Oncogene 2001 Aug 2;20(34):4621-8. doi: 10.1038/sj.onc.1204621. PMID: 11498785

Diagnosis

Lorenz U, Samaseika Y, Balsmeyer U, Neumann N, Ritter M, Froehner M
Urology 2021 Nov;157:41. Epub 2021 Jun 15 doi: 10.1016/j.urology.2021.06.003. PMID: 34139252
Bostwick DG, Egevad L
Pathology 2021 Jan;53(1):12-25. Epub 2020 Nov 13 doi: 10.1016/j.pathol.2020.09.017. PMID: 33190920
Probert JL, O'Rourke JS, Farrow R, Cox P
Eur J Surg Oncol 2000 Feb;26(1):100-1. doi: 10.1053/ejso.1999.0749. PMID: 10718190
Fujita K, Matsushima H, Munakata A
Int J Urol 1996 Mar;3(2):158-60. doi: 10.1111/j.1442-2042.1996.tb00504.x. PMID: 8689514
Olson EM, Trambert MA, Mattrey RF
Abdom Imaging 1994 Mar-Apr;19(2):180-1. doi: 10.1007/BF00203500. PMID: 8199557

Therapy

Zhao M, He H, Cao D, Fan D, Xu M, Zhang X, Ru G
Am J Clin Pathol 2022 Jul 1;158(1):35-46. doi: 10.1093/ajcp/aqab211. PMID: 34999741
Aksnessæther BY, Solberg A, Klepp OH, Myklebust TÅ, Skovlund E, Hoff SR, Vatten LJ, Lund JÅ
Int J Radiat Oncol Biol Phys 2018 May 1;101(1):211-216. Epub 2018 Feb 5 doi: 10.1016/j.ijrobp.2018.01.096. PMID: 29534900
Karihtala P, Rissanen T, Tuominen H
Anticancer Res 2016 Jul;36(7):3433-6. PMID: 27354604
Lam KC, Yeo W
J Urol 2002 Sep;168(3):1104-5. doi: 10.1016/S0022-5347(05)64590-9. PMID: 12187238
De Raeve H, Jeuris W, Wyndaele JJ, Van Marck E
Pathol Res Pract 2001;197(10):657-62. doi: 10.1078/0344-0338-00142. PMID: 11700886

Prognosis

Zhao M, He H, Cao D, Fan D, Xu M, Zhang X, Ru G
Am J Clin Pathol 2022 Jul 1;158(1):35-46. doi: 10.1093/ajcp/aqab211. PMID: 34999741
Zhang X, Hu J, Xu X, Cheng L
Indian J Pathol Microbiol 2020 Feb;63(Supplement):S50-S52. doi: 10.4103/IJPM.IJPM_427_18. PMID: 32108628
Aguilar B, Villalobos M, Sotomayor M
Urology 2009 Feb;73(2):272. Epub 2008 Oct 18 doi: 10.1016/j.urology.2008.08.466. PMID: 18930515
Shabaik A
Crit Rev Clin Lab Sci 2003 Aug;40(4):429-72. doi: 10.1080/10408360390247823. PMID: 14582603
De Raeve H, Jeuris W, Wyndaele JJ, Van Marck E
Pathol Res Pract 2001;197(10):657-62. doi: 10.1078/0344-0338-00142. PMID: 11700886

Clinical prediction guides

Tsai JW, Lee JC, Hsieh TH, Huang SC, Lee PH, Liu TT, Kao YC, Chang CD, Weng TF, Li CF, Lin JC, Liang CW, Su YL, Chang IY, Wang YT, Chang NY, Yu SC, Wang JC, Huang HY
Mod Pathol 2022 Jul;35(7):911-921. Epub 2022 Feb 11 doi: 10.1038/s41379-021-01005-3. PMID: 35149769
Zhao M, He H, Cao D, Fan D, Xu M, Zhang X, Ru G
Am J Clin Pathol 2022 Jul 1;158(1):35-46. doi: 10.1093/ajcp/aqab211. PMID: 34999741
Kämpjärvi K, Kim NH, Keskitalo S, Clark AD, von Nandelstadh P, Turunen M, Heikkinen T, Park MJ, Mäkinen N, Kivinummi K, Lintula S, Hotakainen K, Nevanlinna H, Hokland P, Böhling T, Bützow R, Böhm J, Mecklin JP, Järvinen H, Kontro M, Visakorpi T, Taipale J, Varjosalo M, Boyer TG, Vahteristo P
Prostate 2016 Jan;76(1):22-31. Epub 2015 Sep 18 doi: 10.1002/pros.23092. PMID: 26383637
Reikie BA, Yilmaz A, Medlicott S, Trpkov K
Adv Anat Pathol 2015 Mar;22(2):113-20. doi: 10.1097/PAP.0000000000000057. PMID: 25664946
Bostwick DG, Hossain D, Qian J, Neumann RM, Yang P, Young RH, di Sant'agnese PA, Jones EC
J Urol 2004 Sep;172(3):894-9. doi: 10.1097/01.ju.0000134580.71261.57. PMID: 15310992

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