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Type A Spindle Cell Melanoma

MedGen UID:
83148
•Concept ID:
C0334445
•
Neoplastic Process
Synonyms: Malignant Spindle Cell Type A Melanoma; Spindle cell melanoma - type A; Spindle cell melanoma, type A; Spindle Cell Type A Malignant Melanoma
SNOMED CT: Spindle cell melanoma - type A (24653009); Spindle cell melanoma, type A (24653009)

Definition

A melanoma characterized by the presence of malignant spindle-shaped melanocytes with slender nuclei and no visible nucleoli. Representative example is the type A spindle cell uveal melanoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVType A Spindle Cell Melanoma

Professional guidelines

PubMed

Clinical management of melanocytic tumours of uncertain malignant potential (MelTUMPs), including melanocytomas: A systematic review and meta-analysis.
Varey AHR, Williams GJ, Lo SN, Taing CY, Maurichi A, Santinami M, Scolyer RA, Thompson JF
J Eur Acad Dermatol Venereol 2023 May;37(5):859-870. Epub 2022 Nov 7 doi: 10.1111/jdv.18665. PMID: 36251355
Differential diagnosis of heavily pigmented melanocytic lesions: challenges and diagnostic approach.
Aung PP, Mutyambizi KK, Danialan R, Ivan D, Prieto VG
J Clin Pathol 2015 Dec;68(12):963-70. doi: 10.1136/jclinpath-2015-202887. PMID: 26602414
Differential diagnosis of pheochromocytomas and paragangliomas.
McNichol AM
Endocr Pathol 2001 Winter;12(4):407-15. doi: 10.1385/ep:12:4:407. PMID: 11914474

Recent clinical studies

Etiology

Comparison of Melanocyte-Associated Immunohistochemical Markers in Acral Lentiginous Melanoma and Acral Benign Nevi.
Kim JC, Choi JW, Kim YC
Am J Dermatopathol 2023 Nov 1;45(11):748-752. doi: 10.1097/DAD.0000000000002555. PMID: 37856738
Clinical, Morphologic, and Molecular Features of Benign and Intermediate-grade Melanocytic Tumors With Activating Mutations in MAP2K1.
Fumero-Velázquez M, Hagstrom M, Dhillon S, Geraminejad T, Olivares S, Donati M, Nosek D, Waldenbäck P, Kazakov D, Sheffield BS, Tron VA, Gerami P
Am J Surg Pathol 2023 Dec 1;47(12):1438-1448. Epub 2023 Sep 29 doi: 10.1097/PAS.0000000000002131. PMID: 37773074
A systematic review and meta-analysis of animal-type melanoma.
Vyas R, Keller JJ, Honda K, Cooper KD, Gerstenblith MR
J Am Acad Dermatol 2015 Dec;73(6):1031-9. Epub 2015 Sep 26 doi: 10.1016/j.jaad.2015.08.016. PMID: 26412164
PEComa: what do we know so far?
Hornick JL, Fletcher CD
Histopathology 2006 Jan;48(1):75-82. doi: 10.1111/j.1365-2559.2005.02316.x. PMID: 16359539
Iris melanomas.
Geisse LJ, Robertson DM
Am J Ophthalmol 1985 Jun 15;99(6):638-48. doi: 10.1016/s0002-9394(14)76028-3. PMID: 4014387

Diagnosis

Spitz Melanocytic Tumors: A Fascinating 75-Year Journey.
Chatzopoulos K, Syrnioti A, Linos K
Genes (Basel) 2024 Jan 31;15(2) doi: 10.3390/genes15020195. PMID: 38397186Free PMC Article
Comparison of Melanocyte-Associated Immunohistochemical Markers in Acral Lentiginous Melanoma and Acral Benign Nevi.
Kim JC, Choi JW, Kim YC
Am J Dermatopathol 2023 Nov 1;45(11):748-752. doi: 10.1097/DAD.0000000000002555. PMID: 37856738
Clinical, Morphologic, and Molecular Features of Benign and Intermediate-grade Melanocytic Tumors With Activating Mutations in MAP2K1.
Fumero-Velázquez M, Hagstrom M, Dhillon S, Geraminejad T, Olivares S, Donati M, Nosek D, Waldenbäck P, Kazakov D, Sheffield BS, Tron VA, Gerami P
Am J Surg Pathol 2023 Dec 1;47(12):1438-1448. Epub 2023 Sep 29 doi: 10.1097/PAS.0000000000002131. PMID: 37773074
Morphological aspects and therapeutic options in melanoma: a narrative review of the past decade.
Tinca AC, Raicea A, Szőke AR, Cocuz IG, Şincu MC, Niculescu R, Sabău AH, Popelea MC, Fruntelată RF, Cotoi OS
Rom J Morphol Embryol 2023 Apr-Jun;64(2):135-141. doi: 10.47162/RJME.64.2.02. PMID: 37518869Free PMC Article
The many faces of Atypical fibroxanthoma.
Agaimy A
Semin Diagn Pathol 2023 Jul;40(4):306-312. Epub 2023 Jun 23 doi: 10.1053/j.semdp.2023.06.001. PMID: 37438163

Therapy

Iris melanoma in an Australian cohort.
McGrath LA, Warrier SK, Glasson WJ, D'Mellow MG, Hamilton HR, Palmer JM, Brooks KM, Johansson PA, Hayward NK
Clin Exp Ophthalmol 2024 Nov;52(8):880-887. Epub 2024 Jul 24 doi: 10.1111/ceo.14424. PMID: 39048918
Personalized and targeted mutational analysis of multiple second primary melanomas under kinase inhibitors.
Donati M, Zelano G, Coppola R, Cinelli E, Verri M, Persichetti P, Perrella E, Devirgiliis V, Calvieri S, Crescenzi A, Panasiti V
Ital J Dermatol Venerol 2021 Oct;156(5):593-598. Epub 2019 Dec 4 doi: 10.23736/S2784-8671.19.06516-7. PMID: 31804055
Update in molecular diagnostics in melanocytic neoplasms.
Cooper C, Sorrell J, Gerami P
Adv Anat Pathol 2012 Nov;19(6):410-6. doi: 10.1097/PAP.0b013e318271a5cb. PMID: 23060066
BRAF, NRAS and KIT sequencing analysis of spindle cell melanoma.
Kim J, Lazar AJ, Davies MA, Homsi J, Papadopoulos NE, Hwu WJ, Bedikian AY, Woodman SE, Patel SP, Hwu P, Kim KB
J Cutan Pathol 2012 Sep;39(9):821-5. Epub 2012 Jul 19 doi: 10.1111/j.1600-0560.2012.01950.x. PMID: 22809251Free PMC Article
Clinical and pathologic diagnosis, staging and prognostic factors of melanoma and management of primary disease.
Ruiter DJ
Curr Opin Oncol 1992 Apr;4(2):357-67. doi: 10.1097/00001622-199204000-00019. PMID: 1591309

Prognosis

Morphological aspects and therapeutic options in melanoma: a narrative review of the past decade.
Tinca AC, Raicea A, Szőke AR, Cocuz IG, Şincu MC, Niculescu R, Sabău AH, Popelea MC, Fruntelată RF, Cotoi OS
Rom J Morphol Embryol 2023 Apr-Jun;64(2):135-141. doi: 10.47162/RJME.64.2.02. PMID: 37518869Free PMC Article
A systematic review and meta-analysis of animal-type melanoma.
Vyas R, Keller JJ, Honda K, Cooper KD, Gerstenblith MR
J Am Acad Dermatol 2015 Dec;73(6):1031-9. Epub 2015 Sep 26 doi: 10.1016/j.jaad.2015.08.016. PMID: 26412164
Animal-type melanoma - tumor cell invasion of dermal lymphatics and molecular identification of lymph node metastasis.
Posch C, Vesely M, Monshi B, Feichtinger H, Cziegler K, Rappersberger K
J Dtsch Dermatol Ges 2012 Jan;10(1):38-41. Epub 2011 May 3 doi: 10.1111/j.1610-0387.2011.07688.x. PMID: 21539708
PEComa: what do we know so far?
Hornick JL, Fletcher CD
Histopathology 2006 Jan;48(1):75-82. doi: 10.1111/j.1365-2559.2005.02316.x. PMID: 16359539
Iris melanomas.
Geisse LJ, Robertson DM
Am J Ophthalmol 1985 Jun 15;99(6):638-48. doi: 10.1016/s0002-9394(14)76028-3. PMID: 4014387

Clinical prediction guides

Perineural differentiation in neurotized nevi.
Leblebici C, Mod BN, Cin M, Özcan B
Pathol Res Pract 2024 Mar;255:155184. Epub 2024 Feb 1 doi: 10.1016/j.prp.2024.155184. PMID: 38324967
Morphological aspects and therapeutic options in melanoma: a narrative review of the past decade.
Tinca AC, Raicea A, Szőke AR, Cocuz IG, Şincu MC, Niculescu R, Sabău AH, Popelea MC, Fruntelată RF, Cotoi OS
Rom J Morphol Embryol 2023 Apr-Jun;64(2):135-141. doi: 10.47162/RJME.64.2.02. PMID: 37518869Free PMC Article
Clinicopathologic and Dermoscopic Features of 20 Cases of Spark's Nevus, a Dermoscopic Simulator of Melanoma.
Massone C, Stanganelli I, Ingordo V, Ferrara G, Brunasso AMG, Siri G, Casazza S, Gnone M, Pizzichetta MA, Giovanni B, Chiodi S, Sola S
Am J Dermatopathol 2023 Mar 1;45(3):153-162. Epub 2022 Nov 7 doi: 10.1097/DAD.0000000000002323. PMID: 36730758
Diagnostic Cytologic Features of Uveal Melanoma.
Medina CA, Biscotti CV, Singh N, Singh AD
Ophthalmology 2015 Aug;122(8):1580-4. Epub 2015 May 23 doi: 10.1016/j.ophtha.2015.04.013. PMID: 26012864
PEComa: what do we know so far?
Hornick JL, Fletcher CD
Histopathology 2006 Jan;48(1):75-82. doi: 10.1111/j.1365-2559.2005.02316.x. PMID: 16359539

Recent systematic reviews

Clinical management of melanocytic tumours of uncertain malignant potential (MelTUMPs), including melanocytomas: A systematic review and meta-analysis.
Varey AHR, Williams GJ, Lo SN, Taing CY, Maurichi A, Santinami M, Scolyer RA, Thompson JF
J Eur Acad Dermatol Venereol 2023 May;37(5):859-870. Epub 2022 Nov 7 doi: 10.1111/jdv.18665. PMID: 36251355
Clinical and Dermoscopic Features Associated With Difficult-to-Recognize Variants of Cutaneous Melanoma: A Systematic Review.
Pampena R, Lai M, Lombardi M, Mirra M, Raucci M, Lallas A, Apalla Z, Argenziano G, Pellacani G, Longo C
JAMA Dermatol 2020 Apr 1;156(4):430-439. doi: 10.1001/jamadermatol.2019.4912. PMID: 32101255
A systematic review and meta-analysis of animal-type melanoma.
Vyas R, Keller JJ, Honda K, Cooper KD, Gerstenblith MR
J Am Acad Dermatol 2015 Dec;73(6):1031-9. Epub 2015 Sep 26 doi: 10.1016/j.jaad.2015.08.016. PMID: 26412164

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