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Sarcomatoid carcinoma

MedGen UID:: 60009
•Concept ID:: C0205697
•: Neoplastic Process

Synonyms:	Carcinoma, Spindle Cell; Carcinoma, Spindle-Cell; Spindle-Cell Carcinoma; Spindle-Cell Carcinomas
SNOMED CT:	Spindle cell carcinoma (65692009); Sarcomatoid carcinoma (23109009); Polypoid squamous cell carcinoma (65692009); Pseudosarcomatous carcinoma (23109009)

Monarch Initiative:	MONDO:0006406

Definition

A malignant epithelial neoplasm characterized by the presence of spindle cells and anaplastic morphologic features. Giant cells and a sarcomatous component may also be present. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVSarcomatoid carcinoma

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Neoplasm
      - Malignant neoplastic disease
        Anaplastic cancer
        Sarcomatoid carcinoma
        Colorectal Sarcomatoid Carcinoma
        Rectal sarcomatoid carcinoma
        Lung sarcomatoid carcinoma
        Lung Carcinosarcoma
        Lung giant cell carcinoma
        Lung pleomorphic carcinoma
        Lung Spindle Cell Carcinoma
        Pulmonary blastoma
        Pleomorphic carcinoma
        Prostate Acinar Sarcomatoid Carcinoma
        Sarcomatoid basal cell carcinoma
        Sarcomatoid renal cell carcinoma
        Metastatic Sarcomatoid Renal Cell Carcinoma
        Advanced Sarcomatoid Renal Cell Carcinoma
        Locally Advanced Sarcomatoid Renal Cell Carcinoma
        Sarcomatoid squamous cell skin carcinoma
        Conjunctival Spindle Cell Carcinoma
        Esophageal Spindle Cell Carcinoma
        Gingival Spindle Cell Carcinoma
        Laryngeal Squamous Cell Carcinoma, Spindle Cell Variant
        Sarcomatoid penile squamous cell carcinoma
        Sinonasal Spindle Cell Squamous Cell Carcinoma
        Spindle cell variant squamous cell breast carcinoma
        Sarcomatoid transitional cell carcinoma
        Invasive Sarcomatoid Urothelial Carcinoma
        Infiltrating bladder urothelial carcinoma sarcomatoid variant
        Kidney pelvis sarcomatoid transitional cell carcinoma
        Thymic sarcomatoid carcinoma

Professional guidelines

PubMed

Current Advances in the Management of Nonurothelial Subtypes of Bladder Cancer.

Vlachou E, Johnson BA 3rd, Baraban E, Nadal R, Hoffman-Censits J
Am Soc Clin Oncol Educ Book 2024 Jun;44(3):e438640. doi: 10.1200/EDBK_438640. PMID: 38870453

Clinical analysis of 78 pulmonary sarcomatoid carcinomas with surgical treatment.

Gong T, Jia B, Chen C, Zhang Z, Wang C
J Int Med Res 2022 Oct;50(10):3000605221128092. doi: 10.1177/03000605221128092. PMID: 36224744 Free PMC Article

The treatment of advanced pulmonary sarcomatoid carcinoma.

Zheng Y, Fu Y, Zhong Q, Deng R, Zhang Y
Future Oncol 2022 Feb;18(6):727-738. Epub 2021 Dec 9 doi: 10.2217/fon-2021-1071. PMID: 34879738

See all (23)

Recent clinical studies

Etiology

Immunophenotyping of pulmonary sarcomatoid carcinoma.

Ma Y, Li W, Li Z, Chen J, Wang H, Jiang T, Zhu J
Front Immunol 2022;13:976739. Epub 2022 Oct 20 doi: 10.3389/fimmu.2022.976739. PMID: 36341325 Free PMC Article

Subclassification of pleomorphic sarcomas: How and why should we care?

Hornick JL
Ann Diagn Pathol 2018 Dec;37:118-124. Epub 2018 Oct 11 doi: 10.1016/j.anndiagpath.2018.10.006. PMID: 30340082

Sarcomatoid Carcinoma of the Urinary Bladder.

Malla M, Wang JF, Trepeta R, Feng A, Wang J
Clin Genitourin Cancer 2016 Oct;14(5):366-372. Epub 2016 Mar 10 doi: 10.1016/j.clgc.2016.03.004. PMID: 27050715

Histologic classification of prostate cancer.

Mikuz G
Anal Quant Cytopathol Histpathol 2015 Feb;37(1):39-47. PMID: 26072633

Pulmonary sarcomatous tumors.

Litzky LA
Arch Pathol Lab Med 2008 Jul;132(7):1104-17. doi: 10.5858/2008-132-1104-PST. PMID: 18605765

See all (223)

Diagnosis

Sarcoma of the Lung and Mediastinum.

Yoshida KI, Yoshida A
Surg Pathol Clin 2024 Jun;17(2):243-255. Epub 2023 Dec 15 doi: 10.1016/j.path.2023.11.008. PMID: 38692808

Mesenchymal Neoplasms of the Liver.

Papke DJ Jr
Surg Pathol Clin 2023 Sep;16(3):609-634. Epub 2023 Jun 11 doi: 10.1016/j.path.2023.04.013. PMID: 37536892

Once-daily savolitinib in Chinese patients with pulmonary sarcomatoid carcinomas and other non-small-cell lung cancers harbouring MET exon 14 skipping alterations: a multicentre, single-arm, open-label, phase 2 study.

Lu S, Fang J, Li X, Cao L, Zhou J, Guo Q, Liang Z, Cheng Y, Jiang L, Yang N, Han Z, Shi J, Chen Y, Xu H, Zhang H, Chen G, Ma R, Sun S, Fan Y, Li J, Luo X, Wang L, Ren Y, Su W
Lancet Respir Med 2021 Oct;9(10):1154-1164. Epub 2021 Jun 21 doi: 10.1016/S2213-2600(21)00084-9. PMID: 34166627

Mesenchymal tumors of the prostate.

McKenney JK
Mod Pathol 2018 Jan;31(S1):S133-142. doi: 10.1038/modpathol.2017.155. PMID: 29297486

Pulmonary sarcomatous tumors.

Litzky LA
Arch Pathol Lab Med 2008 Jul;132(7):1104-17. doi: 10.5858/2008-132-1104-PST. PMID: 18605765

See all (498)

Therapy

Genomic Landscape of Pulmonary Sarcomatoid Carcinoma.

Kwon HJ, Lee S, Han YB, Lee J, Kwon S, Kim H, Chung JH
Cancer Res Treat 2024 Apr;56(2):442-454. Epub 2023 Nov 14 doi: 10.4143/crt.2023.764. PMID: 37973906 Free PMC Article

The treatment of advanced pulmonary sarcomatoid carcinoma.

Zheng Y, Fu Y, Zhong Q, Deng R, Zhang Y
Future Oncol 2022 Feb;18(6):727-738. Epub 2021 Dec 9 doi: 10.2217/fon-2021-1071. PMID: 34879738

Savolitinib: First Approval.

Markham A
Drugs 2021 Sep;81(14):1665-1670. doi: 10.1007/s40265-021-01584-0. PMID: 34455538

Sarcomatoid Carcinoma of the Urinary Bladder.

Malla M, Wang JF, Trepeta R, Feng A, Wang J
Clin Genitourin Cancer 2016 Oct;14(5):366-372. Epub 2016 Mar 10 doi: 10.1016/j.clgc.2016.03.004. PMID: 27050715

See all (115)

Prognosis

Genetics of Prostate Carcinoma.

Krušlin B, Škara L, Vodopić T, Vrhovec B, Murgić J, Štimac G, Fröbe A, Lež C, Ulamec M, Gall-Trošelj K
Acta Med Acad 2021 Apr;50(1):71-87. doi: 10.5644/ama2006-124.327. PMID: 34075765

The International Society of Urological Pathology (ISUP) grading system for renal cell carcinoma and other prognostic parameters.

Delahunt B, Cheville JC, Martignoni G, Humphrey PA, Magi-Galluzzi C, McKenney J, Egevad L, Algaba F, Moch H, Grignon DJ, Montironi R, Srigley JR; Members of the ISUP Renal Tumor Panel
Am J Surg Pathol 2013 Oct;37(10):1490-504. doi: 10.1097/PAS.0b013e318299f0fb. PMID: 24025520

Sarcomatoid carcinoma of esophagus.

Raza MA, Mazzara PF
Arch Pathol Lab Med 2011 Jul;135(7):945-8. doi: 10.5858/2010-0074-RSR.1. PMID: 21732788

Pulmonary sarcomatous tumors.

Litzky LA
Arch Pathol Lab Med 2008 Jul;132(7):1104-17. doi: 10.5858/2008-132-1104-PST. PMID: 18605765

Grading prostate cancer.

Bostwick DG
Am J Clin Pathol 1994 Oct;102(4 Suppl 1):S38-56. PMID: 7524306

See all (383)

Clinical prediction guides

Survival analysis and nomogram for pulmonary sarcomatoid carcinoma: an SEER analysis and external validation.

Wu W, Zheng L, Li F, Chen H, Huang C, Chen Q, Lin Y, Xu X, Dai Y
BMJ Open 2023 Oct 17;13(10):e072260. doi: 10.1136/bmjopen-2023-072260. PMID: 37848302 Free PMC Article

Immunophenotyping of pulmonary sarcomatoid carcinoma.

Ma Y, Li W, Li Z, Chen J, Wang H, Jiang T, Zhu J
Front Immunol 2022;13:976739. Epub 2022 Oct 20 doi: 10.3389/fimmu.2022.976739. PMID: 36341325 Free PMC Article

Sarcomatoid Carcinoma of the Urinary Bladder.

Malla M, Wang JF, Trepeta R, Feng A, Wang J
Clin Genitourin Cancer 2016 Oct;14(5):366-372. Epub 2016 Mar 10 doi: 10.1016/j.clgc.2016.03.004. PMID: 27050715

Histologic classification of prostate cancer.

Mikuz G
Anal Quant Cytopathol Histpathol 2015 Feb;37(1):39-47. PMID: 26072633

Grading prostate cancer.

Bostwick DG
Am J Clin Pathol 1994 Oct;102(4 Suppl 1):S38-56. PMID: 7524306

See all (174)

Recent systematic reviews

Basal cell carcinosarcoma: a systematic review and reappraisal of its challenges and the role of Mohs surgery.

Born LJ, Khachemoune A
Arch Dermatol Res 2023 Oct;315(8):2195-2205. Epub 2023 Feb 15 doi: 10.1007/s00403-023-02551-3. PMID: 36790451

Adjuvant chemotherapy could improve the survival of pulmonary sarcomatoid carcinoma: A systematic review and meta-analysis.

Zombori-Tóth N, Kiss S, Oštarijaš E, Alizadeh H, Zombori T
Surg Oncol 2022 Sep;44:101824. Epub 2022 Jul 31 doi: 10.1016/j.suronc.2022.101824. PMID: 35952403

Sarcomatoid carcinoma presenting as cancers of unknown primary: a clinicopathological portrait.

Huey RW, Makawita S, Xiao L, Matamoros A, Estrella JS, Overman MJ, Varadhachary GR, Raghav K
BMC Cancer 2019 Oct 17;19(1):965. doi: 10.1186/s12885-019-6155-6. PMID: 31623602 Free PMC Article

Carcinosarcomas of the esophagus: systematic review of a rare nosologic entity.

Schizas D, Mastoraki A, Bagias G, Ioannidi M, Kanavidis P, Moris D, Tsilimigras DI, Spartalis E, Arkadopoulos N, Liakakos T
J BUON 2018 Sep-Oct;23(5):1432-1438. PMID: 30570870

Prostate sarcomatoid carcinoma as accidental finding in transurethral resection of prostate specimen. A case report and systematic review of current literature.

Stamatiou K, Galariotis N, Olympitis M, Papadopoulos P, Moschouris H, Lambrakopoulos A
G Chir 2011 Jan-Feb;32(1-2):23-8. PMID: 21352703

See all (7)

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Sarcomatoid carcinoma

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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