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Sarcomatoid carcinoma

MedGen UID:
60009
•Concept ID:
C0205697
•
Neoplastic Process
Synonyms: Carcinoma, Spindle Cell; Carcinoma, Spindle-Cell; Spindle-Cell Carcinoma; Spindle-Cell Carcinomas
SNOMED CT: Spindle cell carcinoma (65692009); Sarcomatoid carcinoma (23109009); Polypoid squamous cell carcinoma (65692009); Pseudosarcomatous carcinoma (23109009)
 
Monarch Initiative: MONDO:0006406

Definition

A malignant epithelial neoplasm characterized by the presence of spindle cells and anaplastic morphologic features. Giant cells and a sarcomatous component may also be present. [from NCI]

Professional guidelines

PubMed

Current Advances in the Management of Nonurothelial Subtypes of Bladder Cancer.
Vlachou E, Johnson BA 3rd, Baraban E, Nadal R, Hoffman-Censits J
Am Soc Clin Oncol Educ Book 2024 Jun;44(3):e438640. doi: 10.1200/EDBK_438640. PMID: 38870453
Clinical analysis of 78 pulmonary sarcomatoid carcinomas with surgical treatment.
Gong T, Jia B, Chen C, Zhang Z, Wang C
J Int Med Res 2022 Oct;50(10):3000605221128092. doi: 10.1177/03000605221128092. PMID: 36224744Free PMC Article
The treatment of advanced pulmonary sarcomatoid carcinoma.
Zheng Y, Fu Y, Zhong Q, Deng R, Zhang Y
Future Oncol 2022 Feb;18(6):727-738. Epub 2021 Dec 9 doi: 10.2217/fon-2021-1071. PMID: 34879738

Recent clinical studies

Therapy

Genomic Landscape of Pulmonary Sarcomatoid Carcinoma.
Kwon HJ, Lee S, Han YB, Lee J, Kwon S, Kim H, Chung JH
Cancer Res Treat 2024 Apr;56(2):442-454. Epub 2023 Nov 14 doi: 10.4143/crt.2023.764. PMID: 37973906Free PMC Article
The treatment of advanced pulmonary sarcomatoid carcinoma.
Zheng Y, Fu Y, Zhong Q, Deng R, Zhang Y
Future Oncol 2022 Feb;18(6):727-738. Epub 2021 Dec 9 doi: 10.2217/fon-2021-1071. PMID: 34879738
Savolitinib: First Approval.
Markham A
Drugs 2021 Sep;81(14):1665-1670. doi: 10.1007/s40265-021-01584-0. PMID: 34455538
Once-daily savolitinib in Chinese patients with pulmonary sarcomatoid carcinomas and other non-small-cell lung cancers harbouring MET exon 14 skipping alterations: a multicentre, single-arm, open-label, phase 2 study.
Lu S, Fang J, Li X, Cao L, Zhou J, Guo Q, Liang Z, Cheng Y, Jiang L, Yang N, Han Z, Shi J, Chen Y, Xu H, Zhang H, Chen G, Ma R, Sun S, Fan Y, Li J, Luo X, Wang L, Ren Y, Su W
Lancet Respir Med 2021 Oct;9(10):1154-1164. Epub 2021 Jun 21 doi: 10.1016/S2213-2600(21)00084-9. PMID: 34166627
Sarcomatoid Carcinoma of the Urinary Bladder.
Malla M, Wang JF, Trepeta R, Feng A, Wang J
Clin Genitourin Cancer 2016 Oct;14(5):366-372. Epub 2016 Mar 10 doi: 10.1016/j.clgc.2016.03.004. PMID: 27050715

Prognosis

Genetics of Prostate Carcinoma.
Krušlin B, Škara L, Vodopić T, Vrhovec B, Murgić J, Štimac G, Fröbe A, Lež C, Ulamec M, Gall-Trošelj K
Acta Med Acad 2021 Apr;50(1):71-87. doi: 10.5644/ama2006-124.327. PMID: 34075765
The International Society of Urological Pathology (ISUP) grading system for renal cell carcinoma and other prognostic parameters.
Delahunt B, Cheville JC, Martignoni G, Humphrey PA, Magi-Galluzzi C, McKenney J, Egevad L, Algaba F, Moch H, Grignon DJ, Montironi R, Srigley JR; Members of the ISUP Renal Tumor Panel
Am J Surg Pathol 2013 Oct;37(10):1490-504. doi: 10.1097/PAS.0b013e318299f0fb. PMID: 24025520
Sarcomatoid carcinoma of esophagus.
Raza MA, Mazzara PF
Arch Pathol Lab Med 2011 Jul;135(7):945-8. doi: 10.5858/2010-0074-RSR.1. PMID: 21732788
Pulmonary sarcomatous tumors.
Litzky LA
Arch Pathol Lab Med 2008 Jul;132(7):1104-17. doi: 10.5858/2008-132-1104-PST. PMID: 18605765
Grading prostate cancer.
Bostwick DG
Am J Clin Pathol 1994 Oct;102(4 Suppl 1):S38-56. PMID: 7524306

Clinical prediction guides

Survival analysis and nomogram for pulmonary sarcomatoid carcinoma: an SEER analysis and external validation.
Wu W, Zheng L, Li F, Chen H, Huang C, Chen Q, Lin Y, Xu X, Dai Y
BMJ Open 2023 Oct 17;13(10):e072260. doi: 10.1136/bmjopen-2023-072260. PMID: 37848302Free PMC Article
Immunophenotyping of pulmonary sarcomatoid carcinoma.
Ma Y, Li W, Li Z, Chen J, Wang H, Jiang T, Zhu J
Front Immunol 2022;13:976739. Epub 2022 Oct 20 doi: 10.3389/fimmu.2022.976739. PMID: 36341325Free PMC Article
Sarcomatoid Carcinoma of the Urinary Bladder.
Malla M, Wang JF, Trepeta R, Feng A, Wang J
Clin Genitourin Cancer 2016 Oct;14(5):366-372. Epub 2016 Mar 10 doi: 10.1016/j.clgc.2016.03.004. PMID: 27050715
Histologic classification of prostate cancer.
Mikuz G
Anal Quant Cytopathol Histpathol 2015 Feb;37(1):39-47. PMID: 26072633
Grading prostate cancer.
Bostwick DG
Am J Clin Pathol 1994 Oct;102(4 Suppl 1):S38-56. PMID: 7524306

Recent systematic reviews

Basal cell carcinosarcoma: a systematic review and reappraisal of its challenges and the role of Mohs surgery.
Born LJ, Khachemoune A
Arch Dermatol Res 2023 Oct;315(8):2195-2205. Epub 2023 Feb 15 doi: 10.1007/s00403-023-02551-3. PMID: 36790451
Adjuvant chemotherapy could improve the survival of pulmonary sarcomatoid carcinoma: A systematic review and meta-analysis.
Zombori-Tóth N, Kiss S, Oštarijaš E, Alizadeh H, Zombori T
Surg Oncol 2022 Sep;44:101824. Epub 2022 Jul 31 doi: 10.1016/j.suronc.2022.101824. PMID: 35952403
Sarcomatoid carcinoma presenting as cancers of unknown primary: a clinicopathological portrait.
Huey RW, Makawita S, Xiao L, Matamoros A, Estrella JS, Overman MJ, Varadhachary GR, Raghav K
BMC Cancer 2019 Oct 17;19(1):965. doi: 10.1186/s12885-019-6155-6. PMID: 31623602Free PMC Article
Carcinosarcomas of the esophagus: systematic review of a rare nosologic entity.
Schizas D, Mastoraki A, Bagias G, Ioannidi M, Kanavidis P, Moris D, Tsilimigras DI, Spartalis E, Arkadopoulos N, Liakakos T
J BUON 2018 Sep-Oct;23(5):1432-1438. PMID: 30570870
Prostate sarcomatoid carcinoma as accidental finding in transurethral resection of prostate specimen. A case report and systematic review of current literature.
Stamatiou K, Galariotis N, Olympitis M, Papadopoulos P, Moschouris H, Lambrakopoulos A
G Chir 2011 Jan-Feb;32(1-2):23-8. PMID: 21352703

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