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Transplant-Related Hepatocellular Carcinoma

MedGen UID:
234439
•Concept ID:
C1336811
•
Neoplastic Process

Definition

A hepatocellular carcinoma that arises in a patient with a history of organ transplantation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTransplant-Related Hepatocellular Carcinoma

Professional guidelines

PubMed

Complications after Liver Transplant Related to Preexisting Conditions: Diagnosis, Treatment, and Prevention.
Horrow MM, Huynh ML, Callaghan MM, Rodgers SK
Radiographics 2020 May-Jun;40(3):895-909. Epub 2020 Apr 10 doi: 10.1148/rg.2019190120. PMID: 32281901
Hepatitis C and diabetes: one treatment for two diseases?
Pattullo V, Heathcote J
Liver Int 2010 Mar;30(3):356-64. Epub 2009 Dec 22 doi: 10.1111/j.1478-3231.2009.02185.x. PMID: 20040049

Recent clinical studies

Etiology

Big Data in Transplantation Practice-the Devil Is in the Detail-Fontan-associated Liver Disease.
Kim MH, Nguyen A, Lo M, Kumar SR, Bucuvalas J, Glynn EF, Hoffman MA, Fischer R, Emamaullee J
Transplantation 2021 Jan 1;105(1):18-22. doi: 10.1097/TP.0000000000003308. PMID: 32639398
Research priorities in Fontan-associated liver disease.
Khan S, Aziz H, Emamaullee J
Curr Opin Organ Transplant 2020 Oct;25(5):489-495. doi: 10.1097/MOT.0000000000000803. PMID: 32833705
Pro (With Caution): Extended oncologic indications in liver transplantation.
Mazzaferro V, Battiston C, Sposito C
Liver Transpl 2018 Jan;24(1):98-103. Epub 2017 Dec 8 doi: 10.1002/lt.24963. PMID: 29077253
Aging of Liver Transplant Registrants and Recipients: Trends and Impact on Waitlist Outcomes, Post-Transplantation Outcomes, and Transplant-Related Survival Benefit.
Su F, Yu L, Berry K, Liou IW, Landis CS, Rayhill SC, Reyes JD, Ioannou GN
Gastroenterology 2016 Feb;150(2):441-53.e6; quiz e16. Epub 2015 Oct 30 doi: 10.1053/j.gastro.2015.10.043. PMID: 26522262
Hepatitis C and diabetes: one treatment for two diseases?
Pattullo V, Heathcote J
Liver Int 2010 Mar;30(3):356-64. Epub 2009 Dec 22 doi: 10.1111/j.1478-3231.2009.02185.x. PMID: 20040049

Diagnosis

Big Data in Transplantation Practice-the Devil Is in the Detail-Fontan-associated Liver Disease.
Kim MH, Nguyen A, Lo M, Kumar SR, Bucuvalas J, Glynn EF, Hoffman MA, Fischer R, Emamaullee J
Transplantation 2021 Jan 1;105(1):18-22. doi: 10.1097/TP.0000000000003308. PMID: 32639398
Research priorities in Fontan-associated liver disease.
Khan S, Aziz H, Emamaullee J
Curr Opin Organ Transplant 2020 Oct;25(5):489-495. doi: 10.1097/MOT.0000000000000803. PMID: 32833705
Complications after Liver Transplant Related to Preexisting Conditions: Diagnosis, Treatment, and Prevention.
Horrow MM, Huynh ML, Callaghan MM, Rodgers SK
Radiographics 2020 May-Jun;40(3):895-909. Epub 2020 Apr 10 doi: 10.1148/rg.2019190120. PMID: 32281901
Retransplant as Rescue Treatment for ABO-Compatible Living-Donor Liver Transplant Related Antibody-Mediated Rejection: A Case Report.
Ho MH, Wu SY, Ou KW, Su TF, Hsieh CB
Exp Clin Transplant 2018 Apr;16(2):222-226. Epub 2016 Jan 8 doi: 10.6002/ect.2015.0308. PMID: 26742858
Aging of Liver Transplant Registrants and Recipients: Trends and Impact on Waitlist Outcomes, Post-Transplantation Outcomes, and Transplant-Related Survival Benefit.
Su F, Yu L, Berry K, Liou IW, Landis CS, Rayhill SC, Reyes JD, Ioannou GN
Gastroenterology 2016 Feb;150(2):441-53.e6; quiz e16. Epub 2015 Oct 30 doi: 10.1053/j.gastro.2015.10.043. PMID: 26522262

Therapy

Big Data in Transplantation Practice-the Devil Is in the Detail-Fontan-associated Liver Disease.
Kim MH, Nguyen A, Lo M, Kumar SR, Bucuvalas J, Glynn EF, Hoffman MA, Fischer R, Emamaullee J
Transplantation 2021 Jan 1;105(1):18-22. doi: 10.1097/TP.0000000000003308. PMID: 32639398
Retransplant as Rescue Treatment for ABO-Compatible Living-Donor Liver Transplant Related Antibody-Mediated Rejection: A Case Report.
Ho MH, Wu SY, Ou KW, Su TF, Hsieh CB
Exp Clin Transplant 2018 Apr;16(2):222-226. Epub 2016 Jan 8 doi: 10.6002/ect.2015.0308. PMID: 26742858
Fontan-associated liver disease: Implications for heart transplantation.
Greenway SC, Crossland DS, Hudson M, Martin SR, Myers RP, Prieur T, Hasan A, Kirk R
J Heart Lung Transplant 2016 Jan;35(1):26-33. Epub 2015 Oct 19 doi: 10.1016/j.healun.2015.10.015. PMID: 26586487
Aging of Liver Transplant Registrants and Recipients: Trends and Impact on Waitlist Outcomes, Post-Transplantation Outcomes, and Transplant-Related Survival Benefit.
Su F, Yu L, Berry K, Liou IW, Landis CS, Rayhill SC, Reyes JD, Ioannou GN
Gastroenterology 2016 Feb;150(2):441-53.e6; quiz e16. Epub 2015 Oct 30 doi: 10.1053/j.gastro.2015.10.043. PMID: 26522262
Hepatitis C and diabetes: one treatment for two diseases?
Pattullo V, Heathcote J
Liver Int 2010 Mar;30(3):356-64. Epub 2009 Dec 22 doi: 10.1111/j.1478-3231.2009.02185.x. PMID: 20040049

Prognosis

Big Data in Transplantation Practice-the Devil Is in the Detail-Fontan-associated Liver Disease.
Kim MH, Nguyen A, Lo M, Kumar SR, Bucuvalas J, Glynn EF, Hoffman MA, Fischer R, Emamaullee J
Transplantation 2021 Jan 1;105(1):18-22. doi: 10.1097/TP.0000000000003308. PMID: 32639398
Frailty as Tested by Gait Speed Is a Risk Factor for Liver Transplant Respiratory Complications.
Salim TI, Nestlerode LC, Lucatorto EL, Wasserman TL, Din HA, Landsittel DP, Tevar AD, Johnson JT, Duarte-Rojo A, Dunn MA
Am J Gastroenterol 2020 Jun;115(6):859-866. doi: 10.14309/ajg.0000000000000609. PMID: 32235146
Pro (With Caution): Extended oncologic indications in liver transplantation.
Mazzaferro V, Battiston C, Sposito C
Liver Transpl 2018 Jan;24(1):98-103. Epub 2017 Dec 8 doi: 10.1002/lt.24963. PMID: 29077253
Transplant-related survival benefit should influence prioritization for liver transplantation especially in patients with hepatocellular carcinoma.
Ioannou GN
Liver Transpl 2017 May;23(5):652-662. doi: 10.1002/lt.24690. PMID: 28006870
Comparison of Liver Transplant-Related Survival Benefit in Patients With Versus Without Hepatocellular Carcinoma in the United States.
Berry K, Ioannou GN
Gastroenterology 2015 Sep;149(3):669-80; quiz e15-6. Epub 2015 May 27 doi: 10.1053/j.gastro.2015.05.025. PMID: 26021233

Clinical prediction guides

Frailty as Tested by Gait Speed Is a Risk Factor for Liver Transplant Respiratory Complications.
Salim TI, Nestlerode LC, Lucatorto EL, Wasserman TL, Din HA, Landsittel DP, Tevar AD, Johnson JT, Duarte-Rojo A, Dunn MA
Am J Gastroenterol 2020 Jun;115(6):859-866. doi: 10.14309/ajg.0000000000000609. PMID: 32235146
The optimal timing of hepatitis C therapy in liver transplant-eligible patients: Cost-effectiveness analysis of new opportunities.
Cortesi PA, Belli LS, Facchetti R, Mazzarelli C, Perricone G, De Nicola S, Cesana G, Duvoux C, Mantovani LG, Strazzabosco M; European Liver and Intestine Transplant Association (ELITA)
J Viral Hepat 2018 Jul;25(7):791-801. Epub 2018 Mar 8 doi: 10.1111/jvh.12877. PMID: 29406608
Pro (With Caution): Extended oncologic indications in liver transplantation.
Mazzaferro V, Battiston C, Sposito C
Liver Transpl 2018 Jan;24(1):98-103. Epub 2017 Dec 8 doi: 10.1002/lt.24963. PMID: 29077253
Transplant-related survival benefit should influence prioritization for liver transplantation especially in patients with hepatocellular carcinoma.
Ioannou GN
Liver Transpl 2017 May;23(5):652-662. doi: 10.1002/lt.24690. PMID: 28006870
Aging of Liver Transplant Registrants and Recipients: Trends and Impact on Waitlist Outcomes, Post-Transplantation Outcomes, and Transplant-Related Survival Benefit.
Su F, Yu L, Berry K, Liou IW, Landis CS, Rayhill SC, Reyes JD, Ioannou GN
Gastroenterology 2016 Feb;150(2):441-53.e6; quiz e16. Epub 2015 Oct 30 doi: 10.1053/j.gastro.2015.10.043. PMID: 26522262

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