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Advanced Malignant Germ Cell Tumor

MedGen UID:
1767705
•Concept ID:
C5418911
•
Neoplastic Process

Definition

A malignant germ cell tumor that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Malignant Germ Cell Tumor

Professional guidelines

PubMed

EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood.
Weller M, van den Bent M, Preusser M, Le Rhun E, Tonn JC, Minniti G, Bendszus M, Balana C, Chinot O, Dirven L, French P, Hegi ME, Jakola AS, Platten M, Roth P, Rudà R, Short S, Smits M, Taphoorn MJB, von Deimling A, Westphal M, Soffietti R, Reifenberger G, Wick W
Nat Rev Clin Oncol 2021 Mar;18(3):170-186. Epub 2020 Dec 8 doi: 10.1038/s41571-020-00447-z. PMID: 33293629Free PMC Article
Current state of melanoma diagnosis and treatment.
Davis LE, Shalin SC, Tackett AJ
Cancer Biol Ther 2019;20(11):1366-1379. Epub 2019 Aug 1 doi: 10.1080/15384047.2019.1640032. PMID: 31366280Free PMC Article
Expert consensus document: Clinical and molecular diagnosis, screening and management of Beckwith-Wiedemann syndrome: an international consensus statement.
Brioude F, Kalish JM, Mussa A, Foster AC, Bliek J, Ferrero GB, Boonen SE, Cole T, Baker R, Bertoletti M, Cocchi G, Coze C, De Pellegrin M, Hussain K, Ibrahim A, Kilby MD, Krajewska-Walasek M, Kratz CP, Ladusans EJ, Lapunzina P, Le Bouc Y, Maas SM, Macdonald F, Õunap K, Peruzzi L, Rossignol S, Russo S, Shipster C, Skórka A, Tatton-Brown K, Tenorio J, Tortora C, Grønskov K, Netchine I, Hennekam RC, Prawitt D, Tümer Z, Eggermann T, Mackay DJG, Riccio A, Maher ER
Nat Rev Endocrinol 2018 Apr;14(4):229-249. Epub 2018 Jan 29 doi: 10.1038/nrendo.2017.166. PMID: 29377879Free PMC Article

Recent clinical studies

Etiology

Perinatal (fetal and neonatal) germ cell tumors.
Isaacs H Jr
J Pediatr Surg 2004 Jul;39(7):1003-13. doi: 10.1016/j.jpedsurg.2004.03.045. PMID: 15213888
Response to high-dose cisplatin and etoposide in advanced germ cell tumors in children: results of the Brazilian Germ Cell Tumor Study.
Lopes LF, de Camargo B, Dondonis M, de Araujo RA, Morinaka E
Med Pediatr Oncol 1995 Nov;25(5):396-9. doi: 10.1002/mpo.2950250506. PMID: 7674997

Diagnosis

Perinatal (fetal and neonatal) germ cell tumors.
Isaacs H Jr
J Pediatr Surg 2004 Jul;39(7):1003-13. doi: 10.1016/j.jpedsurg.2004.03.045. PMID: 15213888
Response to high-dose cisplatin and etoposide in advanced germ cell tumors in children: results of the Brazilian Germ Cell Tumor Study.
Lopes LF, de Camargo B, Dondonis M, de Araujo RA, Morinaka E
Med Pediatr Oncol 1995 Nov;25(5):396-9. doi: 10.1002/mpo.2950250506. PMID: 7674997

Therapy

Response to high-dose cisplatin and etoposide in advanced germ cell tumors in children: results of the Brazilian Germ Cell Tumor Study.
Lopes LF, de Camargo B, Dondonis M, de Araujo RA, Morinaka E
Med Pediatr Oncol 1995 Nov;25(5):396-9. doi: 10.1002/mpo.2950250506. PMID: 7674997

Prognosis

Perinatal (fetal and neonatal) germ cell tumors.
Isaacs H Jr
J Pediatr Surg 2004 Jul;39(7):1003-13. doi: 10.1016/j.jpedsurg.2004.03.045. PMID: 15213888
Response to high-dose cisplatin and etoposide in advanced germ cell tumors in children: results of the Brazilian Germ Cell Tumor Study.
Lopes LF, de Camargo B, Dondonis M, de Araujo RA, Morinaka E
Med Pediatr Oncol 1995 Nov;25(5):396-9. doi: 10.1002/mpo.2950250506. PMID: 7674997

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