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Epithelioid cell uveal melanoma

MedGen UID:
234223
•Concept ID:
C1333422
•
Neoplastic Process
Synonyms: epithelioid cell melanoma of uvea; Epithelioid Cell Uveal Melanoma; epithelioid cell uveal melanoma; uvea epithelioid cell melanoma; Uveal Epithelioid Cell Melanoma; uveal epithelioid cell melanoma
 
Monarch Initiative: MONDO:0006200

Definition

A uveal melanoma characterized by the presence of malignant large epithelioid melanocytes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEpithelioid cell uveal melanoma

Professional guidelines

PubMed

Genetic findings in treatment-naïve and proton-beam-radiated iris melanomas.
Krishna Y, Kalirai H, Thornton S, Damato BE, Heimann H, Coupland SE
Br J Ophthalmol 2016 Jul;100(7):1012-1016. Epub 2016 Apr 20 doi: 10.1136/bjophthalmol-2015-308301. PMID: 27098748
Characterization, treatment, and outcome of uveal melanoma in the first two years of life.
Yousef YA, Alkilany M
Hematol Oncol Stem Cell Ther 2015 Mar;8(1):1-5. Epub 2014 Oct 6 doi: 10.1016/j.hemonc.2014.09.004. PMID: 25300563
Update on the management of posterior uveal melanoma.
Zhao DY, Shields CL, Shields JA, Gunduz K
J Ophthalmic Nurs Technol 1998 Mar-Apr;17(2):66-71. PMID: 9677975

Recent clinical studies

Etiology

Biopsy for molecular risk stratification in uveal melanoma: Yields and molecular characteristics in 119 patients.
Lin V, Chung IY, Toumi E, McKay D, McKenzie J, McKelvie P, Zabih F, Hoffmeister A, Wright D, Ntzaferi A, Wu IJ, Hesson L, Fung A, Lim LA, Wong S, Field A, Earls P, Giblin M, Conway RM, Cherepanoff S
Clin Exp Ophthalmol 2022 Jan;50(1):50-61. Epub 2021 Nov 14 doi: 10.1111/ceo.14022. PMID: 34714583
Epidemiological trends in uveal melanoma.
Andreoli MT, Mieler WF, Leiderman YI
Br J Ophthalmol 2015 Nov;99(11):1550-3. Epub 2015 Apr 22 doi: 10.1136/bjophthalmol-2015-306810. PMID: 25904122
Characterization, treatment, and outcome of uveal melanoma in the first two years of life.
Yousef YA, Alkilany M
Hematol Oncol Stem Cell Ther 2015 Mar;8(1):1-5. Epub 2014 Oct 6 doi: 10.1016/j.hemonc.2014.09.004. PMID: 25300563
The pathology of ocular cancer.
Eagle RC Jr
Eye (Lond) 2013 Feb;27(2):128-36. Epub 2012 Nov 16 doi: 10.1038/eye.2012.237. PMID: 23154492Free PMC Article
Eye-wall resection.
Char DH, Miller T, Crawford JB
Trans Am Ophthalmol Soc 2000;98:153-9; discussion 159-61. PMID: 11190019Free PMC Article

Diagnosis

Biopsy for molecular risk stratification in uveal melanoma: Yields and molecular characteristics in 119 patients.
Lin V, Chung IY, Toumi E, McKay D, McKenzie J, McKelvie P, Zabih F, Hoffmeister A, Wright D, Ntzaferi A, Wu IJ, Hesson L, Fung A, Lim LA, Wong S, Field A, Earls P, Giblin M, Conway RM, Cherepanoff S
Clin Exp Ophthalmol 2022 Jan;50(1):50-61. Epub 2021 Nov 14 doi: 10.1111/ceo.14022. PMID: 34714583
Epidemiological trends in uveal melanoma.
Andreoli MT, Mieler WF, Leiderman YI
Br J Ophthalmol 2015 Nov;99(11):1550-3. Epub 2015 Apr 22 doi: 10.1136/bjophthalmol-2015-306810. PMID: 25904122
Uveal melanoma: estimating prognosis.
Kaliki S, Shields CL, Shields JA
Indian J Ophthalmol 2015 Feb;63(2):93-102. doi: 10.4103/0301-4738.154367. PMID: 25827538Free PMC Article
Characterization, treatment, and outcome of uveal melanoma in the first two years of life.
Yousef YA, Alkilany M
Hematol Oncol Stem Cell Ther 2015 Mar;8(1):1-5. Epub 2014 Oct 6 doi: 10.1016/j.hemonc.2014.09.004. PMID: 25300563
Tumours associated with BAP1 mutations.
Murali R, Wiesner T, Scolyer RA
Pathology 2013 Feb;45(2):116-26. doi: 10.1097/PAT.0b013e32835d0efb. PMID: 23277170

Therapy

Utility of next-generation sequencing in the diagnosis of metastatic melanoma: A case report.
Turcios Escobar S, Yang R, Nelson KC, Gershenwald JE, Tawbi H, Aung PP, Patel SP, Torres-Cabala CA
J Cutan Pathol 2024 Sep;51(9):644-648. Epub 2024 May 16 doi: 10.1111/cup.14660. PMID: 38757469
No differences in the long-term prognosis of iris and choroidal melanomas when adjusting for tumor thickness and diameter.
Sabazade S, Herrspiegel C, Gill V, Stålhammar G
BMC Cancer 2021 Nov 24;21(1):1270. doi: 10.1186/s12885-021-09002-0. PMID: 34819035Free PMC Article
Beta-blockers exert potent anti-tumor effects in cutaneous and uveal melanoma.
Bustamante P, Miyamoto D, Goyeneche A, de Alba Graue PG, Jin E, Tsering T, Dias AB, Burnier MN, Burnier JV
Cancer Med 2019 Dec;8(17):7265-7277. Epub 2019 Oct 7 doi: 10.1002/cam4.2594. PMID: 31588689Free PMC Article
GDF11 upregulation independently predicts shorter overall-survival of uveal melanoma.
Liu X, Zhang Q, Fan C, Tian J, Liu X, Li G
PLoS One 2019;14(3):e0214073. Epub 2019 Mar 18 doi: 10.1371/journal.pone.0214073. PMID: 30883611Free PMC Article
Congenital uveal malignant melanoma.
Pukrushpan P, Tulvatana W, Pittayapongpat R
J AAPOS 2014 Apr;18(2):199-201. doi: 10.1016/j.jaapos.2013.11.020. PMID: 24698625

Prognosis

Next-generation sequencing of uveal melanoma with clinical and histological correlations: Prognostic value of new mutations in the PI3K/AKT/mTOR pathway.
Pérez-Pérez M, Agostino A, de Sola-Llamas CG, Ruvolo M, Vilches-Arenas A, Relimpio-López MI, Espejo-Arjona F, Macías-García L, De Miguel-Rodríguez M, García-Escudero A, Idoate MA, Ríos-Martín JJ
Clin Exp Ophthalmol 2023 Nov;51(8):822-834. Epub 2023 Oct 6 doi: 10.1111/ceo.14302. PMID: 37803816
Incidence and mortality of uveal melanoma in Australia (1982-2014).
Beasley AB, Preen DB, McLenachan S, Gray ES, Chen FK
Br J Ophthalmol 2023 Mar;107(3):406-411. Epub 2021 Dec 8 doi: 10.1136/bjophthalmol-2021-319700. PMID: 34880052Free PMC Article
Uveal melanoma: estimating prognosis.
Kaliki S, Shields CL, Shields JA
Indian J Ophthalmol 2015 Feb;63(2):93-102. doi: 10.4103/0301-4738.154367. PMID: 25827538Free PMC Article
Tumours associated with BAP1 mutations.
Murali R, Wiesner T, Scolyer RA
Pathology 2013 Feb;45(2):116-26. doi: 10.1097/PAT.0b013e32835d0efb. PMID: 23277170
The pathology of ocular cancer.
Eagle RC Jr
Eye (Lond) 2013 Feb;27(2):128-36. Epub 2012 Nov 16 doi: 10.1038/eye.2012.237. PMID: 23154492Free PMC Article

Clinical prediction guides

Characterisation of the protein expression of the emerging immunotherapy targets VISTA, LAG-3 and PRAME in primary uveal melanoma: insights from a southern French patient cohort.
Lamas NJ, Lassalle S, Martel A, Nahon-Estève S, Macocco A, Zahaf K, Lalvee S, Fayada J, Lespinet-Fabre V, Bordone O, Pedeutour F, Baillif S, Hofman P
Pathology 2023 Dec;55(7):929-944. Epub 2023 Sep 22 doi: 10.1016/j.pathol.2023.08.003. PMID: 37863710
Expression of Cell Cycle Markers and Proliferation Factors during Human Eye Embryogenesis and Tumorigenesis.
Marin Lovrić J, Filipović N, Znaor L, Rančić A, Petričević J, Kunac N, Šoljić V, Saraga-Babić M, Vukojević K
Int J Mol Sci 2022 Aug 20;23(16) doi: 10.3390/ijms23169421. PMID: 36012688Free PMC Article
Diagnostic Cytologic Features of Uveal Melanoma.
Medina CA, Biscotti CV, Singh N, Singh AD
Ophthalmology 2015 Aug;122(8):1580-4. Epub 2015 May 23 doi: 10.1016/j.ophtha.2015.04.013. PMID: 26012864
Epidemiological trends in uveal melanoma.
Andreoli MT, Mieler WF, Leiderman YI
Br J Ophthalmol 2015 Nov;99(11):1550-3. Epub 2015 Apr 22 doi: 10.1136/bjophthalmol-2015-306810. PMID: 25904122
Uveal melanoma: estimating prognosis.
Kaliki S, Shields CL, Shields JA
Indian J Ophthalmol 2015 Feb;63(2):93-102. doi: 10.4103/0301-4738.154367. PMID: 25827538Free PMC Article

Recent systematic reviews

Characterization, treatment, and outcome of uveal melanoma in the first two years of life.
Yousef YA, Alkilany M
Hematol Oncol Stem Cell Ther 2015 Mar;8(1):1-5. Epub 2014 Oct 6 doi: 10.1016/j.hemonc.2014.09.004. PMID: 25300563

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