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Malignant testicular germ cell tumor

MedGen UID:
163616
•Concept ID:
C0855197
•
Neoplastic Process
Synonyms: Malignant Germ Cell Neoplasm of Testis; malignant germ cell neoplasm of testis; Malignant Germ Cell Neoplasm of the Testis; malignant germ cell neoplasm of the testis; Malignant germ cell tumor of testis; Malignant Germ Cell Tumor of Testis; malignant germ cell tumor of testis; Malignant Germ Cell Tumor of the Testis; malignant germ cell tumor of the testis; malignant germ cell tumour of testis; malignant germ cell tumour of the testis; Malignant Testicular Germ Cell Neoplasm; malignant testicular germ cell neoplasm; Malignant Testicular Germ Cell Tumor; malignant testicular germ cell tumor; testicular ca. (no germ/tropho.); Testicular Cancer; testicular cancer (excluding germ cell or trophoblastic cancer); Testicular Germ Cell Cancer; testicular germ cell cancer; testicular malignant germ cell cancer
SNOMED CT: Malignant germ cell tumor of testis (713646001)
 
Monarch Initiative: MONDO:0003510

Definition

A malignant germ cell tumor that arises from the testis. It predominantly affects young men. Seminoma is the most frequently seen malignant testicular germ cell tumor, followed by embryonal carcinoma and yolk sac tumor. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant testicular germ cell tumor

Professional guidelines

PubMed

Adolescent and Young Adult Germ Cell Tumors: Epidemiology, Genomics, Treatment, and Survivorship.
Travis LB, Feldman DR, Fung C, Poynter JN, Lockley M, Frazier AL
J Clin Oncol 2024 Feb 20;42(6):696-706. Epub 2023 Oct 11 doi: 10.1200/JCO.23.01099. PMID: 37820296
Advances in diagnosis and treatment of testicular cancer.
Chovanec M, Cheng L
BMJ 2022 Nov 28;379:e070499. doi: 10.1136/bmj-2022-070499. PMID: 36442868
Testicular germ cell cancer: recent developments in biology and clinical management.
Rajpert-De Meyts E
Andrology 2019 Jul;7(4):391-393. doi: 10.1111/andr.12675. PMID: 31310059

Recent clinical studies

Etiology

Familial Male-limited Precocious Puberty (FMPP) and Testicular Germ Cell Tumors.
Kooij CD, Mavinkurve-Groothuis AMC, Kremer Hovinga ICL, Looijenga LHJ, Rinne T, Giltay JC, de Kort LMO, Klijn AJ, de Krijger RR, Verrijn Stuart AA
J Clin Endocrinol Metab 2022 Nov 23;107(11):3035-3044. doi: 10.1210/clinem/dgac516. PMID: 36071555Free PMC Article
The International Testicular Cancer Linkage Consortium: a clinicopathologic descriptive analysis of 461 familial malignant testicular germ cell tumor kindred.
Mai PL, Friedlander M, Tucker K, Phillips KA, Hogg D, Jewett MA, Lohynska R, Daugaard G, Richard S, Bonaïti-Pellié C, Heidenreich A, Albers P, Bodrogi I, Geczi L, Olah E, Daly PA, Guilford P, Fosså SD, Heimdal K, Liubchenko L, Tjulandin SA, Stoll H, Weber W, Easton DF, Dudakia D, Huddart R, Stratton MR, Einhorn L, Korde L, Nathanson KL, Bishop DT, Rapley EA, Greene MH
Urol Oncol 2010 Sep-Oct;28(5):492-9. Epub 2009 Jan 22 doi: 10.1016/j.urolonc.2008.10.004. PMID: 19162511Free PMC Article

Diagnosis

Familial Male-limited Precocious Puberty (FMPP) and Testicular Germ Cell Tumors.
Kooij CD, Mavinkurve-Groothuis AMC, Kremer Hovinga ICL, Looijenga LHJ, Rinne T, Giltay JC, de Kort LMO, Klijn AJ, de Krijger RR, Verrijn Stuart AA
J Clin Endocrinol Metab 2022 Nov 23;107(11):3035-3044. doi: 10.1210/clinem/dgac516. PMID: 36071555Free PMC Article
Cellular origin of microRNA-371a-3p in healthy males based on systematic urogenital tract tissue evaluation.
Boellaard WPA, Gillis AJM, van Leenders GJLH, Stoop H, van Agthoven T, Dorssers LCJ, Dinkelman-Smit M, Boormans JL, Looijenga LHJ
Andrology 2019 Jul;7(4):463-468. Epub 2019 Feb 20 doi: 10.1111/andr.12595. PMID: 30786164Free PMC Article
Metastatic cardiac tumors: literature review and own observation of testicular tumor metastasis in the right ventricle of the heart.
Zakhartseva LM, Zakharova VP, Shatrova KM, Chitaeva GE, Vitovsky RM
Exp Oncol 2018 Dec;40(4):336-342. PMID: 30593757
Gigantic spermatocytic seminoma: A rare tumor of germ cell origin.
Prelević R, Milev B, Milović N, Ignjatović M, Spasić A, Petrović N
Vojnosanit Pregl 2016 Jul;73(7):679-81. doi: 10.2298/VSP150527081P. PMID: 29314802
Younger age-at-diagnosis for familial malignant testicular germ cell tumor.
Mai PL, Chen BE, Tucker K, Friedlander M, Phillips KA, Hogg D, Jewett MA, Bodrogi I, Geczi L, Olah E, Heimdal K, Fosså SD, Nathanson KL, Korde L, Easton DF, Dudakia D, Huddart R, Stratton MR, Bishop DT, Rapley EA, Greene MH
Fam Cancer 2009;8(4):451-6. Epub 2009 Jul 17 doi: 10.1007/s10689-009-9264-6. PMID: 19609727Free PMC Article

Prognosis

Gigantic spermatocytic seminoma: A rare tumor of germ cell origin.
Prelević R, Milev B, Milović N, Ignjatović M, Spasić A, Petrović N
Vojnosanit Pregl 2016 Jul;73(7):679-81. doi: 10.2298/VSP150527081P. PMID: 29314802
microRNA-199a-3p functions as tumor suppressor by regulating glucose metabolism in testicular germ cell tumors.
Liu X, Duan H, Zhou S, Liu Z, Wu D, Zhao T, Xu S, Yang L, Li D
Mol Med Rep 2016 Sep;14(3):2311-20. Epub 2016 Jul 6 doi: 10.3892/mmr.2016.5472. PMID: 27432288
Right Cardiac Chambers Involvement by a Malignant Testicular Germ Cell Tumor: An Imaging-pathologic Correlation.
do Nascimento FB, Albieri L, Bento Dos Santos GA, Dolhnikoff M; BIAS (Brazilian Imaging and Autopsy Study)
Urology 2016 Jul;93:e9-e11. Epub 2016 Mar 24 doi: 10.1016/j.urology.2016.03.023. PMID: 27017904

Clinical prediction guides

Cellular origin of microRNA-371a-3p in healthy males based on systematic urogenital tract tissue evaluation.
Boellaard WPA, Gillis AJM, van Leenders GJLH, Stoop H, van Agthoven T, Dorssers LCJ, Dinkelman-Smit M, Boormans JL, Looijenga LHJ
Andrology 2019 Jul;7(4):463-468. Epub 2019 Feb 20 doi: 10.1111/andr.12595. PMID: 30786164Free PMC Article
Metastatic cardiac tumors: literature review and own observation of testicular tumor metastasis in the right ventricle of the heart.
Zakhartseva LM, Zakharova VP, Shatrova KM, Chitaeva GE, Vitovsky RM
Exp Oncol 2018 Dec;40(4):336-342. PMID: 30593757
microRNA-199a-3p functions as tumor suppressor by regulating glucose metabolism in testicular germ cell tumors.
Liu X, Duan H, Zhou S, Liu Z, Wu D, Zhao T, Xu S, Yang L, Li D
Mol Med Rep 2016 Sep;14(3):2311-20. Epub 2016 Jul 6 doi: 10.3892/mmr.2016.5472. PMID: 27432288
The International Testicular Cancer Linkage Consortium: a clinicopathologic descriptive analysis of 461 familial malignant testicular germ cell tumor kindred.
Mai PL, Friedlander M, Tucker K, Phillips KA, Hogg D, Jewett MA, Lohynska R, Daugaard G, Richard S, Bonaïti-Pellié C, Heidenreich A, Albers P, Bodrogi I, Geczi L, Olah E, Daly PA, Guilford P, Fosså SD, Heimdal K, Liubchenko L, Tjulandin SA, Stoll H, Weber W, Easton DF, Dudakia D, Huddart R, Stratton MR, Einhorn L, Korde L, Nathanson KL, Bishop DT, Rapley EA, Greene MH
Urol Oncol 2010 Sep-Oct;28(5):492-9. Epub 2009 Jan 22 doi: 10.1016/j.urolonc.2008.10.004. PMID: 19162511Free PMC Article
Younger age-at-diagnosis for familial malignant testicular germ cell tumor.
Mai PL, Chen BE, Tucker K, Friedlander M, Phillips KA, Hogg D, Jewett MA, Bodrogi I, Geczi L, Olah E, Heimdal K, Fosså SD, Nathanson KL, Korde L, Easton DF, Dudakia D, Huddart R, Stratton MR, Bishop DT, Rapley EA, Greene MH
Fam Cancer 2009;8(4):451-6. Epub 2009 Jul 17 doi: 10.1007/s10689-009-9264-6. PMID: 19609727Free PMC Article

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