U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Refractory Malignant Salivary Gland Neoplasm

MedGen UID:
1786322
•Concept ID:
C5447973
•
Neoplastic Process

Definition

A malignant salivary gland neoplasm that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Malignant Salivary Gland Neoplasm

Professional guidelines

PubMed

New agents in the treatment for malignancies of the salivary and thyroid glands.
Mehra R, Cohen RB
Hematol Oncol Clin North Am 2008 Dec;22(6):1279-95, xi. doi: 10.1016/j.hoc.2008.08.010. PMID: 19010274Free PMC Article

Recent clinical studies

Etiology

Acid reflux and head and neck cancer risk: A nationwide registry over 13 years.
Kuo CL, Chen YT, Shiao AS, Lien CF, Wang SJ
Auris Nasus Larynx 2015 Oct;42(5):401-5. Epub 2015 May 18 doi: 10.1016/j.anl.2015.03.008. PMID: 25998850
Efficacy of nelfinavir as monotherapy in refractory adenoid cystic carcinoma: Results of a phase II clinical trial.
Hoover AC, Milhem MM, Anderson CM, Sun W, Smith BJ, Hoffman HT, Buatti JM
Head Neck 2015 May;37(5):722-6. Epub 2014 Jun 18 doi: 10.1002/hed.23664. PMID: 24596143Free PMC Article
Prevention of Frey syndrome with superficial temporal fascia interpositioning: a retrospective study.
Sharma R
Int J Oral Maxillofac Surg 2014 Apr;43(4):413-7. Epub 2014 Jan 22 doi: 10.1016/j.ijom.2013.12.001. PMID: 24461587
Case series: non vascular considerations in trigeminal neuralgia.
Balasundram S, Cotrufo S, Liew C
Clin Oral Investig 2012 Feb;16(1):63-8. Epub 2011 Jan 6 doi: 10.1007/s00784-010-0499-2. PMID: 21210165
Painful osteolytic metastasis of the atlas: treatment with percutaneous vertebroplasty.
Wetzel SG, Martin JB, Somon T, Wilhelm K, Rufenacht DA
Spine (Phila Pa 1976) 2002 Nov 15;27(22):E493-5. doi: 10.1097/00007632-200211150-00022. PMID: 12436010

Diagnosis

Extranodal diffuse large B-cell lymphoma presenting with extensive organ involvement.
Kim K, Ziyeh S, Kim P
BMJ Case Rep 2024 Jun 30;17(6) doi: 10.1136/bcr-2023-257416. PMID: 38945554
IgG4-related disease: what a hematologist needs to know.
Chen LYC, Mattman A, Seidman MA, Carruthers MN
Haematologica 2019 Mar;104(3):444-455. Epub 2019 Jan 31 doi: 10.3324/haematol.2018.205526. PMID: 30705099Free PMC Article
Unexpected recalcitrant course of drug-induced erythema multiforme-like eruption and interstitial pneumonia sequentially occurring after nivolumab therapy.
Nomura H, Takahashi H, Suzuki S, Kurihara Y, Chubachi S, Kawada I, Yasuda H, Betsuyaku T, Amagai M, Funakoshi T
J Dermatol 2017 Jul;44(7):818-821. Epub 2017 Mar 11 doi: 10.1111/1346-8138.13810. PMID: 28295542
Acid reflux and head and neck cancer risk: A nationwide registry over 13 years.
Kuo CL, Chen YT, Shiao AS, Lien CF, Wang SJ
Auris Nasus Larynx 2015 Oct;42(5):401-5. Epub 2015 May 18 doi: 10.1016/j.anl.2015.03.008. PMID: 25998850
Case series: non vascular considerations in trigeminal neuralgia.
Balasundram S, Cotrufo S, Liew C
Clin Oral Investig 2012 Feb;16(1):63-8. Epub 2011 Jan 6 doi: 10.1007/s00784-010-0499-2. PMID: 21210165

Therapy

Extranodal diffuse large B-cell lymphoma presenting with extensive organ involvement.
Kim K, Ziyeh S, Kim P
BMJ Case Rep 2024 Jun 30;17(6) doi: 10.1136/bcr-2023-257416. PMID: 38945554
Efficacy of anti-PD-1 therapy in a patient with brain metastasis of parotid carcinoma: A case report.
Takemoto K, Miyahara N, Chikuie N, Hamamoto T, Ishino T, Ueda T, Takeno S
Auris Nasus Larynx 2019 Oct;46(5):813-817. Epub 2018 Nov 12 doi: 10.1016/j.anl.2018.10.003. PMID: 30442438
Efficacy of nelfinavir as monotherapy in refractory adenoid cystic carcinoma: Results of a phase II clinical trial.
Hoover AC, Milhem MM, Anderson CM, Sun W, Smith BJ, Hoffman HT, Buatti JM
Head Neck 2015 May;37(5):722-6. Epub 2014 Jun 18 doi: 10.1002/hed.23664. PMID: 24596143Free PMC Article
New agents in the treatment for malignancies of the salivary and thyroid glands.
Mehra R, Cohen RB
Hematol Oncol Clin North Am 2008 Dec;22(6):1279-95, xi. doi: 10.1016/j.hoc.2008.08.010. PMID: 19010274Free PMC Article
Tamoxifen for salivary gland adenoid cystic carcinoma: report of two cases.
Elkin AD, Jacobs CD
J Cancer Res Clin Oncol 2008 Oct;134(10):1151-3. Epub 2008 Mar 18 doi: 10.1007/s00432-008-0377-3. PMID: 18347813

Prognosis

Extranodal diffuse large B-cell lymphoma presenting with extensive organ involvement.
Kim K, Ziyeh S, Kim P
BMJ Case Rep 2024 Jun 30;17(6) doi: 10.1136/bcr-2023-257416. PMID: 38945554
IgG4-related disease: what a hematologist needs to know.
Chen LYC, Mattman A, Seidman MA, Carruthers MN
Haematologica 2019 Mar;104(3):444-455. Epub 2019 Jan 31 doi: 10.3324/haematol.2018.205526. PMID: 30705099Free PMC Article
Unexpected recalcitrant course of drug-induced erythema multiforme-like eruption and interstitial pneumonia sequentially occurring after nivolumab therapy.
Nomura H, Takahashi H, Suzuki S, Kurihara Y, Chubachi S, Kawada I, Yasuda H, Betsuyaku T, Amagai M, Funakoshi T
J Dermatol 2017 Jul;44(7):818-821. Epub 2017 Mar 11 doi: 10.1111/1346-8138.13810. PMID: 28295542
Efficacy of nelfinavir as monotherapy in refractory adenoid cystic carcinoma: Results of a phase II clinical trial.
Hoover AC, Milhem MM, Anderson CM, Sun W, Smith BJ, Hoffman HT, Buatti JM
Head Neck 2015 May;37(5):722-6. Epub 2014 Jun 18 doi: 10.1002/hed.23664. PMID: 24596143Free PMC Article
Case series: non vascular considerations in trigeminal neuralgia.
Balasundram S, Cotrufo S, Liew C
Clin Oral Investig 2012 Feb;16(1):63-8. Epub 2011 Jan 6 doi: 10.1007/s00784-010-0499-2. PMID: 21210165

Clinical prediction guides

Nivolumab for recurrent or metastatic head and neck cancer patients with non-squamous cell carcinoma and/or a primary subsite excluded from CheckMate141, a retrospective study.
Ueda Y, Okano S, Enokida T, Fujisawa T, Ito K, Sato M, Tanaka H, Wada A, Tahara M
Oral Oncol 2022 Jul;130:105932. Epub 2022 May 27 doi: 10.1016/j.oraloncology.2022.105932. PMID: 35636078
First-in-Human Dose-Escalation Study of Cyclin-Dependent Kinase 9 Inhibitor VIP152 in Patients with Advanced Malignancies Shows Early Signs of Clinical Efficacy.
Diamond JR, Boni V, Lim E, Nowakowski G, Cordoba R, Morillo D, Valencia R, Genvresse I, Merz C, Boix O, Frigault MM, Greer JM, Hamdy AM, Huang X, Izumi R, Wong H, Moreno V
Clin Cancer Res 2022 Apr 1;28(7):1285-1293. doi: 10.1158/1078-0432.CCR-21-3617. PMID: 35046056
Pan-Cancer Efficacy of Vemurafenib in BRAF (V600)-Mutant Non-Melanoma Cancers.
Subbiah V, Puzanov I, Blay JY, Chau I, Lockhart AC, Raje NS, Wolf J, Baselga J, Meric-Bernstam F, Roszik J, Diamond EL, Riely GJ, Sherman EJ, Riehl T, Pitcher B, Hyman DM
Cancer Discov 2020 May;10(5):657-663. Epub 2020 Feb 6 doi: 10.1158/2159-8290.CD-19-1265. PMID: 32029534Free PMC Article
Unexpected recalcitrant course of drug-induced erythema multiforme-like eruption and interstitial pneumonia sequentially occurring after nivolumab therapy.
Nomura H, Takahashi H, Suzuki S, Kurihara Y, Chubachi S, Kawada I, Yasuda H, Betsuyaku T, Amagai M, Funakoshi T
J Dermatol 2017 Jul;44(7):818-821. Epub 2017 Mar 11 doi: 10.1111/1346-8138.13810. PMID: 28295542
Acid reflux and head and neck cancer risk: A nationwide registry over 13 years.
Kuo CL, Chen YT, Shiao AS, Lien CF, Wang SJ
Auris Nasus Larynx 2015 Oct;42(5):401-5. Epub 2015 May 18 doi: 10.1016/j.anl.2015.03.008. PMID: 25998850

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...