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Refractory Carcinoma

MedGen UID:
854619
Concept ID:
C3887901
Neoplastic Process

Definition

A carcinoma that does not respond to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Carcinoma

Professional guidelines

PubMed

Yu Y, Chen K, Fan Y
Int J Cancer 2023 Jun 1;152(11):2243-2256. Epub 2022 Nov 29 doi: 10.1002/ijc.34346. PMID: 36346100
Reed N, Glen H, Gerrard G, Good J, Lei M, Lyon AR, Strachan M, Wadsley J, Newbold K
Clin Oncol (R Coll Radiol) 2020 May;32(5):e145-e153. Epub 2019 Dec 13 doi: 10.1016/j.clon.2019.11.010. PMID: 31843241
Sogani PC, Ray B, Whitmore WF Jr
Urology 1975 Aug;6(2):164-6. doi: 10.1016/0090-4295(75)90704-9. PMID: 1145932

Recent clinical studies

Etiology

Parekh DJ, Reis IM, Castle EP, Gonzalgo ML, Woods ME, Svatek RS, Weizer AZ, Konety BR, Tollefson M, Krupski TL, Smith ND, Shabsigh A, Barocas DA, Quek ML, Dash A, Kibel AS, Shemanski L, Pruthi RS, Montgomery JS, Weight CJ, Sharp DS, Chang SS, Cookson MS, Gupta GN, Gorbonos A, Uchio EM, Skinner E, Venkatramani V, Soodana-Prakash N, Kendrick K, Smith JA Jr, Thompson IM
Lancet 2018 Jun 23;391(10139):2525-2536. doi: 10.1016/S0140-6736(18)30996-6. PMID: 29976469
Schmidbauer J, Lindenau G
Curr Opin Urol 2008 Sep;18(5):504-7. doi: 10.1097/MOU.0b013e32830b86a9. PMID: 18670275
Uchibayashi T, Koshida K, Kunimi K, Hisazumi H
Br J Cancer 1995 Mar;71(3):625-8. doi: 10.1038/bjc.1995.122. PMID: 7880749Free PMC Article
Marshall ME, Blumenstein B, Crawford ED, Thompson IM, Craig JB, Eisenberger M, Ahmann F
Am J Clin Oncol 1994 Dec;17(6):514-5. doi: 10.1097/00000421-199412000-00013. PMID: 7977172
Hansen RM
Cancer Invest 1991;9(6):637-42. doi: 10.3109/07357909109039875. PMID: 1747791

Diagnosis

Rebez G, Runti O, Rizzo M, Trombetta C, Liguori G
Urologia 2023 Aug;90(3):584-586. Epub 2021 Jul 24 doi: 10.1177/03915603211033165. PMID: 34304610
Schmidbauer J, Lindenau G
Curr Opin Urol 2008 Sep;18(5):504-7. doi: 10.1097/MOU.0b013e32830b86a9. PMID: 18670275
Hutson TE, Ganapathi R, Elson P, Mekhail T, Olencki T, Budd GT, Bukowski RM
Invest New Drugs 2004 Aug;22(3):277-84. doi: 10.1023/B:DRUG.0000026253.02502.ce. PMID: 15122074
Kim JC, Steinberg GD
J Urol 2001 Mar;165(3):745-56. PMID: 11176460
Douglas TH, Morgan TO, McLeod DG, Moul JW, Murphy GP, Barren R 3rd, Sesterhenn IA, Mostofi FK
Cancer 1997 Jul 1;80(1):107-14. doi: 10.1002/(sici)1097-0142(19970701)80:1<107::aid-cncr14>3.0.co;2-1. PMID: 9210715

Therapy

Yu Y, Chen K, Fan Y
Int J Cancer 2023 Jun 1;152(11):2243-2256. Epub 2022 Nov 29 doi: 10.1002/ijc.34346. PMID: 36346100
Ielasi L, Sansone V, Granito A, Benevento F, De Lorenzo S, Tovoli F
Drugs Today (Barc) 2018 Oct;54(10):615-627. doi: 10.1358/dot.2018.54.10.2880176. PMID: 30398482
Parekh DJ, Reis IM, Castle EP, Gonzalgo ML, Woods ME, Svatek RS, Weizer AZ, Konety BR, Tollefson M, Krupski TL, Smith ND, Shabsigh A, Barocas DA, Quek ML, Dash A, Kibel AS, Shemanski L, Pruthi RS, Montgomery JS, Weight CJ, Sharp DS, Chang SS, Cookson MS, Gupta GN, Gorbonos A, Uchio EM, Skinner E, Venkatramani V, Soodana-Prakash N, Kendrick K, Smith JA Jr, Thompson IM
Lancet 2018 Jun 23;391(10139):2525-2536. doi: 10.1016/S0140-6736(18)30996-6. PMID: 29976469
Sharma P, Zargar-Shoshtari K, Sexton WJ
Expert Rev Anticancer Ther 2015;15(12):1379-87. Epub 2015 Nov 16 doi: 10.1586/14737140.2015.1115350. PMID: 26569509
Hansen RM
Cancer Invest 1991;9(6):637-42. doi: 10.3109/07357909109039875. PMID: 1747791

Prognosis

Ielasi L, Sansone V, Granito A, Benevento F, De Lorenzo S, Tovoli F
Drugs Today (Barc) 2018 Oct;54(10):615-627. doi: 10.1358/dot.2018.54.10.2880176. PMID: 30398482
Shinohara S, Kikuchi M, Suehiro A, Kishimoto I, Harada H, Hino M, Ishihara T
Jpn J Clin Oncol 2015 May;45(5):427-32. Epub 2015 Feb 26 doi: 10.1093/jjco/hyv021. PMID: 25724214
Kim JC, Steinberg GD
Drugs Aging 2001;18(5):335-44. doi: 10.2165/00002512-200118050-00004. PMID: 11392442
Uchibayashi T, Koshida K, Kunimi K, Hisazumi H
Br J Cancer 1995 Mar;71(3):625-8. doi: 10.1038/bjc.1995.122. PMID: 7880749Free PMC Article
Blumenstein B, Crawford ED, Saiers JH, Stephens RL, Rivkin SE, Coltman CA Jr
J Urol 1993 Aug;150(2 Pt 1):411-3. doi: 10.1016/s0022-5347(17)35496-4. PMID: 8326565

Clinical prediction guides

Otsuki S, Hori R, Shinohara S, Kojima T, Tamaki H, Asato R, Kitamura M, Ichimaru K, Kitani Y, Kumabe Y, Honda K, Tsujimura T, Harada H, Ushiro K, Omori K
Auris Nasus Larynx 2022 Oct;49(5):834-844. Epub 2022 Feb 26 doi: 10.1016/j.anl.2022.02.006. PMID: 35232636
Kashiwagi K, Yanagida M, Matsui D, Tanaka M, Sugimoto K, Chen H, Ichikawa-Tomikawa N, Marubashi S, Suzuki H, Chiba H
Histol Histopathol 2018 May;33(5):497-505. Epub 2017 Nov 28 doi: 10.14670/HH-11-949. PMID: 29181837
Singh S, Cunningham C, Buchanan A, Jolly DJ, Nemunaitis J
Mol Ther 2001 Aug;4(2):157-60. doi: 10.1006/mthe.2001.0430. PMID: 11482988
Kim JC, Steinberg GD
J Urol 2001 Mar;165(3):745-56. PMID: 11176460
Kaplan SS, Basford RE, Wing EJ, Shadduck RK
Blood 1989 Feb 15;73(3):636-8. PMID: 2537116

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