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Testis refractory cancer

MedGen UID:
235122
Concept ID:
C1377904
Neoplastic Process
Synonyms: Refractory Cancer of Testis; refractory cancer of testis; Refractory Cancer of the Testis; refractory cancer of the testis; Refractory Malignant Testicular Germ Cell Tumor; refractory malignant testicular germ cell tumor; refractory malignant testicular germ cell tumour; Refractory Testicular Cancer; refractory testicular cancer; refractory testicular carcinoma; testis refractory cancer
 
Monarch Initiative: MONDO:0004401

Definition

Malignant testicular germ cell tumor that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTestis refractory cancer

Professional guidelines

PubMed

Levine EG, Raghavan D
Eur J Cancer 1991;27(7):932-6. doi: 10.1016/0277-5379(91)90150-c. PMID: 1657079

Recent clinical studies

Etiology

Hong DS, Van Tine BA, Biswas S, McAlpine C, Johnson ML, Olszanski AJ, Clarke JM, Araujo D, Blumenschein GR Jr, Kebriaei P, Lin Q, Tipping AJ, Sanderson JP, Wang R, Trivedi T, Annareddy T, Bai J, Rafail S, Sun A, Fernandes L, Navenot JM, Bushman FD, Everett JK, Karadeniz D, Broad R, Isabelle M, Naidoo R, Bath N, Betts G, Wolchinsky Z, Batrakou DG, Van Winkle E, Elefant E, Ghobadi A, Cashen A, Grand'Maison A, McCarthy P, Fracasso PM, Norry E, Williams D, Druta M, Liebner DA, Odunsi K, Butler MO
Nat Med 2023 Jan;29(1):104-114. Epub 2023 Jan 9 doi: 10.1038/s41591-022-02128-z. PMID: 36624315Free PMC Article
Nguyen HTK, Terao MA, Green DM, Pui CH, Inaba H
Cancer 2021 Sep 1;127(17):3067-3081. Epub 2021 May 25 doi: 10.1002/cncr.33609. PMID: 34031876Free PMC Article
Moleti ML, Testi AM, Foà R
Br J Haematol 2020 Jun;189(5):826-843. Epub 2020 Mar 6 doi: 10.1111/bjh.16461. PMID: 32141616
Cheng L, Albers P, Berney DM, Feldman DR, Daugaard G, Gilligan T, Looijenga LHJ
Nat Rev Dis Primers 2018 Oct 5;4(1):29. doi: 10.1038/s41572-018-0029-0. PMID: 30291251
Khan O, Protheroe A
Postgrad Med J 2007 Oct;83(984):624-32. doi: 10.1136/pgmj.2007.057992. PMID: 17916870Free PMC Article

Diagnosis

Tse E, Zhao WL, Xiong J, Kwong YL
J Hematol Oncol 2022 Jun 3;15(1):74. doi: 10.1186/s13045-022-01293-5. PMID: 35659326Free PMC Article
Nguyen HTK, Terao MA, Green DM, Pui CH, Inaba H
Cancer 2021 Sep 1;127(17):3067-3081. Epub 2021 May 25 doi: 10.1002/cncr.33609. PMID: 34031876Free PMC Article
Moleti ML, Testi AM, Foà R
Br J Haematol 2020 Jun;189(5):826-843. Epub 2020 Mar 6 doi: 10.1111/bjh.16461. PMID: 32141616
Cheng L, Albers P, Berney DM, Feldman DR, Daugaard G, Gilligan T, Looijenga LHJ
Nat Rev Dis Primers 2018 Oct 5;4(1):29. doi: 10.1038/s41572-018-0029-0. PMID: 30291251
Khan O, Protheroe A
Postgrad Med J 2007 Oct;83(984):624-32. doi: 10.1136/pgmj.2007.057992. PMID: 17916870Free PMC Article

Therapy

Udvorková N, Fekiačová A, Majtánová K, Mego M, Kučerová L
Am J Physiol Cell Physiol 2024 Aug 1;327(2):C362-C371. Epub 2024 Jun 24 doi: 10.1152/ajpcell.00200.2024. PMID: 38912730
Hong DS, Van Tine BA, Biswas S, McAlpine C, Johnson ML, Olszanski AJ, Clarke JM, Araujo D, Blumenschein GR Jr, Kebriaei P, Lin Q, Tipping AJ, Sanderson JP, Wang R, Trivedi T, Annareddy T, Bai J, Rafail S, Sun A, Fernandes L, Navenot JM, Bushman FD, Everett JK, Karadeniz D, Broad R, Isabelle M, Naidoo R, Bath N, Betts G, Wolchinsky Z, Batrakou DG, Van Winkle E, Elefant E, Ghobadi A, Cashen A, Grand'Maison A, McCarthy P, Fracasso PM, Norry E, Williams D, Druta M, Liebner DA, Odunsi K, Butler MO
Nat Med 2023 Jan;29(1):104-114. Epub 2023 Jan 9 doi: 10.1038/s41591-022-02128-z. PMID: 36624315Free PMC Article
Tse E, Zhao WL, Xiong J, Kwong YL
J Hematol Oncol 2022 Jun 3;15(1):74. doi: 10.1186/s13045-022-01293-5. PMID: 35659326Free PMC Article
Nguyen HTK, Terao MA, Green DM, Pui CH, Inaba H
Cancer 2021 Sep 1;127(17):3067-3081. Epub 2021 May 25 doi: 10.1002/cncr.33609. PMID: 34031876Free PMC Article
Moleti ML, Testi AM, Foà R
Br J Haematol 2020 Jun;189(5):826-843. Epub 2020 Mar 6 doi: 10.1111/bjh.16461. PMID: 32141616

Prognosis

Udvorková N, Fekiačová A, Majtánová K, Mego M, Kučerová L
Am J Physiol Cell Physiol 2024 Aug 1;327(2):C362-C371. Epub 2024 Jun 24 doi: 10.1152/ajpcell.00200.2024. PMID: 38912730
Nabbi A, Danesh A, Espin-Garcia O, Pedersen S, Wellum J, Fu LH, Paulson JN, Geoerger B, Marshall LV, Trippett T, Rossato G, Pugh TJ, Hutchinson KE
Nat Cancer 2023 Apr;4(4):502-515. Epub 2023 Apr 10 doi: 10.1038/s43018-023-00534-x. PMID: 37038005Free PMC Article
Tse E, Zhao WL, Xiong J, Kwong YL
J Hematol Oncol 2022 Jun 3;15(1):74. doi: 10.1186/s13045-022-01293-5. PMID: 35659326Free PMC Article
Moleti ML, Testi AM, Foà R
Br J Haematol 2020 Jun;189(5):826-843. Epub 2020 Mar 6 doi: 10.1111/bjh.16461. PMID: 32141616
Cheng L, Albers P, Berney DM, Feldman DR, Daugaard G, Gilligan T, Looijenga LHJ
Nat Rev Dis Primers 2018 Oct 5;4(1):29. doi: 10.1038/s41572-018-0029-0. PMID: 30291251

Clinical prediction guides

Tse E, Zhao WL, Xiong J, Kwong YL
J Hematol Oncol 2022 Jun 3;15(1):74. doi: 10.1186/s13045-022-01293-5. PMID: 35659326Free PMC Article
Emadali A, Rousseaux S, Bruder-Costa J, Rome C, Duley S, Hamaidia S, Betton P, Debernardi A, Leroux D, Bernay B, Kieffer-Jaquinod S, Combes F, Ferri E, McKenna CE, Petosa C, Bruley C, Garin J, Ferro M, Gressin R, Callanan MB, Khochbin S
EMBO Mol Med 2013 Aug;5(8):1180-95. Epub 2013 Jul 4 doi: 10.1002/emmm.201202034. PMID: 23828858Free PMC Article
Thompson-Wicking K, Francis RW, Stirnweiss A, Ferrari E, Welch MD, Baker E, Murch AR, Gout AM, Carter KW, Charles AK, Phillips MB, Kees UR, Beesley AH
Oncogene 2013 Sep 26;32(39):4664-74. Epub 2012 Nov 5 doi: 10.1038/onc.2012.487. PMID: 23128391
Robbins PF, Morgan RA, Feldman SA, Yang JC, Sherry RM, Dudley ME, Wunderlich JR, Nahvi AV, Helman LJ, Mackall CL, Kammula US, Hughes MS, Restifo NP, Raffeld M, Lee CC, Levy CL, Li YF, El-Gamil M, Schwarz SL, Laurencot C, Rosenberg SA
J Clin Oncol 2011 Mar 1;29(7):917-24. Epub 2011 Jan 31 doi: 10.1200/JCO.2010.32.2537. PMID: 21282551Free PMC Article
Beck SD, Foster RS
World J Urol 2006 Aug;24(3):267-72. Epub 2006 Mar 8 doi: 10.1007/s00345-006-0060-8. PMID: 16523338

Recent systematic reviews

Calabrò F, Albers P, Bokemeyer C, Martin C, Einhorn LH, Horwich A, Krege S, Schmoll HJ, Sternberg CN, Daugaard G
Eur Urol 2012 Jun;61(6):1212-21. Epub 2012 Mar 24 doi: 10.1016/j.eururo.2012.03.038. PMID: 22464311

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