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Breast carcinoma in situ

MedGen UID:
57817
•Concept ID:
C0154084
•
Neoplastic Process
Synonym: Breast Carcinoma In Situ
SNOMED CT: Carcinoma in situ of breast (189336000); Non-invasive carcinoma of breast (189336000)
 
Monarch Initiative: MONDO:0004658

Definition

A in situ carcinoma that involves the breast. [from MONDO]

Professional guidelines

PubMed

Can we improve breast cancer management using an image-guided histopathology workup supported by larger histopathology sections?
Tabár L, Dean PB, Lee Tucker F, Vörös A
Eur J Radiol 2023 Apr;161:110750. Epub 2023 Feb 18 doi: 10.1016/j.ejrad.2023.110750. PMID: 36821956
In situ breast carcinoma: diagnosis and treatment.
Hindle WH
Clin Obstet Gynecol 2002 Sep;45(3):774-7. doi: 10.1097/00003081-200209000-00025. PMID: 12370620
The treatment of in situ breast cancer.
Fentiman IS
Acta Oncol 1989;28(6):923-6. doi: 10.3109/02841868909092333. PMID: 2558695

Recent clinical studies

Etiology

Lobular Carcinoma In Situ during Preoperative Biopsy and the Rate of Upgrade.
Lee J, Ku GY, Lee H, Park HS, Ku JS, Kim JY, Park S, Park BW
Cancer Res Treat 2022 Oct;54(4):1074-1080. Epub 2021 Dec 21 doi: 10.4143/crt.2021.864. PMID: 34942684Free PMC Article
Effective Surveillance of High-Risk Women.
Lotz M, Ghebremichael M, Chervinsky K, Zorc T, Brenner C, Bousvaros G, Pories SE
Clin Breast Cancer 2022 Apr;22(3):e263-e269. Epub 2021 Jul 27 doi: 10.1016/j.clbc.2021.07.014. PMID: 34429241
Lobular carcinoma in situ: diagnostic criteria and molecular correlates.
Sokolova A, Lakhani SR
Mod Pathol 2021 Jan;34(Suppl 1):8-14. Epub 2020 Oct 6 doi: 10.1038/s41379-020-00689-3. PMID: 33024303
Diagnosis and Management of High-Risk Breast Lesions.
Thomas PS
J Natl Compr Canc Netw 2018 Nov;16(11):1391-1396. doi: 10.6004/jnccn.2018.7099. PMID: 30442737
Lobular Carcinoma In Situ.
Wen HY, Brogi E
Surg Pathol Clin 2018 Mar;11(1):123-145. Epub 2017 Dec 8 doi: 10.1016/j.path.2017.09.009. PMID: 29413653Free PMC Article

Diagnosis

Effective Surveillance of High-Risk Women.
Lotz M, Ghebremichael M, Chervinsky K, Zorc T, Brenner C, Bousvaros G, Pories SE
Clin Breast Cancer 2022 Apr;22(3):e263-e269. Epub 2021 Jul 27 doi: 10.1016/j.clbc.2021.07.014. PMID: 34429241
Lobular carcinoma in situ: diagnostic criteria and molecular correlates.
Sokolova A, Lakhani SR
Mod Pathol 2021 Jan;34(Suppl 1):8-14. Epub 2020 Oct 6 doi: 10.1038/s41379-020-00689-3. PMID: 33024303
Overview of breast cancer.
Watkins EJ
JAAPA 2019 Oct;32(10):13-17. doi: 10.1097/01.JAA.0000580524.95733.3d. PMID: 31513033
Diagnosis and Management of High-Risk Breast Lesions.
Thomas PS
J Natl Compr Canc Netw 2018 Nov;16(11):1391-1396. doi: 10.6004/jnccn.2018.7099. PMID: 30442737
Lobular Carcinoma In Situ.
Wen HY, Brogi E
Surg Pathol Clin 2018 Mar;11(1):123-145. Epub 2017 Dec 8 doi: 10.1016/j.path.2017.09.009. PMID: 29413653Free PMC Article

Therapy

Association between gynecologic cancer and Alzheimer's disease: a bidirectional mendelian randomization study.
Cao D, Zhang S, Zhang Y, Shao M, Yang Q, Wang P
BMC Cancer 2024 Aug 21;24(1):1032. doi: 10.1186/s12885-024-12787-5. PMID: 39169299Free PMC Article
Comparing Breast Cancer and Cardiovascular Disease Risk and Use of Chemoprevention and Statins among Women with High-risk Breast Lesions.
Lawal KO, Nilan L, Amenta J, McGuinness JE, Kukafka R, Crew KD
Cancer Prev Res (Phila) 2023 Dec 1;16(12):661-667. doi: 10.1158/1940-6207.CAPR-23-0181. PMID: 37976537Free PMC Article
Chemoprevention acceptance and adherence in women with high-risk breast lesions.
Roche CA, Tang R, Coopey SB, Hughes KS
Breast J 2019 Mar;25(2):190-195. Epub 2018 May 21 doi: 10.1111/tbj.13064. PMID: 29785770
Diagnosis and Management of High-Risk Breast Lesions.
Thomas PS
J Natl Compr Canc Netw 2018 Nov;16(11):1391-1396. doi: 10.6004/jnccn.2018.7099. PMID: 30442737
Overdiagnosis in breast imaging.
Evans A, Vinnicombe S
Breast 2017 Feb;31:270-273. Epub 2016 Oct 28 doi: 10.1016/j.breast.2016.10.011. PMID: 28029492

Prognosis

Should low-risk DCIS lose the cancer label? An evidence review.
Ma T, Semsarian CR, Barratt A, Parker L, Pathmanathan N, Nickel B, Bell KJL
Breast Cancer Res Treat 2023 Jun;199(3):415-433. Epub 2023 Apr 19 doi: 10.1007/s10549-023-06934-y. PMID: 37074481Free PMC Article
Lobular Carcinoma In Situ during Preoperative Biopsy and the Rate of Upgrade.
Lee J, Ku GY, Lee H, Park HS, Ku JS, Kim JY, Park S, Park BW
Cancer Res Treat 2022 Oct;54(4):1074-1080. Epub 2021 Dec 21 doi: 10.4143/crt.2021.864. PMID: 34942684Free PMC Article
Understanding Disparities in Breast Cancer Care in Memphis, Tennessee.
Lamb EP, Pritchard FE, Nouer SS, Tolley EA, Boyd BS, Davidson JT, Munene G, Fleming MD
Am Surg 2018 May 1;84(5):620-627. PMID: 29966559
Myoepithelial cells in lobular carcinoma in situ: distribution and immunophenotype.
Wang Y, Jindal S, Martel M, Wu Y, Schedin P, Troxell M
Hum Pathol 2016 Sep;55:126-34. Epub 2016 May 16 doi: 10.1016/j.humpath.2016.05.003. PMID: 27195907
Cancer statistics: Breast cancer in situ.
Ward EM, DeSantis CE, Lin CC, Kramer JL, Jemal A, Kohler B, Brawley OW, Gansler T
CA Cancer J Clin 2015 Nov-Dec;65(6):481-95. Epub 2015 Oct 2 doi: 10.3322/caac.21321. PMID: 26431342

Clinical prediction guides

Lobular Carcinoma In Situ during Preoperative Biopsy and the Rate of Upgrade.
Lee J, Ku GY, Lee H, Park HS, Ku JS, Kim JY, Park S, Park BW
Cancer Res Treat 2022 Oct;54(4):1074-1080. Epub 2021 Dec 21 doi: 10.4143/crt.2021.864. PMID: 34942684Free PMC Article
Effective Surveillance of High-Risk Women.
Lotz M, Ghebremichael M, Chervinsky K, Zorc T, Brenner C, Bousvaros G, Pories SE
Clin Breast Cancer 2022 Apr;22(3):e263-e269. Epub 2021 Jul 27 doi: 10.1016/j.clbc.2021.07.014. PMID: 34429241
Pleomorphic Lobular Carcinoma In Situ: Imaging Features, Upgrade Rate, and Clinical Outcomes.
Savage JL, Jeffries DO, Noroozian M, Sabel MS, Jorns JM, Helvie MA
AJR Am J Roentgenol 2018 Aug;211(2):462-467. Epub 2018 Jun 12 doi: 10.2214/AJR.17.19088. PMID: 29894223
Clonal relationships between lobular carcinoma in situ and other breast malignancies.
Begg CB, Ostrovnaya I, Carniello JV, Sakr RA, Giri D, Towers R, Schizas M, De Brot M, Andrade VP, Mauguen A, Seshan VE, King TA
Breast Cancer Res 2016 Jun 23;18(1):66. doi: 10.1186/s13058-016-0727-z. PMID: 27334989Free PMC Article
Myoepithelial cells in lobular carcinoma in situ: distribution and immunophenotype.
Wang Y, Jindal S, Martel M, Wu Y, Schedin P, Troxell M
Hum Pathol 2016 Sep;55:126-34. Epub 2016 May 16 doi: 10.1016/j.humpath.2016.05.003. PMID: 27195907

Recent systematic reviews

The natural history of ductal carcinoma in situ (DCIS) in simulation models: A systematic review.
Poelhekken K, Lin Y, Greuter MJW, van der Vegt B, Dorrius M, de Bock GH
Breast 2023 Oct;71:74-81. Epub 2023 Jul 27 doi: 10.1016/j.breast.2023.07.012. PMID: 37541171Free PMC Article
Intercepting Premalignant, Preinvasive Breast Lesions Through Vaccination.
Zachariah NN, Basu A, Gautam N, Ramamoorthi G, Kodumudi KN, Kumar NB, Loftus L, Czerniecki BJ
Front Immunol 2021;12:786286. Epub 2021 Nov 24 doi: 10.3389/fimmu.2021.786286. PMID: 34899753Free PMC Article
Impact of lobular carcinoma in situ on local recurrence in breast cancer treated with breast conservation therapy: a systematic review and meta-analysis.
Harris CG, Eslick GD
ANZ J Surg 2021 Sep;91(9):1696-1703. Epub 2021 Feb 26 doi: 10.1111/ans.16671. PMID: 33634956

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