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Carcinosarcoma of the corpus uteri

MedGen UID:
316458
Concept ID:
C1704376
Neoplastic Process
Synonym: Uterine Corpus Carcinosarcoma
SNOMED CT: Carcinosarcoma of corpus uteri (764952009); Malignant mixed Müllerian neoplasm of corpus uteri (764952009); Malignant mixed Müllerian tumor of corpus uteri (764952009)
 
Monarch Initiative: MONDO:0016259
Orphanet: ORPHA213610

Definition

Carcinosarcoma of the corpus uteri is a rare, malignant, mixed epithelial and mesenchymal tumor of the uterine body composed of high-grade carcinomatous and sarcomatous elements. It may present with vaginal bleeding, abnormal vaginal discharge, abdominal pain and/or pelvic mass, with a polypoid tumor sometimes protruding through the cervical canal. Association with Tamoxifen therapy, long-term unopposed estrogen use and previous pelvic radiotherapy has been reported. [from ORDO]

Professional guidelines

PubMed

Rabban JT, Gilks CB, Malpica A, Matias-Guiu X, Mittal K, Mutter GL, Oliva E, Parkash V, Ronnett BM, Staats P, Stewart CJR, McCluggage WG
Int J Gynecol Pathol 2019 Jan;38 Suppl 1(Iss 1 Suppl 1):S25-S39. doi: 10.1097/PGP.0000000000000512. PMID: 30550482Free PMC Article
Vongtama V, Karlen JR, Piver SM, Tsukada Y, Moore RH
AJR Am J Roentgenol 1976 Jan;126(1):139-47. doi: 10.2214/ajr.126.1.139. PMID: 175673
Nieminen U, Söderlin E
Strahlentherapie 1974 Jul;148(1):57-61. PMID: 4439433

Recent clinical studies

Diagnosis

Zwierzchowska A, Panek G, Gajewska M
Eur J Gynaecol Oncol 2015;36(6):746-9. PMID: 26775366
Sando Z, Fouelifack FY, Fouogue JT, Fouedjio JH, Anoudem CE, Nangue C
Pan Afr Med J 2013;16:145. Epub 2013 Dec 19 doi: 10.11604/pamj.2013.16.145.3497. PMID: 24876903Free PMC Article

Therapy

Zwierzchowska A, Panek G, Gajewska M
Eur J Gynaecol Oncol 2015;36(6):746-9. PMID: 26775366

Prognosis

Zwierzchowska A, Panek G, Gajewska M
Eur J Gynaecol Oncol 2015;36(6):746-9. PMID: 26775366
Sando Z, Fouelifack FY, Fouogue JT, Fouedjio JH, Anoudem CE, Nangue C
Pan Afr Med J 2013;16:145. Epub 2013 Dec 19 doi: 10.11604/pamj.2013.16.145.3497. PMID: 24876903Free PMC Article

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