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Cervical squamous cell carcinoma

MedGen UID:
124644
•Concept ID:
C0279671
•
Neoplastic Process
Synonyms: cervical squamous cell cancer; Cervical Squamous Cell Carcinoma; cervical squamous cell carcinoma; Cervix Squamous Cell Carcinoma; cervix squamous cell carcinoma; Cervix Uteri Squamous Cell Carcinoma; cervix uteri squamous cell carcinoma; CESC; Squamous cell carcinoma of cervix; Squamous Cell Carcinoma of Cervix; squamous cell carcinoma of cervix; Squamous Cell Carcinoma of Cervix Uteri; squamous cell carcinoma of cervix uteri; Squamous Cell Carcinoma of the Cervix; squamous cell carcinoma of the cervix; Squamous Cell Carcinoma of the Cervix Uteri; squamous cell carcinoma of the cervix uteri; Squamous cell carcinoma of the cervix uteri; Squamous Cell Carcinoma of the Uterine Cervix; squamous cell carcinoma of the uterine cervix; Squamous Cell Carcinoma of Uterine Cervix; squamous cell carcinoma of uterine cervix; squamous cervical cancer; Uterine Cervix Squamous Cell Carcinoma; uterine cervix squamous cell carcinoma
SNOMED CT: Squamous cell carcinoma of cervix (254886006)
 
Monarch Initiative: MONDO:0006143
Orphanet: ORPHA213767

Definition

A squamous cell carcinoma arising from the cervical epithelium. It usually evolves from a precancerous cervical lesion. Increased numbers of sexual partners and human papillomavirus (HPV) infection are risk factors for cervical squamous cell carcinoma. Survival is most closely related to the stage of disease at the time of diagnosis. [from NCI]

Professional guidelines

PubMed

Menopause hormone treatment after cancer.
Gompel A
Climacteric 2023 Jun;26(3):240-247. Epub 2023 Apr 3 doi: 10.1080/13697137.2023.2176216. PMID: 37011657
The multifaceted mechanisms of pristimerin in the treatment of tumors state-of-the-art.
Wang Y, Feng W, Wang X, Li X, Mou Y, Wang X, Zhang Y
Biomed Pharmacother 2022 Oct;154:113575. Epub 2022 Aug 18 doi: 10.1016/j.biopha.2022.113575. PMID: 35988422
Management of Vaginal Cancer.
Shrivastava SB, Agrawal G, Mittal M, Mishra P
Rev Recent Clin Trials 2015;10(4):289-97. doi: 10.2174/1574887110666150923112958. PMID: 26411952

Recent clinical studies

Etiology

Expression and Significance of MTA2 and CPNE1 in Cervical Squamous Cell Carcinoma.
Wang L, Chen G, Zhou C, Wu C, Jiang J
Appl Immunohistochem Mol Morphol 2023 Sep 1;31(8):569-573. Epub 2023 Jul 3 doi: 10.1097/PAI.0000000000001138. PMID: 37399268
FTO m6A Demethylase in Obesity and Cancer: Implications and Underlying Molecular Mechanisms.
Azzam SK, Alsafar H, Sajini AA
Int J Mol Sci 2022 Mar 30;23(7) doi: 10.3390/ijms23073800. PMID: 35409166Free PMC Article
Predicting Early Response to Chemoradiotherapy for Uterine Cervical Cancer Using Intravoxel Incoherent Motion MR Imaging.
Kato H, Esaki K, Yamaguchi T, Tanaka H, Kajita K, Furui T, Morishige KI, Goshima S, Matsuo M
Magn Reson Med Sci 2019 Oct 15;18(4):293-298. Epub 2019 Feb 19 doi: 10.2463/mrms.tn.2018-0138. PMID: 30787252Free PMC Article
The contribution of HPV18 to cervical cancer is underestimated using high-grade CIN as a measure of screening efficiency.
Bulk S, Berkhof J, Rozendaal L, Fransen Daalmeijer NC, Gök M, de Schipper FA, van Kemenade FJ, Snijders PJ, Meijer CJ
Br J Cancer 2007 Apr 23;96(8):1234-6. Epub 2007 Mar 20 doi: 10.1038/sj.bjc.6603693. PMID: 17375047Free PMC Article
The role of human papillomavirus in oral carcinogenesis.
Ha PK, Califano JA
Crit Rev Oral Biol Med 2004 Jul 1;15(4):188-96. doi: 10.1177/154411130401500402. PMID: 15284184

Diagnosis

Single-nucleus RNA sequencing reveals heterogenous microenvironments and specific drug response between cervical squamous cell carcinoma and adenocarcinoma.
Lin S, Sun Y, Cao C, Zhu Z, Xu Y, Liu B, Hu B, Peng T, Zhi W, Xu M, Ding W, Ren F, Ma D, Li G, Wu P
EBioMedicine 2023 Nov;97:104846. Epub 2023 Oct 24 doi: 10.1016/j.ebiom.2023.104846. PMID: 37879219Free PMC Article
A Curious Case of Rapidly Progressing Dysphagia.
Pomenti S, Grada Z, Katzka DA
Gastroenterology 2023 Dec;165(6):1334-1337. Epub 2023 May 27 doi: 10.1053/j.gastro.2023.05.027. PMID: 37247643
Single-cell dissection of cellular and molecular features underlying human cervical squamous cell carcinoma initiation and progression.
Liu C, Zhang M, Yan X, Ni Y, Gong Y, Wang C, Zhang X, Wan L, Yang H, Ge C, Li Y, Zou W, Huang R, Li X, Sun B, Liu B, Yue J, Yu J
Sci Adv 2023 Jan 27;9(4):eadd8977. doi: 10.1126/sciadv.add8977. PMID: 36706185Free PMC Article
Pembrolizumab Improves Survival After Resection of Intracardiac Metastatic Cervical Carcinoma.
Steely AM, Watkins AA, Vidal B, White D, Chu LM
Ann Thorac Surg 2022 Nov;114(5):e323-e325. Epub 2022 Jan 26 doi: 10.1016/j.athoracsur.2021.12.066. PMID: 35090858
Predictive value of protease-activated receptor-2 (PAR(2) ) in cervical cancer metastasis.
He S, Xu M, Xiong Z, Hu Y, Huo Q, Lu J, Lin Y, Yang L
J Cell Mol Med 2021 Feb;25(3):1415-1424. Epub 2020 Dec 23 doi: 10.1111/jcmm.16227. PMID: 33369107Free PMC Article

Therapy

Multiomic analysis of cervical squamous cell carcinoma identifies cellular ecosystems with biological and clinical relevance.
Fan J, Lu F, Qin T, Peng W, Zhuang X, Li Y, Hou X, Fang Z, Yang Y, Guo E, Yang B, Li X, Fu Y, Kang X, Wu Z, Han L, Mills GB, Ma X, Li K, Wu P, Ma D, Chen G, Sun C
Nat Genet 2023 Dec;55(12):2175-2188. Epub 2023 Nov 20 doi: 10.1038/s41588-023-01570-0. PMID: 37985817
Pembrolizumab Improves Survival After Resection of Intracardiac Metastatic Cervical Carcinoma.
Steely AM, Watkins AA, Vidal B, White D, Chu LM
Ann Thorac Surg 2022 Nov;114(5):e323-e325. Epub 2022 Jan 26 doi: 10.1016/j.athoracsur.2021.12.066. PMID: 35090858
Takotsubo cardiomyopathy caused by infusion reaction to paclitaxel.
Micho Ulbeh T, Sara A, Uddin MM, Bell K, Elmograbi A, Cardozo S
BMJ Case Rep 2021 Aug 10;14(8) doi: 10.1136/bcr-2021-243863. PMID: 34376418Free PMC Article
Cell Therapy With TILs: Training and Taming T Cells to Fight Cancer.
Kumar A, Watkins R, Vilgelm AE
Front Immunol 2021;12:690499. Epub 2021 Jun 1 doi: 10.3389/fimmu.2021.690499. PMID: 34140957Free PMC Article
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
Chang S, Yim S, Park H
Exp Mol Med 2019 Jun 20;51(6):1-17. doi: 10.1038/s12276-019-0230-6. PMID: 31221981Free PMC Article

Prognosis

Cancer-associated fibroblast-derived PAI-1 promotes lymphatic metastasis via the induction of EndoMT in lymphatic endothelial cells.
Wei WF, Zhou HL, Chen PY, Huang XL, Huang L, Liang LJ, Guo CH, Zhou CF, Yu L, Fan LS, Wang W
J Exp Clin Cancer Res 2023 Jul 6;42(1):160. doi: 10.1186/s13046-023-02714-0. PMID: 37415190Free PMC Article
Single-cell dissection of cellular and molecular features underlying human cervical squamous cell carcinoma initiation and progression.
Liu C, Zhang M, Yan X, Ni Y, Gong Y, Wang C, Zhang X, Wan L, Yang H, Ge C, Li Y, Zou W, Huang R, Li X, Sun B, Liu B, Yue J, Yu J
Sci Adv 2023 Jan 27;9(4):eadd8977. doi: 10.1126/sciadv.add8977. PMID: 36706185Free PMC Article
Racial and Ethnic Disparities in Cervical Cancer Incidence, Survival, and Mortality by Histologic Subtype.
Cohen CM, Wentzensen N, Castle PE, Schiffman M, Zuna R, Arend RC, Clarke MA
J Clin Oncol 2023 Feb 10;41(5):1059-1068. Epub 2022 Dec 1 doi: 10.1200/JCO.22.01424. PMID: 36455190Free PMC Article
Single-Nucleus RNA Sequencing and Spatial Transcriptomics Reveal the Immunological Microenvironment of Cervical Squamous Cell Carcinoma.
Ou Z, Lin S, Qiu J, Ding W, Ren P, Chen D, Wang J, Tong Y, Wu D, Chen A, Deng Y, Cheng M, Peng T, Lu H, Yang H, Wang J, Jin X, Ma D, Xu X, Wang Y, Li J, Wu P
Adv Sci (Weinh) 2022 Oct;9(29):e2203040. Epub 2022 Aug 19 doi: 10.1002/advs.202203040. PMID: 35986392Free PMC Article
Predictive value of protease-activated receptor-2 (PAR(2) ) in cervical cancer metastasis.
He S, Xu M, Xiong Z, Hu Y, Huo Q, Lu J, Lin Y, Yang L
J Cell Mol Med 2021 Feb;25(3):1415-1424. Epub 2020 Dec 23 doi: 10.1111/jcmm.16227. PMID: 33369107Free PMC Article

Clinical prediction guides

Diverse intratumoral heterogeneity and immune microenvironment of two HPV-related cervical cancer types revealed by single-cell RNA sequencing.
Li C, Liu D, Zhao Y, Ding Y, Hua K
J Med Virol 2023 Jun;95(6):e28857. doi: 10.1002/jmv.28857. PMID: 37287196
Racial and Ethnic Disparities in Cervical Cancer Incidence, Survival, and Mortality by Histologic Subtype.
Cohen CM, Wentzensen N, Castle PE, Schiffman M, Zuna R, Arend RC, Clarke MA
J Clin Oncol 2023 Feb 10;41(5):1059-1068. Epub 2022 Dec 1 doi: 10.1200/JCO.22.01424. PMID: 36455190Free PMC Article
Single-Nucleus RNA Sequencing and Spatial Transcriptomics Reveal the Immunological Microenvironment of Cervical Squamous Cell Carcinoma.
Ou Z, Lin S, Qiu J, Ding W, Ren P, Chen D, Wang J, Tong Y, Wu D, Chen A, Deng Y, Cheng M, Peng T, Lu H, Yang H, Wang J, Jin X, Ma D, Xu X, Wang Y, Li J, Wu P
Adv Sci (Weinh) 2022 Oct;9(29):e2203040. Epub 2022 Aug 19 doi: 10.1002/advs.202203040. PMID: 35986392Free PMC Article
Predictive value of protease-activated receptor-2 (PAR(2) ) in cervical cancer metastasis.
He S, Xu M, Xiong Z, Hu Y, Huo Q, Lu J, Lin Y, Yang L
J Cell Mol Med 2021 Feb;25(3):1415-1424. Epub 2020 Dec 23 doi: 10.1111/jcmm.16227. PMID: 33369107Free PMC Article
Predicting Early Response to Chemoradiotherapy for Uterine Cervical Cancer Using Intravoxel Incoherent Motion MR Imaging.
Kato H, Esaki K, Yamaguchi T, Tanaka H, Kajita K, Furui T, Morishige KI, Goshima S, Matsuo M
Magn Reson Med Sci 2019 Oct 15;18(4):293-298. Epub 2019 Feb 19 doi: 10.2463/mrms.tn.2018-0138. PMID: 30787252Free PMC Article

Recent systematic reviews

The impacts of dipeptidyl- peptidase 4 (DPP-4) inhibitors on common female malignancies: A systematic review.
Niazmand A, Nedaeinia R, Vatandoost N, Jafarpour S, Safabakhsh S, Kolahdouz M, Ferns GA, Salehi R
Gene 2024 Nov 15;927:148659. Epub 2024 Jun 10 doi: 10.1016/j.gene.2024.148659. PMID: 38866262
Hormone replacement therapy and cervical cancer: a systematic review of the literature.
Vargiu V, Amar ID, Rosati A, Dinoi G, Turco LC, Capozzi VA, Scambia G, Villa P
Climacteric 2021 Apr;24(2):120-127. Epub 2020 Nov 25 doi: 10.1080/13697137.2020.1826426. PMID: 33236658
The association between serum squamous cell carcinoma antigen and recurrence and survival of patients with cervical squamous cell carcinoma: A systematic review and meta-analysis.
Charakorn C, Thadanipon K, Chaijindaratana S, Rattanasiri S, Numthavaj P, Thakkinstian A
Gynecol Oncol 2018 Jul;150(1):190-200. Epub 2018 Mar 29 doi: 10.1016/j.ygyno.2018.03.056. PMID: 29606483
Chromosomal gains and losses in human papillomavirus-associated neoplasia of the lower genital tract - a systematic review and meta-analysis.
Thomas LK, Bermejo JL, Vinokurova S, Jensen K, Bierkens M, Steenbergen R, Bergmann M, von Knebel Doeberitz M, Reuschenbach M
Eur J Cancer 2014 Jan;50(1):85-98. Epub 2013 Sep 17 doi: 10.1016/j.ejca.2013.08.022. PMID: 24054023
Mutations of the TP53 gene in adenocarcinoma and squamous cell carcinoma of the cervix: a systematic review.
Tornesello ML, Buonaguro L, Buonaguro FM
Gynecol Oncol 2013 Mar;128(3):442-8. Epub 2012 Nov 17 doi: 10.1016/j.ygyno.2012.11.017. PMID: 23168175

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