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High-CSD Melanoma

MedGen UID:
1719520
•Concept ID:
C5237350
•
Neoplastic Process
Synonyms: Cutaneous Melanoma with a High Degree of Cumulative Sun Damage; Cutaneous Melanoma with a High Degree of Cumulative Sun Damage (CSD)

Definition

A finding indicating a high degree of cumulative sun damage in the skin as evidenced by severe solar keratosis. (WHO 2018) [from NCI]

Professional guidelines

PubMed

Dermoscopic Criteria, Histopathological Correlates and Genetic Findings of Thin Melanoma on Non-Volar Skin.
Massone C, Hofman-Wellenhof R, Chiodi S, Sola S
Genes (Basel) 2021 Aug 23;12(8) doi: 10.3390/genes12081288. PMID: 34440462Free PMC Article

Recent clinical studies

Etiology

Clinical history analysis of Japanese melanoma cases and characteristics of melanoma with childhood onset.
Minagawa A, Uhara H, Ashida A, Koga H, Okuyama R
J Dermatol 2022 Dec;49(12):1334-1337. Epub 2022 Aug 10 doi: 10.1111/1346-8138.16545. PMID: 35946357
Molecular Markers and Targets in Melanoma.
Teixido C, Castillo P, Martinez-Vila C, Arance A, Alos L
Cells 2021 Sep 5;10(9) doi: 10.3390/cells10092320. PMID: 34571969Free PMC Article
Histopathologic classification and prognostic factors of melanoma: a 2021 update.
Bobos M
Ital J Dermatol Venerol 2021 Jun;156(3):300-321. Epub 2021 May 13 doi: 10.23736/S2784-8671.21.06958-3. PMID: 33982546
The 2018 World Health Organization Classification of Cutaneous, Mucosal, and Uveal Melanoma: Detailed Analysis of 9 Distinct Subtypes Defined by Their Evolutionary Pathway.
Elder DE, Bastian BC, Cree IA, Massi D, Scolyer RA
Arch Pathol Lab Med 2020 Apr;144(4):500-522. Epub 2020 Feb 14 doi: 10.5858/arpa.2019-0561-RA. PMID: 32057276

Diagnosis

Refining the application of PRAME-a useful marker in high CSD and acral melanoma subtypes.
Wakefield C, O'Keefe L, Heffron CCBB
Virchows Arch 2023 Dec;483(6):847-854. Epub 2023 Sep 19 doi: 10.1007/s00428-023-03648-w. PMID: 37723345
Clinical history analysis of Japanese melanoma cases and characteristics of melanoma with childhood onset.
Minagawa A, Uhara H, Ashida A, Koga H, Okuyama R
J Dermatol 2022 Dec;49(12):1334-1337. Epub 2022 Aug 10 doi: 10.1111/1346-8138.16545. PMID: 35946357
Dermoscopic Criteria, Histopathological Correlates and Genetic Findings of Thin Melanoma on Non-Volar Skin.
Massone C, Hofman-Wellenhof R, Chiodi S, Sola S
Genes (Basel) 2021 Aug 23;12(8) doi: 10.3390/genes12081288. PMID: 34440462Free PMC Article
Histopathologic classification and prognostic factors of melanoma: a 2021 update.
Bobos M
Ital J Dermatol Venerol 2021 Jun;156(3):300-321. Epub 2021 May 13 doi: 10.23736/S2784-8671.21.06958-3. PMID: 33982546

Therapy

Molecular Markers and Targets in Melanoma.
Teixido C, Castillo P, Martinez-Vila C, Arance A, Alos L
Cells 2021 Sep 5;10(9) doi: 10.3390/cells10092320. PMID: 34571969Free PMC Article

Prognosis

Activated Akt expression is associated with the recurrence of primary melanomas and further refines the prognostic and predictive values for relapse in acral melanomas.
Nojima K, Hayashi M, Tanemura A, Al-Busani H, Saito T, Suzuki T, Ishikawa M, Mori T, Wada S, Yamazaki N, Katayama I, Mori H, Yokozeki H, Okiyama N, Sasaki Y, Namiki T
Pigment Cell Melanoma Res 2024 Jan;37(1):36-44. Epub 2023 Aug 18 doi: 10.1111/pcmr.13119. PMID: 37596787
Molecular Markers and Targets in Melanoma.
Teixido C, Castillo P, Martinez-Vila C, Arance A, Alos L
Cells 2021 Sep 5;10(9) doi: 10.3390/cells10092320. PMID: 34571969Free PMC Article
Dermoscopic Criteria, Histopathological Correlates and Genetic Findings of Thin Melanoma on Non-Volar Skin.
Massone C, Hofman-Wellenhof R, Chiodi S, Sola S
Genes (Basel) 2021 Aug 23;12(8) doi: 10.3390/genes12081288. PMID: 34440462Free PMC Article
Histopathologic classification and prognostic factors of melanoma: a 2021 update.
Bobos M
Ital J Dermatol Venerol 2021 Jun;156(3):300-321. Epub 2021 May 13 doi: 10.23736/S2784-8671.21.06958-3. PMID: 33982546

Clinical prediction guides

Activated Akt expression is associated with the recurrence of primary melanomas and further refines the prognostic and predictive values for relapse in acral melanomas.
Nojima K, Hayashi M, Tanemura A, Al-Busani H, Saito T, Suzuki T, Ishikawa M, Mori T, Wada S, Yamazaki N, Katayama I, Mori H, Yokozeki H, Okiyama N, Sasaki Y, Namiki T
Pigment Cell Melanoma Res 2024 Jan;37(1):36-44. Epub 2023 Aug 18 doi: 10.1111/pcmr.13119. PMID: 37596787
Refining the application of PRAME-a useful marker in high CSD and acral melanoma subtypes.
Wakefield C, O'Keefe L, Heffron CCBB
Virchows Arch 2023 Dec;483(6):847-854. Epub 2023 Sep 19 doi: 10.1007/s00428-023-03648-w. PMID: 37723345
Dermoscopic Criteria, Histopathological Correlates and Genetic Findings of Thin Melanoma on Non-Volar Skin.
Massone C, Hofman-Wellenhof R, Chiodi S, Sola S
Genes (Basel) 2021 Aug 23;12(8) doi: 10.3390/genes12081288. PMID: 34440462Free PMC Article
Histopathologic classification and prognostic factors of melanoma: a 2021 update.
Bobos M
Ital J Dermatol Venerol 2021 Jun;156(3):300-321. Epub 2021 May 13 doi: 10.23736/S2784-8671.21.06958-3. PMID: 33982546

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