U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Invasive Cervical Carcinoma

MedGen UID:
233552
•Concept ID:
C1334177
•
Neoplastic Process
Synonyms: Cancer of uterine cervix, invasive; Carcinoma of uterine cervix, invasive; Infiltrating Cervical Carcinoma; Invasive cervical cancer
SNOMED CT: Carcinoma of uterine cervix, invasive (423973006); Cancer of uterine cervix, invasive (423973006); Invasive cervical cancer (423973006)

Definition

A carcinoma that arises from the cervix and invades into the stromal tissue. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInvasive Cervical Carcinoma

Professional guidelines

PubMed

Evidence-Based Treatment Paradigms for Management of Invasive Cervical Carcinoma.
Tewari KS, Monk BJ
J Clin Oncol 2019 Sep 20;37(27):2472-2489. Epub 2019 Aug 12 doi: 10.1200/JCO.18.02303. PMID: 31403858Free PMC Article
HIV-related Malignancies and Mimics: Imaging Findings and Management.
Javadi S, Menias CO, Karbasian N, Shaaban A, Shah K, Osman A, Jensen CT, Lubner MG, Gaballah AH, Elsayes KM
Radiographics 2018 Nov-Dec;38(7):2051-2068. Epub 2018 Oct 19 doi: 10.1148/rg.2018180149. PMID: 30339518
French recommendations on the management of invasive cervical cancer during pregnancy.
Morice P, Narducci F, Mathevet P, Marret H, Darai E, Querleu D; French Working Group on Gynecological Cancers in Pregnancy; Société Française d'Oncologie Gynécologique (SFOG); Société Française de Chirurgie Pelvienne (SFCP); Collège National des Gynécologues Obstétriciens Français (CNGOF)
Int J Gynecol Cancer 2009 Dec;19(9):1638-41. doi: 10.1111/IGC.0b013e3181a83017. PMID: 19955951

Recent clinical studies

Etiology

GLUT1, LDHA, and MCT4 Expression Is Deregulated in Cervical Cancer and Precursor Lesions.
Reyna-Hernández MA, Alarcón-Romero LDC, Ortiz-Ortiz J, Illades-Aguiar B, Jiménez-López MA, Ocampo-Bárcenas A, Morrugares-Ixtepan MO, Torres-Rojas FI
J Histochem Cytochem 2022 Jun;70(6):437-446. Epub 2022 May 26 doi: 10.1369/00221554221101662. PMID: 35615882Free PMC Article
HIV-related Malignancies and Mimics: Imaging Findings and Management.
Javadi S, Menias CO, Karbasian N, Shaaban A, Shah K, Osman A, Jensen CT, Lubner MG, Gaballah AH, Elsayes KM
Radiographics 2018 Nov-Dec;38(7):2051-2068. Epub 2018 Oct 19 doi: 10.1148/rg.2018180149. PMID: 30339518
Final efficacy, immunogenicity, and safety analyses of a nine-valent human papillomavirus vaccine in women aged 16-26 years: a randomised, double-blind trial.
Huh WK, Joura EA, Giuliano AR, Iversen OE, de Andrade RP, Ault KA, Bartholomew D, Cestero RM, Fedrizzi EN, Hirschberg AL, Mayrand MH, Ruiz-Sternberg AM, Stapleton JT, Wiley DJ, Ferenczy A, Kurman R, Ronnett BM, Stoler MH, Cuzick J, Garland SM, Kjaer SK, Bautista OM, Haupt R, Moeller E, Ritter M, Roberts CC, Shields C, Luxembourg A
Lancet 2017 Nov 11;390(10108):2143-2159. Epub 2017 Sep 5 doi: 10.1016/S0140-6736(17)31821-4. PMID: 28886907
The terminology of pre-invasive cervical lesions in the UK cervical screening programme.
Herrington CS
Cytopathology 2015 Dec;26(6):346-50. doi: 10.1111/cyt.12307. PMID: 26767601
Efficacy of HPV-based screening for prevention of invasive cervical cancer: follow-up of four European randomised controlled trials.
Ronco G, Dillner J, Elfström KM, Tunesi S, Snijders PJ, Arbyn M, Kitchener H, Segnan N, Gilham C, Giorgi-Rossi P, Berkhof J, Peto J, Meijer CJ; International HPV screening working group
Lancet 2014 Feb 8;383(9916):524-32. Epub 2013 Nov 3 doi: 10.1016/S0140-6736(13)62218-7. PMID: 24192252

Diagnosis

Perceptions and attitude of women of Luderitz, Namibia on Pap smear and cervical cancer prevention.
Hausiku L, Kouame K, Aboua YG
BMC Womens Health 2022 Apr 21;22(1):126. doi: 10.1186/s12905-022-01698-x. PMID: 35449007Free PMC Article
Prevalence and predictors of HIV screening in invasive cervical cancer: a 10 year cohort study.
Alldredge J, Leaf MC, Patel P, Coakley K, Longoria T, McLaren C, Randall LM
Int J Gynecol Cancer 2020 Jun;30(6):772-776. Epub 2020 Mar 9 doi: 10.1136/ijgc-2019-000909. PMID: 32156714Free PMC Article
HIV-related Malignancies and Mimics: Imaging Findings and Management.
Javadi S, Menias CO, Karbasian N, Shaaban A, Shah K, Osman A, Jensen CT, Lubner MG, Gaballah AH, Elsayes KM
Radiographics 2018 Nov-Dec;38(7):2051-2068. Epub 2018 Oct 19 doi: 10.1148/rg.2018180149. PMID: 30339518
Final efficacy, immunogenicity, and safety analyses of a nine-valent human papillomavirus vaccine in women aged 16-26 years: a randomised, double-blind trial.
Huh WK, Joura EA, Giuliano AR, Iversen OE, de Andrade RP, Ault KA, Bartholomew D, Cestero RM, Fedrizzi EN, Hirschberg AL, Mayrand MH, Ruiz-Sternberg AM, Stapleton JT, Wiley DJ, Ferenczy A, Kurman R, Ronnett BM, Stoler MH, Cuzick J, Garland SM, Kjaer SK, Bautista OM, Haupt R, Moeller E, Ritter M, Roberts CC, Shields C, Luxembourg A
Lancet 2017 Nov 11;390(10108):2143-2159. Epub 2017 Sep 5 doi: 10.1016/S0140-6736(17)31821-4. PMID: 28886907
Colposcopic evaluation of pre-invasive and early cervical carcinoma with histologic correlation.
Shahida SM, Mirza TT, Saleh AF, Islam MA
Mymensingh Med J 2012 Apr;21(2):200-6. PMID: 22561759

Therapy

The Impact of Human Papilloma Viruses, Matrix Metallo-Proteinases and HIV Protease Inhibitors on the Onset and Progression of Uterine Cervix Epithelial Tumors: A Review of Preclinical and Clinical Studies.
Barillari G, Monini P, Sgadari C, Ensoli B
Int J Mol Sci 2018 May 9;19(5) doi: 10.3390/ijms19051418. PMID: 29747434Free PMC Article
Final efficacy, immunogenicity, and safety analyses of a nine-valent human papillomavirus vaccine in women aged 16-26 years: a randomised, double-blind trial.
Huh WK, Joura EA, Giuliano AR, Iversen OE, de Andrade RP, Ault KA, Bartholomew D, Cestero RM, Fedrizzi EN, Hirschberg AL, Mayrand MH, Ruiz-Sternberg AM, Stapleton JT, Wiley DJ, Ferenczy A, Kurman R, Ronnett BM, Stoler MH, Cuzick J, Garland SM, Kjaer SK, Bautista OM, Haupt R, Moeller E, Ritter M, Roberts CC, Shields C, Luxembourg A
Lancet 2017 Nov 11;390(10108):2143-2159. Epub 2017 Sep 5 doi: 10.1016/S0140-6736(17)31821-4. PMID: 28886907
Efficacy of HPV-based screening for prevention of invasive cervical cancer: follow-up of four European randomised controlled trials.
Ronco G, Dillner J, Elfström KM, Tunesi S, Snijders PJ, Arbyn M, Kitchener H, Segnan N, Gilham C, Giorgi-Rossi P, Berkhof J, Peto J, Meijer CJ; International HPV screening working group
Lancet 2014 Feb 8;383(9916):524-32. Epub 2013 Nov 3 doi: 10.1016/S0140-6736(13)62218-7. PMID: 24192252
Retinoids for preventing the progression of cervical intra-epithelial neoplasia.
Helm CW, Lorenz DJ, Meyer NJ, Rising WW, Wulff JL
Cochrane Database Syst Rev 2013 Jun 6;2013(6):CD003296. doi: 10.1002/14651858.CD003296.pub3. PMID: 23740788Free PMC Article
Vaginal cancer.
Grigsby PW
Curr Treat Options Oncol 2002 Apr;3(2):125-30. doi: 10.1007/s11864-002-0058-4. PMID: 12057075

Prognosis

GLUT1, LDHA, and MCT4 Expression Is Deregulated in Cervical Cancer and Precursor Lesions.
Reyna-Hernández MA, Alarcón-Romero LDC, Ortiz-Ortiz J, Illades-Aguiar B, Jiménez-López MA, Ocampo-Bárcenas A, Morrugares-Ixtepan MO, Torres-Rojas FI
J Histochem Cytochem 2022 Jun;70(6):437-446. Epub 2022 May 26 doi: 10.1369/00221554221101662. PMID: 35615882Free PMC Article
Evidence-Based Treatment Paradigms for Management of Invasive Cervical Carcinoma.
Tewari KS, Monk BJ
J Clin Oncol 2019 Sep 20;37(27):2472-2489. Epub 2019 Aug 12 doi: 10.1200/JCO.18.02303. PMID: 31403858Free PMC Article
HIV-related Malignancies and Mimics: Imaging Findings and Management.
Javadi S, Menias CO, Karbasian N, Shaaban A, Shah K, Osman A, Jensen CT, Lubner MG, Gaballah AH, Elsayes KM
Radiographics 2018 Nov-Dec;38(7):2051-2068. Epub 2018 Oct 19 doi: 10.1148/rg.2018180149. PMID: 30339518
Final efficacy, immunogenicity, and safety analyses of a nine-valent human papillomavirus vaccine in women aged 16-26 years: a randomised, double-blind trial.
Huh WK, Joura EA, Giuliano AR, Iversen OE, de Andrade RP, Ault KA, Bartholomew D, Cestero RM, Fedrizzi EN, Hirschberg AL, Mayrand MH, Ruiz-Sternberg AM, Stapleton JT, Wiley DJ, Ferenczy A, Kurman R, Ronnett BM, Stoler MH, Cuzick J, Garland SM, Kjaer SK, Bautista OM, Haupt R, Moeller E, Ritter M, Roberts CC, Shields C, Luxembourg A
Lancet 2017 Nov 11;390(10108):2143-2159. Epub 2017 Sep 5 doi: 10.1016/S0140-6736(17)31821-4. PMID: 28886907
Efficacy of HPV-based screening for prevention of invasive cervical cancer: follow-up of four European randomised controlled trials.
Ronco G, Dillner J, Elfström KM, Tunesi S, Snijders PJ, Arbyn M, Kitchener H, Segnan N, Gilham C, Giorgi-Rossi P, Berkhof J, Peto J, Meijer CJ; International HPV screening working group
Lancet 2014 Feb 8;383(9916):524-32. Epub 2013 Nov 3 doi: 10.1016/S0140-6736(13)62218-7. PMID: 24192252

Clinical prediction guides

GLUT1, LDHA, and MCT4 Expression Is Deregulated in Cervical Cancer and Precursor Lesions.
Reyna-Hernández MA, Alarcón-Romero LDC, Ortiz-Ortiz J, Illades-Aguiar B, Jiménez-López MA, Ocampo-Bárcenas A, Morrugares-Ixtepan MO, Torres-Rojas FI
J Histochem Cytochem 2022 Jun;70(6):437-446. Epub 2022 May 26 doi: 10.1369/00221554221101662. PMID: 35615882Free PMC Article
Perceptions and attitude of women of Luderitz, Namibia on Pap smear and cervical cancer prevention.
Hausiku L, Kouame K, Aboua YG
BMC Womens Health 2022 Apr 21;22(1):126. doi: 10.1186/s12905-022-01698-x. PMID: 35449007Free PMC Article
ALDH1 & CD133 in invasive cervical carcinoma & their association with the outcome of chemoradiation therapy.
Javed S, Sood S, Rai B, Bhattacharyya S, Bagga R, Srinivasan R
Indian J Med Res 2021 Aug;154(2):367-374. doi: 10.4103/ijmr.IJMR_709_20. PMID: 35295009Free PMC Article
A polycomb-mediated epigenetic field defect precedes invasive cervical carcinoma.
Wijetunga NA, Ben-Dayan M, Tozour J, Burk RD, Schlecht NF, Einstein MH, Greally JM
Oncotarget 2016 Sep 20;7(38):62133-62143. doi: 10.18632/oncotarget.11390. PMID: 27557505Free PMC Article
Staging of carcinoma of the uterine cervix and endometrium.
Koyama T, Tamai K, Togashi K
Eur Radiol 2007 Aug;17(8):2009-19. Epub 2007 Jan 12 doi: 10.1007/s00330-006-0555-0. PMID: 17219142

Recent systematic reviews

Prevalence of human papillomavirus genotypes among African women with normal cervical cytology and neoplasia: a systematic review and meta-analysis.
Ogembo RK, Gona PN, Seymour AJ, Park HS, Bain PA, Maranda L, Ogembo JG
PLoS One 2015;10(4):e0122488. Epub 2015 Apr 14 doi: 10.1371/journal.pone.0122488. PMID: 25875167Free PMC Article
Retinoids for preventing the progression of cervical intra-epithelial neoplasia.
Helm CW, Lorenz DJ, Meyer NJ, Rising WW, Wulff JL
Cochrane Database Syst Rev 2013 Jun 6;2013(6):CD003296. doi: 10.1002/14651858.CD003296.pub3. PMID: 23740788Free PMC Article
Retinoids for preventing the progression of cervical intra-epithelial neoplasia.
Helm CW, Lorenz DJ, Meyer NJ, Rising WR, Wulff JL
Cochrane Database Syst Rev 2007 Oct 17;(4):CD003296. doi: 10.1002/14651858.CD003296.pub2. PMID: 17943787

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...