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Breast phyllodes tumor

MedGen UID:
65943
Concept ID:
C0238031
Neoplastic Process
Synonyms: Cystosarcoma phyllodes; Phyllodes tumor of the breast
SNOMED CT: Phyllodes tumor of breast (712989008)
 
Monarch Initiative: MONDO:0021047

Definition

Phyllodes tumour of the breast is a rare fibroepithelial neoplasm accounting for less than 1% of all mammary tumours, usually presenting in adult females (most frequently between the ages of 35-55 years), ranging from benign to malignant and often presenting with well circumscribed mobile masses that grow rapidly and sometimes with additional non-specific symptoms such as dilated skin veins, nipple retraction, skin ulcers, palpable axillary lymphadenopathy or blue discoloration of the skin. [from SNOMEDCT_US]

Professional guidelines

PubMed

Gradishar WJ, Moran MS, Abraham J, Abramson V, Aft R, Agnese D, Allison KH, Anderson B, Bailey J, Burstein HJ, Chen N, Chew H, Dang C, Elias AD, Giordano SH, Goetz MP, Jankowitz RC, Javid SH, Krishnamurthy J, Leitch AM, Lyons J, McCloskey S, McShane M, Mortimer J, Patel SA, Rosenberger LH, Rugo HS, Santa-Maria C, Schneider BP, Smith ML, Soliman H, Stringer-Reasor EM, Telli ML, Wei M, Wisinski KB, Yeung KT, Young JS, Schonfeld R, Kumar R
J Natl Compr Canc Netw 2024 Jul;22(5):331-357. doi: 10.6004/jnccn.2024.0035. PMID: 39019058
Gradishar WJ, Moran MS, Abraham J, Aft R, Agnese D, Allison KH, Anderson B, Burstein HJ, Chew H, Dang C, Elias AD, Giordano SH, Goetz MP, Goldstein LJ, Hurvitz SA, Isakoff SJ, Jankowitz RC, Javid SH, Krishnamurthy J, Leitch M, Lyons J, Mortimer J, Patel SA, Pierce LJ, Rosenberger LH, Rugo HS, Sitapati A, Smith KL, Smith ML, Soliman H, Stringer-Reasor EM, Telli ML, Ward JH, Wisinski KB, Young JS, Burns J, Kumar R
J Natl Compr Canc Netw 2022 Jun;20(6):691-722. doi: 10.6004/jnccn.2022.0030. PMID: 35714673
Zhang Y, Kleer CG
Arch Pathol Lab Med 2016 Jul;140(7):665-71. doi: 10.5858/arpa.2016-0042-RA. PMID: 27362571

Recent clinical studies

Etiology

Liu N, Kang Y, Qu N, Kong C, Han Y
BMC Cancer 2023 Aug 28;23(1):801. doi: 10.1186/s12885-023-11279-2. PMID: 37635229Free PMC Article
Wang Q, Wei L, Zhou Y, Ou Y, Li H
Cancer Rep (Hoboken) 2023 Sep;6(9):e1865. Epub 2023 Aug 14 doi: 10.1002/cnr2.1865. PMID: 37580942Free PMC Article
Zhang L, Bi J, Yu X, Li X, Liu X, Weng X, Shao M
Ann Diagn Pathol 2023 Oct;66:152176. Epub 2023 Jul 4 doi: 10.1016/j.anndiagpath.2023.152176. PMID: 37423116
Kim SI, Koo JS
Cancer Biomark 2020;29(2):235-243. doi: 10.3233/CBM-191276. PMID: 32675396
Spitaleri G, Toesca A, Botteri E, Bottiglieri L, Rotmensz N, Boselli S, Sangalli C, Catania C, Toffalorio F, Noberasco C, Delmonte A, Luini A, Veronesi P, Colleoni M, Viale G, Zurrida S, Goldhirsch A, Veronesi U, De Pas T
Crit Rev Oncol Hematol 2013 Nov;88(2):427-36. Epub 2013 Jul 17 doi: 10.1016/j.critrevonc.2013.06.005. PMID: 23871531

Diagnosis

Liu N, Kang Y, Qu N, Kong C, Han Y
BMC Cancer 2023 Aug 28;23(1):801. doi: 10.1186/s12885-023-11279-2. PMID: 37635229Free PMC Article
Zhang L, Bi J, Yu X, Li X, Liu X, Weng X, Shao M
Ann Diagn Pathol 2023 Oct;66:152176. Epub 2023 Jul 4 doi: 10.1016/j.anndiagpath.2023.152176. PMID: 37423116
Kim SI, Koo JS
Cancer Biomark 2020;29(2):235-243. doi: 10.3233/CBM-191276. PMID: 32675396
Kim SK, Jung WH, Koo JS
Int J Clin Exp Pathol 2014;7(9):5997-6005. Epub 2014 Aug 15 PMID: 25337244Free PMC Article
Spitaleri G, Toesca A, Botteri E, Bottiglieri L, Rotmensz N, Boselli S, Sangalli C, Catania C, Toffalorio F, Noberasco C, Delmonte A, Luini A, Veronesi P, Colleoni M, Viale G, Zurrida S, Goldhirsch A, Veronesi U, De Pas T
Crit Rev Oncol Hematol 2013 Nov;88(2):427-36. Epub 2013 Jul 17 doi: 10.1016/j.critrevonc.2013.06.005. PMID: 23871531

Therapy

Fan Y, Zhang L, Sun Y, Yang M, Wang X, Wu X, Huang W, Chen L, Pan S, Guan J
Cancer Gene Ther 2020 Apr;27(3-4):216-225. Epub 2019 Feb 21 doi: 10.1038/s41417-019-0087-9. PMID: 30787448
Kuo CY, Lin SH, Lee KD, Cheng SJ, Chu JS, Tu SH
BMC Surg 2019 Jul 27;19(1):100. doi: 10.1186/s12893-019-0562-0. PMID: 31351458Free PMC Article

Prognosis

Chen J, Xu Q, Liu D, Li X, Guo M, Chen X, Liao J, Lei R, Li W, Huang H, Saw PE, Song E, Yan X, Nie Y
Cancer Commun (Lond) 2023 Nov;43(11):1244-1266. Epub 2023 Oct 19 doi: 10.1002/cac2.12495. PMID: 37856423Free PMC Article
Liu N, Kang Y, Qu N, Kong C, Han Y
BMC Cancer 2023 Aug 28;23(1):801. doi: 10.1186/s12885-023-11279-2. PMID: 37635229Free PMC Article
Kim SI, Koo JS
Cancer Biomark 2020;29(2):235-243. doi: 10.3233/CBM-191276. PMID: 32675396
Choi J, Kim DH, Jung W, Koo JS
Histol Histopathol 2014 Oct;29(10):1343-54. Epub 2014 May 7 doi: 10.14670/HH-29.1343. PMID: 24807638
Spitaleri G, Toesca A, Botteri E, Bottiglieri L, Rotmensz N, Boselli S, Sangalli C, Catania C, Toffalorio F, Noberasco C, Delmonte A, Luini A, Veronesi P, Colleoni M, Viale G, Zurrida S, Goldhirsch A, Veronesi U, De Pas T
Crit Rev Oncol Hematol 2013 Nov;88(2):427-36. Epub 2013 Jul 17 doi: 10.1016/j.critrevonc.2013.06.005. PMID: 23871531

Clinical prediction guides

Chen J, Xu Q, Liu D, Li X, Guo M, Chen X, Liao J, Lei R, Li W, Huang H, Saw PE, Song E, Yan X, Nie Y
Cancer Commun (Lond) 2023 Nov;43(11):1244-1266. Epub 2023 Oct 19 doi: 10.1002/cac2.12495. PMID: 37856423Free PMC Article
Kim SI, Koo JS
Cancer Biomark 2020;29(2):235-243. doi: 10.3233/CBM-191276. PMID: 32675396
Fan Y, Zhang L, Sun Y, Yang M, Wang X, Wu X, Huang W, Chen L, Pan S, Guan J
Cancer Gene Ther 2020 Apr;27(3-4):216-225. Epub 2019 Feb 21 doi: 10.1038/s41417-019-0087-9. PMID: 30787448
Kim SK, Jung WH, Koo JS
Int J Clin Exp Pathol 2014;7(9):5997-6005. Epub 2014 Aug 15 PMID: 25337244Free PMC Article
Gong C, Nie Y, Qu S, Liao JY, Cui X, Yao H, Zeng Y, Su F, Song E, Liu Q
Cancer Res 2014 Aug 15;74(16):4341-52. Epub 2014 Jun 30 doi: 10.1158/0008-5472.CAN-14-0125. PMID: 24980553

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