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Unresectable Neuroendocrine Carcinoma

MedGen UID:
1744762
•Concept ID:
C5419869
•
Neoplastic Process

Definition

Neuroendocrine carcinoma that is not amenable to surgical resection. [from NCI]

Professional guidelines

PubMed

Radiotherapy in the management of rare gastrointestinal cancers: A systematic review.
Bellefkih FZ, Benchakroun N, Lalya I, Amaoui B, El Kacemi H, Acharki A, El Hfid M, El Mazghi A, Chekrine T, Bouchbika Z, Jouhadi H, Sahraoui S, Tawfiq N, Michalet M
Cancer Radiother 2023 Sep;27(6-7):622-637. Epub 2023 Jul 25 doi: 10.1016/j.canrad.2023.06.010. PMID: 37500390
Molecular Signatures and Their Clinical Utility in Pancreatic Neuroendocrine Tumors.
Chatani PD, Agarwal SK, Sadowski SM
Front Endocrinol (Lausanne) 2020;11:575620. Epub 2021 Jan 18 doi: 10.3389/fendo.2020.575620. PMID: 33537001Free PMC Article
Management of hereditary medullary thyroid carcinoma.
Pappa T, Alevizaki M
Endocrine 2016 Jul;53(1):7-17. Epub 2016 Feb 2 doi: 10.1007/s12020-016-0873-1. PMID: 26839093

Recent clinical studies

Therapy

Combined nivolumab and ipilimumab with or without stereotactic body radiation therapy for advanced Merkel cell carcinoma: a randomised, open label, phase 2 trial.
Kim S, Wuthrick E, Blakaj D, Eroglu Z, Verschraegen C, Thapa R, Mills M, Dibs K, Liveringhouse C, Russell J, Caudell JJ, Tarhini A, Markowitz J, Kendra K, Wu R, Chen DT, Berglund A, Michael L, Aoki M, Wang MH, Hamaidi I, Cheng P, de la Iglesia J, Slebos RJ, Chung CH, Knepper TC, Moran-Segura CM, Nguyen JV, Perez BA, Rose T, Harrison L, Messina JL, Sondak VK, Tsai KY, Khushalani NI, Brohl AS
Lancet 2022 Sep 24;400(10357):1008-1019. Epub 2022 Sep 12 doi: 10.1016/S0140-6736(22)01659-2. PMID: 36108657Free PMC Article
Effectiveness of Etoposide and Cisplatin vs Irinotecan and Cisplatin Therapy for Patients With Advanced Neuroendocrine Carcinoma of the Digestive System: The TOPIC-NEC Phase 3 Randomized Clinical Trial.
Morizane C, Machida N, Honma Y, Okusaka T, Boku N, Kato K, Nomura S, Hiraoka N, Sekine S, Taniguchi H, Okano N, Yamaguchi K, Sato T, Ikeda M, Mizuno N, Ozaka M, Kataoka T, Ueno M, Kitagawa Y, Terashima M, Furuse J; Japan Clinical Oncology Group (JCOG)
JAMA Oncol 2022 Oct 1;8(10):1447-1455. doi: 10.1001/jamaoncol.2022.3395. PMID: 35980649Free PMC Article
Immunotherapy for Merkel cell carcinoma.
Angeles CV, Sabel MS
J Surg Oncol 2021 Mar;123(3):775-781. doi: 10.1002/jso.26319. PMID: 33595894
Efficacy of Pembrolizumab in Patients With Noncolorectal High Microsatellite Instability/Mismatch Repair-Deficient Cancer: Results From the Phase II KEYNOTE-158 Study.
Marabelle A, Le DT, Ascierto PA, Di Giacomo AM, De Jesus-Acosta A, Delord JP, Geva R, Gottfried M, Penel N, Hansen AR, Piha-Paul SA, Doi T, Gao B, Chung HC, Lopez-Martin J, Bang YJ, Frommer RS, Shah M, Ghori R, Joe AK, Pruitt SK, Diaz LA Jr
J Clin Oncol 2020 Jan 1;38(1):1-10. Epub 2019 Nov 4 doi: 10.1200/JCO.19.02105. PMID: 31682550Free PMC Article
Liver transplantation for malignancies.
Eghtesad B, Aucejo F
J Gastrointest Cancer 2014 Sep;45(3):353-62. doi: 10.1007/s12029-014-9590-2. PMID: 24604263

Prognosis

Treating rare tumors with liver transplantation.
Melehy A, Agopian V
Curr Opin Organ Transplant 2024 Feb 1;29(1):30-36. Epub 2023 Oct 18 doi: 10.1097/MOT.0000000000001118. PMID: 37851086
Lung Neuroendocrine Tumors: How Does Molecular Profiling Help?
Sun TY, Hendifar A, Padda SK
Curr Oncol Rep 2022 Jul;24(7):819-824. Epub 2022 Mar 19 doi: 10.1007/s11912-022-01253-9. PMID: 35305210
The Role of Surgery for Pancreatic Neuroendocrine Tumors.
Ziogas IA, Schmitz R, Moris D, Vatsaas CJ
Anticancer Res 2022 Feb;42(2):629-639. doi: 10.21873/anticanres.15520. PMID: 35093860
Biliary tract large cell neuroendocrine carcinoma: current evidence.
Raiker R, Chauhan A, Hasanein H, Burkeen G, Horn M, Veedu J, Vela C, Arnold S, Kolesar J, Anthony L, Evers BM, Cavnar M
Orphanet J Rare Dis 2019 Nov 21;14(1):266. doi: 10.1186/s13023-019-1230-2. PMID: 31752927Free PMC Article
Management of hereditary medullary thyroid carcinoma.
Pappa T, Alevizaki M
Endocrine 2016 Jul;53(1):7-17. Epub 2016 Feb 2 doi: 10.1007/s12020-016-0873-1. PMID: 26839093

Clinical prediction guides

Treating rare tumors with liver transplantation.
Melehy A, Agopian V
Curr Opin Organ Transplant 2024 Feb 1;29(1):30-36. Epub 2023 Oct 18 doi: 10.1097/MOT.0000000000001118. PMID: 37851086
Combined nivolumab and ipilimumab with or without stereotactic body radiation therapy for advanced Merkel cell carcinoma: a randomised, open label, phase 2 trial.
Kim S, Wuthrick E, Blakaj D, Eroglu Z, Verschraegen C, Thapa R, Mills M, Dibs K, Liveringhouse C, Russell J, Caudell JJ, Tarhini A, Markowitz J, Kendra K, Wu R, Chen DT, Berglund A, Michael L, Aoki M, Wang MH, Hamaidi I, Cheng P, de la Iglesia J, Slebos RJ, Chung CH, Knepper TC, Moran-Segura CM, Nguyen JV, Perez BA, Rose T, Harrison L, Messina JL, Sondak VK, Tsai KY, Khushalani NI, Brohl AS
Lancet 2022 Sep 24;400(10357):1008-1019. Epub 2022 Sep 12 doi: 10.1016/S0140-6736(22)01659-2. PMID: 36108657Free PMC Article
Lung Neuroendocrine Tumors: How Does Molecular Profiling Help?
Sun TY, Hendifar A, Padda SK
Curr Oncol Rep 2022 Jul;24(7):819-824. Epub 2022 Mar 19 doi: 10.1007/s11912-022-01253-9. PMID: 35305210
Chemosaturation Percutaneous Hepatic Perfusion: A Systematic Review.
Vogel A, Gupta S, Zeile M, von Haken R, Brüning R, Lotz G, Vahrmeijer A, Vogl T, Wacker F
Adv Ther 2017 Jan;33(12):2122-2138. Epub 2016 Oct 31 doi: 10.1007/s12325-016-0424-4. PMID: 27798773Free PMC Article
Thyroid carcinoma.
Gillenwater AM, Weber RS
Cancer Treat Res 1997;90:149-69. doi: 10.1007/978-1-4615-6165-1_8. PMID: 9367082

Recent systematic reviews

Radiotherapy in the management of rare gastrointestinal cancers: A systematic review.
Bellefkih FZ, Benchakroun N, Lalya I, Amaoui B, El Kacemi H, Acharki A, El Hfid M, El Mazghi A, Chekrine T, Bouchbika Z, Jouhadi H, Sahraoui S, Tawfiq N, Michalet M
Cancer Radiother 2023 Sep;27(6-7):622-637. Epub 2023 Jul 25 doi: 10.1016/j.canrad.2023.06.010. PMID: 37500390
Radioactive iodine in the management of medullary carcinoma of the thyroid.
Rowell NP
Br J Radiol 2023 Aug;96(1148):20220660. Epub 2023 Jun 29 doi: 10.1259/bjr.20220660. PMID: 37335288Free PMC Article
Cabozantinib and vandetanib for unresectable locally advanced or metastatic medullary thyroid cancer: a systematic review and economic model.
Tappenden P, Carroll C, Hamilton J, Kaltenthaler E, Wong R, Wadsley J, Moss L, Balasubramanian S
Health Technol Assess 2019 Feb;23(8):1-144. doi: 10.3310/hta23080. PMID: 30821231Free PMC Article
Chemosaturation Percutaneous Hepatic Perfusion: A Systematic Review.
Vogel A, Gupta S, Zeile M, von Haken R, Brüning R, Lotz G, Vahrmeijer A, Vogl T, Wacker F
Adv Ther 2017 Jan;33(12):2122-2138. Epub 2016 Oct 31 doi: 10.1007/s12325-016-0424-4. PMID: 27798773Free PMC Article
Risk of rash in cancer patients treated with vandetanib: systematic review and meta-analysis.
Rosen AC, Wu S, Damse A, Sherman E, Lacouture ME
J Clin Endocrinol Metab 2012 Apr;97(4):1125-33. Epub 2012 Feb 29 doi: 10.1210/jc.2011-2677. PMID: 22378813

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