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Metastatic NUT Carcinoma

MedGen UID:
1694084
•Concept ID:
C5206968
•
Neoplastic Process
Synonym: Metastatic NMC

Definition

NUT carcinoma that has spread from its original site of growth to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic NUT Carcinoma

Professional guidelines

PubMed

Clinical outcomes of cetuximab-based treatment for distant metastatic head and neck squamous cell carcinoma: A real-world study using Taiwan Head Neck Society registry database.
Lu HJ, Hsieh MC, Wang HM, Hsieh JC, Yen CJ, Wu SY, Huang HC, Wang HC, Chu PY, Chen TH, Chien CY, Huang TL, Chang YF, Hua CH, Lien MY, Chen JP, Lu WC, Lin JC, Wang CC, Liu YC, Yang MH, Lou PJ
Head Neck 2024 May;46(5):1063-1073. Epub 2024 Feb 22 doi: 10.1002/hed.27681. PMID: 38385970
Clinical management of NUT carcinoma (NC) in Germany: Analysis of survival, therapy response, tumor markers and tumor genome sequencing in 35 adult patients.
Kloker LD, Sidiras M, Flaadt T, Brecht IB, Deinzer CKW, Groß T, Benzler K, Zender L, Lauer UM
Lung Cancer 2024 Mar;189:107496. Epub 2024 Jan 29 doi: 10.1016/j.lungcan.2024.107496. PMID: 38301600

Recent clinical studies

Etiology

Porocarcinoma with YAP1-NUTM1 fusion presenting as a NUT immunohistochemistry-positive lymph node metastasis.
Christensen DJ, Tuluc M
J Cutan Pathol 2023 May;50(5):410-414. Epub 2023 Mar 12 doi: 10.1111/cup.14413. PMID: 36794976
Clinicopathological characteristics of primary lung nuclear protein in testis carcinoma: A single-institute experience of 10 cases.
Cho YA, Choi YL, Hwang I, Lee K, Cho JH, Han J
Thorac Cancer 2020 Nov;11(11):3205-3212. Epub 2020 Oct 3 doi: 10.1111/1759-7714.13648. PMID: 33009876Free PMC Article

Diagnosis

Exploring cytologic features and potential diagnostic challenges of metastatic NUT carcinoma to the parotid gland: A case report and a comprehensive literature review.
Li CY, Salihoglu S, Civantos FJ, Velez Torres JM
Diagn Cytopathol 2024 Sep;52(9):E176-E186. Epub 2024 Apr 24 doi: 10.1002/dc.25335. PMID: 38655736
Initial Chemotherapy for Locally Advanced and Metastatic NUT Carcinoma.
Luo J, Sanchez M, Lee E, Hertzler H, Luong N, Mazzola E, Finstein B, Tamen R, Brisbane G, Nguyen T, Paik PK, Chaft JE, Cheng ML, Khalil H, Piha-Paul SA, Sholl LM, Nishino M, Jänne PA, DuBois SG, Hanna GJ, Shapiro GI, French CA
J Thorac Oncol 2024 May;19(5):829-838. Epub 2023 Dec 27 doi: 10.1016/j.jtho.2023.12.022. PMID: 38154515Free PMC Article
Porocarcinoma with YAP1-NUTM1 fusion presenting as a NUT immunohistochemistry-positive lymph node metastasis.
Christensen DJ, Tuluc M
J Cutan Pathol 2023 May;50(5):410-414. Epub 2023 Mar 12 doi: 10.1111/cup.14413. PMID: 36794976
NUT Carcinoma in the Pelvic Cavity With Unusual Pathologic Features.
Jung M, Kim SI, Kim JW, Jeon YK, Lee C
Int J Gynecol Pathol 2022 May 1;41(3):292-297. Epub 2021 Jun 23 doi: 10.1097/PGP.0000000000000801. PMID: 34166280
Clinicopathological and Preclinical Findings of NUT Carcinoma: A Multicenter Study.
Jung M, Kim S, Lee JK, Yoon SO, Park HS, Hong SW, Park WS, Kim JE, Kim J, Keam B, Kim HJ, Kang HJ, Kim DW, Jung KC, Kim YT, Heo DS, Kim TM, Jeon YK
Oncologist 2019 Aug;24(8):e740-e748. Epub 2019 Jan 29 doi: 10.1634/theoncologist.2018-0477. PMID: 30696721Free PMC Article

Therapy

Initial Chemotherapy for Locally Advanced and Metastatic NUT Carcinoma.
Luo J, Sanchez M, Lee E, Hertzler H, Luong N, Mazzola E, Finstein B, Tamen R, Brisbane G, Nguyen T, Paik PK, Chaft JE, Cheng ML, Khalil H, Piha-Paul SA, Sholl LM, Nishino M, Jänne PA, DuBois SG, Hanna GJ, Shapiro GI, French CA
J Thorac Oncol 2024 May;19(5):829-838. Epub 2023 Dec 27 doi: 10.1016/j.jtho.2023.12.022. PMID: 38154515Free PMC Article

Prognosis

Initial Chemotherapy for Locally Advanced and Metastatic NUT Carcinoma.
Luo J, Sanchez M, Lee E, Hertzler H, Luong N, Mazzola E, Finstein B, Tamen R, Brisbane G, Nguyen T, Paik PK, Chaft JE, Cheng ML, Khalil H, Piha-Paul SA, Sholl LM, Nishino M, Jänne PA, DuBois SG, Hanna GJ, Shapiro GI, French CA
J Thorac Oncol 2024 May;19(5):829-838. Epub 2023 Dec 27 doi: 10.1016/j.jtho.2023.12.022. PMID: 38154515Free PMC Article
Lung nuclear protein in testis carcinoma in an elderly Korean woman: A case report with cytohistological analysis.
Cho HJ, Lee HK
Thorac Cancer 2020 Jun;11(6):1724-1727. Epub 2020 Apr 22 doi: 10.1111/1759-7714.13438. PMID: 32319714Free PMC Article

Clinical prediction guides

NUT Carcinoma in the Pelvic Cavity With Unusual Pathologic Features.
Jung M, Kim SI, Kim JW, Jeon YK, Lee C
Int J Gynecol Pathol 2022 May 1;41(3):292-297. Epub 2021 Jun 23 doi: 10.1097/PGP.0000000000000801. PMID: 34166280
Lung nuclear protein in testis carcinoma in an elderly Korean woman: A case report with cytohistological analysis.
Cho HJ, Lee HK
Thorac Cancer 2020 Jun;11(6):1724-1727. Epub 2020 Apr 22 doi: 10.1111/1759-7714.13438. PMID: 32319714Free PMC Article
Clinicopathological and Preclinical Findings of NUT Carcinoma: A Multicenter Study.
Jung M, Kim S, Lee JK, Yoon SO, Park HS, Hong SW, Park WS, Kim JE, Kim J, Keam B, Kim HJ, Kang HJ, Kim DW, Jung KC, Kim YT, Heo DS, Kim TM, Jeon YK
Oncologist 2019 Aug;24(8):e740-e748. Epub 2019 Jan 29 doi: 10.1634/theoncologist.2018-0477. PMID: 30696721Free PMC Article

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