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Laryngeal Giant Cell Carcinoma

MedGen UID:
384472
•Concept ID:
C2011252
•
Neoplastic Process
Synonyms: Giant cell carcinoma of larynx; Laryngeal Anaplastic Carcinoma
SNOMED CT: Giant cell carcinoma of larynx (1255654002)

Definition

A rare undifferentiated carcinoma that arises from the larynx. It is characterized by the presence of multiple bizarre multinucleated giant cells. The prognosis is poor. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLaryngeal Giant Cell Carcinoma

Professional guidelines

PubMed

Acute respiratory failure in goitre patients qualified for operative treatment.
Buła G, Paliga M, Koziołek H, Mucha R, Gawrychowski J
Endokrynol Pol 2013;64(3):215-9. PMID: 23873426
Anaplastic thyroid cancer: prevalence, diagnosis and treatment.
Chiacchio S, Lorenzoni A, Boni G, Rubello D, Elisei R, Mariani G
Minerva Endocrinol 2008 Dec;33(4):341-57. PMID: 18923370

Recent clinical studies

Etiology

The glottic-subglottic laryngectomy: Surgical technique, oncological, and functional outcomes.
Bertolin A, Lionello M, Baldovin M, Ghirardo G, Rizzotto G
J Surg Oncol 2022 Feb;125(2):145-150. Epub 2021 Sep 20 doi: 10.1002/jso.26675. PMID: 34542917
Prognostic impact of sterilized lymph nodes in esophageal squamous cell carcinomas after neoadjuvant chemoradiotherapy.
Zhong J, Wang K, Fang S, Fu J
Eur J Surg Oncol 2021 Dec;47(12):3074-3080. Epub 2021 May 8 doi: 10.1016/j.ejso.2021.04.026. PMID: 34023168
Differing characteristics of cartilaginous lesions of the larynx.
Ferlito A, Devaney KO, Mäkitie AA
Eur Arch Otorhinolaryngol 2019 Oct;276(10):2635-2647. Epub 2019 Jul 23 doi: 10.1007/s00405-019-05563-w. PMID: 31338576Free PMC Article
Acute respiratory failure in goitre patients qualified for operative treatment.
Buła G, Paliga M, Koziołek H, Mucha R, Gawrychowski J
Endokrynol Pol 2013;64(3):215-9. PMID: 23873426
Anaplastic thyroid cancer: prevalence, diagnosis and treatment.
Chiacchio S, Lorenzoni A, Boni G, Rubello D, Elisei R, Mariani G
Minerva Endocrinol 2008 Dec;33(4):341-57. PMID: 18923370

Diagnosis

Top Ten Oncocytic Head and Neck Lesions to Contemplate.
Bullock MJ, Jiang XS
Head Neck Pathol 2023 Mar;17(1):53-65. Epub 2023 Mar 16 doi: 10.1007/s12105-022-01520-y. PMID: 36928735Free PMC Article
Differing characteristics of cartilaginous lesions of the larynx.
Ferlito A, Devaney KO, Mäkitie AA
Eur Arch Otorhinolaryngol 2019 Oct;276(10):2635-2647. Epub 2019 Jul 23 doi: 10.1007/s00405-019-05563-w. PMID: 31338576Free PMC Article
Laryngeal sarcomas: A case series of 5 cases.
AbdullGaffar B, Keloth T
Ann Diagn Pathol 2018 Dec;37:35-41. Epub 2018 Sep 14 doi: 10.1016/j.anndiagpath.2018.09.007. PMID: 30241033
AHNAK and inflammatory markers predict poor survival in laryngeal carcinoma.
Dumitru CA, Bankfalvi A, Gu X, Zeidler R, Brandau S, Lang S
PLoS One 2013;8(2):e56420. Epub 2013 Feb 7 doi: 10.1371/journal.pone.0056420. PMID: 23409183Free PMC Article
Thyroid anaplastic carcinoma transformed from papillary carcinoma in extrathyroid area.
Togashi S, Oka K, Kanayama R, Koyamatsu S, Tobita T, Yatabe Y, Matsumoto T, Hakozaki H
Auris Nasus Larynx 2004 Sep;31(3):287-92. doi: 10.1016/j.anl.2004.03.006. PMID: 15364366

Therapy

The glottic-subglottic laryngectomy: Surgical technique, oncological, and functional outcomes.
Bertolin A, Lionello M, Baldovin M, Ghirardo G, Rizzotto G
J Surg Oncol 2022 Feb;125(2):145-150. Epub 2021 Sep 20 doi: 10.1002/jso.26675. PMID: 34542917
Successful treatment of locally advanced anaplastic thyroid carcinoma by chemotherapy and hyperfractionated radiotherapy.
Shinohara S, Kikuchi M, Naito Y, Fujiwara K, Hori S, Tona Y, Yamazaki H, Kobayashi H, Ishihara T
Auris Nasus Larynx 2009 Dec;36(6):729-32. Epub 2009 Mar 9 doi: 10.1016/j.anl.2009.02.001. PMID: 19269756
Response of the human larynx to silicone.
Tsuzuki T, Fukuda H, Fujioka T
Am J Otolaryngol 1991 Sep-Oct;12(5):288-91. doi: 10.1016/0196-0709(91)90007-3. PMID: 1811424
On the mechanism of cell internalization of chrysotile fibers: an immunocytochemical and ultrastructural study.
Malorni W, Iosi F, Falchi M, Donelli G
Environ Res 1990 Aug;52(2):164-77. doi: 10.1016/s0013-9351(05)80251-8. PMID: 2168315
Active temporal arteritis as a contraindication to elective surgery with general anesthesia.
McGowan BL
Am J Ophthalmol 1967 Sep;64(3):455-7. PMID: 6036308

Prognosis

Prognostic impact of sterilized lymph nodes in esophageal squamous cell carcinomas after neoadjuvant chemoradiotherapy.
Zhong J, Wang K, Fang S, Fu J
Eur J Surg Oncol 2021 Dec;47(12):3074-3080. Epub 2021 May 8 doi: 10.1016/j.ejso.2021.04.026. PMID: 34023168
Differing characteristics of cartilaginous lesions of the larynx.
Ferlito A, Devaney KO, Mäkitie AA
Eur Arch Otorhinolaryngol 2019 Oct;276(10):2635-2647. Epub 2019 Jul 23 doi: 10.1007/s00405-019-05563-w. PMID: 31338576Free PMC Article
AHNAK and inflammatory markers predict poor survival in laryngeal carcinoma.
Dumitru CA, Bankfalvi A, Gu X, Zeidler R, Brandau S, Lang S
PLoS One 2013;8(2):e56420. Epub 2013 Feb 7 doi: 10.1371/journal.pone.0056420. PMID: 23409183Free PMC Article
Anaplastic thyroid cancer: prevalence, diagnosis and treatment.
Chiacchio S, Lorenzoni A, Boni G, Rubello D, Elisei R, Mariani G
Minerva Endocrinol 2008 Dec;33(4):341-57. PMID: 18923370
Laryngeal cancer in Lower Silesia: descriptive analysis of 501 cases.
Krecicki T, Zalesska-Krecicka M, Jagas M, Szajowski K, Rak J
Oral Oncol 1998 Sep;34(5):377-80. doi: 10.1016/s1368-8375(98)00040-2. PMID: 9861343

Clinical prediction guides

The glottic-subglottic laryngectomy: Surgical technique, oncological, and functional outcomes.
Bertolin A, Lionello M, Baldovin M, Ghirardo G, Rizzotto G
J Surg Oncol 2022 Feb;125(2):145-150. Epub 2021 Sep 20 doi: 10.1002/jso.26675. PMID: 34542917
Prognostic impact of sterilized lymph nodes in esophageal squamous cell carcinomas after neoadjuvant chemoradiotherapy.
Zhong J, Wang K, Fang S, Fu J
Eur J Surg Oncol 2021 Dec;47(12):3074-3080. Epub 2021 May 8 doi: 10.1016/j.ejso.2021.04.026. PMID: 34023168
Acute respiratory failure in goitre patients qualified for operative treatment.
Buła G, Paliga M, Koziołek H, Mucha R, Gawrychowski J
Endokrynol Pol 2013;64(3):215-9. PMID: 23873426
AHNAK and inflammatory markers predict poor survival in laryngeal carcinoma.
Dumitru CA, Bankfalvi A, Gu X, Zeidler R, Brandau S, Lang S
PLoS One 2013;8(2):e56420. Epub 2013 Feb 7 doi: 10.1371/journal.pone.0056420. PMID: 23409183Free PMC Article
Expression, purification, and evaluation for anticancer activity of ribosomal protein L31 gene (RPL31) from the giant panda (Ailuropoda melanoleuca).
Su XL, Hou YL, Yan XH, Ding X, Hou WR, Sun B, Zhang SN
Mol Biol Rep 2012 Sep;39(9):8945-54. Epub 2012 Jun 20 doi: 10.1007/s11033-012-1763-0. PMID: 22714919

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