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Refractory Childhood Malignant Neoplasm

MedGen UID:
1691081
Concept ID:
C5206757
Neoplastic Process

Definition

A childhood malignant neoplasm that does not respond to treatment. [from NCI]

Professional guidelines

PubMed

Graiqevci-Uka V, Behluli E, Spahiu L, Liehr T, Temaj G
Curr Pediatr Rev 2023;19(2):150-156. doi: 10.2174/1573396318666220901165247. PMID: 36056858Free PMC Article
Bernstock JD, Hoffman SE, Kappel AD, Valdes PA, Essayed W, Klinger NV, Kang KD, Totsch SK, Olsen HE, Schlappi CW, Filipski K, Gessler FA, Baird L, Filbin MG, Hashizume R, Becher OJ, Friedman GK
Oncoimmunology 2022;11(1):2124058. Epub 2022 Sep 26 doi: 10.1080/2162402X.2022.2124058. PMID: 36185807Free PMC Article
Buchmann S, Schrappe M, Baruchel A, Biondi A, Borowitz M, Campbell M, Cario G, Cazzaniga G, Escherich G, Harrison CJ, Heyman M, Hunger SP, Kiss C, Liu HC, Locatelli F, Loh ML, Manabe A, Mann G, Pieters R, Pui CH, Rives S, Schmiegelow K, Silverman LB, Stary J, Vora A, Brown P
Blood 2022 Mar 24;139(12):1785-1793. doi: 10.1182/blood.2021012328. PMID: 34192312Free PMC Article

Recent clinical studies

Etiology

Cherella CE, Wassner AJ
Best Pract Res Clin Endocrinol Metab 2023 Jan;37(1):101715. Epub 2022 Nov 7 doi: 10.1016/j.beem.2022.101715. PMID: 36404191
Pennesi E, Michels N, Brivio E, van der Velden VHJ, Jiang Y, Thano A, Ammerlaan AJC, Boer JM, Beverloo HB, Sleight B, Chen Y, Vormoor-Bürger B, Rives S, Bielorai B, Rössig C, Petit A, Rizzari C, Engstler G, Starý J, Bautista Sirvent FJ, Chen-Santel C, Bruno B, Bertrand Y, Rialland F, Plat G, Reinhardt D, Vinti L, Von Stackelberg A, Locatelli F, Zwaan CM
Leukemia 2022 Jun;36(6):1516-1524. Epub 2022 Apr 25 doi: 10.1038/s41375-022-01576-3. PMID: 35468945Free PMC Article
Suk Y, Gwynne WD, Burns I, Venugopal C, Singh SK
Methods Mol Biol 2022;2423:1-12. doi: 10.1007/978-1-0716-1952-0_1. PMID: 34978683
Wong M, Mayoh C, Lau LMS, Khuong-Quang DA, Pinese M, Kumar A, Barahona P, Wilkie EE, Sullivan P, Bowen-James R, Syed M, Martincorena I, Abascal F, Sherstyuk A, Bolanos NA, Baber J, Priestley P, Dolman MEM, Fleuren EDG, Gauthier ME, Mould EVA, Gayevskiy V, Gifford AJ, Grebert-Wade D, Strong PA, Manouvrier E, Warby M, Thomas DM, Kirk J, Tucker K, O'Brien T, Alvaro F, McCowage GB, Dalla-Pozza L, Gottardo NG, Tapp H, Wood P, Khaw SL, Hansford JR, Moore AS, Norris MD, Trahair TN, Lock RB, Tyrrell V, Haber M, Marshall GM, Ziegler DS, Ekert PG, Cowley MJ
Nat Med 2020 Nov;26(11):1742-1753. Epub 2020 Oct 5 doi: 10.1038/s41591-020-1072-4. PMID: 33020650
Houghton PJ
Clin Cancer Res 2010 Mar 1;16(5):1368-72. Epub 2010 Feb 23 doi: 10.1158/1078-0432.CCR-09-1314. PMID: 20179227Free PMC Article

Diagnosis

Chisholm KM, Bohling SD
Clin Lab Med 2023 Dec;43(4):639-655. Epub 2023 Aug 7 doi: 10.1016/j.cll.2023.06.005. PMID: 37865508
Joham AE, Norman RJ, Stener-Victorin E, Legro RS, Franks S, Moran LJ, Boyle J, Teede HJ
Lancet Diabetes Endocrinol 2022 Sep;10(9):668-680. Epub 2022 Aug 4 doi: 10.1016/S2213-8587(22)00163-2. PMID: 35934017
Pennesi E, Michels N, Brivio E, van der Velden VHJ, Jiang Y, Thano A, Ammerlaan AJC, Boer JM, Beverloo HB, Sleight B, Chen Y, Vormoor-Bürger B, Rives S, Bielorai B, Rössig C, Petit A, Rizzari C, Engstler G, Starý J, Bautista Sirvent FJ, Chen-Santel C, Bruno B, Bertrand Y, Rialland F, Plat G, Reinhardt D, Vinti L, Von Stackelberg A, Locatelli F, Zwaan CM
Leukemia 2022 Jun;36(6):1516-1524. Epub 2022 Apr 25 doi: 10.1038/s41375-022-01576-3. PMID: 35468945Free PMC Article
Rao R, Honavar SG
Indian J Pediatr 2017 Dec;84(12):937-944. Epub 2017 Jun 16 doi: 10.1007/s12098-017-2395-0. PMID: 28620731
Houghton PJ
Clin Cancer Res 2010 Mar 1;16(5):1368-72. Epub 2010 Feb 23 doi: 10.1158/1078-0432.CCR-09-1314. PMID: 20179227Free PMC Article

Therapy

Berko ER, Witek GM, Matkar S, Petrova ZO, Wu MA, Smith CM, Daniels A, Kalna J, Kennedy A, Gostuski I, Casey C, Krytska K, Gerelus M, Pavlick D, Ghazarian S, Park JR, Marachelian A, Maris JM, Goldsmith KC, Radhakrishnan R, Lemmon MA, Mossé YP
Nat Commun 2023 May 5;14(1):2601. doi: 10.1038/s41467-023-38195-0. PMID: 37147298Free PMC Article
Pennesi E, Michels N, Brivio E, van der Velden VHJ, Jiang Y, Thano A, Ammerlaan AJC, Boer JM, Beverloo HB, Sleight B, Chen Y, Vormoor-Bürger B, Rives S, Bielorai B, Rössig C, Petit A, Rizzari C, Engstler G, Starý J, Bautista Sirvent FJ, Chen-Santel C, Bruno B, Bertrand Y, Rialland F, Plat G, Reinhardt D, Vinti L, Von Stackelberg A, Locatelli F, Zwaan CM
Leukemia 2022 Jun;36(6):1516-1524. Epub 2022 Apr 25 doi: 10.1038/s41375-022-01576-3. PMID: 35468945Free PMC Article
Maude SL, Laetsch TW, Buechner J, Rives S, Boyer M, Bittencourt H, Bader P, Verneris MR, Stefanski HE, Myers GD, Qayed M, De Moerloose B, Hiramatsu H, Schlis K, Davis KL, Martin PL, Nemecek ER, Yanik GA, Peters C, Baruchel A, Boissel N, Mechinaud F, Balduzzi A, Krueger J, June CH, Levine BL, Wood P, Taran T, Leung M, Mueller KT, Zhang Y, Sen K, Lebwohl D, Pulsipher MA, Grupp SA
N Engl J Med 2018 Feb 1;378(5):439-448. doi: 10.1056/NEJMoa1709866. PMID: 29385370Free PMC Article
Kossoff EH, Wang HS
Biomed J 2013 Jan-Feb;36(1):2-8. doi: 10.4103/2319-4170.107152. PMID: 23515147
Houghton PJ
Clin Cancer Res 2010 Mar 1;16(5):1368-72. Epub 2010 Feb 23 doi: 10.1158/1078-0432.CCR-09-1314. PMID: 20179227Free PMC Article

Prognosis

Fazio M, Del Fabro V, Parrinello NL, Allegra A, Markovic U, Botta C, Accardi F, Vincelli ID, Leotta S, Elia F, Esposito B, Garibaldi B, Sapuppo G, Orofino A, Romano A, Palumbo GA, Di Raimondo F, Conticello C
Curr Oncol 2023 Nov 3;30(11):9710-9733. doi: 10.3390/curroncol30110705. PMID: 37999125Free PMC Article
Suk Y, Gwynne WD, Burns I, Venugopal C, Singh SK
Methods Mol Biol 2022;2423:1-12. doi: 10.1007/978-1-0716-1952-0_1. PMID: 34978683
Schmidt E, Burkhardt B
Pediatr Hematol Oncol 2013 Sep;30(6):484-508. Epub 2013 Apr 26 doi: 10.3109/08880018.2013.789574. PMID: 23621872
Kossoff EH, Wang HS
Biomed J 2013 Jan-Feb;36(1):2-8. doi: 10.4103/2319-4170.107152. PMID: 23515147
Houghton PJ
Clin Cancer Res 2010 Mar 1;16(5):1368-72. Epub 2010 Feb 23 doi: 10.1158/1078-0432.CCR-09-1314. PMID: 20179227Free PMC Article

Clinical prediction guides

Brancati VU, Minutoli L, Marini HR, Puzzolo D, Allegra A
Curr Oncol 2023 Apr 29;30(5):4603-4617. doi: 10.3390/curroncol30050348. PMID: 37232806Free PMC Article
Pei K, Xu H, Wang P, Gan W, Hu Z, Su X, Zhang H, He Y
Cancer Med 2023 Apr;12(8):9655-9661. Epub 2023 Apr 9 doi: 10.1002/cam4.5916. PMID: 37031462Free PMC Article
Sbirkov Y, Burnusuzov H, Sarafian V
Pediatr Blood Cancer 2020 Jun;67(6):e28255. Epub 2020 Apr 15 doi: 10.1002/pbc.28255. PMID: 32293782
Maude SL, Laetsch TW, Buechner J, Rives S, Boyer M, Bittencourt H, Bader P, Verneris MR, Stefanski HE, Myers GD, Qayed M, De Moerloose B, Hiramatsu H, Schlis K, Davis KL, Martin PL, Nemecek ER, Yanik GA, Peters C, Baruchel A, Boissel N, Mechinaud F, Balduzzi A, Krueger J, June CH, Levine BL, Wood P, Taran T, Leung M, Mueller KT, Zhang Y, Sen K, Lebwohl D, Pulsipher MA, Grupp SA
N Engl J Med 2018 Feb 1;378(5):439-448. doi: 10.1056/NEJMoa1709866. PMID: 29385370Free PMC Article
Houghton PJ
Clin Cancer Res 2010 Mar 1;16(5):1368-72. Epub 2010 Feb 23 doi: 10.1158/1078-0432.CCR-09-1314. PMID: 20179227Free PMC Article

Recent systematic reviews

Ballantyne E, Evans C, Shepherd L, Fulbright H, Wakeling S, Phillips B, Morgan JE
Pediatr Blood Cancer 2024 Jun;71(6):e30952. Epub 2024 Apr 2 doi: 10.1002/pbc.30952. PMID: 38566349
Evans C, Shepherd L, Bryan G, Fulbright H, Crowther S, Wakeling S, Stewart A, Stewart C, Chisholm J, Gibson F, Phillips B, Morgan JE
Int J Cancer 2024 Apr 1;154(7):1235-1260. Epub 2023 Dec 10 doi: 10.1002/ijc.34808. PMID: 38071594
V Stackelberg A, Jäschke K, Jousseaume E, Templin C, Jeratsch U, Kosmides D, Steffen I, Gökbuget N, Peters C
Leukemia 2023 Dec;37(12):2346-2355. Epub 2023 Oct 25 doi: 10.1038/s41375-023-02042-4. PMID: 37880478Free PMC Article
Aamir S, Anwar MY, Khalid F, Khan SI, Ali MA, Khattak ZE
Clin Lymphoma Myeloma Leuk 2021 Apr;21(4):e334-e347. Epub 2020 Dec 17 doi: 10.1016/j.clml.2020.12.010. PMID: 33573914
Man BL, Mok CC, Fu YP
Int J Rheum Dis 2014 Jun;17(5):494-501. Epub 2014 Mar 28 doi: 10.1111/1756-185X.12337. PMID: 24673755

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