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AIDS-Related Lymphoma

MedGen UID:
43099
•Concept ID:
C0085090
•
Neoplastic Process
Synonyms: AIDS Associated Lymphoma; AIDS Related Lymphoma; AIDS-Associated Lymphoma; AIDS-Associated Lymphomas; AIDS-Related Lymphomas; HIV Related Lymphoma; HIV-Related Lymphoma; HIV-Related Lymphomas; Lymphoma, AIDS Associated; Lymphoma, AIDS Related; Lymphoma, AIDS-Associated; Lymphoma, AIDS-Related; Lymphoma, HIV Related; Lymphoma, HIV-Related; Lymphomas, AIDS-Associated; Lymphomas, AIDS-Related; Lymphomas, HIV-Related

Definition

An aggressive lymphoma that develops in HIV-positive patients. There is a significant increase in the incidence of lymphomas associated with the AIDS epidemic. These lymphomas are usually extranodal, most often express a B-cell phenotype and morphologically are classified as Burkitt, diffuse large B-cell, and Hodgkin lymphomas. The prognosis is closely related to the severity of immunodeficiency. [from NCI]

Professional guidelines

PubMed

Management of AIDS-related lymphoma.
Levine AM
Curr Opin Oncol 2008 Sep;20(5):522-8. doi: 10.1097/CCO.0b013e3283094ec7. PMID: 19106654
The management of lymphoma in the immunosuppressed patient.
Bower M
Best Pract Res Clin Haematol 2002 Sep;15(3):517-32. doi: 10.1053/beha.2002.0213. PMID: 12468403
Incidence and management of AIDS-related lymphoma.
Levine AM, Seneviratne L, Tulpule A
Oncology (Williston Park) 2001 May;15(5):629-39; discussion 639-40, 645-6. PMID: 11396357

Recent clinical studies

Etiology

Hematologic cancers in individuals infected by HIV.
Carbone A, Vaccher E, Gloghini A
Blood 2022 Feb 17;139(7):995-1012. doi: 10.1182/blood.2020005469. PMID: 34469512
Optimizing treatment of HIV-associated lymphoma.
Noy A
Blood 2019 Oct 24;134(17):1385-1394. doi: 10.1182/blood-2018-01-791400. PMID: 30992269Free PMC Article
Microenvironment and HIV-related lymphomagenesis.
Pantanowitz L, Carbone A, Dolcetti R
Semin Cancer Biol 2015 Oct;34:52-7. Epub 2015 Jun 26 doi: 10.1016/j.semcancer.2015.06.002. PMID: 26118690
HIV-associated lymphoma.
Kaplan LD
Best Pract Res Clin Haematol 2012 Mar;25(1):101-17. Epub 2012 Feb 22 doi: 10.1016/j.beha.2012.01.001. PMID: 22409827
AIDS-related malignancies.
Scadden DT
Annu Rev Med 2003;54:285-303. Epub 2001 Dec 3 doi: 10.1146/annurev.med.54.101601.152143. PMID: 12525676

Diagnosis

Primary Vitreoretinal Lymphoma in HIV Infection.
Steffen J, Coupland SE, Smith JR
Ocul Immunol Inflamm 2021 Apr 3;29(3):621-627. Epub 2020 May 26 doi: 10.1080/09273948.2020.1751856. PMID: 32453669
Malignant lymphoma in the HIV-positive patient.
Meister A, Hentrich M, Wyen C, Hübel K
Eur J Haematol 2018 Jul;101(1):119-126. Epub 2018 May 22 doi: 10.1111/ejh.13082. PMID: 29663523
HIV-Associated Malignancies.
Hübel K
Oncol Res Treat 2017;40(3):80-81. Epub 2017 Feb 20 doi: 10.1159/000456716. PMID: 28273669
Microenvironment and HIV-related lymphomagenesis.
Pantanowitz L, Carbone A, Dolcetti R
Semin Cancer Biol 2015 Oct;34:52-7. Epub 2015 Jun 26 doi: 10.1016/j.semcancer.2015.06.002. PMID: 26118690
AIDS lymphomas.
Middleton GW, Lau RK
Int J STD AIDS 1992 May-Jun;3(3):173-81. doi: 10.1177/095646249200300304. PMID: 1616963

Therapy

Optimizing treatment of HIV-associated lymphoma.
Noy A
Blood 2019 Oct 24;134(17):1385-1394. doi: 10.1182/blood-2018-01-791400. PMID: 30992269Free PMC Article
HIV-associated lymphoma.
Kaplan LD
Best Pract Res Clin Haematol 2012 Mar;25(1):101-17. Epub 2012 Feb 22 doi: 10.1016/j.beha.2012.01.001. PMID: 22409827
HIV-associated Hodgkin lymphoma.
Carbone A, Gloghini A, Serraino D, Spina M
Curr Opin HIV AIDS 2009 Jan;4(1):3-10. doi: 10.1097/COH.0b013e32831a722b. PMID: 19339934
AIDS-related lymphoma.
Levine AM
Semin Oncol Nurs 2006 May;22(2):80-9. doi: 10.1016/j.soncn.2006.01.004. PMID: 16720230
AIDS-related lymphoproliferative disease.
Navarro WH, Kaplan LD
Blood 2006 Jan 1;107(1):13-20. Epub 2005 Aug 11 doi: 10.1182/blood-2004-11-4278. PMID: 16099881

Prognosis

HIV-Associated Malignancies.
Hübel K
Oncol Res Treat 2017;40(3):80-81. Epub 2017 Feb 20 doi: 10.1159/000456716. PMID: 28273669
KSHV/HHV8-associated lymphomas.
Carbone A, Gloghini A
Br J Haematol 2008 Jan;140(1):13-24. Epub 2007 Nov 7 doi: 10.1111/j.1365-2141.2007.06879.x. PMID: 17991301
AIDS-associated malignancies.
Akanmu AS
Afr J Med Med Sci 2006 Dec;35 Suppl:57-70. PMID: 18050776
AIDS-related lymphoma.
Levine AM
Semin Oncol Nurs 2006 May;22(2):80-9. doi: 10.1016/j.soncn.2006.01.004. PMID: 16720230
AIDS-related lymphoma.
Tulpule A, Levine A
Blood Rev 1999 Sep;13(3):147-50. doi: 10.1054/blre.1999.0112. PMID: 10527266

Clinical prediction guides

A Novel Prognostic Score Including the CD4/CD8 for AIDS-Related Lymphoma.
Chen J, Liu X, Qin S, Ruan G, Lu A, Zhang J, Wu Y, Xie Z, Peng J
Front Cell Infect Microbiol 2022;12:919446. Epub 2022 Jul 6 doi: 10.3389/fcimb.2022.919446. PMID: 35873145Free PMC Article
HIV-Related Lymphoproliferative Diseases in the Era of Combination Antiretroviral Therapy.
Castelli R, Schiavon R, Preti C, Ferraris L
Cardiovasc Hematol Disord Drug Targets 2020;20(3):175-180. doi: 10.2174/1871529X20666200415121009. PMID: 32294049Free PMC Article
Associations of Viral Seroreactivity with AIDS-Related Non-Hodgkin Lymphoma.
Song M, Bassig BA, Bender N, Goedert JJ, Winkler CA, Brenner N, Waterboer T, Rabkin CS
AIDS Res Hum Retroviruses 2020 May;36(5):381-388. Epub 2020 Mar 2 doi: 10.1089/AID.2019.0208. PMID: 31789046Free PMC Article
HIV-associated Hodgkin lymphoma.
Carbone A, Gloghini A, Serraino D, Spina M
Curr Opin HIV AIDS 2009 Jan;4(1):3-10. doi: 10.1097/COH.0b013e32831a722b. PMID: 19339934
AIDS-associated malignant lymphoma.
Levine AM
Med Clin North Am 1992 Jan;76(1):253-68. doi: 10.1016/s0025-7125(16)30379-0. PMID: 1727539

Recent systematic reviews

Changes in the influence of lymphoma- and HIV-specific factors on outcomes in AIDS-related non-Hodgkin lymphoma.
Barta SK, Samuel MS, Xue X, Wang D, Lee JY, Mounier N, Ribera JM, Spina M, Tirelli U, Weiss R, Galicier L, Boue F, Little RF, Dunleavy K, Wilson WH, Wyen C, Remick SC, Kaplan LD, Ratner L, Noy A, Sparano JA
Ann Oncol 2015 May;26(5):958-966. Epub 2015 Jan 28 doi: 10.1093/annonc/mdv036. PMID: 25632071Free PMC Article
Assessing the impact of HAART on the incidence of defining and non-defining AIDS cancers among patients with HIV/AIDS: a systematic review.
Cobucci RN, Lima PH, de Souza PC, Costa VV, Cornetta Mda C, Fernandes JV, Gonçalves AK
J Infect Public Health 2015 Jan-Feb;8(1):1-10. Epub 2014 Oct 5 doi: 10.1016/j.jiph.2014.08.003. PMID: 25294086
Interventions for previously untreated patients with AIDS-associated non-Hodgkin's lymphoma.
Martí-Carvajal AJ, Cardona AF, Lawrence A
Cochrane Database Syst Rev 2009 Jul 8;(3):CD005419. doi: 10.1002/14651858.CD005419.pub2. PMID: 19588373
Interventions for treating AIDS-associated Hodgkin s lymphoma in treatment-naive adults.
Martí-Carvajal AJ, Cardona AF, Rodríguez ML
Cochrane Database Syst Rev 2007 Apr 18;(2):CD006149. doi: 10.1002/14651858.CD006149.pub2. PMID: 17443616
Strategies to overcome myelotoxic therapy for the treatment of Burkitt's and AIDS-related non-Hodgkin's lymphoma.
Rochford R, Feuer G, Orem J, Banura C, Katongole-Mbidde E, Mwanda WO, Moormann A, Harrington WJ, Remick SC
East Afr Med J 2005 Sep;82(9 Suppl):S155-60. doi: 10.4314/eamj.v82i9.9388. PMID: 16619692

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