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Adenocarcinoma with Neuroendocrine Differentiation

MedGen UID:
224758
•Concept ID:
C1266088
•
Neoplastic Process
Synonyms: Adenocarcinoma with neuroendocrine differentiation; Carcinoma with neuroendocrine differentiation
SNOMED CT: Carcinoma with neuroendocrine differentiation (128704005); Adenocarcinoma with neuroendocrine differentiation (128704005)

Definition

An invasive adenocarcinoma characterized by the presence of focal or extensive neuroendocrine differentiation. [from NCI]

Professional guidelines

PubMed

Lung adenocarcinoma with neuroendocrine differentiation: Molecular markers testing and treatment outcomes.
Chang HC, Chen KY, Chang YL, Shih JY, Yu CJ
J Formos Med Assoc 2023 Aug;122(8):731-737. Epub 2022 Dec 30 doi: 10.1016/j.jfma.2022.12.011. PMID: 36586785

Recent clinical studies

Etiology

(18) F-FDG PET/CT imaging in neuroendocrine prostate cancer: Relation to histopathology and prognosis.
Shen K, Yu M, Ji Y, Zhou X, Liu B, Zhang W, Su R, Qi J, Wang Q, Xue W
Prostate 2023 Sep;83(12):1167-1175. Epub 2023 May 15 doi: 10.1002/pros.24559. PMID: 37189301
Lung adenocarcinoma with neuroendocrine differentiation: Molecular markers testing and treatment outcomes.
Chang HC, Chen KY, Chang YL, Shih JY, Yu CJ
J Formos Med Assoc 2023 Aug;122(8):731-737. Epub 2022 Dec 30 doi: 10.1016/j.jfma.2022.12.011. PMID: 36586785
Clinicopathological characteristics of thrombospondin type 1 domain-containing 7A-associated membranous nephropathy.
Hara S, Tsuji T, Fukasawa Y, Hisano S, Morito S, Hyodo T, Goto S, Nishi S, Yoshimoto A, Itoh T
Virchows Arch 2019 Jun;474(6):735-743. Epub 2019 Mar 14 doi: 10.1007/s00428-019-02558-0. PMID: 30868298Free PMC Article
The Colorful Palette of Neuroendocrine Neoplasms in the Genitourinary Tract.
Pósfai B, Kuthi L, Varga L, Laczó I, Révész J, Kránicz R, Maráz A
Anticancer Res 2018 Jun;38(6):3243-3254. doi: 10.21873/anticanres.12589. PMID: 29848671
Gastric adenocarcinoma with neuroendocrine differentiation: Clinicopathological features and efficacy of modified DCF chemotherapy.
Bozkaya Y, Ozdemir N, Colak A, Zengin N
J BUON 2017 Jul-Aug;22(4):919-925. PMID: 29155521

Diagnosis

Lung adenocarcinoma with neuroendocrine differentiation: Molecular markers testing and treatment outcomes.
Chang HC, Chen KY, Chang YL, Shih JY, Yu CJ
J Formos Med Assoc 2023 Aug;122(8):731-737. Epub 2022 Dec 30 doi: 10.1016/j.jfma.2022.12.011. PMID: 36586785
Dermatomyositis associated with prostate adenocarcinoma with neuroendocrine differentiation.
Minagawa H, Kawai T, Matsumoto A, Makino K, Sato Y, Nagasaka K, Tokura M, Tanaka N, Ito E, Yamada Y, Nakamura M, Yamada D, Suzuki M, Murata T, Kume H
BMC Urol 2021 Jan 7;21(1):8. doi: 10.1186/s12894-020-00779-z. PMID: 33413292Free PMC Article
The Colorful Palette of Neuroendocrine Neoplasms in the Genitourinary Tract.
Pósfai B, Kuthi L, Varga L, Laczó I, Révész J, Kránicz R, Maráz A
Anticancer Res 2018 Jun;38(6):3243-3254. doi: 10.21873/anticanres.12589. PMID: 29848671
Gastric adenocarcinoma with neuroendocrine differentiation: Clinicopathological features and efficacy of modified DCF chemotherapy.
Bozkaya Y, Ozdemir N, Colak A, Zengin N
J BUON 2017 Jul-Aug;22(4):919-925. PMID: 29155521
Metastatic prostatic adenocarcinoma with neuroendocrine differentiation to meningioma.
Guraya SS, Prayson RA
J Clin Neurosci 2016 Dec;34:30-32. Epub 2016 Aug 5 doi: 10.1016/j.jocn.2016.06.004. PMID: 27503809

Therapy

Transformation of NSCLC to SCLC harboring EML4-ALK fusion with V1180L mutation after alectinib resistance and response to lorlatinib: A case report and literature review.
Lingling X, Maoxi C, Wei Y, Jieting Z, Yuanyuan Y, Ning X
Lung Cancer 2023 Dec;186:107415. Epub 2023 Oct 28 doi: 10.1016/j.lungcan.2023.107415. PMID: 37907052
Selpercatinib monotherapy in a Chinese patient with RET fusion/ EGFR co-mutated nonsmall cell lung cancer from the Phase II LIBRETTO-321 study: a case report.
Wu L, Cheng Y, Huang D, Sun Y, Zhou C, Zhou J, Guo Y, Shao J, Zhang W, Lu S
Anticancer Drugs 2023 Oct 1;34(9):1058-1064. Epub 2023 Jun 2 doi: 10.1097/CAD.0000000000001527. PMID: 37265026Free PMC Article
Lung adenocarcinoma with neuroendocrine differentiation: Molecular markers testing and treatment outcomes.
Chang HC, Chen KY, Chang YL, Shih JY, Yu CJ
J Formos Med Assoc 2023 Aug;122(8):731-737. Epub 2022 Dec 30 doi: 10.1016/j.jfma.2022.12.011. PMID: 36586785
Emergence of NOTCH2-NTRK1 After Osimertinib in a Patient With Lung Adenocarcinoma With Neuroendocrine Differentiation.
Lin G, Liu Y, Li H, Chen S, Guo Y
Clin Lung Cancer 2021 Mar;22(2):e157-e159. Epub 2020 Oct 15 doi: 10.1016/j.cllc.2020.10.003. PMID: 33158763
Gastric adenocarcinoma with neuroendocrine differentiation: Clinicopathological features and efficacy of modified DCF chemotherapy.
Bozkaya Y, Ozdemir N, Colak A, Zengin N
J BUON 2017 Jul-Aug;22(4):919-925. PMID: 29155521

Prognosis

Transformation of NSCLC to SCLC harboring EML4-ALK fusion with V1180L mutation after alectinib resistance and response to lorlatinib: A case report and literature review.
Lingling X, Maoxi C, Wei Y, Jieting Z, Yuanyuan Y, Ning X
Lung Cancer 2023 Dec;186:107415. Epub 2023 Oct 28 doi: 10.1016/j.lungcan.2023.107415. PMID: 37907052
(18) F-FDG PET/CT imaging in neuroendocrine prostate cancer: Relation to histopathology and prognosis.
Shen K, Yu M, Ji Y, Zhou X, Liu B, Zhang W, Su R, Qi J, Wang Q, Xue W
Prostate 2023 Sep;83(12):1167-1175. Epub 2023 May 15 doi: 10.1002/pros.24559. PMID: 37189301
The Colorful Palette of Neuroendocrine Neoplasms in the Genitourinary Tract.
Pósfai B, Kuthi L, Varga L, Laczó I, Révész J, Kránicz R, Maráz A
Anticancer Res 2018 Jun;38(6):3243-3254. doi: 10.21873/anticanres.12589. PMID: 29848671
Gastric adenocarcinoma with neuroendocrine differentiation: Clinicopathological features and efficacy of modified DCF chemotherapy.
Bozkaya Y, Ozdemir N, Colak A, Zengin N
J BUON 2017 Jul-Aug;22(4):919-925. PMID: 29155521
Neuroendocrine differentiation in sporadic CRC and hereditary nonpolyosis colorectal cancer.
Sun MH
Dis Markers 2004;20(4-5):283-8. doi: 10.1155/2004/379053. PMID: 15528794Free PMC Article

Clinical prediction guides

(18) F-FDG PET/CT imaging in neuroendocrine prostate cancer: Relation to histopathology and prognosis.
Shen K, Yu M, Ji Y, Zhou X, Liu B, Zhang W, Su R, Qi J, Wang Q, Xue W
Prostate 2023 Sep;83(12):1167-1175. Epub 2023 May 15 doi: 10.1002/pros.24559. PMID: 37189301
Dermatomyositis associated with prostate adenocarcinoma with neuroendocrine differentiation.
Minagawa H, Kawai T, Matsumoto A, Makino K, Sato Y, Nagasaka K, Tokura M, Tanaka N, Ito E, Yamada Y, Nakamura M, Yamada D, Suzuki M, Murata T, Kume H
BMC Urol 2021 Jan 7;21(1):8. doi: 10.1186/s12894-020-00779-z. PMID: 33413292Free PMC Article
Low-serum prostate-specific antigen level predicts poor outcomes in patients with primary neuroendocrine prostate cancer.
Wang J, Xu W, Mierxiati A, Huang Y, Wei Y, Lin G, Dai B, Freedland SJ, Qin X, Zhu Y, Ye DW
Prostate 2019 Sep;79(13):1563-1571. Epub 2019 Aug 2 doi: 10.1002/pros.23878. PMID: 31376193
EGFR mediates activation of RET in lung adenocarcinoma with neuroendocrine differentiation characterized by ASCL1 expression.
Bhinge K, Yang L, Terra S, Nasir A, Muppa P, Aubry MC, Yi J, Janaki N, Kovtun IV, Murphy SJ, Halling G, Rahi H, Mansfield A, de Andrade M, Yang P, Vasmatzis G, Peikert T, Kosari F
Oncotarget 2017 Apr 18;8(16):27155-27165. doi: 10.18632/oncotarget.15676. PMID: 28460442Free PMC Article
Elevated serum alpha-fetoprotein in poorly differentiated adenocarcinoma with neuroendocrine differentiation of the ascending colon: a case report.
Lin HH, Chang CC, Yang SH, Chang SC, Chen WS, Liang WY, Lin JK, Jiang JK
World J Surg Oncol 2016 Mar 15;14:84. doi: 10.1186/s12957-016-0838-0. PMID: 26976278Free PMC Article

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