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Refractory Malignant Solid Neoplasm

MedGen UID:
1618566
•Concept ID:
C4524857
•
Neoplastic Process
Synonym: Refractory Malignant Solid Tumor

Definition

A malignant solid neoplasm that does not respond to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Malignant Solid Neoplasm

Professional guidelines

PubMed

CAR-cell therapy in the era of solid tumor treatment: current challenges and emerging therapeutic advances.
Maalej KM, Merhi M, Inchakalody VP, Mestiri S, Alam M, Maccalli C, Cherif H, Uddin S, Steinhoff M, Marincola FM, Dermime S
Mol Cancer 2023 Jan 30;22(1):20. doi: 10.1186/s12943-023-01723-z. PMID: 36717905Free PMC Article
Tumor-infiltrating lymphocytes for treatment of solid tumors: It takes two to tango?
Kazemi MH, Sadri M, Najafi A, Rahimi A, Baghernejadan Z, Khorramdelazad H, Falak R
Front Immunol 2022;13:1018962. Epub 2022 Oct 28 doi: 10.3389/fimmu.2022.1018962. PMID: 36389779Free PMC Article
CAR-NK Cells in the Treatment of Solid Tumors.
Wrona E, Borowiec M, Potemski P
Int J Mol Sci 2021 May 31;22(11) doi: 10.3390/ijms22115899. PMID: 34072732Free PMC Article

Recent clinical studies

Etiology

CAR-cell therapy in the era of solid tumor treatment: current challenges and emerging therapeutic advances.
Maalej KM, Merhi M, Inchakalody VP, Mestiri S, Alam M, Maccalli C, Cherif H, Uddin S, Steinhoff M, Marincola FM, Dermime S
Mol Cancer 2023 Jan 30;22(1):20. doi: 10.1186/s12943-023-01723-z. PMID: 36717905Free PMC Article
Toxicities following CAR-T therapy for hematological malignancies.
Hernani R, Benzaquén A, Solano C
Cancer Treat Rev 2022 Dec;111:102479. Epub 2022 Oct 22 doi: 10.1016/j.ctrv.2022.102479. PMID: 36308910
Gangliosides and Neuroblastomas.
Schengrund CL
Int J Mol Sci 2020 Jul 27;21(15) doi: 10.3390/ijms21155313. PMID: 32726962Free PMC Article
An Improved Method to Produce Clinical-Scale Natural Killer Cells from Human Pluripotent Stem Cells.
Zhu H, Kaufman DS
Methods Mol Biol 2019;2048:107-119. doi: 10.1007/978-1-4939-9728-2_12. PMID: 31396935
Testicular cancer.
Cheng L, Albers P, Berney DM, Feldman DR, Daugaard G, Gilligan T, Looijenga LHJ
Nat Rev Dis Primers 2018 Oct 5;4(1):29. doi: 10.1038/s41572-018-0029-0. PMID: 30291251

Diagnosis

Cancer-related hypercalcemia and potential treatments.
Almuradova E, Cicin I
Front Endocrinol (Lausanne) 2023;14:1039490. Epub 2023 Mar 22 doi: 10.3389/fendo.2023.1039490. PMID: 37033238Free PMC Article
Engineering the next generation of CAR-NK immunotherapies.
Biederstädt A, Rezvani K
Int J Hematol 2021 Nov;114(5):554-571. Epub 2021 Aug 28 doi: 10.1007/s12185-021-03209-4. PMID: 34453686Free PMC Article
CAR-NK Cells in the Treatment of Solid Tumors.
Wrona E, Borowiec M, Potemski P
Int J Mol Sci 2021 May 31;22(11) doi: 10.3390/ijms22115899. PMID: 34072732Free PMC Article
Gangliosides and Neuroblastomas.
Schengrund CL
Int J Mol Sci 2020 Jul 27;21(15) doi: 10.3390/ijms21155313. PMID: 32726962Free PMC Article
Phase I Study of Lentiviral-Transduced Chimeric Antigen Receptor-Modified T Cells Recognizing Mesothelin in Advanced Solid Cancers.
Haas AR, Tanyi JL, O'Hara MH, Gladney WL, Lacey SF, Torigian DA, Soulen MC, Tian L, McGarvey M, Nelson AM, Farabaugh CS, Moon E, Levine BL, Melenhorst JJ, Plesa G, June CH, Albelda SM, Beatty GL
Mol Ther 2019 Nov 6;27(11):1919-1929. Epub 2019 Jul 30 doi: 10.1016/j.ymthe.2019.07.015. PMID: 31420241Free PMC Article

Therapy

Cancer-related hypercalcemia and potential treatments.
Almuradova E, Cicin I
Front Endocrinol (Lausanne) 2023;14:1039490. Epub 2023 Mar 22 doi: 10.3389/fendo.2023.1039490. PMID: 37033238Free PMC Article
CAR-NK Cells in the Treatment of Solid Tumors.
Wrona E, Borowiec M, Potemski P
Int J Mol Sci 2021 May 31;22(11) doi: 10.3390/ijms22115899. PMID: 34072732Free PMC Article
Gilteritinib: First Global Approval.
Dhillon S
Drugs 2019 Feb;79(3):331-339. doi: 10.1007/s40265-019-1062-3. PMID: 30721452
Bispecific antibodies in haematological malignancies.
Viardot A, Bargou R
Cancer Treat Rev 2018 Apr;65:87-95. Epub 2018 Apr 4 doi: 10.1016/j.ctrv.2018.04.002. PMID: 29635163
Talaporfin sodium.
Wang S, Bromley E, Xu L, Chen JC, Keltner L
Expert Opin Pharmacother 2010 Jan;11(1):133-40. doi: 10.1517/14656560903463893. PMID: 20001435

Prognosis

Cancer-related hypercalcemia and potential treatments.
Almuradova E, Cicin I
Front Endocrinol (Lausanne) 2023;14:1039490. Epub 2023 Mar 22 doi: 10.3389/fendo.2023.1039490. PMID: 37033238Free PMC Article
Gangliosides and Neuroblastomas.
Schengrund CL
Int J Mol Sci 2020 Jul 27;21(15) doi: 10.3390/ijms21155313. PMID: 32726962Free PMC Article
Selinexor for advanced hematologic malignancies.
Walker JS, Garzon R, Lapalombella R
Leuk Lymphoma 2020 Oct;61(10):2335-2350. Epub 2020 Jun 14 doi: 10.1080/10428194.2020.1775210. PMID: 32536290
Testicular cancer.
Cheng L, Albers P, Berney DM, Feldman DR, Daugaard G, Gilligan T, Looijenga LHJ
Nat Rev Dis Primers 2018 Oct 5;4(1):29. doi: 10.1038/s41572-018-0029-0. PMID: 30291251
Nivolumab for previously treated unresectable metastatic anal cancer (NCI9673): a multicentre, single-arm, phase 2 study.
Morris VK, Salem ME, Nimeiri H, Iqbal S, Singh P, Ciombor K, Polite B, Deming D, Chan E, Wade JL, Xiao L, Bekaii-Saab T, Vence L, Blando J, Mahvash A, Foo WC, Ohaji C, Pasia M, Bland G, Ohinata A, Rogers J, Mehdizadeh A, Banks K, Lanman R, Wolff RA, Streicher H, Allison J, Sharma P, Eng C
Lancet Oncol 2017 Apr;18(4):446-453. Epub 2017 Feb 18 doi: 10.1016/S1470-2045(17)30104-3. PMID: 28223062Free PMC Article

Clinical prediction guides

Non-viral precision T cell receptor replacement for personalized cell therapy.
Foy SP, Jacoby K, Bota DA, Hunter T, Pan Z, Stawiski E, Ma Y, Lu W, Peng S, Wang CL, Yuen B, Dalmas O, Heeringa K, Sennino B, Conroy A, Bethune MT, Mende I, White W, Kukreja M, Gunturu S, Humphrey E, Hussaini A, An D, Litterman AJ, Quach BB, Ng AHC, Lu Y, Smith C, Campbell KM, Anaya D, Skrdlant L, Huang EY, Mendoza V, Mathur J, Dengler L, Purandare B, Moot R, Yi MC, Funke R, Sibley A, Stallings-Schmitt T, Oh DY, Chmielowski B, Abedi M, Yuan Y, Sosman JA, Lee SM, Schoenfeld AJ, Baltimore D, Heath JR, Franzusoff A, Ribas A, Rao AV, Mandl SJ
Nature 2023 Mar;615(7953):687-696. Epub 2022 Nov 10 doi: 10.1038/s41586-022-05531-1. PMID: 36356599Free PMC Article
Pembrolizumab (Keytruda).
Kwok G, Yau TC, Chiu JW, Tse E, Kwong YL
Hum Vaccin Immunother 2016 Nov;12(11):2777-2789. Epub 2016 Jul 11 doi: 10.1080/21645515.2016.1199310. PMID: 27398650Free PMC Article
Lenvatinib in Advanced, Radioactive Iodine-Refractory, Differentiated Thyroid Carcinoma.
Yeung KT, Cohen EE
Clin Cancer Res 2015 Dec 15;21(24):5420-6. Epub 2015 Oct 20 doi: 10.1158/1078-0432.CCR-15-0923. PMID: 26487760
Prognostic biomarkers in thyroid cancer.
Soares P, Celestino R, Melo M, Fonseca E, Sobrinho-Simões M
Virchows Arch 2014 Mar;464(3):333-46. Epub 2014 Feb 1 doi: 10.1007/s00428-013-1521-2. PMID: 24487783
Sunitinib.
Rini BI
Expert Opin Pharmacother 2007 Oct;8(14):2359-69. doi: 10.1517/14656566.8.14.2359. PMID: 17927489

Recent systematic reviews

Incidence of second primary malignancies in patients with multiple myeloma receiving anti-CD38 monoclonal antibodies: A systematic review and meta-analysis.
Mian A, Naqvi SAA, Ayaz A, Husnain M, Aljama MA, Mohyuddin GR, Koehn K, Mohan M, Bin Riaz I, Chakraborty R
Leuk Res 2023 Aug;131:107324. Epub 2023 May 23 doi: 10.1016/j.leukres.2023.107324. PMID: 37285641
Feasibility of myelosuppressive chemotherapy in psychiatric patients on clozapine: A systematic review of the literature.
Grainger BT, Arcasoy MO, Kenedi CA
Eur J Haematol 2019 Oct;103(4):277-286. Epub 2019 Jul 17 doi: 10.1111/ejh.13285. PMID: 31257631
Risks and Benefits of Chimeric Antigen Receptor T-Cell (CAR-T) Therapy in Cancer: A Systematic Review and Meta-Analysis.
Grigor EJM, Fergusson D, Kekre N, Montroy J, Atkins H, Seftel MD, Daugaard M, Presseau J, Thavorn K, Hutton B, Holt RA, Lalu MM
Transfus Med Rev 2019 Apr;33(2):98-110. Epub 2019 Feb 14 doi: 10.1016/j.tmrv.2019.01.005. PMID: 30948292
Platelet Transfusion for Patients With Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update.
Schiffer CA, Bohlke K, Delaney M, Hume H, Magdalinski AJ, McCullough JJ, Omel JL, Rainey JM, Rebulla P, Rowley SD, Troner MB, Anderson KC
J Clin Oncol 2018 Jan 20;36(3):283-299. Epub 2017 Nov 28 doi: 10.1200/JCO.2017.76.1734. PMID: 29182495
Docetaxel for treatment of solid tumours: a systematic review of clinical data.
Montero A, Fossella F, Hortobagyi G, Valero V
Lancet Oncol 2005 Apr;6(4):229-39. doi: 10.1016/S1470-2045(05)70094-2. PMID: 15811618

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