U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Splenic Lymphoma

MedGen UID:
96607
•Concept ID:
C0432562
•
Neoplastic Process
Synonyms: Malignant lymphoma of spleen; Primary Splenic Lymphoma
SNOMED CT: Malignant lymphoma of spleen (93198004)

Definition

A non-Hodgkin lymphoma or rarely Hodgkin lymphoma that arises from the spleen. [from NCI]

Professional guidelines

PubMed

Untangling hairy cell leukaemia (HCL) variant and other HCL-like disorders: Diagnosis and treatment.
Troussard X, Maitre E
J Cell Mol Med 2024 Feb;28(3):e18060. Epub 2023 Dec 14 doi: 10.1111/jcmm.18060. PMID: 38095234Free PMC Article
Clinical Characteristics, Treatment and Evolution of Splenic and Nodal Marginal Zone Lymphomas-Retrospective and Multicentric Analysis of Portuguese Centers.
Rodrigues CD, Peixeiro RP, Viegas D, Chorão P, Couto ME, Gaspar CL, Fernandes JP, Alves D, Ribeiro LA, de Vasconcelos M P, Tomé AL, Badior M, Coelho H, Príncipe F, Chacim S, da Silva MG, Coutinho R
Clin Lymphoma Myeloma Leuk 2021 Nov;21(11):e839-e844. Epub 2021 Jun 24 doi: 10.1016/j.clml.2021.06.013. PMID: 34326035
Multi-Database Description of Primary Splenic Diffuse Large B-Cell Lymphoma.
Byrd KP, Vontela NR, McCullar B, Martin MG
Anticancer Res 2017 Dec;37(12):6839-6843. doi: 10.21873/anticanres.12145. PMID: 29187463

Recent clinical studies

Etiology

The role of splenectomy in management of splenic B-cell lymphomas.
Archibald WJ, Baran AM, Williams AM, Salloum RM, Richard Burack W, Evans AG, Syposs CR, Zent CS
Leuk Res 2023 May;128:107053. Epub 2023 Mar 2 doi: 10.1016/j.leukres.2023.107053. PMID: 36906942
How we treat mature B-cell neoplasms (indolent B-cell lymphomas).
Lumish M, Falchi L, Imber BS, Scordo M, von Keudell G, Joffe E
J Hematol Oncol 2021 Jan 6;14(1):5. doi: 10.1186/s13045-020-01018-6. PMID: 33407745Free PMC Article
Promises and Dangers of Combination Therapy.
Kruis W, Nguyen PG, Morgenstern J
Dig Dis 2017;35(1-2):56-60. Epub 2017 Feb 1 doi: 10.1159/000449084. PMID: 28147380
Chronic lymphocytic leukemia.
Keating MJ
Semin Oncol 1999 Oct;26(5 Suppl 14):107-14. PMID: 10561025
Chronic lymphoproliferative disorders.
Montserrat E
Curr Opin Oncol 1997 Jan;9(1):34-41. doi: 10.1097/00001622-199701000-00006. PMID: 9090492

Diagnosis

Low-Grade Primary Splenic CD10-Positive Small B-Cell Lymphoma/Follicular Lymphoma.
Abdulbaki R, Tizro P, Nava VE, Gomes da Silva M, Ascensão JL
Curr Oncol 2021 Nov 18;28(6):4821-4831. doi: 10.3390/curroncol28060407. PMID: 34898578Free PMC Article
How we treat mature B-cell neoplasms (indolent B-cell lymphomas).
Lumish M, Falchi L, Imber BS, Scordo M, von Keudell G, Joffe E
J Hematol Oncol 2021 Jan 6;14(1):5. doi: 10.1186/s13045-020-01018-6. PMID: 33407745Free PMC Article
Primary splenic lymphoma-best identified early.
Schattner A, Lampner A, Dubin I
QJM 2021 Apr 27;114(2):129. doi: 10.1093/qjmed/hcaa283. PMID: 33035347
Splenic marginal zone lymphoma.
Piris MA, Onaindía A, Mollejo M
Best Pract Res Clin Haematol 2017 Mar-Jun;30(1-2):56-64. Epub 2016 Nov 5 doi: 10.1016/j.beha.2016.09.005. PMID: 28288718
Lymphoma of the spleen.
Bhatia K, Sahdev A, Reznek RH
Semin Ultrasound CT MR 2007 Feb;28(1):12-20. doi: 10.1053/j.sult.2006.10.010. PMID: 17366704

Therapy

How we treat mature B-cell neoplasms (indolent B-cell lymphomas).
Lumish M, Falchi L, Imber BS, Scordo M, von Keudell G, Joffe E
J Hematol Oncol 2021 Jan 6;14(1):5. doi: 10.1186/s13045-020-01018-6. PMID: 33407745Free PMC Article
Promises and Dangers of Combination Therapy.
Kruis W, Nguyen PG, Morgenstern J
Dig Dis 2017;35(1-2):56-60. Epub 2017 Feb 1 doi: 10.1159/000449084. PMID: 28147380
Non-Hodgkin lymphoma and hepatitis C: where we are and what next?
Sulyok M, Makara M, Újhelyi E, Vályi-Nagy I
Pathol Oncol Res 2015 Jan;21(1):1-7. Epub 2014 Oct 2 doi: 10.1007/s12253-014-9845-z. PMID: 25273531
Chronic lymphocytic leukemia.
Keating MJ
Semin Oncol 1999 Oct;26(5 Suppl 14):107-14. PMID: 10561025
Chronic lymphoproliferative disorders.
Montserrat E
Curr Opin Oncol 1997 Jan;9(1):34-41. doi: 10.1097/00001622-199701000-00006. PMID: 9090492

Prognosis

How to Diagnose and Treat CD5-Positive Lymphomas Involving the Spleen.
Cabeçadas J, Nava VE, Ascensao JL, Gomes da Silva M
Curr Oncol 2021 Nov 11;28(6):4611-4633. doi: 10.3390/curroncol28060390. PMID: 34898558Free PMC Article
Promises and Dangers of Combination Therapy.
Kruis W, Nguyen PG, Morgenstern J
Dig Dis 2017;35(1-2):56-60. Epub 2017 Feb 1 doi: 10.1159/000449084. PMID: 28147380
Non-Hodgkin lymphoma and hepatitis C: where we are and what next?
Sulyok M, Makara M, Újhelyi E, Vályi-Nagy I
Pathol Oncol Res 2015 Jan;21(1):1-7. Epub 2014 Oct 2 doi: 10.1007/s12253-014-9845-z. PMID: 25273531
Lymphoma of the spleen.
Bhatia K, Sahdev A, Reznek RH
Semin Ultrasound CT MR 2007 Feb;28(1):12-20. doi: 10.1053/j.sult.2006.10.010. PMID: 17366704
Chronic lymphocytic leukemia.
Keating MJ
Semin Oncol 1999 Oct;26(5 Suppl 14):107-14. PMID: 10561025

Clinical prediction guides

The role of splenectomy in management of splenic B-cell lymphomas.
Archibald WJ, Baran AM, Williams AM, Salloum RM, Richard Burack W, Evans AG, Syposs CR, Zent CS
Leuk Res 2023 May;128:107053. Epub 2023 Mar 2 doi: 10.1016/j.leukres.2023.107053. PMID: 36906942
Characteristics and survival outcomes of primary splenic cancers: A SEER population-based study.
Lei Y, Huang Q, Li X, Zheng X, Liu M
Medicine (Baltimore) 2022 Jan 21;101(3):e28539. doi: 10.1097/MD.0000000000028539. PMID: 35060511Free PMC Article
CD27-positive hairy cell leukemia-Japanese variant.
Tabata R, Tabata C, Iwama H, Yasumizu R, Kojima M
Virchows Arch 2016 Mar;468(3):375-9. Epub 2016 Feb 11 doi: 10.1007/s00428-015-1881-x. PMID: 26868143
Characteristics of primary splenic diffuse large B-cell lymphoma and role of splenectomy in improving survival.
Bairey O, Shvidel L, Perry C, Dann EJ, Ruchlemer R, Tadmor T, Goldschmidt N
Cancer 2015 Sep 1;121(17):2909-16. Epub 2015 Jun 19 doi: 10.1002/cncr.29487. PMID: 26096161
Imaging findings of primary splenic lymphoma: a review of 17 cases in which diagnosis was made at splenectomy.
Li M, Zhang L, Wu N, Huang W, Lv N
PLoS One 2013;8(11):e80264. Epub 2013 Nov 21 doi: 10.1371/journal.pone.0080264. PMID: 24278265Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...