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Testicular lymphoma

MedGen UID:
138110
•Concept ID:
C0349644
•
Neoplastic Process
Synonyms: Lymphoma of Testis; lymphoma of testis; Lymphoma of the Testis; lymphoma of the testis; Malignant lymphoma of testis; malignant lymphoma of testis; Primary Testicular Lymphoma; primary testicular lymphoma; Testicular Lymphoma; testicular lymphoma; TLYM
SNOMED CT: Malignant lymphoma of testis (277664004)
 
Monarch Initiative: MONDO:0001472

Definition

A lymphoma that arises from the testis and is not associated with lymphoma in another anatomic site. [from NCI]

Professional guidelines

PubMed

High prevalence of the MYD88 mutation in testicular lymphoma: Immunohistochemical and genetic analyses.
Oishi N, Kondo T, Nakazawa T, Mochizuki K, Tanioka F, Oyama T, Yamamoto T, Iizuka J, Tanabe K, Shibata N, Kirito K, Katoh R
Pathol Int 2015 Oct;65(10):528-35. Epub 2015 Aug 4 doi: 10.1111/pin.12336. PMID: 26388135
Primary testicular lymphoma.
Cheah CY, Wirth A, Seymour JF
Blood 2014 Jan 23;123(4):486-93. Epub 2013 Nov 26 doi: 10.1182/blood-2013-10-530659. PMID: 24282217
Scrotal irradiation in primary testicular lymphoma: review of the literature and in silico planning comparative study.
Brouwer CL, Wiesendanger EM, van der Hulst PC, van Imhoff GW, Langendijk JA, Beijert M
Int J Radiat Oncol Biol Phys 2013 Feb 1;85(2):298-308. Epub 2012 Jul 24 doi: 10.1016/j.ijrobp.2012.06.019. PMID: 22836054

Recent clinical studies

Etiology

Four versus six cycles of CHOP chemotherapy in combination with six applications of rituximab in patients with aggressive B-cell lymphoma with favourable prognosis (FLYER): a randomised, phase 3, non-inferiority trial.
Poeschel V, Held G, Ziepert M, Witzens-Harig M, Holte H, Thurner L, Borchmann P, Viardot A, Soekler M, Keller U, Schmidt C, Truemper L, Mahlberg R, Marks R, Hoeffkes HG, Metzner B, Dierlamm J, Frickhofen N, Haenel M, Neubauer A, Kneba M, Merli F, Tucci A, de Nully Brown P, Federico M, Lengfelder E, di Rocco A, Trappe R, Rosenwald A, Berdel C, Maisenhoelder M, Shpilberg O, Amam J, Christofyllakis K, Hartmann F, Murawski N, Stilgenbauer S, Nickelsen M, Wulf G, Glass B, Schmitz N, Altmann B, Loeffler M, Pfreundschuh M; FLYER Trial Investigators; German Lymphoma Alliance
Lancet 2019 Dec 21;394(10216):2271-2281. doi: 10.1016/S0140-6736(19)33008-9. PMID: 31868632
Extranodal Diffuse Large B Cell Lymphoma: Molecular Features, Prognosis, and Risk of Central Nervous System Recurrence.
Ollila TA, Olszewski AJ
Curr Treat Options Oncol 2018 Jun 21;19(8):38. doi: 10.1007/s11864-018-0555-8. PMID: 29931605Free PMC Article
First-line treatment for primary testicular diffuse large B-cell lymphoma with rituximab-CHOP, CNS prophylaxis, and contralateral testis irradiation: final results of an international phase II trial.
Vitolo U, Chiappella A, Ferreri AJ, Martelli M, Baldi I, Balzarotti M, Bottelli C, Conconi A, Gomez H, Lopez-Guillermo A, Martinelli G, Merli F, Novero D, Orsucci L, Pavone V, Ricardi U, Storti S, Gospodarowicz MK, Cavalli F, Sarris AH, Zucca E
J Clin Oncol 2011 Jul 10;29(20):2766-72. Epub 2011 Jun 6 doi: 10.1200/JCO.2010.31.4187. PMID: 21646602
Primary testicular lymphoma.
Zouhair A, Herrmann E, Ugurluer G, Gaye PM, Mirimanoff RO, Ozsahin M
Swiss Med Wkly 2010;140:w13076. Epub 2010 Sep 24 doi: 10.4414/smw.2010.13076. PMID: 20872294
Primary testicular lymphoma.
Vitolo U, Ferreri AJ, Zucca E
Crit Rev Oncol Hematol 2008 Feb;65(2):183-9. Epub 2007 Oct 24 doi: 10.1016/j.critrevonc.2007.08.005. PMID: 17962036

Diagnosis

Checkpoint Inhibitors Hodgkin Lymphoma and Non-Hodgkin Lymphoma.
Hu B, Jacobs R, Ghosh N
Curr Hematol Malig Rep 2018 Dec;13(6):543-554. doi: 10.1007/s11899-018-0484-4. PMID: 30338457
Extranodal Diffuse Large B Cell Lymphoma: Molecular Features, Prognosis, and Risk of Central Nervous System Recurrence.
Ollila TA, Olszewski AJ
Curr Treat Options Oncol 2018 Jun 21;19(8):38. doi: 10.1007/s11864-018-0555-8. PMID: 29931605Free PMC Article
Primary testicular lymphoma.
Cheah CY, Wirth A, Seymour JF
Blood 2014 Jan 23;123(4):486-93. Epub 2013 Nov 26 doi: 10.1182/blood-2013-10-530659. PMID: 24282217
Primary testicular lymphoma.
Ahmad SS, Idris SF, Follows GA, Williams MV
Clin Oncol (R Coll Radiol) 2012 Jun;24(5):358-65. Epub 2012 Mar 17 doi: 10.1016/j.clon.2012.02.005. PMID: 22424983
Testicular lymphoma.
Shahab N, Doll DC
Semin Oncol 1999 Jun;26(3):259-69. PMID: 10375083

Therapy

Four versus six cycles of CHOP chemotherapy in combination with six applications of rituximab in patients with aggressive B-cell lymphoma with favourable prognosis (FLYER): a randomised, phase 3, non-inferiority trial.
Poeschel V, Held G, Ziepert M, Witzens-Harig M, Holte H, Thurner L, Borchmann P, Viardot A, Soekler M, Keller U, Schmidt C, Truemper L, Mahlberg R, Marks R, Hoeffkes HG, Metzner B, Dierlamm J, Frickhofen N, Haenel M, Neubauer A, Kneba M, Merli F, Tucci A, de Nully Brown P, Federico M, Lengfelder E, di Rocco A, Trappe R, Rosenwald A, Berdel C, Maisenhoelder M, Shpilberg O, Amam J, Christofyllakis K, Hartmann F, Murawski N, Stilgenbauer S, Nickelsen M, Wulf G, Glass B, Schmitz N, Altmann B, Loeffler M, Pfreundschuh M; FLYER Trial Investigators; German Lymphoma Alliance
Lancet 2019 Dec 21;394(10216):2271-2281. doi: 10.1016/S0140-6736(19)33008-9. PMID: 31868632
Checkpoint Inhibitors Hodgkin Lymphoma and Non-Hodgkin Lymphoma.
Hu B, Jacobs R, Ghosh N
Curr Hematol Malig Rep 2018 Dec;13(6):543-554. doi: 10.1007/s11899-018-0484-4. PMID: 30338457
Primary testicular lymphoma.
Cheah CY, Wirth A, Seymour JF
Blood 2014 Jan 23;123(4):486-93. Epub 2013 Nov 26 doi: 10.1182/blood-2013-10-530659. PMID: 24282217
First-line treatment for primary testicular diffuse large B-cell lymphoma with rituximab-CHOP, CNS prophylaxis, and contralateral testis irradiation: final results of an international phase II trial.
Vitolo U, Chiappella A, Ferreri AJ, Martelli M, Baldi I, Balzarotti M, Bottelli C, Conconi A, Gomez H, Lopez-Guillermo A, Martinelli G, Merli F, Novero D, Orsucci L, Pavone V, Ricardi U, Storti S, Gospodarowicz MK, Cavalli F, Sarris AH, Zucca E
J Clin Oncol 2011 Jul 10;29(20):2766-72. Epub 2011 Jun 6 doi: 10.1200/JCO.2010.31.4187. PMID: 21646602
Primary testicular lymphoma.
Zouhair A, Herrmann E, Ugurluer G, Gaye PM, Mirimanoff RO, Ozsahin M
Swiss Med Wkly 2010;140:w13076. Epub 2010 Sep 24 doi: 10.4414/smw.2010.13076. PMID: 20872294

Prognosis

Four versus six cycles of CHOP chemotherapy in combination with six applications of rituximab in patients with aggressive B-cell lymphoma with favourable prognosis (FLYER): a randomised, phase 3, non-inferiority trial.
Poeschel V, Held G, Ziepert M, Witzens-Harig M, Holte H, Thurner L, Borchmann P, Viardot A, Soekler M, Keller U, Schmidt C, Truemper L, Mahlberg R, Marks R, Hoeffkes HG, Metzner B, Dierlamm J, Frickhofen N, Haenel M, Neubauer A, Kneba M, Merli F, Tucci A, de Nully Brown P, Federico M, Lengfelder E, di Rocco A, Trappe R, Rosenwald A, Berdel C, Maisenhoelder M, Shpilberg O, Amam J, Christofyllakis K, Hartmann F, Murawski N, Stilgenbauer S, Nickelsen M, Wulf G, Glass B, Schmitz N, Altmann B, Loeffler M, Pfreundschuh M; FLYER Trial Investigators; German Lymphoma Alliance
Lancet 2019 Dec 21;394(10216):2271-2281. doi: 10.1016/S0140-6736(19)33008-9. PMID: 31868632
Extranodal Diffuse Large B Cell Lymphoma: Molecular Features, Prognosis, and Risk of Central Nervous System Recurrence.
Ollila TA, Olszewski AJ
Curr Treat Options Oncol 2018 Jun 21;19(8):38. doi: 10.1007/s11864-018-0555-8. PMID: 29931605Free PMC Article
Primary testicular lymphoma.
Cheah CY, Wirth A, Seymour JF
Blood 2014 Jan 23;123(4):486-93. Epub 2013 Nov 26 doi: 10.1182/blood-2013-10-530659. PMID: 24282217
First-line treatment for primary testicular diffuse large B-cell lymphoma with rituximab-CHOP, CNS prophylaxis, and contralateral testis irradiation: final results of an international phase II trial.
Vitolo U, Chiappella A, Ferreri AJ, Martelli M, Baldi I, Balzarotti M, Bottelli C, Conconi A, Gomez H, Lopez-Guillermo A, Martinelli G, Merli F, Novero D, Orsucci L, Pavone V, Ricardi U, Storti S, Gospodarowicz MK, Cavalli F, Sarris AH, Zucca E
J Clin Oncol 2011 Jul 10;29(20):2766-72. Epub 2011 Jun 6 doi: 10.1200/JCO.2010.31.4187. PMID: 21646602
Testicular lymphoma.
Shahab N, Doll DC
Semin Oncol 1999 Jun;26(3):259-69. PMID: 10375083

Clinical prediction guides

Characteristic features of primary testicular lymphoma and survival trends: a multicenter clinical study.
Sun Y, Yan X, Zhao H, Cui Z, Wang Y, Sun S, Ning X, Xu H
Hematology 2022 Dec;27(1):1019-1025. doi: 10.1080/16078454.2022.2119345. PMID: 36066282
Molecular classification of aggressive lymphomas-past, present, future.
Wienand K, Chapuy B
Hematol Oncol 2021 Jun;39 Suppl 1:24-30. doi: 10.1002/hon.2847. PMID: 34105819
Adult primary testicular lymphoma: clinical features and survival in a series of patients treated at a high-volume institution in China.
Chen B, Cao DH, Lai L, Guo JB, Chen ZY, Huang Y, Qiu S, Lin TH, Gou Y, Ma N, Yang L, Liu LR, Wei Q
BMC Cancer 2020 Mar 14;20(1):220. doi: 10.1186/s12885-020-6711-0. PMID: 32171265Free PMC Article
The survival and prognostic factors of primary testicular lymphoma: two-decade single-center experience.
Ma RZ, Tian L, Tao LY, He HY, Li M, Lu M, Ma LL, Jiang H, Lu J
Asian J Androl 2018 Nov-Dec;20(6):615-620. doi: 10.4103/aja.aja_73_18. PMID: 30246707Free PMC Article
Extranodal Diffuse Large B Cell Lymphoma: Molecular Features, Prognosis, and Risk of Central Nervous System Recurrence.
Ollila TA, Olszewski AJ
Curr Treat Options Oncol 2018 Jun 21;19(8):38. doi: 10.1007/s11864-018-0555-8. PMID: 29931605Free PMC Article

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