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Adult Soft Tissue Sarcoma

MedGen UID:
66309
•Concept ID:
C0220613
•
Neoplastic Process
Synonyms: Adult Sarcoma of Soft Tissue; Adult Sarcoma of the Soft Tissue

Definition

Soft tissue sarcoma occurring in adults. [from NCI]

Professional guidelines

PubMed

Advances of systemic treatment for adult soft-tissue sarcoma.
Liu W, Jiang Q, Zhou Y
Chin Clin Oncol 2018 Aug;7(4):42. doi: 10.21037/cco.2018.08.02. PMID: 30173532
Management of adult soft tissue sarcomas of the head and neck.
de Bree R, van der Waal I, de Bree E, Leemans CR
Oral Oncol 2010 Nov;46(11):786-90. Epub 2010 Oct 13 doi: 10.1016/j.oraloncology.2010.09.001. PMID: 20947413
Systemic treatment options for patients with refractory adult-type sarcoma beyond anthracyclines.
Hartmann JT
Anticancer Drugs 2007 Mar;18(3):245-54. doi: 10.1097/CAD.0b013e3280124e41. PMID: 17264755

Recent clinical studies

Etiology

Management of Low and Intermediate Risk Adult Rhabdomyosarcoma: A Pooled Survival Analysis of 553 Patients.
Elsebaie MAT, Amgad M, Elkashash A, Elgebaly AS, Ashal GGEL, Shash E, Elsayed Z
Sci Rep 2018 Jun 19;8(1):9337. doi: 10.1038/s41598-018-27556-1. PMID: 29921891Free PMC Article
Head and neck soft-tissue sarcoma in adults.
Galy-Bernadoy C, Garrel R
Eur Ann Otorhinolaryngol Head Neck Dis 2016 Feb;133(1):37-42. Epub 2015 Sep 26 doi: 10.1016/j.anorl.2015.09.003. PMID: 26403655
Angiosarcoma: state of the art and perspectives.
Penel N, Marréaud S, Robin YM, Hohenberger P
Crit Rev Oncol Hematol 2011 Nov;80(2):257-63. Epub 2010 Nov 4 doi: 10.1016/j.critrevonc.2010.10.007. PMID: 21055965
Adult soft tissue sarcoma.
Mann GB, Lewis JJ, Brennan MF
Aust N Z J Surg 1999 May;69(5):336-43. doi: 10.1046/j.1440-1622.1999.01568.x. PMID: 10353547
Lipomatous tumors.
Weiss SW
Monogr Pathol 1996;38:207-39. PMID: 8744279

Diagnosis

Advances of systemic treatment for adult soft-tissue sarcoma.
Liu W, Jiang Q, Zhou Y
Chin Clin Oncol 2018 Aug;7(4):42. doi: 10.21037/cco.2018.08.02. PMID: 30173532
Head and neck soft-tissue sarcoma in adults.
Galy-Bernadoy C, Garrel R
Eur Ann Otorhinolaryngol Head Neck Dis 2016 Feb;133(1):37-42. Epub 2015 Sep 26 doi: 10.1016/j.anorl.2015.09.003. PMID: 26403655
Management of adult soft tissue sarcomas of the head and neck.
de Bree R, van der Waal I, de Bree E, Leemans CR
Oral Oncol 2010 Nov;46(11):786-90. Epub 2010 Oct 13 doi: 10.1016/j.oraloncology.2010.09.001. PMID: 20947413
Adult soft tissue sarcoma.
Mann GB, Lewis JJ, Brennan MF
Aust N Z J Surg 1999 May;69(5):336-43. doi: 10.1046/j.1440-1622.1999.01568.x. PMID: 10353547
Lipomatous tumors.
Weiss SW
Monogr Pathol 1996;38:207-39. PMID: 8744279

Therapy

Advances of systemic treatment for adult soft-tissue sarcoma.
Liu W, Jiang Q, Zhou Y
Chin Clin Oncol 2018 Aug;7(4):42. doi: 10.21037/cco.2018.08.02. PMID: 30173532
Emerging therapies for adult soft tissue sarcoma.
Radaelli S, Stacchiotti S, Casali PG, Gronchi A
Expert Rev Anticancer Ther 2014 Jun;14(6):689-704. Epub 2014 Feb 20 doi: 10.1586/14737140.2014.885840. PMID: 24555529
Angiosarcoma: state of the art and perspectives.
Penel N, Marréaud S, Robin YM, Hohenberger P
Crit Rev Oncol Hematol 2011 Nov;80(2):257-63. Epub 2010 Nov 4 doi: 10.1016/j.critrevonc.2010.10.007. PMID: 21055965
Chemotherapy in adult soft tissue sarcoma.
Jain A, Sajeevan KV, Babu KG, Lakshmaiah KC
Indian J Cancer 2009 Oct-Dec;46(4):274-87. doi: 10.4103/0019-509X.55547. PMID: 19749457
Adult soft tissue sarcoma.
Mann GB, Lewis JJ, Brennan MF
Aust N Z J Surg 1999 May;69(5):336-43. doi: 10.1046/j.1440-1622.1999.01568.x. PMID: 10353547

Prognosis

Management of Low and Intermediate Risk Adult Rhabdomyosarcoma: A Pooled Survival Analysis of 553 Patients.
Elsebaie MAT, Amgad M, Elkashash A, Elgebaly AS, Ashal GGEL, Shash E, Elsayed Z
Sci Rep 2018 Jun 19;8(1):9337. doi: 10.1038/s41598-018-27556-1. PMID: 29921891Free PMC Article
Salvage Therapy in Advanced Adult Soft Tissue Sarcoma: A Systematic Review and Meta-Analysis of Randomized Trials.
Comandone A, Petrelli F, Boglione A, Barni S
Oncologist 2017 Dec;22(12):1518-1527. Epub 2017 Aug 23 doi: 10.1634/theoncologist.2016-0474. PMID: 28835514Free PMC Article
Head and neck soft-tissue sarcoma in adults.
Galy-Bernadoy C, Garrel R
Eur Ann Otorhinolaryngol Head Neck Dis 2016 Feb;133(1):37-42. Epub 2015 Sep 26 doi: 10.1016/j.anorl.2015.09.003. PMID: 26403655
Adult soft tissue sarcoma.
Mann GB, Lewis JJ, Brennan MF
Aust N Z J Surg 1999 May;69(5):336-43. doi: 10.1046/j.1440-1622.1999.01568.x. PMID: 10353547
Lipomatous tumors.
Weiss SW
Monogr Pathol 1996;38:207-39. PMID: 8744279

Clinical prediction guides

Adult genitourinary sarcoma: The era of optional chemotherapeutic agents for soft tissue sarcoma.
Urasaki T, Nakano K, Tomomatsu J, Komai Y, Yuasa T, Yamashita K, Takazawa Y, Yamamoto S, Yonese J, Takahashi S
Int J Urol 2021 Jan;28(1):91-97. Epub 2020 Nov 9 doi: 10.1111/iju.14417. PMID: 33169456
Salvage Therapy in Advanced Adult Soft Tissue Sarcoma: A Systematic Review and Meta-Analysis of Randomized Trials.
Comandone A, Petrelli F, Boglione A, Barni S
Oncologist 2017 Dec;22(12):1518-1527. Epub 2017 Aug 23 doi: 10.1634/theoncologist.2016-0474. PMID: 28835514Free PMC Article
Treatment of adult soft tissue sarcoma: old concepts, new insights, and potential for drug discovery.
Aragon-Ching JB, Maki RG
Cancer Invest 2012 May;30(4):300-8. Epub 2012 Apr 5 doi: 10.3109/07357907.2012.658936. PMID: 22480231
Inter- and intra-observer variation in soft-tissue sarcoma target definition.
Roberge D, Skamene T, Turcotte RE, Powell T, Saran N, Freeman C
Cancer Radiother 2011 Aug;15(5):421-5. Epub 2011 Jul 8 doi: 10.1016/j.canrad.2011.03.006. PMID: 21741872
High-dose chemotherapy in adult soft tissue sarcoma.
Reichardt P
Crit Rev Oncol Hematol 2002 Feb;41(2):157-67. doi: 10.1016/s1040-8428(01)00153-6. PMID: 11856592

Recent systematic reviews

Salvage Therapy in Advanced Adult Soft Tissue Sarcoma: A Systematic Review and Meta-Analysis of Randomized Trials.
Comandone A, Petrelli F, Boglione A, Barni S
Oncologist 2017 Dec;22(12):1518-1527. Epub 2017 Aug 23 doi: 10.1634/theoncologist.2016-0474. PMID: 28835514Free PMC Article
Dose-intensive chemotherapy with growth factor or autologous bone marrow/stem cell transplant support in first-line treatment of advanced or metastatic adult soft tissue sarcoma: a systematic review.
Verma S, Younus J, Stys-Norman D, Haynes AE, Blackstein M; Sarcoma Disease Site Group of Cancer Care Ontario's Program in Evidence-based Care
Cancer 2008 Mar 15;112(6):1197-205. doi: 10.1002/cncr.23302. PMID: 18224666

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