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Refractory Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor

MedGen UID:
1652936
Concept ID:
C4727144
Neoplastic Process

Definition

A malignant small round cell tumor with or without neural differentiation that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Professional guidelines

PubMed

Büyükkapu Bay S, Kebudi R, Görgün O, Zülfikar B, Darendeliler E, Çakır FB
J Oncol Pharm Pract 2019 Sep;25(6):1343-1348. Epub 2018 Aug 6 doi: 10.1177/1078155218790798. PMID: 30080131
Graham-Pole J, Lazarus HM, Herzig RH, Gross S, Coccia P, Weiner R, Strandjord S
Am J Pediatr Hematol Oncol 1984 Spring;6(1):17-26. PMID: 6370012
Lazarus HM, Herzig RH, Graham-Pole J, Wolff SN, Phillips GL, Strandjord S, Hurd D, Forman W, Gordon EM, Coccia P
J Clin Oncol 1983 Jun;1(6):359-67. doi: 10.1200/JCO.1983.1.6.359. PMID: 6366139

Recent clinical studies

Etiology

Amoroso L, Castel V, Bisogno G, Casanova M, Marquez-Vega C, Chisholm JC, Doz F, Moreno L, Ruggiero A, Gerber NU, Fagioli F, Hingorani P, Melcón SG, Slepetis R, Chen N, le Bruchec Y, Simcock M, Vassal G
Eur J Cancer 2020 Aug;135:89-97. Epub 2020 Jun 15 doi: 10.1016/j.ejca.2020.04.031. PMID: 32554315
Qayed M, Cash T, Tighiouart M, MacDonald TJ, Goldsmith KC, Tanos R, Kean L, Watkins B, Suessmuth Y, Wetmore C, Katzenstein HM
Pediatr Blood Cancer 2020 Apr;67(4):e28134. Epub 2019 Dec 25 doi: 10.1002/pbc.28134. PMID: 31876107
Warwick AB, Malempati S, Krailo M, Melemed A, Gorlick R, Ames MM, Safgren SL, Adamson PC, Blaney SM
Pediatr Blood Cancer 2013 Feb;60(2):237-41. Epub 2012 Jun 28 doi: 10.1002/pbc.24244. PMID: 22745043Free PMC Article
Pérez-Martínez A, Leung W, Muñoz E, Iyengar R, Ramírez M, Vicario JL, Lassaletta A, Sevilla J, González-Vicent M, Madero L, Díaz-Pérez MA
Pediatr Blood Cancer 2009 Jul;53(1):120-4. doi: 10.1002/pbc.21955. PMID: 19215002
Van Winkle P, Angiolillo A, Krailo M, Cheung YK, Anderson B, Davenport V, Reaman G, Cairo MS
Pediatr Blood Cancer 2005 Apr;44(4):338-47. doi: 10.1002/pbc.20227. PMID: 15503297

Diagnosis

Cash T, Jonus HC, Tsvetkova M, Beumer JH, Sadanand A, Lee JY, Henry CJ, Aguilera D, Harvey RD, Goldsmith KC
Pediatr Blood Cancer 2023 Aug;70(8):e30405. Epub 2023 May 9 doi: 10.1002/pbc.30405. PMID: 37158620Free PMC Article
Qayed M, Cash T, Tighiouart M, MacDonald TJ, Goldsmith KC, Tanos R, Kean L, Watkins B, Suessmuth Y, Wetmore C, Katzenstein HM
Pediatr Blood Cancer 2020 Apr;67(4):e28134. Epub 2019 Dec 25 doi: 10.1002/pbc.28134. PMID: 31876107
Rokita JL, Rathi KS, Cardenas MF, Upton KA, Jayaseelan J, Cross KL, Pfeil J, Egolf LE, Way GP, Farrel A, Kendsersky NM, Patel K, Gaonkar KS, Modi A, Berko ER, Lopez G, Vaksman Z, Mayoh C, Nance J, McCoy K, Haber M, Evans K, McCalmont H, Bendak K, Böhm JW, Marshall GM, Tyrrell V, Kalletla K, Braun FK, Qi L, Du Y, Zhang H, Lindsay HB, Zhao S, Shu J, Baxter P, Morton C, Kurmashev D, Zheng S, Chen Y, Bowen J, Bryan AC, Leraas KM, Coppens SE, Doddapaneni H, Momin Z, Zhang W, Sacks GI, Hart LS, Krytska K, Mosse YP, Gatto GJ, Sanchez Y, Greene CS, Diskin SJ, Vaske OM, Haussler D, Gastier-Foster JM, Kolb EA, Gorlick R, Li XN, Reynolds CP, Kurmasheva RT, Houghton PJ, Smith MA, Lock RB, Raman P, Wheeler DA, Maris JM
Cell Rep 2019 Nov 5;29(6):1675-1689.e9. doi: 10.1016/j.celrep.2019.09.071. PMID: 31693904Free PMC Article
Büyükkapu Bay S, Kebudi R, Görgün O, Zülfikar B, Darendeliler E, Çakır FB
J Oncol Pharm Pract 2019 Sep;25(6):1343-1348. Epub 2018 Aug 6 doi: 10.1177/1078155218790798. PMID: 30080131
Graham-Pole J, Lazarus HM, Herzig RH, Gross S, Coccia P, Weiner R, Strandjord S
Am J Pediatr Hematol Oncol 1984 Spring;6(1):17-26. PMID: 6370012

Therapy

Cash T, Jonus HC, Tsvetkova M, Beumer JH, Sadanand A, Lee JY, Henry CJ, Aguilera D, Harvey RD, Goldsmith KC
Pediatr Blood Cancer 2023 Aug;70(8):e30405. Epub 2023 May 9 doi: 10.1002/pbc.30405. PMID: 37158620Free PMC Article
Saulnier-Sholler G, Duda DG, Bergendahl G, Ebb D, Snuderl M, Laetsch TW, Michlitsch J, Hanson D, Isakoff MS, Bielamowicz K, Kraveka JM, Ferguson W, Carmeliet P, De Deene A, Gijsen L, Jain RK
Clin Cancer Res 2022 Sep 15;28(18):3950-3957. doi: 10.1158/1078-0432.CCR-22-1169. PMID: 35833850Free PMC Article
Qayed M, Cash T, Tighiouart M, MacDonald TJ, Goldsmith KC, Tanos R, Kean L, Watkins B, Suessmuth Y, Wetmore C, Katzenstein HM
Pediatr Blood Cancer 2020 Apr;67(4):e28134. Epub 2019 Dec 25 doi: 10.1002/pbc.28134. PMID: 31876107
Büyükkapu Bay S, Kebudi R, Görgün O, Zülfikar B, Darendeliler E, Çakır FB
J Oncol Pharm Pract 2019 Sep;25(6):1343-1348. Epub 2018 Aug 6 doi: 10.1177/1078155218790798. PMID: 30080131
Graham-Pole J, Lazarus HM, Herzig RH, Gross S, Coccia P, Weiner R, Strandjord S
Am J Pediatr Hematol Oncol 1984 Spring;6(1):17-26. PMID: 6370012

Prognosis

Thakur MD, Franz CJ, Brennan L, Brouwer-Visser J, Tam R, Korski K, Koeppen H, Ziai J, Babitzki G, Ranchere-Vince D, Vasiljevic A, Dijoud F, Marec-Bérard P, Rochet I, Cannarile MA, Marabelle A
Eur J Cancer 2022 Jul;170:179-193. Epub 2022 May 31 doi: 10.1016/j.ejca.2022.03.012. PMID: 35660252
Büyükkapu Bay S, Kebudi R, Görgün O, Zülfikar B, Darendeliler E, Çakır FB
J Oncol Pharm Pract 2019 Sep;25(6):1343-1348. Epub 2018 Aug 6 doi: 10.1177/1078155218790798. PMID: 30080131
Pérez-Martínez A, Leung W, Muñoz E, Iyengar R, Ramírez M, Vicario JL, Lassaletta A, Sevilla J, González-Vicent M, Madero L, Díaz-Pérez MA
Pediatr Blood Cancer 2009 Jul;53(1):120-4. doi: 10.1002/pbc.21955. PMID: 19215002
Van Winkle P, Angiolillo A, Krailo M, Cheung YK, Anderson B, Davenport V, Reaman G, Cairo MS
Pediatr Blood Cancer 2005 Apr;44(4):338-47. doi: 10.1002/pbc.20227. PMID: 15503297
Graham-Pole J, Lazarus HM, Herzig RH, Gross S, Coccia P, Weiner R, Strandjord S
Am J Pediatr Hematol Oncol 1984 Spring;6(1):17-26. PMID: 6370012

Clinical prediction guides

Saulnier-Sholler G, Duda DG, Bergendahl G, Ebb D, Snuderl M, Laetsch TW, Michlitsch J, Hanson D, Isakoff MS, Bielamowicz K, Kraveka JM, Ferguson W, Carmeliet P, De Deene A, Gijsen L, Jain RK
Clin Cancer Res 2022 Sep 15;28(18):3950-3957. doi: 10.1158/1078-0432.CCR-22-1169. PMID: 35833850Free PMC Article
Qayed M, Cash T, Tighiouart M, MacDonald TJ, Goldsmith KC, Tanos R, Kean L, Watkins B, Suessmuth Y, Wetmore C, Katzenstein HM
Pediatr Blood Cancer 2020 Apr;67(4):e28134. Epub 2019 Dec 25 doi: 10.1002/pbc.28134. PMID: 31876107
Pérez-Martínez A, Leung W, Muñoz E, Iyengar R, Ramírez M, Vicario JL, Lassaletta A, Sevilla J, González-Vicent M, Madero L, Díaz-Pérez MA
Pediatr Blood Cancer 2009 Jul;53(1):120-4. doi: 10.1002/pbc.21955. PMID: 19215002
Suminoe A, Matsuzaki A, Hattori H, Koga Y, Hara T
Pediatr Transplant 2009 Sep;13(6):746-53. Epub 2008 Nov 1 doi: 10.1111/j.1399-3046.2008.01066.x. PMID: 19067917
Graham-Pole J, Lazarus HM, Herzig RH, Gross S, Coccia P, Weiner R, Strandjord S
Am J Pediatr Hematol Oncol 1984 Spring;6(1):17-26. PMID: 6370012

Supplemental Content

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