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Thymus squamous cell carcinoma

MedGen UID:
234814
•Concept ID:
C1336082
•
Neoplastic Process
Synonyms: Epidermoid Thymic Carcinoma; epidermoid thymic carcinoma; Squamous Cell Carcinoma of the Thymus; squamous cell carcinoma of the Thymus; Squamous Cell Carcinoma of Thymus; squamous cell carcinoma of Thymus; Thymic Squamous Cell Carcinoma; thymic squamous cell carcinoma; Thymus Squamous Cell Carcinoma; thymus squamous cell carcinoma
 
Monarch Initiative: MONDO:0003493

Definition

A rare primary thymic carcinoma, characterized by the presence of keratinizing or non-keratinizing malignant squamous cells. Approximately 10-20% of cases occur in combination with thymoma. The prognosis depends on the tumor stage and the degree of cellular differentiation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThymus squamous cell carcinoma

Professional guidelines

PubMed

Carcinoma Showing Thymus-Like Differentiation (CASTLE): Cytopathological Features and Differential Diagnosis.
Collins JA, Ping B, Bishop JA, Ali SZ
Acta Cytol 2016;60(5):421-428. Epub 2016 Sep 17 doi: 10.1159/000448836. PMID: 27643719
About thymic carcinomas: challenges in diagnosis and management.
Mlika M, Boudaya S, Braham E, Chermiti F, Sayi A, Marghli A, El Mezni F
Asian Cardiovasc Thorac Ann 2016 May;24(4):350-4. Epub 2016 Mar 21 doi: 10.1177/0218492316640129. PMID: 27002097
Surgical treatment and prognosis of thymic squamous cell carcinoma: a retrospective analysis of 105 cases.
Zhao Y, Zhao H, Hu D, Fan L, Shi J, Fang W
Ann Thorac Surg 2013 Sep;96(3):1019-24. Epub 2013 Jul 16 doi: 10.1016/j.athoracsur.2013.04.078. PMID: 23866799

Recent clinical studies

Therapy

Comparison of Efficacy and Safety of Platinum-Based Chemotherapy as First-Line Therapy between B3 Thymoma and Thymic Carcinoma.
Hao Y, Si J, Jin J, Wei J, Xiang J, Xu C, Song Z
Curr Oncol 2022 Dec 2;29(12):9452-9460. doi: 10.3390/curroncol29120743. PMID: 36547157Free PMC Article
Serum levels of squamous cell carcinoma antigens 1 and 2 reflect disease severity and clinical type of atopic dermatitis in adult patients.
Okawa T, Yamaguchi Y, Kou K, Ono J, Azuma Y, Komitsu N, Inoue Y, Kohno M, Matsukura S, Kambara T, Ohta S, Izuhara K, Aihara M
Allergol Int 2018 Jan;67(1):124-130. Epub 2017 Jul 19 doi: 10.1016/j.alit.2017.06.016. PMID: 28734739
Combination chemotherapy with carboplatin and paclitaxel for advanced thymic cancer.
Furugen M, Sekine I, Tsuta K, Horinouchi H, Nokihara H, Yamamoto N, Kubota K, Tamura T
Jpn J Clin Oncol 2011 Aug;41(8):1013-6. Epub 2011 Jul 7 doi: 10.1093/jjco/hyr089. PMID: 21742653
Thymic carcinoma: is it a separate entity? From molecular to clinical evidence.
Marx A, Rieker R, Toker A, Länger F, Ströbel P
Thorac Surg Clin 2011 Feb;21(1):25-31. v-vi. doi: 10.1016/j.thorsurg.2010.08.010. PMID: 21070984
Thymostimulin enhancement of T-cell infiltration into head and neck squamous cell carcinoma.
Kerrebijn JD, Simons PJ, Balm AJ, Tas M, Knegt PP, de Vries N, Tan IB, Drexhage HA
Head Neck 1996 Jul-Aug;18(4):335-42. doi: 10.1002/(SICI)1097-0347(199607/08)18:4<335::AID-HED4>3.0.CO;2-Z. PMID: 8780944

Prognosis

Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Common and rare carcinomas of the thymus.
Roden AC, Szolkowska M
Virchows Arch 2021 Jan;478(1):111-128. Epub 2021 Jan 3 doi: 10.1007/s00428-020-03000-6. PMID: 33389148
C-KIT mutation in thymic carcinomas.
Terzi N, Yilmaz I, Batur S, Yegen G, Yol C, Arikan E, Oz A
Pol J Pathol 2020;71(2):120-126. doi: 10.5114/pjp.2020.97019. PMID: 32729302
The diagnosis of thymoma: a review.
Hammond EH, Flinner RL
Ultrastruct Pathol 1991 Jul-Oct;15(4-5):419-38. doi: 10.3109/01913129109016250. PMID: 1755103
Thymomas and thymic carcinomas.
Walker AN, Mills SE, Fechner RE
Semin Diagn Pathol 1990 Nov;7(4):250-65. PMID: 2284513

Clinical prediction guides

PAX1 expression in thymic epithelial neoplasms and morphologic mimics.
Parrack PH, Hornick JL, Sholl LM
Hum Pathol 2023 Dec;142:7-14. Epub 2023 Sep 28 doi: 10.1016/j.humpath.2023.09.007. PMID: 37776957
Intrathyroid thymic carcinoma: clinicopathological features and whole exome sequencing analysis.
Li J, Xiang R, Li Y, Liao Q, Liu Y
Virchows Arch 2023 May;482(5):813-822. Epub 2023 Apr 5 doi: 10.1007/s00428-023-03536-3. PMID: 37016248
Differences in Thymus and Activation-Regulated Chemokine and Squamous Cell Carcinoma Antigen 2 Levels in Food Protein-Induced Enterocolitis Syndrome and Atopic Dermatitis.
Makita E, Sugawara D, Kuroda S, Itabashi K, Hirakubo Y, Nonaka K, Ichihashi K
Int Arch Allergy Immunol 2022;183(9):967-974. Epub 2022 May 10 doi: 10.1159/000524683. PMID: 35537383
Usefulness of (18)F-FDG PET/CT in treatment-naive patients with thymic squamous cell carcinoma.
Li Y, Li Y, Huang Y, Wu X, Yang Z, Wu C, Jiang L
Ann Nucl Med 2021 Sep;35(9):1048-1057. Epub 2021 Jun 8 doi: 10.1007/s12149-021-01640-5. PMID: 34101153
Immunohistochemical differentiation between type B3 thymomas and thymic squamous cell carcinomas.
Su XY, Wang WY, Li JN, Liao DY, Wu WL, Li GD
Int J Clin Exp Pathol 2015;8(5):5354-62. Epub 2015 May 1 PMID: 26191237Free PMC Article

Recent systematic reviews

Carcinoma showing thymic-like elements--a rare malignancy of the thyroid gland.
Roka S, Kornek G, Schüller J, Ortmann E, Feichtinger J, Armbruster C
Br J Surg 2004 Feb;91(2):142-5. doi: 10.1002/bjs.4510. PMID: 14760659

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