U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Metastatic Malignant Neoplasm in the Breast

MedGen UID:
1787931
•Concept ID:
C5441655
•
Neoplastic Process
Synonyms: Breast Metastases; Breast Metastasis; Metastatic Cancer to the Breast; Metastatic malignant neoplasm of breast; Metastatic malignant neoplasm to breast; Metastatic Malignant Neoplasm to the Breast; Metastatic Neoplasm to the Breast; Metastatic Tumor to the Breast; Secondary malignant neoplasm of breast
SNOMED CT: Secondary malignant neoplasm of breast (145501000119108); Metastatic malignant neoplasm of breast (145501000119108); Metastatic malignant neoplasm to breast (145501000119108)

Definition

The spread of a malignant neoplasm to the breast. This may be from a primary breast malignant neoplasm on the opposite side, or from a malignant neoplasm at a distant site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Malignant Neoplasm in the Breast

Professional guidelines

PubMed

Metastatic and Malignant Phyllodes Tumors of the Breast: An Update for Current Management.
Goodwin B, Oyinlola AF, Palhang M, Lehman D, Platoff R, Atabek U, Spitz F, Hong Y
Am Surg 2023 Dec;89(12):6190-6196. Epub 2023 Aug 23 doi: 10.1177/00031348231198114. PMID: 37611540
Bone Pain in Cancer Patients: Mechanisms and Current Treatment.
Zajączkowska R, Kocot-Kępska M, Leppert W, Wordliczek J
Int J Mol Sci 2019 Nov 30;20(23) doi: 10.3390/ijms20236047. PMID: 31801267Free PMC Article
Over-treatment in metastatic breast cancer.
Senkus E, Łacko A
Breast 2017 Feb;31:309-317. Epub 2016 Jul 21 doi: 10.1016/j.breast.2016.06.024. PMID: 27453572

Recent clinical studies

Etiology

Evolving treatments and outcomes in HER2-Positive metastatic breast cancer: Data from the GIM14/BIOMETA study.
Di Maio M, Bighin C, Schettini F, Ruelle T, Marandino L, Fabi A, De Angelis C, Giuliano M, De Placido P, De Laurentiis M, Riccardi F, Picotto C, Puglisi F, Del Mastro L, Arpino G; Gruppo Italiano Mammella (GIM) Study Group
Breast 2023 Dec;72:103583. Epub 2023 Sep 25 doi: 10.1016/j.breast.2023.103583. PMID: 37783133Free PMC Article
Metastatic and Malignant Phyllodes Tumors of the Breast: An Update for Current Management.
Goodwin B, Oyinlola AF, Palhang M, Lehman D, Platoff R, Atabek U, Spitz F, Hong Y
Am Surg 2023 Dec;89(12):6190-6196. Epub 2023 Aug 23 doi: 10.1177/00031348231198114. PMID: 37611540
Metastatic nonhematopoietic neoplasms to the breast: a study of 238 cases.
Zhou P, Chang N, Abraham SC, Albarracin CT, Huo L, Chen H, Ding Q, Resetkova E, Middleton LP, Sahin AA, Bu H, Wu Y
Hum Pathol 2022 Jul;125:59-67. Epub 2022 Apr 18 doi: 10.1016/j.humpath.2022.04.009. PMID: 35447141
Clinical implications of the intrinsic molecular subtypes of breast cancer.
Prat A, Pineda E, Adamo B, Galván P, Fernández A, Gaba L, Díez M, Viladot M, Arance A, Muñoz M
Breast 2015 Nov;24 Suppl 2:S26-35. Epub 2015 Aug 5 doi: 10.1016/j.breast.2015.07.008. PMID: 26253814
'Occult' breast cancer.
Lloyd MS, Nash AG
Ann R Coll Surg Engl 2001 Nov;83(6):420-4. PMID: 11777139Free PMC Article

Diagnosis

Metastatic and Malignant Phyllodes Tumors of the Breast: An Update for Current Management.
Goodwin B, Oyinlola AF, Palhang M, Lehman D, Platoff R, Atabek U, Spitz F, Hong Y
Am Surg 2023 Dec;89(12):6190-6196. Epub 2023 Aug 23 doi: 10.1177/00031348231198114. PMID: 37611540
Diagnosis, biology and epidemiology of oligometastatic breast cancer.
Lacaze JL, Aziza R, Chira C, De Maio E, Izar F, Jouve E, Massabeau C, Pradines A, Selmes G, Ung M, Zerdoud S, Dalenc F
Breast 2021 Oct;59:144-156. Epub 2021 Jul 1 doi: 10.1016/j.breast.2021.06.010. PMID: 34252822Free PMC Article
Occult breast cancer: Where are we at?
Ofri A, Moore K
Breast 2020 Dec;54:211-215. Epub 2020 Oct 27 doi: 10.1016/j.breast.2020.10.012. PMID: 33130487Free PMC Article
Interventional radiology in breast cancer.
Kenny LM, Orsi F, Adam A
Breast 2017 Oct;35:98-103. Epub 2017 Jul 10 doi: 10.1016/j.breast.2017.06.012. PMID: 28704698
'Occult' breast cancer.
Lloyd MS, Nash AG
Ann R Coll Surg Engl 2001 Nov;83(6):420-4. PMID: 11777139Free PMC Article

Therapy

Future potential targets of antibody-drug conjugates in breast cancer.
Corti C, Boscolo Bielo L, Schianca AC, Salimbeni BT, Criscitiello C, Curigliano G
Breast 2023 Jun;69:312-322. Epub 2023 Mar 24 doi: 10.1016/j.breast.2023.03.007. PMID: 36996620Free PMC Article
Antibody-drug conjugates targeting TROP-2: Clinical development in metastatic breast cancer.
Shastry M, Jacob S, Rugo HS, Hamilton E
Breast 2022 Dec;66:169-177. Epub 2022 Oct 18 doi: 10.1016/j.breast.2022.10.007. PMID: 36302269Free PMC Article
Biosimilars for breast cancer.
Migliavacca Zucchetti B, Nicolò E, Curigliano G
Expert Opin Biol Ther 2019 Oct;19(10):1015-1021. Epub 2019 Jul 10 doi: 10.1080/14712598.2019.1638362. PMID: 31248290
Locoregional treatment versus no treatment of the primary tumour in metastatic breast cancer: an open-label randomised controlled trial.
Badwe R, Hawaldar R, Nair N, Kaushik R, Parmar V, Siddique S, Budrukkar A, Mittra I, Gupta S
Lancet Oncol 2015 Oct;16(13):1380-8. Epub 2015 Sep 9 doi: 10.1016/S1470-2045(15)00135-7. PMID: 26363985
Clinical implications of the intrinsic molecular subtypes of breast cancer.
Prat A, Pineda E, Adamo B, Galván P, Fernández A, Gaba L, Díez M, Viladot M, Arance A, Muñoz M
Breast 2015 Nov;24 Suppl 2:S26-35. Epub 2015 Aug 5 doi: 10.1016/j.breast.2015.07.008. PMID: 26253814

Prognosis

Survival and prognostic factors in oligometastatic breast cancer.
van Ommen-Nijhof A, Steenbruggen TG, Capel L, Vergouwen M, Vrancken Peeters MT, Wiersma TG, Sonke GS
Breast 2023 Feb;67:14-20. Epub 2022 Dec 14 doi: 10.1016/j.breast.2022.12.007. PMID: 36549169Free PMC Article
Locoregional therapy in de novo metastatic breast cancer: Systemic review and meta-analysis.
Reinhorn D, Mutai R, Yerushalmi R, Moore A, Amir E, Goldvaser H
Breast 2021 Aug;58:173-181. doi: 10.1016/j.breast.2021.05.003. PMID: 34158167Free PMC Article
Stereotactic radiotherapy in metastatic breast cancer.
Possanzini M, Greco C
Breast 2018 Oct;41:57-66. Epub 2018 Jun 28 doi: 10.1016/j.breast.2018.06.011. PMID: 30007269
Metastatic Breast Cancer.
Peart O
Radiol Technol 2017 May;88(5):519M-539M. PMID: 28500107
Clinical implications of the intrinsic molecular subtypes of breast cancer.
Prat A, Pineda E, Adamo B, Galván P, Fernández A, Gaba L, Díez M, Viladot M, Arance A, Muñoz M
Breast 2015 Nov;24 Suppl 2:S26-35. Epub 2015 Aug 5 doi: 10.1016/j.breast.2015.07.008. PMID: 26253814

Clinical prediction guides

Fibroepithelial lesions; The WHO spectrum.
Krings G, Bean GR, Chen YY
Semin Diagn Pathol 2017 Sep;34(5):438-452. Epub 2017 May 28 doi: 10.1053/j.semdp.2017.05.006. PMID: 28688536
Hematolymphoid lesions of the breast.
Hoffmann J, Ohgami RS
Semin Diagn Pathol 2017 Sep;34(5):462-469. Epub 2017 May 28 doi: 10.1053/j.semdp.2017.05.007. PMID: 28662998
Clinical implications of the intrinsic molecular subtypes of breast cancer.
Prat A, Pineda E, Adamo B, Galván P, Fernández A, Gaba L, Díez M, Viladot M, Arance A, Muñoz M
Breast 2015 Nov;24 Suppl 2:S26-35. Epub 2015 Aug 5 doi: 10.1016/j.breast.2015.07.008. PMID: 26253814
Angiogenesis and tumor microenvironment: bevacizumab in the breast cancer model.
Trédan O, Lacroix-Triki M, Guiu S, Mouret-Reynier MA, Barrière J, Bidard FC, Braccini AL, Mir O, Villanueva C, Barthélémy P
Target Oncol 2015 Jun;10(2):189-98. Epub 2014 Sep 5 doi: 10.1007/s11523-014-0334-9. PMID: 25185646
GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumors.
Miettinen M, McCue PA, Sarlomo-Rikala M, Rys J, Czapiewski P, Wazny K, Langfort R, Waloszczyk P, Biernat W, Lasota J, Wang Z
Am J Surg Pathol 2014 Jan;38(1):13-22. doi: 10.1097/PAS.0b013e3182a0218f. PMID: 24145643Free PMC Article

Recent systematic reviews

Metastatic and Malignant Phyllodes Tumors of the Breast: An Update for Current Management.
Goodwin B, Oyinlola AF, Palhang M, Lehman D, Platoff R, Atabek U, Spitz F, Hong Y
Am Surg 2023 Dec;89(12):6190-6196. Epub 2023 Aug 23 doi: 10.1177/00031348231198114. PMID: 37611540
Malignant breast myoepithelioma: A systematic review.
Huin M, Body G, Arbion F, Ouldamer L
J Gynecol Obstet Hum Reprod 2022 Dec;51(10):102481. Epub 2022 Oct 5 doi: 10.1016/j.jogoh.2022.102481. PMID: 36208828
Oncoplastic breast-conserving surgery for women with primary breast cancer.
Nanda A, Hu J, Hodgkinson S, Ali S, Rainsbury R, Roy PG
Cochrane Database Syst Rev 2021 Oct 29;10(10):CD013658. doi: 10.1002/14651858.CD013658.pub2. PMID: 34713449Free PMC Article
HER2-enriched subtype and pathological complete response in HER2-positive breast cancer: A systematic review and meta-analysis.
Schettini F, Pascual T, Conte B, Chic N, Brasó-Maristany F, Galván P, Martínez O, Adamo B, Vidal M, Muñoz M, Fernández-Martinez A, Rognoni C, Griguolo G, Guarneri V, Conte PF, Locci M, Brase JC, Gonzalez-Farre B, Villagrasa P, De Placido S, Schiff R, Veeraraghavan J, Rimawi MF, Osborne CK, Pernas S, Perou CM, Carey LA, Prat A
Cancer Treat Rev 2020 Mar;84:101965. Epub 2020 Jan 17 doi: 10.1016/j.ctrv.2020.101965. PMID: 32000054Free PMC Article
The Breast-Thyroid Cancer Link: A Systematic Review and Meta-analysis.
Nielsen SM, White MG, Hong S, Aschebrook-Kilfoy B, Kaplan EL, Angelos P, Kulkarni SA, Olopade OI, Grogan RH
Cancer Epidemiol Biomarkers Prev 2016 Feb;25(2):231-8. doi: 10.1158/1055-9965.EPI-15-0833. PMID: 26908594Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...