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Digestive System Carcinoma In Situ

MedGen UID:: 284246
•Concept ID:: C1542107
•: Neoplastic Process

Synonym:

Gastrointestinal System Carcinoma In Situ

Definition

An intraepithelial carcinoma arising from any part of the digestive system without evidence of invasion. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVDigestive System Carcinoma In Situ

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Disorder by Site
      - Disorder of gastrointestinal tract
        Digestive System Precancerous Condition
        Digestive System Carcinoma In Situ
        Anal canal carcinoma in situ
        Stage 0 AIDS-Related Anal Canal Cancer AJCC v6 and v7
        Clinical Stage 0 Esophageal Adenocarcinoma AJCC v8
        Clinical Stage 0 Esophageal Squamous Cell Carcinoma AJCC v8
        Clinical Stage 0 Gastric Cancer AJCC v8
        Clinical Stage 0 Gastroesophageal Junction Adenocarcinoma AJCC v8
        High-Grade Biliary Intraepithelial Neoplasia
        Pathologic Stage 0 Esophageal Adenocarcinoma AJCC v8
        Pathologic Stage 0 Esophageal Squamous Cell Carcinoma AJCC v8
        Pathologic Stage 0 Gastric Cancer AJCC v8
        Pathologic Stage 0 Gastroesophageal Junction Adenocarcinoma AJCC v8
        Stage 0 Ampulla of Vater Cancer AJCC v7
        Stage 0 Ampulla of Vater Cancer AJCC v8
        Stage 0 Anal Cancer AJCC v8
        Anal Intraepithelial Neoplasia 3
        Stage 0 Appendix Carcinoma AJCC v7
        Stage 0 Appendix Carcinoma AJCC v8
        Stage 0 Colorectal Cancer AJCC v6 and v7
        Stage 0 Colon Cancer AJCC v6 and v7
        Carcinoma in situ of cecum
        Stage 0 Rectal Cancer AJCC v6 and v7
        Stage 0 Rectosigmoid Cancer AJCC v6 and v7
        Stage 0 Colorectal Cancer AJCC v8
        Stage 0 Colon Cancer AJCC v8
        Stage 0 Rectal Cancer AJCC v8
        Stage 0 Esophageal Cancer AJCC v6
        Stage 0 Esophageal Cancer AJCC v7
        Stage 0 Esophageal Adenocarcinoma AJCC v7
        Stage 0 Esophageal Squamous Cell Carcinoma AJCC v7
        Stage 0 Gallbladder Cancer AJCC v6 and v7
        Stage 0 Gallbladder Cancer AJCC v8
        Stage 0 Gastric Cancer AJCC v6 and v7
        Gastric Body Carcinoma In Situ AJCC v6 and v7
        Gastric Cardia Carcinoma In Situ AJCC v6 and v7
        Gastric Fundus Carcinoma In Situ AJCC v6 and v7
        Gastric Pylorus Carcinoma In Situ AJCC v6 and v7
        Gastric Antrum Carcinoma In Situ AJCC v6 and v7
        Stage 0 Pancreatic Cancer AJCC v6 and v7
        Stage 0 Pancreatic Cancer AJCC v8
        Stage 0 Small Intestinal Adenocarcinoma AJCC v8
        Stage 0 Small Intestinal Cancer AJCC v7

Professional guidelines

PubMed

Diagnosis and screening for anal intraepithelial neoplasia in Belgium: position statement.

Roelandt P, De Looze D, De Schepper H, Ledouble V, Surmont M, Cuming T
Acta Gastroenterol Belg 2022 Oct-Dec;85(4):625-631. doi: 10.51821/85.4.10820. PMID: 36566372

Diagnosis and management of gastric dysplasia.

Sung JK
Korean J Intern Med 2016 Mar;31(2):201-9. Epub 2016 Feb 26 doi: 10.3904/kjim.2016.021. PMID: 26932397 Free PMC Article

Pathogenesis, diagnosis, and management of cholangiocarcinoma.

Ilyas SI, Gores GJ
Gastroenterology 2013 Dec;145(6):1215-29. Epub 2013 Oct 15 doi: 10.1053/j.gastro.2013.10.013. PMID: 24140396 Free PMC Article

See all (47)

Recent clinical studies

Etiology

Adenosquamous carcinoma in situ of the anus: a case series.

Keske A, Weisman PS, Xu J
Virchows Arch 2023 Jun;482(6):993-997. Epub 2023 Apr 1 doi: 10.1007/s00428-023-03525-6. PMID: 37004554

Submucosal gland neoplasms of the esophagus: an update and review.

Nie L, Li W, Xue L, Wang L, Shen Y, Fan X
Esophagus 2020 Oct;17(4):376-384. Epub 2020 Jul 3 doi: 10.1007/s10388-020-00758-1. PMID: 32621256 Free PMC Article

Diagnosis and management of gastric dysplasia.

Sung JK
Korean J Intern Med 2016 Mar;31(2):201-9. Epub 2016 Feb 26 doi: 10.3904/kjim.2016.021. PMID: 26932397 Free PMC Article

Anal intraepitelial neoplasia: A narrative review.

Elorza G, Saralegui Y, Enríquez-Navascués JM, Placer C, Velaz L
Rev Esp Enferm Dig 2016 Jan;108(1):31-9. PMID: 26765233

Hereditary gastric cancer.

Carneiro F
Pathologe 2012 Nov;33 Suppl 2:231-4. doi: 10.1007/s00292-012-1677-6. PMID: 23052347

See all (781)

Diagnosis

Gene fusions in gastrointestinal tract cancers.

Rahi H, Olave MC, Fritchie KJ, Greipp PT, Halling KC, Kipp BR, Graham RP
Genes Chromosomes Cancer 2022 May;61(5):285-297. doi: 10.1002/gcc.23035. PMID: 35239225

Submucosal gland neoplasms of the esophagus: an update and review.

Nie L, Li W, Xue L, Wang L, Shen Y, Fan X
Esophagus 2020 Oct;17(4):376-384. Epub 2020 Jul 3 doi: 10.1007/s10388-020-00758-1. PMID: 32621256 Free PMC Article

Diagnosis and management of gastric dysplasia.

Sung JK
Korean J Intern Med 2016 Mar;31(2):201-9. Epub 2016 Feb 26 doi: 10.3904/kjim.2016.021. PMID: 26932397 Free PMC Article

Anal intraepitelial neoplasia: A narrative review.

Elorza G, Saralegui Y, Enríquez-Navascués JM, Placer C, Velaz L
Rev Esp Enferm Dig 2016 Jan;108(1):31-9. PMID: 26765233

Anal neoplasms.

Garrett K, Kalady MF
Surg Clin North Am 2010 Feb;90(1):147-61, Table of Contents. doi: 10.1016/j.suc.2009.09.008. PMID: 20109639

See all (810)

Therapy

Clonally expanded EOMES(+) Tr1-like cells in primary and metastatic tumors are associated with disease progression.

Bonnal RJP, Rossetti G, Lugli E, De Simone M, Gruarin P, Brummelman J, Drufuca L, Passaro M, Bason R, Gervasoni F, Della Chiara G, D'Oria C, Martinovic M, Curti S, Ranzani V, Cordiglieri C, Alvisi G, Mazza EMC, Oliveto S, Silvestri Y, Carelli E, Mazzara S, Bosotti R, Sarnicola ML, Godano C, Bevilacqua V, Lorenzo M, Siena S, Bonoldi E, Sartore-Bianchi A, Amatu A, Veronesi G, Novellis P, Alloisio M, Giani A, Zucchini N, Opocher E, Ceretti AP, Mariani N, Biffo S, Prati D, Bardelli A, Geginat J, Lanzavecchia A, Abrignani S, Pagani M
Nat Immunol 2021 Jun;22(6):735-745. Epub 2021 May 20 doi: 10.1038/s41590-021-00930-4. PMID: 34017124

Advanced endoscopy imaging in inflammatory bowel diseases.

Kiesslich R, Neurath MF
Gastrointest Endosc 2017 Mar;85(3):496-508. Epub 2016 Nov 2 doi: 10.1016/j.gie.2016.10.034. PMID: 27816496

Pathogenesis of primary sclerosing cholangitis and advances in diagnosis and management.

Eaton JE, Talwalkar JA, Lazaridis KN, Gores GJ, Lindor KD
Gastroenterology 2013 Sep;145(3):521-36. Epub 2013 Jul 1 doi: 10.1053/j.gastro.2013.06.052. PMID: 23827861 Free PMC Article

Case-control study of human papillomavirus and oropharyngeal cancer.

D'Souza G, Kreimer AR, Viscidi R, Pawlita M, Fakhry C, Koch WM, Westra WH, Gillison ML
N Engl J Med 2007 May 10;356(19):1944-56. doi: 10.1056/NEJMoa065497. PMID: 17494927

Gastroesophageal junction adenocarcinoma.

Swisher SG, Pisters PW, Komaki R, Lahoti S, Ajani JA
Curr Treat Options Oncol 2000 Dec;1(5):387-98. doi: 10.1007/s11864-000-0066-1. PMID: 12057146

See all (213)

Prognosis

Single-cell genomics and spatial transcriptomics: Discovery of novel cell states and cellular interactions in liver physiology and disease biology.

Saviano A, Henderson NC, Baumert TF
J Hepatol 2020 Nov;73(5):1219-1230. Epub 2020 Jun 10 doi: 10.1016/j.jhep.2020.06.004. PMID: 32534107 Free PMC Article

Salivary duct carcinoma.

D'heygere E, Meulemans J, Vander Poorten V
Curr Opin Otolaryngol Head Neck Surg 2018 Apr;26(2):142-151. doi: 10.1097/MOO.0000000000000436. PMID: 29373327

Mammary Analogue Secretory Carcinoma.

Parekh V, Stevens TM
Arch Pathol Lab Med 2016 Sep;140(9):997-1001. doi: 10.5858/arpa.2015-0075-RS. PMID: 27575269

Pathogenesis, diagnosis, and management of cholangiocarcinoma.

Ilyas SI, Gores GJ
Gastroenterology 2013 Dec;145(6):1215-29. Epub 2013 Oct 15 doi: 10.1053/j.gastro.2013.10.013. PMID: 24140396 Free PMC Article

Anal neoplasms.

Garrett K, Kalady MF
Surg Clin North Am 2010 Feb;90(1):147-61, Table of Contents. doi: 10.1016/j.suc.2009.09.008. PMID: 20109639

See all (620)

Clinical prediction guides

Analysis of Donor Pancreata Defines the Transcriptomic Signature and Microenvironment of Early Neoplastic Lesions.

Carpenter ES, Elhossiny AM, Kadiyala P, Li J, McGue J, Griffith BD, Zhang Y, Edwards J, Nelson S, Lima F, Donahue KL, Du W, Bischoff AC, Alomari D, Watkoske HR, Mattea M, The S, Espinoza CE, Barrett M, Sonnenday CJ, Olden N, Chen CT, Peterson N, Gunchick V, Sahai V, Rao A, Bednar F, Shi J, Frankel TL, Pasca di Magliano M
Cancer Discov 2023 Jun 2;13(6):1324-1345. doi: 10.1158/2159-8290.CD-23-0013. PMID: 37021392 Free PMC Article

MiR-126 in Hepatocellular Carcinoma and Cholangiocellular Carcinoma: A Reappraisal with an in situ Detection of miR-126.

Zailaie SA, Sergi CM
Ann Clin Lab Sci 2022 Jan;52(1):73-85. PMID: 35181620

Salivary duct carcinoma.

D'heygere E, Meulemans J, Vander Poorten V
Curr Opin Otolaryngol Head Neck Surg 2018 Apr;26(2):142-151. doi: 10.1097/MOO.0000000000000436. PMID: 29373327

Diagnosis and management of gastric dysplasia.

Sung JK
Korean J Intern Med 2016 Mar;31(2):201-9. Epub 2016 Feb 26 doi: 10.3904/kjim.2016.021. PMID: 26932397 Free PMC Article

Practising high-resolution anoscopy.

Palefsky JM
Sex Health 2012 Dec;9(6):580-6. doi: 10.1071/SH12045. PMID: 23380236

See all (588)

Recent systematic reviews

Whether long-term use of proton pump inhibitor increases the risk of precancerous lesions in the stomach: A systematic review and meta-analysis of randomized controlled trials.

Lv F, Wang J, Mao L, Zhou X, Zhang T, Zhou S
Medicine (Baltimore) 2023 Sep 22;102(38):e35062. doi: 10.1097/MD.0000000000035062. PMID: 37747015 Free PMC Article

The incidence of malignancy in the residual rectum of IBD patients after colectomy: a systematic review and meta-analysis.

Georganta I, McIntosh S, Boldovjakova D, Parnaby CN, Watson AJM, Ramsay G
Tech Coloproctol 2023 Sep;27(9):699-712. Epub 2023 Mar 12 doi: 10.1007/s10151-023-02762-w. PMID: 36906886 Free PMC Article

Evaluation of HER2/neu expression in different types of salivary gland tumors: a systematic review and meta-analysis.

Javaheripour A, Saatloo MV, Vahed N, Gavgani LF, Kouhsoltani M
J Med Life 2022 May;15(5):595-600. doi: 10.25122/jml-2021-0394. PMID: 35815077 Free PMC Article

Interventions for anal canal intraepithelial neoplasia.

Macaya A, Muñoz-Santos C, Balaguer A, Barberà MJ
Cochrane Database Syst Rev 2012 Dec 12;12(12):CD009244. doi: 10.1002/14651858.CD009244.pub2. PMID: 23235673 Free PMC Article

Anal human papillomavirus infection and associated neoplastic lesions in men who have sex with men: a systematic review and meta-analysis.

Machalek DA, Poynten M, Jin F, Fairley CK, Farnsworth A, Garland SM, Hillman RJ, Petoumenos K, Roberts J, Tabrizi SN, Templeton DJ, Grulich AE
Lancet Oncol 2012 May;13(5):487-500. Epub 2012 Mar 23 doi: 10.1016/S1470-2045(12)70080-3. PMID: 22445259

See all (11)

MedGen

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Digestive System Carcinoma In Situ

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

Related information

Recent activity