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RISS Stage III Multiple Myeloma

MedGen UID:
1641034
•Concept ID:
C4683785
•
Neoplastic Process
Synonyms: Revised International Staging System Stage IIII Plasma Cell Myeloma; RISS Stage III Plasma Cell Myeloma

Definition

Serum beta-2-microglobulin 5.5 mg/L or more and high-risk cytogenetics and/or high LDH. High risk cytogenetics consist of one or more of the following: del17p, t(4;14), or t(14;16). (from AJCC 8th Ed.) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRISS Stage III Multiple Myeloma

Professional guidelines

PubMed

Comparison of clinical characteristics, treatment efficacy and survival in patients with newly diagnosed multiple myeloma with single- versus multi-site extramedullary invasion.
Zhao Y, Zhou F
J Cancer Res Clin Oncol 2023 Mar;149(3):995-1006. Epub 2022 Feb 25 doi: 10.1007/s00432-022-03948-9. PMID: 35212816
Diagnosis and treatment of multiple myeloma in Hunan Province.
Liu F, Cheng Q, Song K, Yu H, Li J, Zhang H, Hu G, Zhou M, Wang J, Ding Z, Luo Z, Peng T, Ding L, Zhao L, Liu J, He Y, Peng H
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2022 Apr 28;47(4):497-504. doi: 10.11817/j.issn.1672-7347.2022.210555. PMID: 35545345Free PMC Article
Efficacy of VDT PACE-like regimens in treatment of relapsed/refractory multiple myeloma.
Lakshman A, Singh PP, Rajkumar SV, Dispenzieri A, Lacy MQ, Gertz MA, Buadi FK, Dingli D, Hwa YL, Fonder AL, Hobbs M, Hayman SR, Zeldenrust SR, Lust JA, Russell SJ, Leung N, Kapoor P, Go RS, Lin Y, Gonsalves WI, Kourelis T, Warsame R, Kyle RA, Kumar SK
Am J Hematol 2018 Feb;93(2):179-186. Epub 2017 Nov 10 doi: 10.1002/ajh.24954. PMID: 29067723

Recent clinical studies

Therapy

Real-life experiences with CAR T-cell therapy with idecabtagene vicleucel (ide-cel) for triple-class exposed relapsed/refractory multiple myeloma patients.
Sanoyan DA, Seipel K, Bacher U, Kronig MN, Porret N, Wiedemann G, Daskalakis M, Pabst T
BMC Cancer 2023 Apr 15;23(1):345. doi: 10.1186/s12885-023-10824-3. PMID: 37061680Free PMC Article
Risk-benefit ratio of percutaneous kyphoplasty and percutaneous vertebroplasty in patients with newly diagnosed multiple myeloma with vertebral fracture: a single-center retrospective study.
Xiang QQ, Chu B, Lu MQ, Shi L, Gao S, Wang YT, Fang LJ, Ding YH, Zhao X, Chen Y, Wang MZ, Hu WK, Wang LF, Sun K, Bao L
Ann Hematol 2023 Jun;102(6):1513-1522. Epub 2023 Mar 30 doi: 10.1007/s00277-023-05202-9. PMID: 36997718Free PMC Article
Isatuximab Plus Carfilzomib and Dexamethasone Versus Carfilzomib and Dexamethasone in Patients with Relapsed Multiple Myeloma: IKEMA Subgroup Analysis by Prior Transplantation.
Martin TG, Capra M, Mohty M, Suzuki K, Quach H, Cavo M, Moreau P, Dimopoulos M, Yong K, Tekle C, Foster MC, Barnes Y, Risse ML, Mikhael J
Transplant Cell Ther 2023 Feb;29(2):134.e1-134.e7. Epub 2022 Nov 11 doi: 10.1016/j.jtct.2022.11.005. PMID: 36372355
Diagnosis and treatment of multiple myeloma in Hunan Province.
Liu F, Cheng Q, Song K, Yu H, Li J, Zhang H, Hu G, Zhou M, Wang J, Ding Z, Luo Z, Peng T, Ding L, Zhao L, Liu J, He Y, Peng H
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2022 Apr 28;47(4):497-504. doi: 10.11817/j.issn.1672-7347.2022.210555. PMID: 35545345Free PMC Article
Correlations between apparent diffusion coefficient values of WB-DWI and clinical parameters in multiple myeloma.
Zhang B, Bian B, Zhao Z, Lin F, Zhu Z, Lou M
BMC Med Imaging 2021 Jun 8;21(1):98. doi: 10.1186/s12880-021-00631-2. PMID: 34103001Free PMC Article

Prognosis

Circulating plasma cells as a predictive biomarker in Multiple myeloma: an updated systematic review and meta-analysis.
Li Q, Ai L, Zuo L, Li J, Zhao F, Xu A, Zhang B, Cai L, Hu Y, Sun C
Ann Med 2024 Dec;56(1):2338604. Epub 2024 Apr 10 doi: 10.1080/07853890.2024.2338604. PMID: 38599340Free PMC Article
Second Revision of the International Staging System (R2-ISS) for Overall Survival in Multiple Myeloma: A European Myeloma Network (EMN) Report Within the HARMONY Project.
D'Agostino M, Cairns DA, Lahuerta JJ, Wester R, Bertsch U, Waage A, Zamagni E, Mateos MV, Dall'Olio D, van de Donk NWCJ, Jackson G, Rocchi S, Salwender H, Bladé Creixenti J, van der Holt B, Castellani G, Bonello F, Capra A, Mai EK, Dürig J, Gay F, Zweegman S, Cavo M, Kaiser MF, Goldschmidt H, Hernández Rivas JM, Larocca A, Cook G, San-Miguel JF, Boccadoro M, Sonneveld P
J Clin Oncol 2022 Oct 10;40(29):3406-3418. Epub 2022 May 23 doi: 10.1200/JCO.21.02614. PMID: 35605179
Diagnosis and treatment of multiple myeloma in Hunan Province.
Liu F, Cheng Q, Song K, Yu H, Li J, Zhang H, Hu G, Zhou M, Wang J, Ding Z, Luo Z, Peng T, Ding L, Zhao L, Liu J, He Y, Peng H
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2022 Apr 28;47(4):497-504. doi: 10.11817/j.issn.1672-7347.2022.210555. PMID: 35545345Free PMC Article
Characteristics and clinical outcome of high-risk multiple myeloma patients in Korea (KMM 1805).
Kim K, Kim JS, Yoon SS, Yoon DH, Eom HS, Lee JJ, Yim HW, Park M, Lee H, Min CK; Korean Multiple Myeloma Working Party (KMMWP)
Int J Hematol 2022 Jul;116(1):110-121. Epub 2022 May 11 doi: 10.1007/s12185-022-03332-w. PMID: 35543899
Revised International Staging System for Multiple Myeloma: A Report From International Myeloma Working Group.
Palumbo A, Avet-Loiseau H, Oliva S, Lokhorst HM, Goldschmidt H, Rosinol L, Richardson P, Caltagirone S, Lahuerta JJ, Facon T, Bringhen S, Gay F, Attal M, Passera R, Spencer A, Offidani M, Kumar S, Musto P, Lonial S, Petrucci MT, Orlowski RZ, Zamagni E, Morgan G, Dimopoulos MA, Durie BG, Anderson KC, Sonneveld P, San Miguel J, Cavo M, Rajkumar SV, Moreau P
J Clin Oncol 2015 Sep 10;33(26):2863-9. Epub 2015 Aug 3 doi: 10.1200/JCO.2015.61.2267. PMID: 26240224Free PMC Article

Clinical prediction guides

Circulating plasma cells as a predictive biomarker in Multiple myeloma: an updated systematic review and meta-analysis.
Li Q, Ai L, Zuo L, Li J, Zhao F, Xu A, Zhang B, Cai L, Hu Y, Sun C
Ann Med 2024 Dec;56(1):2338604. Epub 2024 Apr 10 doi: 10.1080/07853890.2024.2338604. PMID: 38599340Free PMC Article
[(68)Ga]Pentixafor PET/CT for staging and prognostic assessment of newly diagnosed multiple myeloma: comparison to [(18)F]FDG PET/CT.
Chen Z, Yang A, Chen A, Dong J, Lin J, Huang C, Zhang J, Liu H, Zeng Z, Miao W
Eur J Nucl Med Mol Imaging 2024 Jun;51(7):1926-1936. Epub 2024 Jan 30 doi: 10.1007/s00259-024-06621-0. PMID: 38286937
Development and validation of an individualized and weighted Myeloma Prognostic Score System (MPSS) in patients with newly diagnosed multiple myeloma.
Mao X, Yan W, Mery D, Liu J, Fan H, Xu J, Xu Y, Sui W, Deng S, Zou D, Du C, Yi S, van Rhee F, Barlogie B, Shaughnessy JD Jr, Anderson KC, Zhan F, Qiu L, An G
Am J Hematol 2024 Apr;99(4):523-533. Epub 2024 Jan 21 doi: 10.1002/ajh.27207. PMID: 38247315Free PMC Article
Second Revision of the International Staging System (R2-ISS) for Overall Survival in Multiple Myeloma: A European Myeloma Network (EMN) Report Within the HARMONY Project.
D'Agostino M, Cairns DA, Lahuerta JJ, Wester R, Bertsch U, Waage A, Zamagni E, Mateos MV, Dall'Olio D, van de Donk NWCJ, Jackson G, Rocchi S, Salwender H, Bladé Creixenti J, van der Holt B, Castellani G, Bonello F, Capra A, Mai EK, Dürig J, Gay F, Zweegman S, Cavo M, Kaiser MF, Goldschmidt H, Hernández Rivas JM, Larocca A, Cook G, San-Miguel JF, Boccadoro M, Sonneveld P
J Clin Oncol 2022 Oct 10;40(29):3406-3418. Epub 2022 May 23 doi: 10.1200/JCO.21.02614. PMID: 35605179
Clinical characteristics and prognosis of immunoglobulin D myeloma in the novel agent era.
Chen L, Fan F, Deng J, Xu J, Xu A, Sun C, Hu Y
Ann Hematol 2019 Apr;98(4):963-970. Epub 2019 Jan 4 doi: 10.1007/s00277-018-3582-4. PMID: 30610280

Recent systematic reviews

Circulating plasma cells as a predictive biomarker in Multiple myeloma: an updated systematic review and meta-analysis.
Li Q, Ai L, Zuo L, Li J, Zhao F, Xu A, Zhang B, Cai L, Hu Y, Sun C
Ann Med 2024 Dec;56(1):2338604. Epub 2024 Apr 10 doi: 10.1080/07853890.2024.2338604. PMID: 38599340Free PMC Article

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