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Head and neck cancer

MedGen UID:
78920
•Concept ID:
C0278996
•
Neoplastic Process
Synonyms: Cancer of Head and Neck; Cancer of the Head and Neck; Head and Neck Cancer
SNOMED CT: Malignant tumor of head and/or neck (255056009); Malignant tumor of head and neck (255056009)
 
Monarch Initiative: MONDO:0005627

Definition

A primary or metastatic malignant neoplasm affecting the head and neck. Representative examples include oral cavity squamous cell carcinoma, laryngeal squamous cell carcinoma, and salivary gland carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Head and neck cancer

Professional guidelines

PubMed

International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors.
Kuan EC, Wang EW, Adappa ND, Beswick DM, London NR Jr, Su SY, Wang MB, Abuzeid WM, Alexiev B, Alt JA, Antognoni P, Alonso-Basanta M, Batra PS, Bhayani M, Bell D, Bernal-Sprekelsen M, Betz CS, Blay JY, Bleier BS, Bonilla-Velez J, Callejas C, Carrau RL, Casiano RR, Castelnuovo P, Chandra RK, Chatzinakis V, Chen SB, Chiu AG, Choby G, Chowdhury NI, Citardi MJ, Cohen MA, Dagan R, Dalfino G, Dallan I, Dassi CS, de Almeida J, Dei Tos AP, DelGaudio JM, Ebert CS, El-Sayed IH, Eloy JA, Evans JJ, Fang CH, Farrell NF, Ferrari M, Fischbein N, Folbe A, Fokkens WJ, Fox MG, Lund VJ, Gallia GL, Gardner PA, Geltzeiler M, Georgalas C, Getz AE, Govindaraj S, Gray ST, Grayson JW, Gross BA, Grube JG, Guo R, Ha PK, Halderman AA, Hanna EY, Harvey RJ, Hernandez SC, Holtzman AL, Hopkins C, Huang Z, Huang Z, Humphreys IM, Hwang PH, Iloreta AM, Ishii M, Ivan ME, Jafari A, Kennedy DW, Khan M, Kimple AJ, Kingdom TT, Knisely A, Kuo YJ, Lal D, Lamarre ED, Lan MY, Le H, Lechner M, Lee NY, Lee JK, Lee VH, Levine CG, Lin JC, Lin DT, Lobo BC, Locke T, Luong AU, Magliocca KR, Markovic SN, Matnjani G, McKean EL, Meço C, Mendenhall WM, Michel L, Na'ara S, Nicolai P, Nuss DW, Nyquist GG, Oakley GM, Omura K, Orlandi RR, Otori N, Papagiannopoulos P, Patel ZM, Pfister DG, Phan J, Psaltis AJ, Rabinowitz MR, Ramanathan M Jr, Rimmer R, Rosen MR, Sanusi O, Sargi ZB, Schafhausen P, Schlosser RJ, Sedaghat AR, Senior BA, Shrivastava R, Sindwani R, Smith TL, Smith KA, Snyderman CH, Solares CA, Sreenath SB, Stamm A, Stölzel K, Sumer B, Surda P, Tajudeen BA, Thompson LDR, Thorp BD, Tong CCL, Tsang RK, Turner JH, Turri-Zanoni M, Udager AM, van Zele T, VanKoevering K, Welch KC, Wise SK, Witterick IJ, Won TB, Wong SN, Woodworth BA, Wormald PJ, Yao WC, Yeh CF, Zhou B, Palmer JN
Int Forum Allergy Rhinol 2024 Feb;14(2):149-608. Epub 2024 Jan 2 doi: 10.1002/alr.23262. PMID: 37658764
Proliferative verrucous leukoplakia: diagnosis, management and current advances.
Capella DL, Gonçalves JM, Abrantes AAA, Grando LJ, Daniel FI
Braz J Otorhinolaryngol 2017 Sep-Oct;83(5):585-593. Epub 2017 Jan 24 doi: 10.1016/j.bjorl.2016.12.005. PMID: 28209441Free PMC Article
Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment.
Marur S, Forastiere AA
Mayo Clin Proc 2016 Mar;91(3):386-96. doi: 10.1016/j.mayocp.2015.12.017. PMID: 26944243

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Head and Neck Cancers, 2024

UK NICE Guideline NG12, Suspected cancer: recognition and referral, 2023

Recent clinical studies

Etiology

Nutritional prehabilitation in head and neck cancer: A systematic review of literature.
De Pasquale G, Mancin S, Matteucci S, Cattani D, Pastore M, Franzese C, Scorsetti M, Mazzoleni B
Clin Nutr ESPEN 2023 Dec;58:326-334. Epub 2023 Oct 31 doi: 10.1016/j.clnesp.2023.10.033. PMID: 38057023
Obesity and head and neck cancer risk: a mendelian randomization study.
Gui L, He X, Tang L, Yao J, Pi J
BMC Med Genomics 2023 Aug 24;16(1):200. doi: 10.1186/s12920-023-01634-4. PMID: 37620971Free PMC Article
Smoking and Head and Neck Cancer.
Yu VX, Long S, Tassler A
JAMA Otolaryngol Head Neck Surg 2023 May 1;149(5):470. doi: 10.1001/jamaoto.2023.0195. PMID: 36995722
Diet and Health in Otolaryngology.
Juszczak HM, Rosenfeld RM
Otolaryngol Clin North Am 2022 Oct;55(5):909-927. Epub 2022 Sep 7 doi: 10.1016/j.otc.2022.06.001. PMID: 36088162
Notch in Head and Neck Cancer.
Porcheri C, Mitsiadis TA
Adv Exp Med Biol 2021;1287:81-103. doi: 10.1007/978-3-030-55031-8_7. PMID: 33034028

Diagnosis

Nutritional prehabilitation in head and neck cancer: A systematic review of literature.
De Pasquale G, Mancin S, Matteucci S, Cattani D, Pastore M, Franzese C, Scorsetti M, Mazzoleni B
Clin Nutr ESPEN 2023 Dec;58:326-334. Epub 2023 Oct 31 doi: 10.1016/j.clnesp.2023.10.033. PMID: 38057023
Challenges in diagnosing ceruminous adenocarcinoma.
Abelardo E, Ng S, Pope L, Prabhu V
BMJ Case Rep 2021 May 6;14(5) doi: 10.1136/bcr-2020-241069. PMID: 33958359Free PMC Article
Exosomes in cancer.
Müller Bark J, Kulasinghe A, Amenábar JM, Punyadeera C
Adv Clin Chem 2021;101:1-40. Epub 2020 Aug 18 doi: 10.1016/bs.acc.2020.06.006. PMID: 33706886
Head and Neck Masses.
Yan K, Agrawal N, Gooi Z
Med Clin North Am 2018 Nov;102(6):1013-1025. Epub 2018 Sep 20 doi: 10.1016/j.mcna.2018.06.012. PMID: 30342605
Overview of the 8th Edition TNM Classification for Head and Neck Cancer.
Huang SH, O'Sullivan B
Curr Treat Options Oncol 2017 Jul;18(7):40. doi: 10.1007/s11864-017-0484-y. PMID: 28555375

Therapy

Neutron activation survey on patients following BNCT clinical trials at THOR.
Huang CK, Liu CT, Jiang SH
Appl Radiat Isot 2021 Aug;174:109747. Epub 2021 May 6 doi: 10.1016/j.apradiso.2021.109747. PMID: 33990034
Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): An update on 107 randomized trials and 19,805 patients, on behalf of MACH-NC Group.
Lacas B, Carmel A, Landais C, Wong SJ, Licitra L, Tobias JS, Burtness B, Ghi MG, Cohen EEW, Grau C, Wolf G, Hitt R, Corvò R, Budach V, Kumar S, Laskar SG, Mazeron JJ, Zhong LP, Dobrowsky W, Ghadjar P, Fallai C, Zakotnik B, Sharma A, Bensadoun RJ, Ruo Redda MG, Racadot S, Fountzilas G, Brizel D, Rovea P, Argiris A, Nagy ZT, Lee JW, Fortpied C, Harris J, Bourhis J, Aupérin A, Blanchard P, Pignon JP; MACH-NC Collaborative Group
Radiother Oncol 2021 Mar;156:281-293. Epub 2021 Jan 27 doi: 10.1016/j.radonc.2021.01.013. PMID: 33515668Free PMC Article
Oncolytic virus therapy: A new era of cancer treatment at dawn.
Fukuhara H, Ino Y, Todo T
Cancer Sci 2016 Oct;107(10):1373-1379. Epub 2016 Sep 9 doi: 10.1111/cas.13027. PMID: 27486853Free PMC Article
Clinical Trials with Oncolytic Viruses: Current and Future Prospects.
Patil S, Rao RS, Majumdar B
J Contemp Dent Pract 2015 Aug 1;16(8):i-ii. PMID: 26423510
Cetuximab in metastatic or recurrent head and neck cancer: the EXTREME trial.
Rivera F, García-Castaño A, Vega N, Vega-Villegas ME, Gutiérrez-Sanz L
Expert Rev Anticancer Ther 2009 Oct;9(10):1421-8. doi: 10.1586/era.09.113. PMID: 19828002

Prognosis

Lymph node density as a predictive factor for worse outcomes in laryngeal cancer.
Petrarolha S, Dedivitis R, Matos L, Ramos D, Kulcsar M
Eur Arch Otorhinolaryngol 2020 Mar;277(3):833-840. Epub 2020 Jan 29 doi: 10.1007/s00405-020-05789-z. PMID: 31993768
Survival outcomes after treatment of cancer of the oral cavity (1985-2015).
Zanoni DK, Montero PH, Migliacci JC, Shah JP, Wong RJ, Ganly I, Patel SG
Oral Oncol 2019 Mar;90:115-121. Epub 2019 Feb 15 doi: 10.1016/j.oraloncology.2019.02.001. PMID: 30846169Free PMC Article
Oropharyngeal cancer survivorship in Denmark, 1977-2012.
Fakhry C, Andersen KK, Eisele DW, Gillison ML
Oral Oncol 2015 Nov;51(11):982-984. Epub 2015 Aug 28 doi: 10.1016/j.oraloncology.2015.08.006. PMID: 26319353
External auditory canal cholesteatoma in patients given radiotherapy for nasopharyngeal carcinoma.
Yu SS, Lee KJ, Lin YS
Head Neck 2015 Dec;37(12):1794-8. Epub 2015 May 22 doi: 10.1002/hed.23826. PMID: 24989318
Salivary gland malignancies in children.
Yoshida EJ, García J, Eisele DW, Chen AM
Int J Pediatr Otorhinolaryngol 2014 Feb;78(2):174-8. Epub 2013 Nov 19 doi: 10.1016/j.ijporl.2013.11.001. PMID: 24332197

Clinical prediction guides

Digital Otoscopy Videos Versus Composite Images: A Reader Study to Compare the Accuracy of ENT Physicians.
Binol H, Niazi MKK, Essig G, Shah J, Mattingly JK, Harris MS, Elmaraghy C, Teknos T, Taj-Schaal N, Yu L, Gurcan MN, Moberly AC
Laryngoscope 2021 May;131(5):E1668-E1676. Epub 2020 Nov 10 doi: 10.1002/lary.29253. PMID: 33170529Free PMC Article
Predictive factors for osteoradionecrosis of the jaws: A retrospective study.
Sathasivam HP, Davies GR, Boyd NM
Head Neck 2018 Jan;40(1):46-54. Epub 2017 Nov 17 doi: 10.1002/hed.24907. PMID: 29149496
Predictive value of human papillomavirus in oropharyngeal carcinoma treated with radiotherapy: An updated systematic review and meta-analysis of 30 trials.
Petrelli F, Sarti E, Barni S
Head Neck 2014 May;36(5):750-9. Epub 2013 Oct 7 doi: 10.1002/hed.23351. PMID: 23606404
Factors affecting swallow outcome following treatment for advanced oral and oropharyngeal malignancies.
Kalavrezos N, Cotrufo S, Govender R, Rogers P, Pirgousis P, Balasundram S, Lalabekyan B, Liew C
Head Neck 2014 Jan;36(1):47-54. Epub 2013 Apr 4 doi: 10.1002/hed.23262. PMID: 23559533
Cetuximab in metastatic or recurrent head and neck cancer: the EXTREME trial.
Rivera F, García-Castaño A, Vega N, Vega-Villegas ME, Gutiérrez-Sanz L
Expert Rev Anticancer Ther 2009 Oct;9(10):1421-8. doi: 10.1586/era.09.113. PMID: 19828002

Recent systematic reviews

Nutritional prehabilitation in head and neck cancer: A systematic review of literature.
De Pasquale G, Mancin S, Matteucci S, Cattani D, Pastore M, Franzese C, Scorsetti M, Mazzoleni B
Clin Nutr ESPEN 2023 Dec;58:326-334. Epub 2023 Oct 31 doi: 10.1016/j.clnesp.2023.10.033. PMID: 38057023
Managing Cachexia in Head and Neck Cancer: a Systematic Scoping Review.
Mäkitie AA, Alabi RO, Orell H, Youssef O, Almangush A, Homma A, Takes RP, López F, de Bree R, Rodrigo JP, Ferlito A
Adv Ther 2022 Apr;39(4):1502-1523. Epub 2022 Feb 27 doi: 10.1007/s12325-022-02074-9. PMID: 35224702Free PMC Article
Optimal Perioperative Care in Major Head and Neck Cancer Surgery With Free Flap Reconstruction: A Consensus Review and Recommendations From the Enhanced Recovery After Surgery Society.
Dort JC, Farwell DG, Findlay M, Huber GF, Kerr P, Shea-Budgell MA, Simon C, Uppington J, Zygun D, Ljungqvist O, Harris J
JAMA Otolaryngol Head Neck Surg 2017 Mar 1;143(3):292-303. doi: 10.1001/jamaoto.2016.2981. PMID: 27737447
American Cancer Society Head and Neck Cancer Survivorship Care Guideline.
Cohen EE, LaMonte SJ, Erb NL, Beckman KL, Sadeghi N, Hutcheson KA, Stubblefield MD, Abbott DM, Fisher PS, Stein KD, Lyman GH, Pratt-Chapman ML
CA Cancer J Clin 2016 May;66(3):203-39. Epub 2016 Mar 22 doi: 10.3322/caac.21343. PMID: 27002678
Regenerative medicine in otorhinolaryngology.
Wormald JC, Fishman JM, Juniat S, Tolley N, Birchall MA
J Laryngol Otol 2015 Aug;129(8):732-9. Epub 2015 Jun 24 doi: 10.1017/S0022215115001577. PMID: 26104952

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Head and Neck Cancers, 2024
    • NICE, 2023
      UK NICE Guideline NG12, Suspected cancer: recognition and referral, 2023

    Consumer resources

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

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