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Anal melanoma

MedGen UID:
91151
•Concept ID:
C0349538
•
Neoplastic Process
Synonyms: Anal Malignant Melanoma; anal malignant melanoma; Anal Melanoma; anal melanoma; anus melanoma; anus melanoma (disease); Cancer anal melanoma; malignant anus melanoma; Malignant melanoma of anus; Malignant Melanoma of Anus; malignant melanoma of anus; Malignant Melanoma of the Anus; malignant melanoma of the anus; melanoma (disease) of anus; Melanoma of Anus; melanoma of anus; Melanoma of the Anus; melanoma of the anus
SNOMED CT: Cancer anal melanoma (276821000); Malignant melanoma of anus (276821000)
 
Monarch Initiative: MONDO:0006081

Definition

A melanoma arising from the anus. Clinical presentation includes rectal bleeding, tenesmus, pain, and change in bowel habit. The prognosis is usually poor. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnal melanoma

Professional guidelines

PubMed

Patterns of Care and Survival Outcomes in the Treatment of Anal Melanoma.
Naqvi J, Lee A, Lederman A, Kavi A, Osborn VW, Schreiber D
J Gastrointest Cancer 2020 Mar;51(1):211-216. doi: 10.1007/s12029-019-00238-5. PMID: 30982929
A case series of anal melanoma including the results of treatment with imatinib in selected patients.
Knowles J, Lynch AC, Warrier SK, Henderson M, Heriot AG
Colorectal Dis 2016 Sep;18(9):877-82. doi: 10.1111/codi.13209. PMID: 26546509
Rare anal canal cancers in the U.S. veteran: patterns of disease and results of treatment.
Longo WE, Vernava AM 3rd, Wade TP, Coplin MA, Virgo KS, Johnson FE
Am Surg 1995 Jun;61(6):495-500. PMID: 7762897

Recent clinical studies

Etiology

Impact of adjuvant therapies following surgery for anal melanoma.
Wong DL, Glazer ES, Tsao M, Deneve JL, Fleming MD, Shibata D
Am J Surg 2022 Jun;223(6):1132-1143. Epub 2021 Nov 11 doi: 10.1016/j.amjsurg.2021.10.041. PMID: 34801225
Patterns of Care and Survival Outcomes in the Treatment of Anal Melanoma.
Naqvi J, Lee A, Lederman A, Kavi A, Osborn VW, Schreiber D
J Gastrointest Cancer 2020 Mar;51(1):211-216. doi: 10.1007/s12029-019-00238-5. PMID: 30982929
Anal melanoma: Outcomes of current surgical approaches.
Kaya S, Kement M, Altuntas YE, Altin O, Seker A, Mazmanoglu S, Kaptanoglu L, Bildik N, Kucuk HF
Niger J Clin Pract 2018 Dec;21(12):1622-1626. doi: 10.4103/njcp.njcp_254_18. PMID: 30560827
Contemporary Surgical Management and Outcomes for Anal Melanoma: A National Cancer Database Analysis.
Fields AC, Goldberg J, Senturk J, Saadat LV, Jolissaint J, Shabat G, Irani J, Bleday R, Melnitchouk N
Ann Surg Oncol 2018 Dec;25(13):3883-3888. Epub 2018 Sep 12 doi: 10.1245/s10434-018-6769-y. PMID: 30209727
Resection for anal melanoma: Is there an optimal approach?
Ford MM, Kauffmann RM, Geiger TM, Hopkins MB, Muldoon RL, Hawkins AT
Surgery 2018 Sep;164(3):466-472. Epub 2018 Jul 2 doi: 10.1016/j.surg.2018.05.026. PMID: 30041967

Diagnosis

Resectable Anal Melanoma Detected by Rectal Retroflexion.
Pagani W, Sheikh U, Skef W
Clin Gastroenterol Hepatol 2021 May;19(5):A25. Epub 2020 Apr 6 doi: 10.1016/j.cgh.2020.03.061. PMID: 32272246
Patterns of Care and Survival Outcomes in the Treatment of Anal Melanoma.
Naqvi J, Lee A, Lederman A, Kavi A, Osborn VW, Schreiber D
J Gastrointest Cancer 2020 Mar;51(1):211-216. doi: 10.1007/s12029-019-00238-5. PMID: 30982929
Resection for anal melanoma: Is there an optimal approach?
Ford MM, Kauffmann RM, Geiger TM, Hopkins MB, Muldoon RL, Hawkins AT
Surgery 2018 Sep;164(3):466-472. Epub 2018 Jul 2 doi: 10.1016/j.surg.2018.05.026. PMID: 30041967
Uncommon Anal Neoplasms.
Roy AC, Wattchow D, Astill D, Singh S, Pendlebury S, Gormly K, Segelov E
Surg Oncol Clin N Am 2017 Jan;26(1):143-161. doi: 10.1016/j.soc.2016.07.009. PMID: 27889033
Polypoid anal melanoma. A case report and review of the literature.
Tutino R, Clerico G, Luc AR, Gallo G, Trompetto M
Ann Ital Chir 2016 Nov 12;87 PMID: 27857005

Therapy

Polypoid anal melanoma. A case report and review of the literature.
Tutino R, Clerico G, Luc AR, Gallo G, Trompetto M
Ann Ital Chir 2016 Nov 12;87 PMID: 27857005
Anorectal malignant melanoma: curative abdominoperineal resection: patient selection with 18F-FDG-PET/CT.
Falch C, Mueller S, Kirschniak A, Braun M, Koenigsrainer A, Klumpp B
World J Surg Oncol 2016 Jul 15;14(1):185. doi: 10.1186/s12957-016-0938-x. PMID: 27422527Free PMC Article
A case series of anal melanoma including the results of treatment with imatinib in selected patients.
Knowles J, Lynch AC, Warrier SK, Henderson M, Heriot AG
Colorectal Dis 2016 Sep;18(9):877-82. doi: 10.1111/codi.13209. PMID: 26546509
Pregnancy and maternal outcomes in women with prior or current gastrointestinal malignancies.
Al-Ibrahim A, Parrish J, Dunn E, Swallow C, Maxwell C
J Obstet Gynaecol Can 2014 Jan;36(1):34-41. doi: 10.1016/S1701-2163(15)30681-2. PMID: 24444285
Melanoma of the anal canal: a case series.
Homsi J, Garrett C
Dis Colon Rectum 2007 Jul;50(7):1004-10. doi: 10.1007/s10350-007-0242-5. PMID: 17468984

Prognosis

Contemporary Surgical Management and Outcomes for Anal Melanoma: A National Cancer Database Analysis.
Fields AC, Goldberg J, Senturk J, Saadat LV, Jolissaint J, Shabat G, Irani J, Bleday R, Melnitchouk N
Ann Surg Oncol 2018 Dec;25(13):3883-3888. Epub 2018 Sep 12 doi: 10.1245/s10434-018-6769-y. PMID: 30209727
Resection for anal melanoma: Is there an optimal approach?
Ford MM, Kauffmann RM, Geiger TM, Hopkins MB, Muldoon RL, Hawkins AT
Surgery 2018 Sep;164(3):466-472. Epub 2018 Jul 2 doi: 10.1016/j.surg.2018.05.026. PMID: 30041967
Uncommon Anal Neoplasms.
Roy AC, Wattchow D, Astill D, Singh S, Pendlebury S, Gormly K, Segelov E
Surg Oncol Clin N Am 2017 Jan;26(1):143-161. doi: 10.1016/j.soc.2016.07.009. PMID: 27889033
Polypoid anal melanoma. A case report and review of the literature.
Tutino R, Clerico G, Luc AR, Gallo G, Trompetto M
Ann Ital Chir 2016 Nov 12;87 PMID: 27857005
Incidence, Surgical Treatment, and Prognosis of Anorectal Melanoma From 1973 to 2011: A Population-Based SEER Analysis.
Chen H, Cai Y, Liu Y, He J, Hu Y, Xiao Q, Hu W, Ding K
Medicine (Baltimore) 2016 Feb;95(7):e2770. doi: 10.1097/MD.0000000000002770. PMID: 26886623Free PMC Article

Clinical prediction guides

A national database analysis of the evolution of outcomes of surgery for anal melanoma.
Emile SH, Horesh N, Garoufalia Z, Gefen R, Dourado J, Wexner SD
J Surg Oncol 2024 Jun;129(7):1213-1223. Epub 2024 Mar 27 doi: 10.1002/jso.27631. PMID: 38533993
Contemporary Surgical Management and Outcomes for Anal Melanoma: A National Cancer Database Analysis.
Fields AC, Goldberg J, Senturk J, Saadat LV, Jolissaint J, Shabat G, Irani J, Bleday R, Melnitchouk N
Ann Surg Oncol 2018 Dec;25(13):3883-3888. Epub 2018 Sep 12 doi: 10.1245/s10434-018-6769-y. PMID: 30209727
Anorectal malignant melanoma: curative abdominoperineal resection: patient selection with 18F-FDG-PET/CT.
Falch C, Mueller S, Kirschniak A, Braun M, Koenigsrainer A, Klumpp B
World J Surg Oncol 2016 Jul 15;14(1):185. doi: 10.1186/s12957-016-0938-x. PMID: 27422527Free PMC Article
Malignant melanoma of anorectal region: a clinicopathologic study of 61 cases.
Tariq MU, Ud Din N, Ud Din NF, Fatima S, Ahmad Z
Ann Diagn Pathol 2014 Oct;18(5):275-81. Epub 2014 Aug 8 doi: 10.1016/j.anndiagpath.2014.08.002. PMID: 25163722
Anal versus rectal melanoma: does site of origin predict outcome?
Bello DM, Smyth E, Perez D, Khan S, Temple LK, Ariyan CE, Weiser MR, Carvajal RD
Dis Colon Rectum 2013 Feb;56(2):150-7. doi: 10.1097/DCR.0b013e31827901dd. PMID: 23303142Free PMC Article

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