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Undifferentiated carcinoma

MedGen UID:
60010
•Concept ID:
C0205698
•
Neoplastic Process
Synonyms: Carcinoma, Undifferentiated; Undifferentiated Carcinoma; Undifferentiated Carcinomas
SNOMED CT: Undifferentiated carcinoma (38549000); Carcinoma, undifferentiated (38549000)
 
Monarch Initiative: MONDO:0005617

Definition

A usually aggressive malignant epithelial neoplasm composed of atypical cells which do not display evidence of glandular, squamous, or transitional cell differentiation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUndifferentiated carcinoma

Professional guidelines

PubMed

International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors.
Kuan EC, Wang EW, Adappa ND, Beswick DM, London NR Jr, Su SY, Wang MB, Abuzeid WM, Alexiev B, Alt JA, Antognoni P, Alonso-Basanta M, Batra PS, Bhayani M, Bell D, Bernal-Sprekelsen M, Betz CS, Blay JY, Bleier BS, Bonilla-Velez J, Callejas C, Carrau RL, Casiano RR, Castelnuovo P, Chandra RK, Chatzinakis V, Chen SB, Chiu AG, Choby G, Chowdhury NI, Citardi MJ, Cohen MA, Dagan R, Dalfino G, Dallan I, Dassi CS, de Almeida J, Dei Tos AP, DelGaudio JM, Ebert CS, El-Sayed IH, Eloy JA, Evans JJ, Fang CH, Farrell NF, Ferrari M, Fischbein N, Folbe A, Fokkens WJ, Fox MG, Lund VJ, Gallia GL, Gardner PA, Geltzeiler M, Georgalas C, Getz AE, Govindaraj S, Gray ST, Grayson JW, Gross BA, Grube JG, Guo R, Ha PK, Halderman AA, Hanna EY, Harvey RJ, Hernandez SC, Holtzman AL, Hopkins C, Huang Z, Huang Z, Humphreys IM, Hwang PH, Iloreta AM, Ishii M, Ivan ME, Jafari A, Kennedy DW, Khan M, Kimple AJ, Kingdom TT, Knisely A, Kuo YJ, Lal D, Lamarre ED, Lan MY, Le H, Lechner M, Lee NY, Lee JK, Lee VH, Levine CG, Lin JC, Lin DT, Lobo BC, Locke T, Luong AU, Magliocca KR, Markovic SN, Matnjani G, McKean EL, Meço C, Mendenhall WM, Michel L, Na'ara S, Nicolai P, Nuss DW, Nyquist GG, Oakley GM, Omura K, Orlandi RR, Otori N, Papagiannopoulos P, Patel ZM, Pfister DG, Phan J, Psaltis AJ, Rabinowitz MR, Ramanathan M Jr, Rimmer R, Rosen MR, Sanusi O, Sargi ZB, Schafhausen P, Schlosser RJ, Sedaghat AR, Senior BA, Shrivastava R, Sindwani R, Smith TL, Smith KA, Snyderman CH, Solares CA, Sreenath SB, Stamm A, Stölzel K, Sumer B, Surda P, Tajudeen BA, Thompson LDR, Thorp BD, Tong CCL, Tsang RK, Turner JH, Turri-Zanoni M, Udager AM, van Zele T, VanKoevering K, Welch KC, Wise SK, Witterick IJ, Won TB, Wong SN, Woodworth BA, Wormald PJ, Yao WC, Yeh CF, Zhou B, Palmer JN
Int Forum Allergy Rhinol 2024 Feb;14(2):149-608. Epub 2024 Jan 2 doi: 10.1002/alr.23262. PMID: 37658764
The contemporary management of cancers of the sinonasal tract in adults.
Thawani R, Kim MS, Arastu A, Feng Z, West MT, Taflin NF, Thein KZ, Li R, Geltzeiler M, Lee N, Fuller CD, Grandis JR, Floudas CS, Heinrich MC, Hanna E, Chandra RA
CA Cancer J Clin 2023 Jan;73(1):72-112. Epub 2022 Aug 2 doi: 10.3322/caac.21752. PMID: 35916666Free PMC Article
Serous tubal intraepithelial carcinoma (STIC) - clinical impact and management.
Weinberger V, Bednarikova M, Cibula D, Zikan M
Expert Rev Anticancer Ther 2016 Dec;16(12):1311-1321. Epub 2016 Oct 22 doi: 10.1080/14737140.2016.1247699. PMID: 27732120

Recent clinical studies

Etiology

Oncology for the rhinologist.
Tam K, Dunn LA, Cohen MA
Curr Opin Otolaryngol Head Neck Surg 2024 Feb 1;32(1):14-19. Epub 2023 Dec 6 doi: 10.1097/MOO.0000000000000951. PMID: 38116847
Modern treatment of sinonasal undifferentiated carcinoma.
Neo WL, Hanna EY, Kiong KL
Curr Opin Otolaryngol Head Neck Surg 2023 Apr 1;31(2):89-93. Epub 2023 Feb 7 doi: 10.1097/MOO.0000000000000877. PMID: 36912221
Induction Chemotherapy Response as a Guide for Treatment Optimization in Sinonasal Undifferentiated Carcinoma.
Amit M, Abdelmeguid AS, Watcherporn T, Takahashi H, Tam S, Bell D, Ferrarotto R, Glisson B, Kupferman ME, Roberts DB, Su SY, Raza SM, DeMonte F, Hanna EY
J Clin Oncol 2019 Feb 20;37(6):504-512. Epub 2019 Jan 7 doi: 10.1200/JCO.18.00353. PMID: 30615549Free PMC Article
Evolving Roles of Histologic Evaluation and Molecular/Genomic Profiling in the Management of Endometrial Cancer.
Murali R, Delair DF, Bean SM, Abu-Rustum NR, Soslow RA
J Natl Compr Canc Netw 2018 Feb;16(2):201-209. doi: 10.6004/jnccn.2017.7066. PMID: 29439179Free PMC Article
Serous tubal intraepithelial carcinoma (STIC) - clinical impact and management.
Weinberger V, Bednarikova M, Cibula D, Zikan M
Expert Rev Anticancer Ther 2016 Dec;16(12):1311-1321. Epub 2016 Oct 22 doi: 10.1080/14737140.2016.1247699. PMID: 27732120

Diagnosis

SWI/SNF-deficient Sinonasal Carcinomas.
Agaimy A
Adv Anat Pathol 2023 Mar 1;30(2):95-103. Epub 2022 Oct 20 doi: 10.1097/PAP.0000000000000372. PMID: 36580412
SMARCA4/BRG1-Deficient Sinonasal Carcinoma.
Kakkar A, Ashraf SF, Rathor A, Adhya AK, Mani S, Sikka K, Jain D
Arch Pathol Lab Med 2022 Sep 1;146(9):1122-1130. doi: 10.5858/arpa.2021-0001-OA. PMID: 34871352
The updated WHO classification of digestive system tumours-gastric adenocarcinoma and dysplasia.
Kushima R
Pathologe 2022 Feb;43(1):8-15. Epub 2021 Nov 22 doi: 10.1007/s00292-021-01023-7. PMID: 34807275
Pancreatic Ductal Adenocarcinoma.
Dhillon J, Betancourt M
Monogr Clin Cytol 2020;26:74-91. Epub 2020 Sep 28 doi: 10.1159/000455736. PMID: 32987385
Sinonasal Undifferentiated Carcinoma.
Abdelmeguid AS, Bell D, Hanna EY
Curr Oncol Rep 2019 Feb 26;21(3):26. doi: 10.1007/s11912-019-0776-4. PMID: 30806835

Therapy

Oncology for the rhinologist.
Tam K, Dunn LA, Cohen MA
Curr Opin Otolaryngol Head Neck Surg 2024 Feb 1;32(1):14-19. Epub 2023 Dec 6 doi: 10.1097/MOO.0000000000000951. PMID: 38116847
Modern treatment of sinonasal undifferentiated carcinoma.
Neo WL, Hanna EY, Kiong KL
Curr Opin Otolaryngol Head Neck Surg 2023 Apr 1;31(2):89-93. Epub 2023 Feb 7 doi: 10.1097/MOO.0000000000000877. PMID: 36912221
Induction Chemotherapy Response as a Guide for Treatment Optimization in Sinonasal Undifferentiated Carcinoma.
Amit M, Abdelmeguid AS, Watcherporn T, Takahashi H, Tam S, Bell D, Ferrarotto R, Glisson B, Kupferman ME, Roberts DB, Su SY, Raza SM, DeMonte F, Hanna EY
J Clin Oncol 2019 Feb 20;37(6):504-512. Epub 2019 Jan 7 doi: 10.1200/JCO.18.00353. PMID: 30615549Free PMC Article
Preoperative chemoradiotherapy for esophageal or junctional cancer.
van Hagen P, Hulshof MC, van Lanschot JJ, Steyerberg EW, van Berge Henegouwen MI, Wijnhoven BP, Richel DJ, Nieuwenhuijzen GA, Hospers GA, Bonenkamp JJ, Cuesta MA, Blaisse RJ, Busch OR, ten Kate FJ, Creemers GJ, Punt CJ, Plukker JT, Verheul HM, Spillenaar Bilgen EJ, van Dekken H, van der Sangen MJ, Rozema T, Biermann K, Beukema JC, Piet AH, van Rij CM, Reinders JG, Tilanus HW, van der Gaast A; CROSS Group
N Engl J Med 2012 May 31;366(22):2074-84. doi: 10.1056/NEJMoa1112088. PMID: 22646630
Nasopharyngeal carcinoma.
Brennan B
Orphanet J Rare Dis 2006 Jun 26;1:23. doi: 10.1186/1750-1172-1-23. PMID: 16800883Free PMC Article

Prognosis

Single-cell RNA-seq reveals the genesis and heterogeneity of tumor microenvironment in pancreatic undifferentiated carcinoma with osteoclast-like giant-cells.
Wang X, Miao J, Wang S, Shen R, Zhang S, Tian Y, Li M, Zhu D, Yao A, Bao W, Zhang Q, Tang X, Wang X, Li J
Mol Cancer 2022 Jun 22;21(1):133. doi: 10.1186/s12943-022-01596-8. PMID: 35733218Free PMC Article
Neuroendocrine Carcinoma and Sinonasal Undifferentiated Carcinoma.
Abdelmeguid AS, Bell D, Hanna EY
Adv Otorhinolaryngol 2020;84:168-184. Epub 2020 Jul 30 doi: 10.1159/000457936. PMID: 32731236
Sinonasal Undifferentiated Carcinoma.
Abdelmeguid AS, Bell D, Hanna EY
Curr Oncol Rep 2019 Feb 26;21(3):26. doi: 10.1007/s11912-019-0776-4. PMID: 30806835
Serous tubal intraepithelial carcinoma (STIC) - clinical impact and management.
Weinberger V, Bednarikova M, Cibula D, Zikan M
Expert Rev Anticancer Ther 2016 Dec;16(12):1311-1321. Epub 2016 Oct 22 doi: 10.1080/14737140.2016.1247699. PMID: 27732120
Preoperative chemoradiotherapy for esophageal or junctional cancer.
van Hagen P, Hulshof MC, van Lanschot JJ, Steyerberg EW, van Berge Henegouwen MI, Wijnhoven BP, Richel DJ, Nieuwenhuijzen GA, Hospers GA, Bonenkamp JJ, Cuesta MA, Blaisse RJ, Busch OR, ten Kate FJ, Creemers GJ, Punt CJ, Plukker JT, Verheul HM, Spillenaar Bilgen EJ, van Dekken H, van der Sangen MJ, Rozema T, Biermann K, Beukema JC, Piet AH, van Rij CM, Reinders JG, Tilanus HW, van der Gaast A; CROSS Group
N Engl J Med 2012 May 31;366(22):2074-84. doi: 10.1056/NEJMoa1112088. PMID: 22646630

Clinical prediction guides

Long-term outcomes of modern multidisciplinary management of sinonasal cancers: The M. D. Anderson experience.
Bahig H, Ehab HY, Garden AS, Ng SP, Frank SJ, Nguyen T, Gunn GB, Rosenthal DI, Fuller CD, Ferrarotto R, Bell D, Su S, Phan J
Head Neck 2023 Jul;45(7):1692-1703. Epub 2023 May 10 doi: 10.1002/hed.27381. PMID: 37165701
Poorly Differentiated and Undifferentiated Thyroid Carcinomas.
Eloy C, Ferreira L, Salgado C, Soares P, Sobrinho-Simões M
Turk Patoloji Derg 2015;31 Suppl 1:48-59. doi: 10.5146/tjpath.2015.01314. PMID: 26177317
Lymphoepithelial-like carcinomas of the head and neck.
Wenig BM
Semin Diagn Pathol 2015 Jan;32(1):74-86. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.004. PMID: 25804344
Sinonasal undifferentiated carcinoma.
Mendenhall WM, Mendenhall CM, Riggs CE Jr, Villaret DB, Mendenhall NP
Am J Clin Oncol 2006 Feb;29(1):27-31. doi: 10.1097/01.coc.0000189691.04140.02. PMID: 16462499
Grading prostate cancer.
Bostwick DG
Am J Clin Pathol 1994 Oct;102(4 Suppl 1):S38-56. PMID: 7524306

Recent systematic reviews

Meta-analysis of multi-modality therapies in sinonasal undifferentiated carcinoma-A timely update.
See ASY, Chu C, Lim ICZY, Tan BKJ, Ang SXQ, Xu S, Teo NWY, Charn TC
Clin Otolaryngol 2024 Jan;49(1):29-40. Epub 2023 Oct 20 doi: 10.1111/coa.14100. PMID: 37859617
Radiotherapy in the management of rare gastrointestinal cancers: A systematic review.
Bellefkih FZ, Benchakroun N, Lalya I, Amaoui B, El Kacemi H, Acharki A, El Hfid M, El Mazghi A, Chekrine T, Bouchbika Z, Jouhadi H, Sahraoui S, Tawfiq N, Michalet M
Cancer Radiother 2023 Sep;27(6-7):622-637. Epub 2023 Jul 25 doi: 10.1016/j.canrad.2023.06.010. PMID: 37500390
Elective neck dissection in salivary gland malignancies: Systematic review and meta-analysis.
Yan F, Lao WP, Nguyen SA, Sharma AK, Day TA
Head Neck 2022 Feb;44(2):505-517. Epub 2021 Dec 4 doi: 10.1002/hed.26923. PMID: 34862810
Elective neck treatment in sinonasal undifferentiated carcinoma: Systematic review and meta-analysis.
Faisal M, Seemann R, Lill C, Hamzavi S, Wutzl A, Erovic BM, Janik S
Head Neck 2020 May;42(5):1057-1066. Epub 2020 Jan 10 doi: 10.1002/hed.26077. PMID: 31922316Free PMC Article
Outcome by treatment modality in sinonasal undifferentiated carcinoma (SNUC): A case-series, systematic review and meta-analysis.
Morand GB, Anderegg N, Vital D, Ikenberg K, Huber GF, Soyka MB, Egger M, Holzmann D
Oral Oncol 2017 Dec;75:28-34. Epub 2017 Oct 22 doi: 10.1016/j.oraloncology.2017.10.008. PMID: 29224819

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