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Lung giant cell carcinoma

MedGen UID:
83392
•Concept ID:
C0345960
•
Neoplastic Process
Synonyms: GCLC; Giant cell carcinoma of lung; Giant Cell Carcinoma of Lung; giant cell carcinoma of lung; Giant Cell Carcinoma of the Lung; giant cell carcinoma of the lung; giant cell lung carcinoma; Lung Giant Cell Carcinoma; lung giant cell carcinoma
SNOMED CT: Giant cell carcinoma of lung (254631008)
 
Monarch Initiative: MONDO:0006275

Definition

A morphologic variant of lung sarcomatoid carcinoma characterized by the presence of mononuclear and multinucleated pleomorphic neoplastic giant cells that lack cohesion. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLung giant cell carcinoma

Professional guidelines

PubMed

Video-assisted thoracoscopic surgery for diagnosis, staging, and management of lung cancer with suspected mediastinal lymphadenopathy.
Brega Massone PP, Conti B, Magnani B, Lequaglie C, Cataldo I
Surg Laparosc Endosc Percutan Tech 2002 Apr;12(2):104-9. doi: 10.1097/00129689-200204000-00006. PMID: 11948296

Recent clinical studies

Etiology

Experimental study on mechanism and rarity of metastases in skeletal muscle.
Luo C, Jiang Y, Liu Y, Li X
Chin Med J (Engl) 2002 Nov;115(11):1645-9. PMID: 12609079

Diagnosis

Epidemiological features of lung giant cell carcinoma and therapy for patients with EGFR mutations based on case reports and the surveillance, epidemiology, and end results (SEER) database.
Weng SS, Cao Y, Tang XJ, Zhu LZ, Tan YN, Dong CX, Chen JQ, Shen H, Yuan Y
Oncotarget 2017 Apr 11;8(15):25323-25333. doi: 10.18632/oncotarget.15831. PMID: 28445978Free PMC Article
Selective effect of O-alkyl lysophospholipids on the growth of a human lung giant cell carcinoma cell line.
Goto I, Hozumi M, Honma Y
Anticancer Res 1994 Mar-Apr;14(2A):357-62. PMID: 8017834

Prognosis

Epidemiological features of lung giant cell carcinoma and therapy for patients with EGFR mutations based on case reports and the surveillance, epidemiology, and end results (SEER) database.
Weng SS, Cao Y, Tang XJ, Zhu LZ, Tan YN, Dong CX, Chen JQ, Shen H, Yuan Y
Oncotarget 2017 Apr 11;8(15):25323-25333. doi: 10.18632/oncotarget.15831. PMID: 28445978Free PMC Article

Clinical prediction guides

Experimental study on mechanism and rarity of metastases in skeletal muscle.
Luo C, Jiang Y, Liu Y, Li X
Chin Med J (Engl) 2002 Nov;115(11):1645-9. PMID: 12609079
Characterization of a 64-kd protein phosphorylated during chemotactic activation with IL-8 and fMLP of human polymorphonuclear leukocytes. I. Phosphorylation of a 64-kd protein and other proteins.
Shibata M, Ohoka T, Mizuno S, Suzuki K
J Leukoc Biol 1993 Jul;54(1):1-9. doi: 10.1002/jlb.54.1.1. PMID: 8393062

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