U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Refractory Melanoma

MedGen UID:
1643370
Concept ID:
C4688319
Neoplastic Process

Definition

Melanoma that does not respond to treatment. [from NCI]

Professional guidelines

PubMed

Le ST, Ji-Xu A, Liakos W, Toussi AM, Cheng MY, Ma C, Wang EA, Wilken R, Boddu S, Downing L, Kao J, Davis JR, Monjazeb AM, Fung MA, Konia TH, Maverakis E, Kirane AR
Dermatol Ther 2022 Nov;35(11):e15853. Epub 2022 Oct 6 doi: 10.1111/dth.15853. PMID: 36151592
Dar AA, Bezrookove V, Nosrati M, Ice R, Patino JM, Vaquero EM, Parrett B, Leong SP, Kim KB, Debs RJ, Soroceanu L, Miller JR 3rd, Desprez PY, Cleaver JE, Salomonis N, McAllister S, Kashani-Sabet M
Proc Natl Acad Sci U S A 2022 Aug 23;119(34):e2206824119. Epub 2022 Aug 15 doi: 10.1073/pnas.2206824119. PMID: 35969744Free PMC Article
Hao X, Falo Iii LD, Chen G, Zhang J, Carey CD, Storkus WJ, Falo LD Jr, You Z
J Immunother Cancer 2021 Jan;9(1) doi: 10.1136/jitc-2020-001179. PMID: 33408093Free PMC Article

Recent clinical studies

Etiology

Connell E, Gerard É, Oules B, Brunet-Possenti F, Lamoureux A, Bonnefille H, Mary-Prey S, Carrasquilla A, Mouret S, Kramkimel N, Lesage C, Stoebner PE, Bartoli A, Monestier S, Correard F, Gros A, Jeanson A, Ouafik L, Gaudy-Marqueste C, Tomasini P, Charles J, Amini-Adle M, Malissen N
Oncologist 2024 Sep 6;29(9):e1180-e1188. doi: 10.1093/oncolo/oyae085. PMID: 38761384Free PMC Article
Li JJ, Wang JH, Dingv Y, Li DD, Wen XZ, Zhao JJ, Jiang H, Liu X, Huang FX, Zhang XS
J Cancer Res Clin Oncol 2022 May;148(5):1159-1169. Epub 2021 Jun 28 doi: 10.1007/s00432-021-03700-9. PMID: 34181096
Lepletier A, Madore J, O'Donnell JS, Johnston RL, Li XY, McDonald E, Ahern E, Kuchel A, Eastgate M, Pearson SA, Mallardo D, Ascierto PA, Massi D, Merelli B, Mandala M, Wilmott JS, Menzies AM, Leduc C, Stagg J, Routy B, Long GV, Scolyer RA, Bald T, Waddell N, Dougall WC, Teng MWL, Smyth MJ
Clin Cancer Res 2020 Jul 15;26(14):3671-3681. Epub 2020 Apr 28 doi: 10.1158/1078-0432.CCR-19-3925. PMID: 32345648
Kemper K, Krijgsman O, Kong X, Cornelissen-Steijger P, Shahrabi A, Weeber F, van der Velden DL, Bleijerveld OB, Kuilman T, Kluin RJC, Sun C, Voest EE, Ju YS, Schumacher TNM, Altelaar AFM, McDermott U, Adams DJ, Blank CU, Haanen JB, Peeper DS
Cell Rep 2016 Jun 28;16(1):263-277. Epub 2016 Jun 16 doi: 10.1016/j.celrep.2016.05.064. PMID: 27320919Free PMC Article
Ribas A, Puzanov I, Dummer R, Schadendorf D, Hamid O, Robert C, Hodi FS, Schachter J, Pavlick AC, Lewis KD, Cranmer LD, Blank CU, O'Day SJ, Ascierto PA, Salama AK, Margolin KA, Loquai C, Eigentler TK, Gangadhar TC, Carlino MS, Agarwala SS, Moschos SJ, Sosman JA, Goldinger SM, Shapira-Frommer R, Gonzalez R, Kirkwood JM, Wolchok JD, Eggermont A, Li XN, Zhou W, Zernhelt AM, Lis J, Ebbinghaus S, Kang SP, Daud A
Lancet Oncol 2015 Aug;16(8):908-18. Epub 2015 Jun 23 doi: 10.1016/S1470-2045(15)00083-2. PMID: 26115796Free PMC Article

Diagnosis

Mallardo D, Woodford R, Menzies AM, Zimmer L, Williamson A, Ramelyte E, Dimitriou F, Wicky A, Wallace R, Mallardo M, Cortellini A, Budillon A, Atkinson V, Sandhu S, Olivier M, Dummer R, Lorigan P, Schadendorf D, Long GV, Simeone E, Ascierto PA
J Transl Med 2023 Oct 25;21(1):753. doi: 10.1186/s12967-023-04607-4. PMID: 37880788Free PMC Article
Lin Z, Chen X, Li Z, Luo Y, Fang Z, Xu B, Han M
PLoS One 2016;11(8):e0160485. Epub 2016 Aug 2 doi: 10.1371/journal.pone.0160485. PMID: 27483468Free PMC Article
Kemper K, Krijgsman O, Kong X, Cornelissen-Steijger P, Shahrabi A, Weeber F, van der Velden DL, Bleijerveld OB, Kuilman T, Kluin RJC, Sun C, Voest EE, Ju YS, Schumacher TNM, Altelaar AFM, McDermott U, Adams DJ, Blank CU, Haanen JB, Peeper DS
Cell Rep 2016 Jun 28;16(1):263-277. Epub 2016 Jun 16 doi: 10.1016/j.celrep.2016.05.064. PMID: 27320919Free PMC Article
Zikich D, Schachter J, Besser MJ
Immunotherapy 2016;8(1):35-43. Epub 2015 Dec 10 doi: 10.2217/imt.15.99. PMID: 26653685
Lord JD, Hackman RC, Moklebust A, Thompson JA, Higano CS, Chielens D, Steinbach G, McDonald GB
Dig Dis Sci 2010 May;55(5):1396-405. Epub 2009 Jun 9 doi: 10.1007/s10620-009-0839-8. PMID: 19507029Free PMC Article

Therapy

Ziogas DC, Theocharopoulos C, Koutouratsas T, Haanen J, Gogas H
Cancer Treat Rev 2023 Feb;113:102499. Epub 2022 Dec 13 doi: 10.1016/j.ctrv.2022.102499. PMID: 36542945
Davar D, Dzutsev AK, McCulloch JA, Rodrigues RR, Chauvin JM, Morrison RM, Deblasio RN, Menna C, Ding Q, Pagliano O, Zidi B, Zhang S, Badger JH, Vetizou M, Cole AM, Fernandes MR, Prescott S, Costa RGF, Balaji AK, Morgun A, Vujkovic-Cvijin I, Wang H, Borhani AA, Schwartz MB, Dubner HM, Ernst SJ, Rose A, Najjar YG, Belkaid Y, Kirkwood JM, Trinchieri G, Zarour HM
Science 2021 Feb 5;371(6529):595-602. doi: 10.1126/science.abf3363. PMID: 33542131Free PMC Article
Baruch EN, Youngster I, Ben-Betzalel G, Ortenberg R, Lahat A, Katz L, Adler K, Dick-Necula D, Raskin S, Bloch N, Rotin D, Anafi L, Avivi C, Melnichenko J, Steinberg-Silman Y, Mamtani R, Harati H, Asher N, Shapira-Frommer R, Brosh-Nissimov T, Eshet Y, Ben-Simon S, Ziv O, Khan MAW, Amit M, Ajami NJ, Barshack I, Schachter J, Wargo JA, Koren O, Markel G, Boursi B
Science 2021 Feb 5;371(6529):602-609. Epub 2020 Dec 10 doi: 10.1126/science.abb5920. PMID: 33303685
Lin Z, Chen X, Li Z, Luo Y, Fang Z, Xu B, Han M
PLoS One 2016;11(8):e0160485. Epub 2016 Aug 2 doi: 10.1371/journal.pone.0160485. PMID: 27483468Free PMC Article
Bagcchi S
Lancet Oncol 2014 Sep;15(10):e419. doi: 10.1016/s1470-2045(14)70348-1. PMID: 25328942

Prognosis

Ziogas DC, Theocharopoulos C, Koutouratsas T, Haanen J, Gogas H
Cancer Treat Rev 2023 Feb;113:102499. Epub 2022 Dec 13 doi: 10.1016/j.ctrv.2022.102499. PMID: 36542945
Beasley GM, Nair SK, Farrow NE, Landa K, Selim MA, Wiggs CA, Jung SH, Bigner DD, True Kelly A, Gromeier M, Salama AK
J Immunother Cancer 2021 Apr;9(4) doi: 10.1136/jitc-2020-002203. PMID: 33875611Free PMC Article
Zikich D, Schachter J, Besser MJ
Immunotherapy 2016;8(1):35-43. Epub 2015 Dec 10 doi: 10.2217/imt.15.99. PMID: 26653685
Lord JD, Hackman RC, Moklebust A, Thompson JA, Higano CS, Chielens D, Steinbach G, McDonald GB
Dig Dis Sci 2010 May;55(5):1396-405. Epub 2009 Jun 9 doi: 10.1007/s10620-009-0839-8. PMID: 19507029Free PMC Article
Lewis KD, Thompson JA, Weber JS, Robinson WA, O'Day S, Lutzky J, Legha SS, Floret S, Ruvuna F, Gonzalez R
Invest New Drugs 2006 Jan;24(1):89-94. doi: 10.1007/s10637-005-4544-y. PMID: 16379038

Clinical prediction guides

Zhou A, Butt O, Ansstas M, Mauer E, Khaddour K, Ansstas G
J Natl Compr Canc Netw 2023 Jul;21(7):688-693.e3. doi: 10.6004/jnccn.2022.7102. PMID: 37433433
Beasley GM, Nair SK, Farrow NE, Landa K, Selim MA, Wiggs CA, Jung SH, Bigner DD, True Kelly A, Gromeier M, Salama AK
J Immunother Cancer 2021 Apr;9(4) doi: 10.1136/jitc-2020-002203. PMID: 33875611Free PMC Article
Baruch EN, Youngster I, Ben-Betzalel G, Ortenberg R, Lahat A, Katz L, Adler K, Dick-Necula D, Raskin S, Bloch N, Rotin D, Anafi L, Avivi C, Melnichenko J, Steinberg-Silman Y, Mamtani R, Harati H, Asher N, Shapira-Frommer R, Brosh-Nissimov T, Eshet Y, Ben-Simon S, Ziv O, Khan MAW, Amit M, Ajami NJ, Barshack I, Schachter J, Wargo JA, Koren O, Markel G, Boursi B
Science 2021 Feb 5;371(6529):602-609. Epub 2020 Dec 10 doi: 10.1126/science.abb5920. PMID: 33303685
Lewis KD, Thompson JA, Weber JS, Robinson WA, O'Day S, Lutzky J, Legha SS, Floret S, Ruvuna F, Gonzalez R
Invest New Drugs 2006 Jan;24(1):89-94. doi: 10.1007/s10637-005-4544-y. PMID: 16379038
Grosios K
Curr Opin Investig Drugs 2001 Feb;2(2):287-97. PMID: 11816846

Recent systematic reviews

Lin Z, Chen X, Li Z, Luo Y, Fang Z, Xu B, Han M
PLoS One 2016;11(8):e0160485. Epub 2016 Aug 2 doi: 10.1371/journal.pone.0160485. PMID: 27483468Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...