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Regressing Melanoma

MedGen UID:
90781
•Concept ID:
C0334427
•
Neoplastic Process
Synonyms: Malignant melanoma, regressing; Regressing Malignant Melanoma
SNOMED CT: Malignant melanoma, regressing (39896009)

Definition

A skin lesion characterized by the disappearance of the melanoma cells from the primary melanoma site. The disappearance of the malignant cells is associated with fibroplasia of the papillary dermis. According to some authors, complete regression of the primary melanoma may occur in 4-8% of patients. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRegressing Melanoma

Professional guidelines

PubMed

Repurposing Metabolic Inhibitors in the Treatment of Colon Adenocarcinoma Patient-Derived Models.
Lee B, Lee C, Moon HM, Jo SY, Jang SJ, Suh YA
Cells 2023 Dec 18;12(24) doi: 10.3390/cells12242859. PMID: 38132178Free PMC Article
Diagnosis and treatment of peripheral exudative haemorrhagic chorioretinopathy.
Vandefonteyne S, Caujolle JP, Rosier L, Conrath J, Quentel G, Tadayoni R, Maschi C, Le Mer Y, Dot C, Aknin I, Thariat J, Baillif S
Br J Ophthalmol 2020 Jun;104(6):874-878. Epub 2019 Oct 23 doi: 10.1136/bjophthalmol-2018-313307. PMID: 31645320
Differential diagnosis of heavily pigmented melanocytic lesions: challenges and diagnostic approach.
Aung PP, Mutyambizi KK, Danialan R, Ivan D, Prieto VG
J Clin Pathol 2015 Dec;68(12):963-70. doi: 10.1136/jclinpath-2015-202887. PMID: 26602414

Recent clinical studies

Etiology

Association between natural killer cells and regression in melanocytic lesions.
McKay K, Moore PC, Smoller BR, Hiatt KM
Hum Pathol 2011 Dec;42(12):1960-4. Epub 2011 Jun 14 doi: 10.1016/j.humpath.2011.02.019. PMID: 21676435
Sclerosing nevus with pseudomelanomatous features (nevus with regression-like fibrosis): clinical and dermoscopic features of a recently characterized histopathologic entity.
Ferrara G, Giorgio CM, Zalaudek I, Broganelli P, Pellacani G, Tomasini C, Argenziano G
Dermatology 2009;219(3):202-8. Epub 2009 Jul 8 doi: 10.1159/000228317. PMID: 19590167
The paradoxical association of regression with a poor prognosis in melanoma contrasted with a good prognosis in keratoacanthoma.
Prehn RT
Cancer Res 1996 Mar 1;56(5):937-940. PMID: 8640780
Pitfalls in frozen section diagnosis of malignant melanoma.
Shafir R, Hiss J, Tsur H, Bubis JJ
Cancer 1983 Mar 15;51(6):1168-70. doi: 10.1002/1097-0142(19830315)51:6<1168::aid-cncr2820510632>3.0.co;2-p. PMID: 6336989
The thin malignant melanoma: changing patterns of epidemiology and treatment.
Shafir R, Hiss J, Tsur H, Bubis JJ
Cancer 1982 Aug 15;50(4):817-9. doi: 10.1002/1097-0142(19820815)50:4<817::aid-cncr2820500434>3.0.co;2-v. PMID: 7093918

Diagnosis

Melanocytic and pseudomelanocytic nests coexist in interface dermatitis from head-neck sun-exposed skin: A report of three cases.
Ferrara G, Bradamante M, Broglia I, Petrillo G, Stefanato CM
J Cutan Pathol 2020 Jul;47(7):649-653. Epub 2020 Mar 20 doi: 10.1111/cup.13672. PMID: 32109330
Comparison of the Inflammatory Infiltrates in Tumoral Melanosis, Regressing Nevi, and Regressing Melanoma.
George EV, Kalen JE, Kapil JP, Motaparthi K
Am J Dermatopathol 2019 Jul;41(7):480-487. doi: 10.1097/DAD.0000000000001346. PMID: 30601204
Regressing seborrheic keratosis - clinically and dermoscopically mimicking a regressing melanoma.
Pastar Z, Lipozencić J, Rados J, Stajminger G
Acta Dermatovenerol Croat 2007;15(1):24-6. PMID: 17433176
Seborrheic keratoses, solar lentigines, and lichenoid keratoses. Dermatoscopic features and correlation to histology and clinical signs.
Elgart GW
Dermatol Clin 2001 Apr;19(2):347-57. doi: 10.1016/s0733-8635(05)70272-2. PMID: 11556243
Complete response of melanoma-in-transit metastasis after isolated limb perfusion with tumor necrosis factor alpha and melphalan without massive tumor necrosis: a clinical and histopathological study of the delayed-type reaction pattern.
Nooijen PT, Eggermont AM, Schalkwijk L, Henzen-Logmans S, de Waal RM, Ruiter DJ
Cancer Res 1998 Nov 1;58(21):4880-7. PMID: 9809994

Therapy

Melanocytic and pseudomelanocytic nests coexist in interface dermatitis from head-neck sun-exposed skin: A report of three cases.
Ferrara G, Bradamante M, Broglia I, Petrillo G, Stefanato CM
J Cutan Pathol 2020 Jul;47(7):649-653. Epub 2020 Mar 20 doi: 10.1111/cup.13672. PMID: 32109330
PD-1 Blockade Expands Intratumoral Memory T Cells.
Ribas A, Shin DS, Zaretsky J, Frederiksen J, Cornish A, Avramis E, Seja E, Kivork C, Siebert J, Kaplan-Lefko P, Wang X, Chmielowski B, Glaspy JA, Tumeh PC, Chodon T, Pe'er D, Comin-Anduix B
Cancer Immunol Res 2016 Mar;4(3):194-203. Epub 2016 Jan 19 doi: 10.1158/2326-6066.CIR-15-0210. PMID: 26787823Free PMC Article
Restricted T-cell receptor repertoire in melanoma metastases regressing after cytokine therapy.
Willhauck M, Scheibenbogen C, Pawlita M, Möhler T, Thiel E, Keilholz U
Cancer Res 2003 Jul 1;63(13):3483-5. PMID: 12839930
Complete response of melanoma-in-transit metastasis after isolated limb perfusion with tumor necrosis factor alpha and melphalan without massive tumor necrosis: a clinical and histopathological study of the delayed-type reaction pattern.
Nooijen PT, Eggermont AM, Schalkwijk L, Henzen-Logmans S, de Waal RM, Ruiter DJ
Cancer Res 1998 Nov 1;58(21):4880-7. PMID: 9809994
T-cell receptor beta variable region diversity in melanoma metastases after interleukin 2-based immunotherapy.
Willhauck M, Möhler T, Scheibenbogen C, Pawlita M, Brossart P, Schmier JW, Keilholz U
Clin Cancer Res 1996 Apr;2(4):767-72. PMID: 9816229

Prognosis

Comparison of the Inflammatory Infiltrates in Tumoral Melanosis, Regressing Nevi, and Regressing Melanoma.
George EV, Kalen JE, Kapil JP, Motaparthi K
Am J Dermatopathol 2019 Jul;41(7):480-487. doi: 10.1097/DAD.0000000000001346. PMID: 30601204
Sclerosing nevus with pseudomelanomatous features (nevus with regression-like fibrosis): clinical and dermoscopic features of a recently characterized histopathologic entity.
Ferrara G, Giorgio CM, Zalaudek I, Broganelli P, Pellacani G, Tomasini C, Argenziano G
Dermatology 2009;219(3):202-8. Epub 2009 Jul 8 doi: 10.1159/000228317. PMID: 19590167
The paradoxical association of regression with a poor prognosis in melanoma contrasted with a good prognosis in keratoacanthoma.
Prehn RT
Cancer Res 1996 Mar 1;56(5):937-940. PMID: 8640780
The thin malignant melanoma: changing patterns of epidemiology and treatment.
Shafir R, Hiss J, Tsur H, Bubis JJ
Cancer 1982 Aug 15;50(4):817-9. doi: 10.1002/1097-0142(19820815)50:4<817::aid-cncr2820500434>3.0.co;2-v. PMID: 7093918

Clinical prediction guides

Comparison of the Inflammatory Infiltrates in Tumoral Melanosis, Regressing Nevi, and Regressing Melanoma.
George EV, Kalen JE, Kapil JP, Motaparthi K
Am J Dermatopathol 2019 Jul;41(7):480-487. doi: 10.1097/DAD.0000000000001346. PMID: 30601204
Spontaneous regression of cutaneous melanoma in sinclair swine is associated with defective telomerase activity and extensive telomere erosion.
Pathak S, Multani AS, McConkey DJ, Imam AS, Amoss MS Jr
Int J Oncol 2000 Dec;17(6):1219-24. doi: 10.3892/ijo.17.6.1219. PMID: 11078808
The paradoxical association of regression with a poor prognosis in melanoma contrasted with a good prognosis in keratoacanthoma.
Prehn RT
Cancer Res 1996 Mar 1;56(5):937-940. PMID: 8640780

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