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Bone marrow cancer

MedGen UID:: 438070
•Concept ID:: C2703042
•: Neoplastic Process

Synonyms:	bone marrow cancer; cancer of bone marrow; Malignant Bone Marrow Neoplasm; malignant bone marrow neoplasm; Malignant Bone Marrow Tumor; malignant bone marrow tumor; malignant bone marrow tumour; malignant neoplasm of bone marrow

Monarch Initiative:	MONDO:0021138

Definition

Malignant neoplasms that either originate from the bone marrow (e.g. myeloid leukemias) or involve the bone marrow as secondary-metastatic tumors (e.g. metastatic carcinomas to the bone marrow). [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVBone marrow cancer

Disease
- Disorder by Site
  - Hematopoietic and Lymphoid System Disorder
    - Hematologic disorder
      - Bone marrow disorder
        Bone marrow neoplasm
        Bone marrow cancer
        Erythroid neoplasm
        Acquired polycythemia vera
        Polycythemia Vera, Polycythemic Phase
        Polycythemia Vera, Post-Polycythemic Myelofibrosis Phase
        Acute myeloid leukemia, M6 type
        Adult Acute Erythroid Leukemia
        Childhood Acute Erythroid Leukemia
        Erythroleukemia
        Erythroleukemia, familial, susceptibility to
        Pure Erythroid Leukemia
        Recurrent Acute Erythroid Leukemia
        Megakaryocytic Neoplasm
        Acute megakaryoblastic leukemia
        Acute megakaryoblastic leukemia in down syndrome
        Acute megakaryoblastic leukemia without down syndrome
        Adult Acute Megakaryoblastic Leukemia
        Childhood acute megakaryoblastic leukemia
        Recurrent Acute Megakaryoblastic Leukemia
        Essential thrombocythemia
        Thrombocythemia 1
        Thrombocythemia 2
        Thrombocythemia 3
        Metastatic Malignant Neoplasm in the Bone Marrow
        Myelodysplastic syndrome
        Adult Myelodysplastic Syndrome
        Childhood myelodysplastic syndrome
        Refractory cytopenia of childhood
        de novo Myelodysplastic Syndrome
        Familial monosomy 7 syndrome
        Monosomy 7 myelodysplasia and leukemia syndrome 1
        Monosomy 7 myelodysplasia and leukemia syndrome 2
        Hereditary Myelodysplastic Syndrome
        SAMD9-Associated Hereditary Myelodysplastic Syndrome
        SAMD9L-Associated Hereditary Myelodysplastic Syndrome
        Monocytopenia with susceptibility to infections
        Myelodysplastic syndrome associated with isolated del(5q)
        Myelodysplastic Syndrome with del(5q)
        Myelodysplastic syndrome with excess blasts
        Myelodysplastic Syndrome with Excess Blasts and Fibrosis
        Myelodysplastic syndrome with excess blasts-1
        Myelodysplastic syndrome with excess blasts-2
        Myelodysplastic syndrome with multilineage dysplasia
        Aregenerative anemia
        Congenital progressive bone marrow failure-B-cell immunodeficiency-skeletal dysplasia syndrome
        Refractory cytopenia with unilineage dysplasia
        Unclassified myelodysplastic syndrome
        Myelodysplastic syndrome with ring sideroblasts
        Myelodysplastic Syndrome with Somatic Mutation
        Myelodysplastic Syndrome, Unclassifiable
        Myelodysplastic Syndrome, Unclassifiable, with 1 Percent Blasts
        Myelodysplastic Syndrome, Unclassifiable, with Defining Cytogenetic Abnormality
        Myelodysplastic Syndrome, Unclassifiable, with Single Lineage Dysplasia
        Paroxysmal Hemoglobinuria
        Recurrent Myelodysplastic Syndrome
        Refractory anemia
        Refractory anemia with excess blasts in transformation
        Refractory anemia with ringed sideroblasts
        Myelodysplastic Syndrome with Ring Sideroblasts and Multilineage Dysplasia
        Myelodysplastic Syndrome with Ring Sideroblasts and Single Lineage Dysplasia
        Refractory Myelodysplastic Syndrome
        Secondary Myelodysplastic Syndrome
        Myelodysplastic Syndrome Post Cytotoxic Therapy
        Sideroblastic anemia
        Pyridoxine-responsive sideroblastic anemia
        Myelodysplastic/myeloproliferative neoplasm
        Atypical chronic myeloid leukemia, BCR-ABL1 negative
        Chronic Myeloid Leukemia, Philadelphia Chromosome Negative, BCR-ABL1 Positive
        Chronic myelomonocytic leukemia
        Chronic Myelomonocytic Leukemia with Eosinophilia
        Chronic Myelomonocytic Leukemia-0
        Chronic Myelomonocytic Leukemia-1
        Chronic Myelomonocytic Leukemia-2
        Recurrent Chronic Myelomonocytic Leukemia
        Refractory Chronic Myelomonocytic Leukemia
        Juvenile myelomonocytic leukemia
        Myelodysplastic/Myeloproliferative Neoplasm Post Cytotoxic Therapy
        Myelodysplastic/Myeloproliferative Neoplasm with Ring Sideroblasts and Thrombocytosis, Not Otherwise Specified
        Recurrent Myelodysplastic/Myeloproliferative Neoplasm
        Refractory Myelodysplastic/Myeloproliferative Neoplasm
        Unclassified myelodysplastic/myeloproliferative disease
        Myeloid leukemia
        Acute myeloid leukemia
        Acute basophilic leukemia
        Acute Eosinophilic Leukemia
        Acute Monoblastic and Monocytic Leukemia
        Acute monocytic leukemia
        Acute myeloblastic leukemia with maturation
        Acute myeloblastic leukemia without maturation
        Acute myeloid leukemia with minimal differentiation
        Acute myeloid leukemia with multilineage dysplasia
        Acute myeloid leukemia with recurrent genetic anomaly
        Acute Myeloid Leukemia, Myelodysplasia-Related
        Acute myelomonocytic leukemia M4
        Acute panmyelosis with myelofibrosis
        Acute promyelocytic leukemia
        Adult Acute Myeloid Leukemia
        Childhood acute myeloid leukemia
        Childhood Acute Myeloid Leukemia Not Otherwise Specified
        Cytogenetically Normal Acute Myeloid Leukemia
        Inherited acute myeloid leukemia
        Mast cell leukemia
        Recurrent Acute Myeloid Leukemia
        Recurrent Acute Myeloid Leukemia Not Otherwise Specified
        Refractory Acute Myeloid Leukemia
        Refractory Acute Myeloid Leukemia Not Otherwise Specified
        Secondary Acute Myeloid Leukemia
        Chronic myelogenous leukemia, BCR-ABL1 positive
        Blast phase chronic myelogenous leukemia, BCR-ABL1 positive
        Chronic Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive
        Leukemia, myeloid, accelerated-phase
        Chronic Myeloid Leukemia, BCR-ABL1 Positive
        Childhood Chronic Myeloid Leukemia, BCR-ABL1 Positive
        Meningeal Chronic Myeloid Leukemia, BCR-ABL1 Positive
        Recurrent Chronic Myeloid Leukemia, BCR-ABL1 Positive
        Refractory Chronic Myeloid Leukemia, BCR-ABL1 Positive
        Splenic Manifestation of Chronic Myeloid Leukemia, BCR-ABL1 Positive
        Myeloid sarcoma
        Cardiac Myeloid Sarcoma
        Granulocytic sarcoma
        Intracranial Myeloid Sarcoma
        Mediastinal Myeloid Sarcoma
        Monoblastic Sarcoma
        Oral Cavity Myeloid Sarcoma
        Prostate Myeloid Sarcoma
        Small Intestinal Myeloid Sarcoma
        Testicular Myeloid Sarcoma
        Philadelphia-positive myelogenous leukemia
        Myeloproliferative neoplasm
        14q32 duplication syndrome
        Chronic eosinophilic leukemia
        Chronic neutrophilic leukemia
        Myeloproliferative neoplasm, unclassifiable
        Primary myelofibrosis
        Cellular phase chronic idiopathic myelofibrosis
        Overt Primary Myelofibrosis
        Recurrent Primary Myelofibrosis
        Refractory Primary Myelofibrosis
        Recurrent Myeloproliferative Neoplasm
        Refractory Myeloproliferative Neoplasm
        Thrombocytopenia 6
        Transient myeloproliferative syndrome
        Therapy related acute myeloid leukemia and myelodysplastic syndrome
        Acute myeloid leukemia and myelodysplastic syndromes related to alkylating agent
        Alkylating Agent-Related Acute Myeloid Leukemia
        Alkylating Agent-Related Myelodysplastic Syndrome
        Acute myeloid leukemia and myelodysplastic syndromes related to radiation
        Acute myeloid leukemia and myelodysplastic syndromes related to topoisomerase type 2 inhibitor
        Acute Myeloid Leukemia Post Cytotoxic Therapy
        Topoisomerase II Inhibitor-Related Acute Myeloid Leukemia

Professional guidelines

PubMed

Biomimetic nanoparticles for siRNA delivery in the treatment of leukaemia.

Guo J, Cahill MR, McKenna SL, O'Driscoll CM
Biotechnol Adv 2014 Dec;32(8):1396-409. Epub 2014 Sep 16 doi: 10.1016/j.biotechadv.2014.08.007. PMID: 25218571

Colony-stimulating factors for prevention and treatment of infectious complications in patients with acute myelogenous leukemia.

Gurion R, Belnik-Plitman Y, Gafter-Gvili A, Paul M, Vidal L, Ben-Bassat I, Shpilberg O, Raanani P
Cochrane Database Syst Rev 2012 Jun 13;2012(6):CD008238. doi: 10.1002/14651858.CD008238.pub3. PMID: 22696376 Free PMC Article

Colony-stimulating factors for prevention and treatment of infectious complications in patients with acute myelogenous leukemia.

Gurion R, Belnik-Plitman Y, Gafter-Gvili A, Paul M, Vidal L, Ben-Bassat I, Shpilberg O, Raanani P
Cochrane Database Syst Rev 2011 Sep 7;(9):CD008238. doi: 10.1002/14651858.CD008238.pub2. PMID: 21901718

See all (6)

Recent clinical studies

Etiology

Early intervention in myelofibrosis and impact on outcomes: A pooled analysis of the COMFORT-I and COMFORT-II studies.

Verstovsek S, Kiladjian JJ, Vannucchi AM, Mesa RA, Squier P, Hamer-Maansson JE, Harrison C
Cancer 2023 Jun 1;129(11):1681-1690. Epub 2023 Feb 25 doi: 10.1002/cncr.34707. PMID: 36840971

Cellular senescence in cancers: relationship between bone marrow cancer and cellular senescence.

Sarikhani M, Firouzamandi M
Mol Biol Rep 2022 May;49(5):4003-4012. Epub 2022 Apr 21 doi: 10.1007/s11033-021-07101-6. PMID: 35449316

Leveraging RSF and PET images for prognosis of multiple myeloma at diagnosis.

Morvan L, Carlier T, Jamet B, Bailly C, Bodet-Milin C, Moreau P, Kraeber-Bodéré F, Mateus D
Int J Comput Assist Radiol Surg 2020 Jan;15(1):129-139. Epub 2019 Jun 29 doi: 10.1007/s11548-019-02015-y. PMID: 31256359

Prophylaxis and treatment of respiratory syncytial virus in adult immunocompromised patients.

Hynicka LM, Ensor CR
Ann Pharmacother 2012 Apr;46(4):558-66. Epub 2012 Mar 6 doi: 10.1345/aph.1Q553. PMID: 22395247

Hematological and toxicological evaluation of formaldehyde as a potential cause of human leukemia.

Goldstein BD
Hum Exp Toxicol 2011 Jul;30(7):725-35. Epub 2010 Aug 20 doi: 10.1177/0960327110381682. PMID: 20729258

See all (15)

Diagnosis

Circulating neutrophils from patients with early breast cancer have distinct subtype-dependent phenotypes.

Ramessur A, Ambasager B, Valle Aramburu I, Peakman F, Gleason K, Lehmann C, Papayannopoulos V, Coombes RC, Malanchi I
Breast Cancer Res 2023 Oct 19;25(1):125. doi: 10.1186/s13058-023-01707-3. PMID: 37858168 Free PMC Article

Predicting outcomes and monitoring disease in patients with multiple myeloma.

Kim S, Berenson JR
Clin Adv Hematol Oncol 2023 Sep;21(9):484-493. PMID: 37647495

Early intervention in myelofibrosis and impact on outcomes: A pooled analysis of the COMFORT-I and COMFORT-II studies.

Verstovsek S, Kiladjian JJ, Vannucchi AM, Mesa RA, Squier P, Hamer-Maansson JE, Harrison C
Cancer 2023 Jun 1;129(11):1681-1690. Epub 2023 Feb 25 doi: 10.1002/cncr.34707. PMID: 36840971

Microfluidic isolation of aptamers with affinity towards multiple myeloma monoclonal immunoglobulins.

Olsen TR, Tapia-Alveal C, Wen K, Worgall TS, Stojanovic MN, Lin Q
Biomed Microdevices 2022 Dec 8;25(1):3. doi: 10.1007/s10544-022-00643-x. PMID: 36480127 Free PMC Article

Leveraging RSF and PET images for prognosis of multiple myeloma at diagnosis.

See all (14)

Therapy

A trispecific antibody induces potent tumor-directed T-cell activation and antitumor activity by CD3/CD28 co-engagement.

Chen L, Qian W, Pan F, Li D, Yu W, Tong L, Yang Y, Xu Q, Ding J, Dai R, Xian W, Zhu X, Ren P, Zhu H
Immunotherapy 2024 Feb;16(3):143-159. Epub 2023 Dec 21 doi: 10.2217/imt-2023-0256. PMID: 38126157

Bispecific Monoclonal Antibodies in Multiple Myeloma: Data from ASH 2022: A Podcast.

Landgren O, Nadeem O
Adv Ther 2023 Aug;40(8):3291-3303. Epub 2023 Jun 16 doi: 10.1007/s12325-023-02551-9. PMID: 37328635 Free PMC Article

Proteasome inhibition in multiple myeloma: lessons for other cancers.

Saavedra-García P, Martini F, Auner HW
Am J Physiol Cell Physiol 2020 Mar 1;318(3):C451-C462. Epub 2019 Dec 25 doi: 10.1152/ajpcell.00286.2019. PMID: 31875696

Leveraging RSF and PET images for prognosis of multiple myeloma at diagnosis.

Biomimetic nanoparticles for siRNA delivery in the treatment of leukaemia.

Guo J, Cahill MR, McKenna SL, O'Driscoll CM
Biotechnol Adv 2014 Dec;32(8):1396-409. Epub 2014 Sep 16 doi: 10.1016/j.biotechadv.2014.08.007. PMID: 25218571

See all (24)

Prognosis

Circulating neutrophils from patients with early breast cancer have distinct subtype-dependent phenotypes.

Predicting outcomes and monitoring disease in patients with multiple myeloma.

Kim S, Berenson JR
Clin Adv Hematol Oncol 2023 Sep;21(9):484-493. PMID: 37647495

Withanolide-Type Steroids from Withania aristata as Potential Anti-Leukemic Agents.

Moujir LM, Llanos GG, Araujo L, Amesty A, Bazzocchi IL, Jiménez IA
Molecules 2020 Dec 5;25(23) doi: 10.3390/molecules25235744. PMID: 33291428 Free PMC Article

High-risk smoldering myeloma versus early detection of multiple myeloma: Current models, goals of therapy, and clinical implications.

Kunacheewa C, Manasanch EE
Best Pract Res Clin Haematol 2020 Mar;33(1):101152. Epub 2020 Jan 25 doi: 10.1016/j.beha.2020.101152. PMID: 32139017 Free PMC Article

Leveraging RSF and PET images for prognosis of multiple myeloma at diagnosis.

See all (7)

Clinical prediction guides

Predicting outcomes and monitoring disease in patients with multiple myeloma.

Kim S, Berenson JR
Clin Adv Hematol Oncol 2023 Sep;21(9):484-493. PMID: 37647495

Early intervention in myelofibrosis and impact on outcomes: A pooled analysis of the COMFORT-I and COMFORT-II studies.

Verstovsek S, Kiladjian JJ, Vannucchi AM, Mesa RA, Squier P, Hamer-Maansson JE, Harrison C
Cancer 2023 Jun 1;129(11):1681-1690. Epub 2023 Feb 25 doi: 10.1002/cncr.34707. PMID: 36840971

Withanolide-Type Steroids from Withania aristata as Potential Anti-Leukemic Agents.

Moujir LM, Llanos GG, Araujo L, Amesty A, Bazzocchi IL, Jiménez IA
Molecules 2020 Dec 5;25(23) doi: 10.3390/molecules25235744. PMID: 33291428 Free PMC Article

Leveraging RSF and PET images for prognosis of multiple myeloma at diagnosis.

Exploration of quinolone and quinoline derivatives as potential anticancer agents.

Iqbal J, Ejaz SA, Khan I, Ausekle E, Miliutina M, Langer P
Daru 2019 Dec;27(2):613-626. Epub 2019 Aug 13 doi: 10.1007/s40199-019-00290-3. PMID: 31410781 Free PMC Article

See all (13)

Recent systematic reviews

A systematic review of recent trends in research on therapeutically significant L-asparaginase and acute lymphoblastic leukemia.

Suresh SA, Ethiraj S, Rajnish KN
Mol Biol Rep 2022 Dec;49(12):11281-11287. Epub 2022 Jul 10 doi: 10.1007/s11033-022-07688-4. PMID: 35816224

Colony-stimulating factors for prevention and treatment of infectious complications in patients with acute myelogenous leukemia.

See all (3)

MedGen

National Center for Biotechnology Information

Send to:

Bone marrow cancer

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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