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Ovarian transitional cell carcinoma

MedGen UID:
233811
•Concept ID:
C1335184
•
Neoplastic Process
Synonyms: malignant ovarian transitional cell neoplasm; ovarian transitional cell cancer; Ovarian Transitional Cell Carcinoma; ovarian transitional cell carcinoma; ovarian transitional cell neoplasm; ovary transitional cell carcinoma; Transitional Cell Carcinoma of Ovary; transitional cell carcinoma of ovary; Transitional Cell Carcinoma of the Ovary; transitional cell carcinoma of the ovary
 
Monarch Initiative: MONDO:0006343

Definition

A carcinoma that arises from the ovary and is characterized by the presence of malignant epithelial cells that resemble malignant urothelial cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOvarian transitional cell carcinoma

Professional guidelines

PubMed

APOBEC3C is a novel target for the immune treatment of lower-grade gliomas.
Zhao S, Li Y, Xu J, Shen L
Neurol Res 2024 Mar;46(3):227-242. Epub 2024 Jan 22 doi: 10.1080/01616412.2023.2287340. PMID: 38007705
Morphologic patterns associated with BRCA1 and BRCA2 genotype in ovarian carcinoma.
Soslow RA, Han G, Park KJ, Garg K, Olvera N, Spriggs DR, Kauff ND, Levine DA
Mod Pathol 2012 Apr;25(4):625-36. Epub 2011 Dec 23 doi: 10.1038/modpathol.2011.183. PMID: 22193042
Cytokeratins 20 and 7 in the differential diagnosis of metastatic carcinoma in cytologic specimens.
Sack MJ, Roberts SA
Diagn Cytopathol 1997 Feb;16(2):132-6. doi: 10.1002/(sici)1097-0339(199702)16:2<132::aid-dc7>3.0.co;2-j. PMID: 9067104

Recent clinical studies

Etiology

Tubo-Ovarian Transitional Cell Carcinoma and High-grade Serous Carcinoma Show Subtly Different Immunohistochemistry Profiles.
Magrill J, Karnezis AN, Tessier-Cloutier B, Talhouk A, Kommoss S, Cochrane D, Chow C, Cheng A, Soslow R, Hauptmann S, du Bois A, Pfisterer J, Gilks CB, Huntsman DG, Kommoss F
Int J Gynecol Pathol 2019 Nov;38(6):552-561. doi: 10.1097/PGP.0000000000000538. PMID: 30059451Free PMC Article
Superficially invasive cervical squamous cell carcinoma metastatic to ovarian endometriotic cyst wall, a case report and brief review of the literature.
Zhang M, Lucas E, Xiong H, Liu S, Molberg K, Jiang Q, Zheng W
J Ovarian Res 2018 May 30;11(1):44. doi: 10.1186/s13048-018-0417-9. PMID: 29848369Free PMC Article
Transitional cell-like morphology in ovarian endometrioid carcinoma: morphologic, immunohistochemical, and behavioral features distinguishing it from high-grade serous carcinoma.
Karnezis AN, Aysal A, Zaloudek CJ, Rabban JT
Am J Surg Pathol 2013 Jan;37(1):24-37. doi: 10.1097/PAS.0b013e31826a5399. PMID: 23108017
Transitional cell neoplasms of the ovary and urinary bladder: a comparative immunohistochemical analysis.
Soslow RA, Rouse RV, Hendrickson MR, Silva EG, Longacre TA
Int J Gynecol Pathol 1996 Jul;15(3):257-65. doi: 10.1097/00004347-199607000-00011. PMID: 8811388

Diagnosis

Superficially invasive cervical squamous cell carcinoma metastatic to ovarian endometriotic cyst wall, a case report and brief review of the literature.
Zhang M, Lucas E, Xiong H, Liu S, Molberg K, Jiang Q, Zheng W
J Ovarian Res 2018 May 30;11(1):44. doi: 10.1186/s13048-018-0417-9. PMID: 29848369Free PMC Article
Synchronous malignant mixed Müllerian tumor of the uterus with transitional cell carcinoma of the ovary.
Sahai P, Kakkar A, Pathy S, Kumar L, Bhatla N, Chander S
J Obstet Gynaecol Res 2015 Feb;41(2):319-23. Epub 2014 Sep 17 doi: 10.1111/jog.12510. PMID: 25227514
Ovarian transitional cell carcinoma represents a poorly differentiated form of high-grade serous or endometrioid adenocarcinoma.
Takeuchi T, Ohishi Y, Imamura H, Aman M, Shida K, Kobayashi H, Kato K, Oda Y
Am J Surg Pathol 2013 Jul;37(7):1091-9. doi: 10.1097/PAS.0b013e3182834d41. PMID: 23681072
Transitional cell-like morphology in ovarian endometrioid carcinoma: morphologic, immunohistochemical, and behavioral features distinguishing it from high-grade serous carcinoma.
Karnezis AN, Aysal A, Zaloudek CJ, Rabban JT
Am J Surg Pathol 2013 Jan;37(1):24-37. doi: 10.1097/PAS.0b013e31826a5399. PMID: 23108017
Problems arising in the diagnosis of primary ovarian transitional cell carcinoma after the occurrence of a transitional cell carcinoma of the bladder: a report of a difficult case and a critical review of literature.
Raspollini MR, Paglierani M, Taddei GL
Appl Immunohistochem Mol Morphol 2009 Mar;17(2):178-83. doi: 10.1097/PAI.0b013e31818637c5. PMID: 19521281

Prognosis

Tubo-Ovarian Transitional Cell Carcinoma and High-grade Serous Carcinoma Show Subtly Different Immunohistochemistry Profiles.
Magrill J, Karnezis AN, Tessier-Cloutier B, Talhouk A, Kommoss S, Cochrane D, Chow C, Cheng A, Soslow R, Hauptmann S, du Bois A, Pfisterer J, Gilks CB, Huntsman DG, Kommoss F
Int J Gynecol Pathol 2019 Nov;38(6):552-561. doi: 10.1097/PGP.0000000000000538. PMID: 30059451Free PMC Article
Late, isolated, secondary ovarian transitional cell carcinoma: an unusual course of bladder malignancy.
Groutz A, Gillon G, Shimonov M, Zehavi S, Servadio C
Br J Urol 1996 Nov;78(5):795-6. doi: 10.1046/j.1464-410x.1996.24829.x. PMID: 8976786

Clinical prediction guides

Ovarian transitional cell carcinoma represents a poorly differentiated form of high-grade serous or endometrioid adenocarcinoma.
Takeuchi T, Ohishi Y, Imamura H, Aman M, Shida K, Kobayashi H, Kato K, Oda Y
Am J Surg Pathol 2013 Jul;37(7):1091-9. doi: 10.1097/PAS.0b013e3182834d41. PMID: 23681072
Problems arising in the diagnosis of primary ovarian transitional cell carcinoma after the occurrence of a transitional cell carcinoma of the bladder: a report of a difficult case and a critical review of literature.
Raspollini MR, Paglierani M, Taddei GL
Appl Immunohistochem Mol Morphol 2009 Mar;17(2):178-83. doi: 10.1097/PAI.0b013e31818637c5. PMID: 19521281

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