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Malignant Retropharyngeal Neoplasm

MedGen UID:
1706499
•Concept ID:
C5206838
•
Neoplastic Process

Definition

A primary or metastatic malignant neoplasm that affects the retropharyngeal space. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Retropharyngeal Neoplasm

Professional guidelines

PubMed

Evaluation and management of neck masses in children.
Meier JD, Grimmer JF
Am Fam Physician 2014 Mar 1;89(5):353-8. PMID: 24695506
Current status of oral cancer treatment strategies: surgical treatments for oral squamous cell carcinoma.
Omura K
Int J Clin Oncol 2014;19(3):423-30. Epub 2014 Apr 1 doi: 10.1007/s10147-014-0689-z. PMID: 24682763
Metastatic retropharyngeal lymph nodes in nasopharyngeal carcinoma: imaging criteria.
Sharma M, Bartlett E, Yu E
Expert Rev Anticancer Ther 2010 Nov;10(11):1703-6. doi: 10.1586/era.10.159. PMID: 21080798

Recent clinical studies

Etiology

Integrating pretreatment MRI-detected nodal features and Epstein-Barr virus DNA to identify optimal candidates for intensity-modulated radiotherapy alone in patients with stage II nasopharyngeal carcinoma.
Guo J, He Y, Lin C, Jiang Q, Xing HW, Zhang YC, Shen GZ, Lin HX, Guo L, Yang Q
Oral Oncol 2023 Nov;146:106574. Epub 2023 Sep 22 doi: 10.1016/j.oraloncology.2023.106574. PMID: 37741017
Medial retropharyngeal nodal region sparing radiotherapy versus standard radiotherapy in patients with nasopharyngeal carcinoma: open label, non-inferiority, multicentre, randomised, phase 3 trial.
Mao YP, Wang SX, Gao TS, Zhang N, Liang XY, Xie FY, Zhang Y, Zhou GQ, Guo R, Luo WJ, Li YJ, Liang SQ, Lin L, Li WF, Liu X, Xu C, Chen YP, Lv JW, Huang SH, Liu LZ, Li JB, Tang LL, Chen L, Sun Y, Ma J
BMJ 2023 Feb 6;380:e072133. doi: 10.1136/bmj-2022-072133. PMID: 36746459Free PMC Article
Elective upper-neck versus whole-neck irradiation of the uninvolved neck in patients with nasopharyngeal carcinoma: an open-label, non-inferiority, multicentre, randomised phase 3 trial.
Tang LL, Huang CL, Zhang N, Jiang W, Wu YS, Huang SH, Mao YP, Liu Q, Li JB, Liang SQ, Qin GJ, Hu WH, Sun Y, Xie FY, Chen L, Zhou GQ, Ma J
Lancet Oncol 2022 Apr;23(4):479-490. Epub 2022 Feb 28 doi: 10.1016/S1470-2045(22)00058-4. PMID: 35240053
Retropharyngeal abscess after chemotherapy.
Mettias B, Robertson S, Buchanan MA
BMJ Case Rep 2018 Mar 5;2018 doi: 10.1136/bcr-2017-222610. PMID: 29507016Free PMC Article
Craniocervical chordomas.
Harwick RD, Miller AS
Am J Surg 1979 Oct;138(4):512-6. doi: 10.1016/0002-9610(79)90410-0. PMID: 114069

Diagnosis

Medial retropharyngeal nodal region sparing radiotherapy versus standard radiotherapy in patients with nasopharyngeal carcinoma: open label, non-inferiority, multicentre, randomised, phase 3 trial.
Mao YP, Wang SX, Gao TS, Zhang N, Liang XY, Xie FY, Zhang Y, Zhou GQ, Guo R, Luo WJ, Li YJ, Liang SQ, Lin L, Li WF, Liu X, Xu C, Chen YP, Lv JW, Huang SH, Liu LZ, Li JB, Tang LL, Chen L, Sun Y, Ma J
BMJ 2023 Feb 6;380:e072133. doi: 10.1136/bmj-2022-072133. PMID: 36746459Free PMC Article
Imaging of Anaplastic Thyroid Carcinoma.
Ahmed S, Ghazarian MP, Cabanillas ME, Zafereo ME, Williams MD, Vu T, Schomer DF, Debnam JM
AJNR Am J Neuroradiol 2018 Mar;39(3):547-551. Epub 2017 Dec 14 doi: 10.3174/ajnr.A5487. PMID: 29242360Free PMC Article
Pitfalls in the staging of cancer of thyroid.
Saindane AM
Neuroimaging Clin N Am 2013 Feb;23(1):123-45. doi: 10.1016/j.nic.2012.08.010. PMID: 23199665
Retropharyngeal and prevertebral spaces: anatomic imaging and diagnosis.
Debnam JM, Guha-Thakurta N
Otolaryngol Clin North Am 2012 Dec;45(6):1293-310. doi: 10.1016/j.otc.2012.08.004. PMID: 23153750Free PMC Article
Oral cavity and pharynx.
Yousem DM, Chalian AA
Radiol Clin North Am 1998 Sep;36(5):967-81, vii. doi: 10.1016/s0033-8389(05)70071-3. PMID: 9747196

Therapy

Medial retropharyngeal nodal region sparing radiotherapy versus standard radiotherapy in patients with nasopharyngeal carcinoma: open label, non-inferiority, multicentre, randomised, phase 3 trial.
Mao YP, Wang SX, Gao TS, Zhang N, Liang XY, Xie FY, Zhang Y, Zhou GQ, Guo R, Luo WJ, Li YJ, Liang SQ, Lin L, Li WF, Liu X, Xu C, Chen YP, Lv JW, Huang SH, Liu LZ, Li JB, Tang LL, Chen L, Sun Y, Ma J
BMJ 2023 Feb 6;380:e072133. doi: 10.1136/bmj-2022-072133. PMID: 36746459Free PMC Article
Elective upper-neck versus whole-neck irradiation of the uninvolved neck in patients with nasopharyngeal carcinoma: an open-label, non-inferiority, multicentre, randomised phase 3 trial.
Tang LL, Huang CL, Zhang N, Jiang W, Wu YS, Huang SH, Mao YP, Liu Q, Li JB, Liang SQ, Qin GJ, Hu WH, Sun Y, Xie FY, Chen L, Zhou GQ, Ma J
Lancet Oncol 2022 Apr;23(4):479-490. Epub 2022 Feb 28 doi: 10.1016/S1470-2045(22)00058-4. PMID: 35240053
Retropharyngeal abscess after chemotherapy.
Mettias B, Robertson S, Buchanan MA
BMJ Case Rep 2018 Mar 5;2018 doi: 10.1136/bcr-2017-222610. PMID: 29507016Free PMC Article
Management of locally advanced HPV-related oropharyngeal squamous cell carcinoma: where are we?
Samuels SE, Eisbruch A, Beitler JJ, Corry J, Bradford CR, Saba NF, van den Brekel MW, Smee R, Strojan P, Suárez C, Mendenhall WM, Takes RP, Rodrigo JP, Haigentz M Jr, Rapidis AD, Rinaldo A, Ferlito A
Eur Arch Otorhinolaryngol 2016 Oct;273(10):2877-94. Epub 2015 Oct 13 doi: 10.1007/s00405-015-3771-x. PMID: 26463714
Hypopharyngeal carcinoma.
Hinerman RW, Amdur RJ, Mendenhall WM, Villaret DB, Robbins KT
Curr Treat Options Oncol 2002 Feb;3(1):41-9. doi: 10.1007/s11864-002-0040-1. PMID: 12057086

Prognosis

Integrating pretreatment MRI-detected nodal features and Epstein-Barr virus DNA to identify optimal candidates for intensity-modulated radiotherapy alone in patients with stage II nasopharyngeal carcinoma.
Guo J, He Y, Lin C, Jiang Q, Xing HW, Zhang YC, Shen GZ, Lin HX, Guo L, Yang Q
Oral Oncol 2023 Nov;146:106574. Epub 2023 Sep 22 doi: 10.1016/j.oraloncology.2023.106574. PMID: 37741017
Patterns and prognosis of regional recurrence in nasopharyngeal carcinoma after intensity-modulated radiotherapy.
Xiao XT, Wu YS, Chen YP, Liu X, Guo R, Tang LL, Ma J, Li WF
Cancer Med 2023 Jan;12(2):1399-1408. Epub 2022 Jul 13 doi: 10.1002/cam4.5020. PMID: 35822664Free PMC Article
Hybrid PET/MRI in major cancers: a scoping review.
Morsing A, Hildebrandt MG, Vilstrup MH, Wallenius SE, Gerke O, Petersen H, Johansen A, Andersen TL, Høilund-Carlsen PF
Eur J Nucl Med Mol Imaging 2019 Sep;46(10):2138-2151. Epub 2019 Jul 2 doi: 10.1007/s00259-019-04402-8. PMID: 31267161
Imaging of Anaplastic Thyroid Carcinoma.
Ahmed S, Ghazarian MP, Cabanillas ME, Zafereo ME, Williams MD, Vu T, Schomer DF, Debnam JM
AJNR Am J Neuroradiol 2018 Mar;39(3):547-551. Epub 2017 Dec 14 doi: 10.3174/ajnr.A5487. PMID: 29242360Free PMC Article
Craniocervical chordomas.
Harwick RD, Miller AS
Am J Surg 1979 Oct;138(4):512-6. doi: 10.1016/0002-9610(79)90410-0. PMID: 114069

Clinical prediction guides

Integrating pretreatment MRI-detected nodal features and Epstein-Barr virus DNA to identify optimal candidates for intensity-modulated radiotherapy alone in patients with stage II nasopharyngeal carcinoma.
Guo J, He Y, Lin C, Jiang Q, Xing HW, Zhang YC, Shen GZ, Lin HX, Guo L, Yang Q
Oral Oncol 2023 Nov;146:106574. Epub 2023 Sep 22 doi: 10.1016/j.oraloncology.2023.106574. PMID: 37741017
Importance of the Number and Location of Lymph Node Metastasis in Oropharyngeal Cancer.
Iida M, Murai T, Kuno M, Osumi K, Nakanishi-Imai M, Okazaki D, Murase T, Kawakita D, Iwasaki S, Inagaki H, Tomita N, Shibamoto Y, Hiwatashi A
In Vivo 2023 Sep-Oct;37(5):2210-2218. doi: 10.21873/invivo.13321. PMID: 37652496Free PMC Article
Medial retropharyngeal nodal region sparing radiotherapy versus standard radiotherapy in patients with nasopharyngeal carcinoma: open label, non-inferiority, multicentre, randomised, phase 3 trial.
Mao YP, Wang SX, Gao TS, Zhang N, Liang XY, Xie FY, Zhang Y, Zhou GQ, Guo R, Luo WJ, Li YJ, Liang SQ, Lin L, Li WF, Liu X, Xu C, Chen YP, Lv JW, Huang SH, Liu LZ, Li JB, Tang LL, Chen L, Sun Y, Ma J
BMJ 2023 Feb 6;380:e072133. doi: 10.1136/bmj-2022-072133. PMID: 36746459Free PMC Article
Elective upper-neck versus whole-neck irradiation of the uninvolved neck in patients with nasopharyngeal carcinoma: an open-label, non-inferiority, multicentre, randomised phase 3 trial.
Tang LL, Huang CL, Zhang N, Jiang W, Wu YS, Huang SH, Mao YP, Liu Q, Li JB, Liang SQ, Qin GJ, Hu WH, Sun Y, Xie FY, Chen L, Zhou GQ, Ma J
Lancet Oncol 2022 Apr;23(4):479-490. Epub 2022 Feb 28 doi: 10.1016/S1470-2045(22)00058-4. PMID: 35240053
Hybrid PET/MRI in major cancers: a scoping review.
Morsing A, Hildebrandt MG, Vilstrup MH, Wallenius SE, Gerke O, Petersen H, Johansen A, Andersen TL, Høilund-Carlsen PF
Eur J Nucl Med Mol Imaging 2019 Sep;46(10):2138-2151. Epub 2019 Jul 2 doi: 10.1007/s00259-019-04402-8. PMID: 31267161

Recent systematic reviews

A Comparison of Transoral Versus Transcervical Surgical Approaches to Retropharyngeal Lymphadenectomy: A Scoping Review.
Tzelnick S, Tsai J, Hosni A, Goldstein DP, Almeida JR, Yao CMKL
J Otolaryngol Head Neck Surg 2024 Jan-Dec;53:19160216241265092. doi: 10.1177/19160216241265092. PMID: 39077912Free PMC Article
Different surgical approaches in retropharyngeal lymph nodes dissection in head and neck cancer: A systematic review.
Russo E, Accorona R, Costantino A, Ferreli F, Malvezzi L, Pellini R, Colombo G, Wang CC, Spriano G, Mercante G, De Virgilio A
Auris Nasus Larynx 2023 Jun;50(3):327-336. Epub 2022 Sep 30 doi: 10.1016/j.anl.2022.09.002. PMID: 36184298
Prevalence and prognostic impact of retropharyngeal lymph nodes metastases in oropharyngeal squamous cell carcinoma: Meta-analysis of published literature.
Tirelli G, Gardenal N, Zanelli E, Borsetto D, Phillips V, Marcuzzo AV, Fussey J, Polesel J, Boscolo-Rizzo P
Head Neck 2022 Oct;44(10):2265-2276. Epub 2022 Aug 1 doi: 10.1002/hed.27166. PMID: 35913029Free PMC Article
Retropharyngeal lymph node metastasis in oral cancer. Systematic review and survival analysis.
Abdelrahman A, McGoldrick D, Aggarwal A, Idle MR, Praveen P, Martin T, Parmar S
Br J Oral Maxillofac Surg 2022 Jun;60(5):563-569. Epub 2021 Jun 10 doi: 10.1016/j.bjoms.2021.06.001. PMID: 35337688
Management of retropharyngeal node metastases from thyroid carcinoma.
Hartl DM, Leboulleux S, Vélayoudom-Céphise FL, Mirghani H, Déandréis D, Schlumberger M
World J Surg 2015 May;39(5):1274-81. doi: 10.1007/s00268-015-2947-2. PMID: 25585526

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