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Small Intestinal Undifferentiated Carcinoma

MedGen UID:
328037
Concept ID:
C1710114
Neoplastic Process

Definition

A carcinoma that arises from the small intestine. It is composed of malignant epithelial cells which do not display evidence of glandular, squamous, or transitional cell differentiation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSmall Intestinal Undifferentiated Carcinoma

Professional guidelines

PubMed

Walter D, Schnitzbauer AA, Schulze F, Trojan J
Dtsch Arztebl Int 2023 Oct 27;120(43):729-735. doi: 10.3238/arztebl.m2023.0195. PMID: 37656482Free PMC Article
Vlachou E, Koffas A, Toumpanakis C, Keuchel M
Best Pract Res Clin Gastroenterol 2023 Jun-Aug;64-65:101860. Epub 2023 Aug 12 doi: 10.1016/j.bpg.2023.101860. PMID: 37652650
Chiorean EG, Chiaro MD, Tempero MA, Malafa MP, Benson AB, Cardin DB, Christensen JA, Chung V, Czito B, Dillhoff M, Donahue TR, Dotan E, Fountzilas C, Glazer ES, Hardacre J, Hawkins WG, Klute K, Ko AH, Kunstman JW, LoConte N, Lowy AM, Masood A, Moravek C, Nakakura EK, Narang AK, Nardo L, Obando J, Polanco PM, Reddy S, Reyngold M, Scaife C, Shen J, Truty MJ, Vollmer C, Wolff RA, Wolpin BM, Rn BM, Lubin S, Darlow SD
J Natl Compr Canc Netw 2023 Jul;21(7):753-782. doi: 10.6004/jnccn.2023.0034. PMID: 37433437

Recent clinical studies

Etiology

Vlachou E, Koffas A, Toumpanakis C, Keuchel M
Best Pract Res Clin Gastroenterol 2023 Jun-Aug;64-65:101860. Epub 2023 Aug 12 doi: 10.1016/j.bpg.2023.101860. PMID: 37652650
Gudan A, Kozłowska-Petriczko K, Wunsch E, Bodnarczuk T, Stachowska E
Nutrients 2023 Mar 8;15(6) doi: 10.3390/nu15061323. PMID: 36986052Free PMC Article
Benson AB, Venook AP, Al-Hawary MM, Arain MA, Chen YJ, Ciombor KK, Cohen SA, Cooper HS, Deming DA, Garrido-Laguna I, Grem JL, Hoffe SE, Hubbard J, Hunt S, Kamel A, Kirilcuk N, Krishnamurthi S, Messersmith WA, Meyerhardt J, Miller ED, Mulcahy MF, Nurkin S, Overman MJ, Parikh A, Patel H, Pedersen KS, Saltz LB, Schneider C, Shibata D, Skibber JM, Sofocleous CT, Stoffel EM, Stotsky-Himelfarb E, Willett CG, Johnson-Chilla A, Gregory KM, Gurski LA
J Natl Compr Canc Netw 2019 Sep 1;17(9):1109-1133. doi: 10.6004/jnccn.2019.0043. PMID: 31487687Free PMC Article
Durmush D, Kaffes AJ
Curr Opin Gastroenterol 2019 May;35(3):235-242. doi: 10.1097/MOG.0000000000000531. PMID: 30865041
Aparicio T, Zaanan A, Mary F, Afchain P, Manfredi S, Evans TR
Gastroenterol Clin North Am 2016 Sep;45(3):447-57. doi: 10.1016/j.gtc.2016.04.004. PMID: 27546842

Diagnosis

Vlachou E, Koffas A, Toumpanakis C, Keuchel M
Best Pract Res Clin Gastroenterol 2023 Jun-Aug;64-65:101860. Epub 2023 Aug 12 doi: 10.1016/j.bpg.2023.101860. PMID: 37652650
Bailey R, LeGout JD
Abdom Radiol (NY) 2020 Apr;45(4):1218-1219. doi: 10.1007/s00261-020-02422-9. PMID: 32008113
Benson AB, Venook AP, Al-Hawary MM, Arain MA, Chen YJ, Ciombor KK, Cohen SA, Cooper HS, Deming DA, Garrido-Laguna I, Grem JL, Hoffe SE, Hubbard J, Hunt S, Kamel A, Kirilcuk N, Krishnamurthi S, Messersmith WA, Meyerhardt J, Miller ED, Mulcahy MF, Nurkin S, Overman MJ, Parikh A, Patel H, Pedersen KS, Saltz LB, Schneider C, Shibata D, Skibber JM, Sofocleous CT, Stoffel EM, Stotsky-Himelfarb E, Willett CG, Johnson-Chilla A, Gregory KM, Gurski LA
J Natl Compr Canc Netw 2019 Sep 1;17(9):1109-1133. doi: 10.6004/jnccn.2019.0043. PMID: 31487687Free PMC Article
Durmush D, Kaffes AJ
Curr Opin Gastroenterol 2019 May;35(3):235-242. doi: 10.1097/MOG.0000000000000531. PMID: 30865041
Zouhairi ME, Venner A, Charabaty A, Pishvaian MJ
Curr Treat Options Oncol 2008 Dec;9(4-6):388-99. Epub 2009 Apr 14 doi: 10.1007/s11864-009-0098-0. PMID: 19365735

Therapy

Symons R, Daly D, Gandy R, Goldstein D, Aghmesheh M
Curr Treat Options Oncol 2023 Apr;24(4):241-261. Epub 2023 Feb 24 doi: 10.1007/s11864-023-01058-3. PMID: 36826686
Bureš J, Kohoutová D, Zavoral M
Klin Onkol 2022 Fall;35(5):346-357. doi: 10.48095/ccko2022346. PMID: 36443091
Durmush D, Kaffes AJ
Curr Opin Gastroenterol 2019 May;35(3):235-242. doi: 10.1097/MOG.0000000000000531. PMID: 30865041
Aparicio T, Zaanan A, Mary F, Afchain P, Manfredi S, Evans TR
Gastroenterol Clin North Am 2016 Sep;45(3):447-57. doi: 10.1016/j.gtc.2016.04.004. PMID: 27546842
Zouhairi ME, Venner A, Charabaty A, Pishvaian MJ
Curr Treat Options Oncol 2008 Dec;9(4-6):388-99. Epub 2009 Apr 14 doi: 10.1007/s11864-009-0098-0. PMID: 19365735

Prognosis

Gelsomino F, Balsano R, De Lorenzo S, Garajová I
Curr Oncol 2022 Feb 17;29(2):1223-1236. doi: 10.3390/curroncol29020104. PMID: 35200603Free PMC Article
Zhu M, Li H, Wu Y, An Y, Wang Y, Ye C, Zhang D, Ma R, Wang X, Shao X, Guo X, Qi X
Adv Ther 2021 Jun;38(6):2779-2794. Epub 2021 Apr 29 doi: 10.1007/s12325-021-01750-6. PMID: 33914269Free PMC Article
Zouhairi ME, Venner A, Charabaty A, Pishvaian MJ
Curr Treat Options Oncol 2008 Dec;9(4-6):388-99. Epub 2009 Apr 14 doi: 10.1007/s11864-009-0098-0. PMID: 19365735
Schölmerich J
Endoscopy 1999 Jan;31(1):66-73. doi: 10.1055/s-1999-13650. PMID: 10082412
Tilson MD
Surg Clin North Am 1974 Apr;54(2):409-23. doi: 10.1016/s0039-6109(16)40288-4. PMID: 4593912

Clinical prediction guides

Chang B, Sheng W, Wang L, Zhu X, Tan C, Ni S, Weng W, Huang D, Wang J
Am J Surg Pathol 2022 Jul 1;46(7):889-906. Epub 2021 Nov 23 doi: 10.1097/PAS.0000000000001836. PMID: 34812766
Matsueda K, Kanzaki H, Takenaka R, Nakagawa M, Matsueda K, Iwamuro M, Kawano S, Kawahara Y, Toji T, Tanaka T, Yagi T, Fujiwara T, Okada H
PLoS One 2021;16(8):e0256797. Epub 2021 Aug 27 doi: 10.1371/journal.pone.0256797. PMID: 34449813Free PMC Article
Latham A, Shia J, Patel Z, Reidy-Lagunes DL, Segal NH, Yaeger R, Ganesh K, Connell L, Kemeny NE, Kelsen DP, Hechtman JF, Nash GM, Paty PB, Zehir A, Tkachuk KA, Sheikh R, Markowitz AJ, Mandelker D, Offit K, Berger MF, Cercek A, Garcia-Aguilar J, Saltz LB, Weiser MR, Stadler ZK
Clin Cancer Res 2021 Mar 1;27(5):1429-1437. Epub 2020 Nov 16 doi: 10.1158/1078-0432.CCR-20-2892. PMID: 33199489Free PMC Article
Bozhkov V, Magjov R, Chernopolsky P, Arnaudov P, Plachkov I, Ivanov T
Khirurgiia (Sofiia) 2015;81(2):4-8. PMID: 26668984
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article

Recent systematic reviews

Shin DW, Kim S, Jung K, Jung JH, Kim B, Ahn J, Kim J, Hwang JH, Lee JC
Eur J Surg Oncol 2023 Feb;49(2):306-315. Epub 2022 Oct 9 doi: 10.1016/j.ejso.2022.10.001. PMID: 36272870
Vleugels JLA, Hazewinkel Y, Fockens P, Dekker E
Gastrointest Endosc 2017 Jun;85(6):1169-1176.e1. Epub 2016 Dec 23 doi: 10.1016/j.gie.2016.12.014. PMID: 28024986
Bennett CM, Coleman HG, Veal PG, Cantwell MM, Lau CC, Murray LJ
Cancer Epidemiol 2015 Jun;39(3):265-73. Epub 2015 Feb 27 doi: 10.1016/j.canep.2015.02.001. PMID: 25736860
McDermott FD, Heeney A, Courtney D, Mohan H, Winter D
Surg Endosc 2014 Jul;28(7):2020-6. Epub 2014 Mar 1 doi: 10.1007/s00464-014-3430-0. PMID: 24584484
Heloury Y, Muthucumaru M, Panabokke G, Cheng W, Kimber C, Leclair MD
J Pediatr Surg 2012 Feb;47(2):415-21. doi: 10.1016/j.jpedsurg.2011.08.003. PMID: 22325405

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