U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Refractory Leukemia

MedGen UID:
1655716
•Concept ID:
C4725024
•
Neoplastic Process
Synonym: Advanced Leukemia

Definition

Leukemia that is resistant to treatment. [from NCI]

Professional guidelines

PubMed

Targeted cellular therapy for treatment of relapsed or refractory leukemia.
Scherer LD, Rouce RH
Best Pract Res Clin Haematol 2023 Sep;36(3):101481. Epub 2023 May 25 doi: 10.1016/j.beha.2023.101481. PMID: 37612000
Use of CAR T-cell for acute lymphoblastic leukemia (ALL) treatment: a review study.
Sheykhhasan M, Manoochehri H, Dama P
Cancer Gene Ther 2022 Aug;29(8-9):1080-1096. Epub 2022 Jan 5 doi: 10.1038/s41417-021-00418-1. PMID: 34987176Free PMC Article
The Role of Granulocyte Transfusions in Optimizing Candidacy for Chimeric Antigen Receptor T-cell Therapy in Patients With Treatment-refractory Infections.
Tambaro FP, Ragoonanan D, Tewari P, Petropoulos D, Aung FM, Mahadeo KM, Khazal S
J Pediatr Hematol Oncol 2022 Mar 1;44(2):e463-e466. doi: 10.1097/MPH.0000000000002111. PMID: 33625094

Recent clinical studies

Etiology

CAR-T Cell Therapy: the Efficacy and Toxicity Balance.
Chohan KL, Siegler EL, Kenderian SS
Curr Hematol Malig Rep 2023 Apr;18(2):9-18. Epub 2023 Feb 10 doi: 10.1007/s11899-023-00687-7. PMID: 36763238Free PMC Article
AVALON: The Italian cohort study on real-life efficacy of hypomethylating agents plus venetoclax in newly diagnosed or relapsed/refractory patients with acute myeloid leukemia.
Todisco E, Papayannidis C, Fracchiolla N, Petracci E, Zingaretti C, Vetro C, Martelli MP, Zappasodi P, Di Renzo N, Gallo S, Audisio E, Griguolo D, Cerchione C, Selleri C, Mattei D, Bernardi M, Fumagalli M, Rizzuto G, Facchini L, Basilico CM, Manfra I, Borlenghi E, Cairoli R, Salutari P, Gottardi M, Molteni A, Martini V, Lunghi M, Fianchi L, Cilloni D, Lanza F, Abruzzese E, Cascavilla N, Rivellini F, Ferrara F, Maurillo L, Nanni J, Romano A, Cardinali V, Gigli F, Roncoroni E, Federico V, Marconi G, Volpi R, Sciumè M, Tarella C, Rossi G, Martinelli G; AVALON Cooperative Group
Cancer 2023 Apr 1;129(7):992-1004. Epub 2023 Jan 24 doi: 10.1002/cncr.34608. PMID: 36692409
Characteristics and risk factors of infections following CD28-based CD19 CAR-T cells.
Wittmann Dayagi T, Sherman G, Bielorai B, Adam E, Besser MJ, Shimoni A, Nagler A, Toren A, Jacoby E, Avigdor A
Leuk Lymphoma 2021 Jul;62(7):1692-1701. Epub 2021 Feb 10 doi: 10.1080/10428194.2021.1881506. PMID: 33563059
Cord blood CD8+ T-cell expansion following granulocyte transfusions eradicates refractory leukemia.
Hiwarkar P, Adams S, Gilmour K, Nataraj R, Bonney D, Poulton K, Wynn R
Blood Adv 2020 Sep 8;4(17):4165-4174. doi: 10.1182/bloodadvances.2020001737. PMID: 32886752Free PMC Article
TACL'ing supportive care needs in pediatric early phase clinical trials for acute leukemia: A report from the therapeutic advances in childhood leukemia & lymphoma (TACL) consortium supportive care committee.
Orgel E, Auletta JJ
Pediatr Hematol Oncol 2017 Sep-Oct;34(6-7):409-417. Epub 2017 Nov 30 doi: 10.1080/08880018.2017.1395936. PMID: 29190169Free PMC Article

Diagnosis

CAR-T cells for the treatment of pediatric chronic myeloid leukemia in repeatedly relapsed lymphoid blast phase.
Kramp LJ, Heydrich-Karsten C, Sembill S, Karow A, Lion T, Chitadze G, Suttorp M, Cario G, Metzler M
Ann Hematol 2024 Nov;103(11):4811-4815. Epub 2024 Sep 21 doi: 10.1007/s00277-024-06011-4. PMID: 39304585Free PMC Article
The palmitoyltransferase ZDHHC21 regulates oxidative phosphorylation to induce differentiation block and stemness in AML.
Shao X, Xu A, Du W, Xu T, Huang Y, Xia Z, Wang W, Cai M, Zhang X, Zhang J, Cao J, Xu X, Yang B, He Q, Ying M
Blood 2023 Jul 27;142(4):365-381. doi: 10.1182/blood.2022019056. PMID: 37216691
Successful Treatment of Relapsed Pediatric Acute Myeloid Leukemia Presenting as Central Nervous System Myeloid Sarcoma: A Single-Institution Case Series.
Bujold KE, Dandekar S, Barbour M
J Pediatr Hematol Oncol 2020 May;42(4):319-321. doi: 10.1097/MPH.0000000000001383. PMID: 30543582
Palatal Swelling in a Patient With Refractory Leukemia.
France K, Stoopler ET, Tanaka TI
JAMA Dermatol 2019 Jan 1;155(1):109-110. doi: 10.1001/jamadermatol.2018.2299. PMID: 30140847
Poly (ADP-ribose) polymerase inhibitors selectively induce cytotoxicity in TCF3-HLF-positive leukemic cells.
Piao J, Takai S, Kamiya T, Inukai T, Sugita K, Ohyashiki K, Delia D, Masutani M, Mizutani S, Takagi M
Cancer Lett 2017 Feb 1;386:131-140. Epub 2016 Nov 25 doi: 10.1016/j.canlet.2016.11.021. PMID: 27894958

Therapy

CAR as Booster to Launch Allogeneic Transplantation in Refractory Leukemia.
Blaise D
N Engl J Med 2024 Apr 25;390(16):1526-1527. doi: 10.1056/NEJMe2403003. PMID: 38657249
The palmitoyltransferase ZDHHC21 regulates oxidative phosphorylation to induce differentiation block and stemness in AML.
Shao X, Xu A, Du W, Xu T, Huang Y, Xia Z, Wang W, Cai M, Zhang X, Zhang J, Cao J, Xu X, Yang B, He Q, Ying M
Blood 2023 Jul 27;142(4):365-381. doi: 10.1182/blood.2022019056. PMID: 37216691
CAR-T Cell Therapy: the Efficacy and Toxicity Balance.
Chohan KL, Siegler EL, Kenderian SS
Curr Hematol Malig Rep 2023 Apr;18(2):9-18. Epub 2023 Feb 10 doi: 10.1007/s11899-023-00687-7. PMID: 36763238Free PMC Article
Safety and efficacy of Sofosbuvir and Velpatasvir in children with active hepatitis C virus infection undergoing haploidentical transplantation.
Jaiswal SR, Bhakuni P, Soni M, Gupta M, Thatai A, Chakrabarti S
Transpl Infect Dis 2021 Apr;23(2):e13490. Epub 2020 Oct 22 doi: 10.1111/tid.13490. PMID: 33037697
Trials of 9-amino-20(S)-camptothecin in Boston.
Eder JP, Rubin E, Stone R, Bryant M, Xu G, Supko J, Kinchla N, Lynch T, Hurwitz S, Rodriguez D, Shapiro C, Toppmeyer D, Grossbard M, Vosburg E, Huberman M, Schnipper L, Shulman L, Kufe DW
Ann N Y Acad Sci 1996 Dec 13;803:247-55. doi: 10.1111/j.1749-6632.1996.tb26394.x. PMID: 8993518

Prognosis

Should Physicians Offer a Ventricular Assist Device to a Pediatric Oncology Patient With a Poor Prognosis?
Patel A, Joong A, Lelkes E, Gossett JG
AMA J Ethics 2019 May 1;21(5):E380-386. doi: 10.1001/amajethics.2019.380. PMID: 31127916
Poly (ADP-ribose) polymerase inhibitors selectively induce cytotoxicity in TCF3-HLF-positive leukemic cells.
Piao J, Takai S, Kamiya T, Inukai T, Sugita K, Ohyashiki K, Delia D, Masutani M, Mizutani S, Takagi M
Cancer Lett 2017 Feb 1;386:131-140. Epub 2016 Nov 25 doi: 10.1016/j.canlet.2016.11.021. PMID: 27894958
Acute myeloid leukemia with severe aplastic anemia following immunosuppressive therapy.
Bakhshi S, Gupta A, Kumar L
Indian J Pediatr 2006 Nov;73(11):1033-5. doi: 10.1007/BF02758313. PMID: 17127787
Phase I study of cloretazine (VNP40101M), a novel sulfonylhydrazine alkylating agent, combined with cytarabine in patients with refractory leukemia.
Giles F, Verstovsek S, Thomas D, Gerson S, Cortes J, Faderl S, Ferrajoli A, Ravandi F, Kornblau S, Garcia-Manero G, Jabbour E, O'Brien S, Karsten V, Cahill A, Yee K, Albitar M, Sznol M, Kantarjian H
Clin Cancer Res 2005 Nov 1;11(21):7817-24. doi: 10.1158/1078-0432.CCR-05-1070. PMID: 16278404
Trials of 9-amino-20(S)-camptothecin in Boston.
Eder JP, Rubin E, Stone R, Bryant M, Xu G, Supko J, Kinchla N, Lynch T, Hurwitz S, Rodriguez D, Shapiro C, Toppmeyer D, Grossbard M, Vosburg E, Huberman M, Schnipper L, Shulman L, Kufe DW
Ann N Y Acad Sci 1996 Dec 13;803:247-55. doi: 10.1111/j.1749-6632.1996.tb26394.x. PMID: 8993518

Clinical prediction guides

Cord blood CD8+ T-cell expansion following granulocyte transfusions eradicates refractory leukemia.
Hiwarkar P, Adams S, Gilmour K, Nataraj R, Bonney D, Poulton K, Wynn R
Blood Adv 2020 Sep 8;4(17):4165-4174. doi: 10.1182/bloodadvances.2020001737. PMID: 32886752Free PMC Article
Enhanced Bone Marrow Homing of Natural Killer Cells Following mRNA Transfection With Gain-of-Function Variant CXCR4(R334X).
Levy E, Reger R, Segerberg F, Lambert M, Leijonhufvud C, Baumer Y, Carlsten M, Childs R
Front Immunol 2019;10:1262. Epub 2019 Jun 5 doi: 10.3389/fimmu.2019.01262. PMID: 31231387Free PMC Article
Poly (ADP-ribose) polymerase inhibitors selectively induce cytotoxicity in TCF3-HLF-positive leukemic cells.
Piao J, Takai S, Kamiya T, Inukai T, Sugita K, Ohyashiki K, Delia D, Masutani M, Mizutani S, Takagi M
Cancer Lett 2017 Feb 1;386:131-140. Epub 2016 Nov 25 doi: 10.1016/j.canlet.2016.11.021. PMID: 27894958
Phase I study of cloretazine (VNP40101M), a novel sulfonylhydrazine alkylating agent, combined with cytarabine in patients with refractory leukemia.
Giles F, Verstovsek S, Thomas D, Gerson S, Cortes J, Faderl S, Ferrajoli A, Ravandi F, Kornblau S, Garcia-Manero G, Jabbour E, O'Brien S, Karsten V, Cahill A, Yee K, Albitar M, Sznol M, Kantarjian H
Clin Cancer Res 2005 Nov 1;11(21):7817-24. doi: 10.1158/1078-0432.CCR-05-1070. PMID: 16278404
Trials of 9-amino-20(S)-camptothecin in Boston.
Eder JP, Rubin E, Stone R, Bryant M, Xu G, Supko J, Kinchla N, Lynch T, Hurwitz S, Rodriguez D, Shapiro C, Toppmeyer D, Grossbard M, Vosburg E, Huberman M, Schnipper L, Shulman L, Kufe DW
Ann N Y Acad Sci 1996 Dec 13;803:247-55. doi: 10.1111/j.1749-6632.1996.tb26394.x. PMID: 8993518

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...