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T-cell large granular lymphocyte leukemia

MedGen UID:
363038
•Concept ID:
C1955861
•
Neoplastic Process
Synonyms: Granular Lymphocytoses, Large; Granular Lymphocytosis, Large; Large Granular Lymphocytoses; Large Granular Lymphocytosis; Leukemia, T Cell Large Granular Lymphocytic; Leukemia, T LGL; Leukemia, T-Cell Large Granular Lymphocytic; Leukemia, T-LGL; Leukemias, T-LGL; Lymphocytoses, Large Granular; Lymphocytosis, Large Granular; T Cell Large Granular Lymphocyte Leukemia; T Cell Large Granular Lymphocytic Leukemia; T LGL Leukemia; T-Cell Large Granular Lymphocyte Leukemia; T-Cell Large Granular Lymphocytic Leukemia; T-LGL Leukemia; T-LGL Leukemias
SNOMED CT: T-cell large granular lymphocytosis (128819001); T-cell large granular lymphocytic leukemia (128819001); T-cell large granular lymphocytic leukemia (699818003); T-cell large granular lymphocytosis (699818003); T-gamma lymphoproliferative disease (55081009)
 
Monarch Initiative: MONDO:0019469
Orphanet: ORPHA86872

Definition

T-cell large granular lymphocyte leukemia (T-cell LGL leukemia) is a lymphoproliferative malignancy that arises from the mature T-cell (CD3+) lineage. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVT-cell large granular lymphocyte leukemia
Follow this link to review classifications for T-cell large granular lymphocyte leukemia in Orphanet.

Professional guidelines

PubMed

Clinical features and treatment outcomes in patients with T-cell large granular lymphocytic leukemia: A single-institution experience.
Zhu Y, Gao Q, Hu J, Liu X, Guan D, Zhang F
Leuk Res 2020 Mar;90:106299. Epub 2020 Jan 21 doi: 10.1016/j.leukres.2020.106299. PMID: 32035354
T-cell large granular lymphocyte leukemia: A report on the treatment of 29 patients and a review of the literature.
Osuji N, Matutes E, Tjonnfjord G, Grech H, Del Giudice I, Wotherspoon A, Swansbury JG, Catovsky D
Cancer 2006 Aug 1;107(3):570-8. doi: 10.1002/cncr.22032. PMID: 16795070
CD52 expression in T-cell large granular lymphocyte leukemia--implications for treatment with alemtuzumab.
Osuji N, Del Giudice I, Matutes E, Morilla A, Owusu-Ankomah K, Morilla R, Dunlop A, Catovksy D
Leuk Lymphoma 2005 May;46(5):723-7. doi: 10.1080/10428190500052156. PMID: 16019510

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), T-Cell Lymphomas, 2024

Recent clinical studies

Etiology

Pro-inflammatory cells sustain leukemic clonal expansion in T-cell large granular lymphocyte leukemia.
Vicenzetto C, Gasparini VR, Barila G, Teramo A, Calabretto G, Rampazzo E, Carraro S, Trimarco V, Trentin L, Facco M, Semenzato G, Zambello R
Haematologica 2024 Jan 1;109(1):163-174. doi: 10.3324/haematol.2022.282306. PMID: 37439335Free PMC Article
Distinct mutational pattern of T-cell large granular lymphocyte leukemia combined with pure red cell aplasia: low mutational burden of STAT3.
Park S, Yun J, Choi SY, Jeong D, Gu JY, Lee JS, Seong MW, Chang YH, Yun H, Kim HK
Sci Rep 2023 May 4;13(1):7280. doi: 10.1038/s41598-023-33928-z. PMID: 37142644Free PMC Article
Aggressive T-cell large granular lymphocyte leukemia: a case report and review of the literature.
Alekshun TJ, Tao J, Sokol L
Am J Hematol 2007 Jun;82(6):481-5. doi: 10.1002/ajh.20853. PMID: 17205534
T-cell large granular lymphocyte leukemia: A report on the treatment of 29 patients and a review of the literature.
Osuji N, Matutes E, Tjonnfjord G, Grech H, Del Giudice I, Wotherspoon A, Swansbury JG, Catovsky D
Cancer 2006 Aug 1;107(3):570-8. doi: 10.1002/cncr.22032. PMID: 16795070
Histopathology of the spleen in T-cell large granular lymphocyte leukemia and T-cell prolymphocytic leukemia: a comparative review.
Osuji N, Matutes E, Catovsky D, Lampert I, Wotherspoon A
Am J Surg Pathol 2005 Jul;29(7):935-41. doi: 10.1097/01.pas.0000160732.43909.3f. PMID: 15958859

Diagnosis

Molecular Features and Diagnostic Challenges in Alpha/Beta T-Cell Large Granular Lymphocyte Leukemia.
Gaudio F, Masciopinto P, Bellitti E, Musto P, Arcuti E, Battisti O, Cazzato G, Solombrino A, Laddaga FE, Specchia G, Maiorano E, Ingravallo G
Int J Mol Sci 2022 Nov 2;23(21) doi: 10.3390/ijms232113392. PMID: 36362180Free PMC Article
Belinostat in Relapsed/Refractory T-Cell Large Granular Lymphocyte Leukemia.
Poh C, Arora M, Ghuman S, Tuscano J
Acta Haematol 2021;144(1):95-99. Epub 2020 Apr 29 doi: 10.1159/000506918. PMID: 32348994
T-Cell Large Granular Lymphocyte Leukemia in a Patient With Rheumatoid Arthritis.
Naji Rad S, Rafiee B, Raju G, Solhjoo M, Anand P
J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620941303. doi: 10.1177/2324709620941303. PMID: 32646239Free PMC Article
CD20-positive T-cell large granular lymphocyte leukemia: case report and review of the literature.
Miyazaki K, Ohsaka M, Suzuki Y, Danbara M, Horie R, Higashihara M
Intern Med 2009;48(16):1443-7. Epub 2009 Aug 17 doi: 10.2169/internalmedicine.48.2141. PMID: 19687595
T-cell large granular lymphocyte leukemia and related disorders.
Rose MG, Berliner N
Oncologist 2004;9(3):247-58. doi: 10.1634/theoncologist.9-3-247. PMID: 15169980

Therapy

Single-cell RNA sequencing coupled to TCR profiling of large granular lymphocyte leukemia T cells.
Gao S, Wu Z, Arnold B, Diamond C, Batchu S, Giudice V, Alemu L, Raffo DQ, Feng X, Kajigaya S, Barrett J, Ito S, Young NS
Nat Commun 2022 Apr 11;13(1):1982. doi: 10.1038/s41467-022-29175-x. PMID: 35411048Free PMC Article
Case Report: HTLV-1-Induced Adult T-Cell Leukemia and Tropical Spastic Paresis.
Rosenthal R, Kaplan J, Ahmed M, Mims M, Weatherhead JE
Am J Trop Med Hyg 2021 Sep 20;105(5):1298-1300. doi: 10.4269/ajtmh.20-1656. PMID: 34544038Free PMC Article
Belinostat in Relapsed/Refractory T-Cell Large Granular Lymphocyte Leukemia.
Poh C, Arora M, Ghuman S, Tuscano J
Acta Haematol 2021;144(1):95-99. Epub 2020 Apr 29 doi: 10.1159/000506918. PMID: 32348994
Aggressive T-cell large granular lymphocyte leukemia: a case report and review of the literature.
Alekshun TJ, Tao J, Sokol L
Am J Hematol 2007 Jun;82(6):481-5. doi: 10.1002/ajh.20853. PMID: 17205534
T-cell large granular lymphocyte leukemia: A report on the treatment of 29 patients and a review of the literature.
Osuji N, Matutes E, Tjonnfjord G, Grech H, Del Giudice I, Wotherspoon A, Swansbury JG, Catovsky D
Cancer 2006 Aug 1;107(3):570-8. doi: 10.1002/cncr.22032. PMID: 16795070

Prognosis

Molecular Features and Diagnostic Challenges in Alpha/Beta T-Cell Large Granular Lymphocyte Leukemia.
Gaudio F, Masciopinto P, Bellitti E, Musto P, Arcuti E, Battisti O, Cazzato G, Solombrino A, Laddaga FE, Specchia G, Maiorano E, Ingravallo G
Int J Mol Sci 2022 Nov 2;23(21) doi: 10.3390/ijms232113392. PMID: 36362180Free PMC Article
Single-cell RNA sequencing coupled to TCR profiling of large granular lymphocyte leukemia T cells.
Gao S, Wu Z, Arnold B, Diamond C, Batchu S, Giudice V, Alemu L, Raffo DQ, Feng X, Kajigaya S, Barrett J, Ito S, Young NS
Nat Commun 2022 Apr 11;13(1):1982. doi: 10.1038/s41467-022-29175-x. PMID: 35411048Free PMC Article
T-Cell Large Granular Lymphocyte Leukemia in a Patient With Rheumatoid Arthritis.
Naji Rad S, Rafiee B, Raju G, Solhjoo M, Anand P
J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620941303. doi: 10.1177/2324709620941303. PMID: 32646239Free PMC Article
T-cell large granular lymphocyte leukemia in solid organ transplant recipients: case series and review of the literature.
Alfano G, Fontana F, Colaci E, Mori G, Cerami C, Messerotti A, Potenza L, Luppi M, Cappelli G
Int J Hematol 2019 Sep;110(3):313-321. Epub 2019 Jun 27 doi: 10.1007/s12185-019-02682-2. PMID: 31250283
Diagnosis and therapy of neutropenia in large granular lymphocyte leukemia.
Mohan SR, Maciejewski JP
Curr Opin Hematol 2009 Jan;16(1):27-34. doi: 10.1097/MOH.0b013e32831c8407. PMID: 19057202

Clinical prediction guides

Single-cell RNA sequencing coupled to TCR profiling of large granular lymphocyte leukemia T cells.
Gao S, Wu Z, Arnold B, Diamond C, Batchu S, Giudice V, Alemu L, Raffo DQ, Feng X, Kajigaya S, Barrett J, Ito S, Young NS
Nat Commun 2022 Apr 11;13(1):1982. doi: 10.1038/s41467-022-29175-x. PMID: 35411048Free PMC Article
T-cell large granular lymphocyte leukemia: an Asian perspective.
Kwong YL, Au WY, Leung AY, Tse EW
Ann Hematol 2010 Apr;89(4):331-9. doi: 10.1007/s00277-009-0895-3. PMID: 20084380Free PMC Article
T-cell large granular lymphocyte leukemia: A report on the treatment of 29 patients and a review of the literature.
Osuji N, Matutes E, Tjonnfjord G, Grech H, Del Giudice I, Wotherspoon A, Swansbury JG, Catovsky D
Cancer 2006 Aug 1;107(3):570-8. doi: 10.1002/cncr.22032. PMID: 16795070
Pathogenesis of neutropenia in large granular lymphocyte leukemia and Felty syndrome.
Burks EJ, Loughran TP Jr
Blood Rev 2006 Sep;20(5):245-66. Epub 2006 Mar 10 doi: 10.1016/j.blre.2006.01.003. PMID: 16530306
Splenic involvement by peripheral T-cell and NK-cell neoplasms.
Chan JK
Semin Diagn Pathol 2003 May;20(2):105-20. doi: 10.1016/s0740-2570(03)00013-3. PMID: 12945934

Recent systematic reviews

Aggressive T-cell large granular lymphocyte leukemia: a case report and review of the literature.
Alekshun TJ, Tao J, Sokol L
Am J Hematol 2007 Jun;82(6):481-5. doi: 10.1002/ajh.20853. PMID: 17205534

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    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), T-Cell Lymphomas, 2024

    Reviews

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