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Metastatic Malignant Colorectal Neoplasm

MedGen UID:: 1690980
•Concept ID:: C5206819
•: Neoplastic Process

Definition

A malignant neoplasm that arises in the colon or rectum that has spread from its original site of growth to other anatomic sites. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVMetastatic Malignant Colorectal Neoplasm

Disorder by Site
- Disorder of gastrointestinal tract
  - Intestinal disorder
    - Intestinal neoplasm
      - Intestinal cancer
        Colorectal cancer
        Metastatic Malignant Colorectal Neoplasm
        Metastatic Colorectal Carcinoma
        Advanced Colorectal Carcinoma
        Advanced Colon Carcinoma
        Advanced Colorectal Adenocarcinoma
        Advanced Microsatellite Stable Colorectal Carcinoma
        Advanced Rectal Carcinoma
        Colorectal Carcinoma Metastatic in the Liver
        Colon Carcinoma Metastatic in the Liver
        Colorectal Adenocarcinoma Metastatic in the Liver
        Rectal Carcinoma Metastatic in the Liver
        Colorectal Carcinoma Metastatic in the Lung
        Colon Carcinoma Metastatic in the Lung
        Locally Advanced Colorectal Carcinoma
        Locally Advanced Colon Carcinoma
        Locally Advanced Microsatellite Stable Colorectal Carcinoma
        Locally Advanced Rectal Carcinoma
        Locally Advanced Unresectable Colorectal Adenocarcinoma
        Metastatic Colon Carcinoma
        Metastatic Colon Adenocarcinoma
        Metastatic Microsatellite Stable Colon Carcinoma
        Metastatic Colorectal Adenocarcinoma
        Metastatic Colorectal Mucinous Adenocarcinoma
        Metastatic Rectal Adenocarcinoma
        Metastatic Microsatellite Stable Colorectal Carcinoma
        Metastatic Rectal Carcinoma
        Metastatic Rectal Squamous Cell Carcinoma

Professional guidelines

PubMed

Metastatic colorectal cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up.

Cervantes A, Adam R, Roselló S, Arnold D, Normanno N, Taïeb J, Seligmann J, De Baere T, Osterlund P, Yoshino T, Martinelli E; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2023 Jan;34(1):10-32. Epub 2022 Oct 25 doi: 10.1016/j.annonc.2022.10.003. PMID: 36307056

Evidence-Based Clinical Practice Guidelines for Extramammary Paget Disease.

Kibbi N, Owen JL, Worley B, Wang JX, Harikumar V, Downing MB, Aasi SZ, Aung PP, Barker CA, Bolotin D, Bordeaux JS, Cartee TV, Chandra S, Cho NL, Choi JN, Chung KY, Cliby WA, Dorigo O, Eisen DB, Fujisawa Y, Golda N, Halfdanarson TR, Iavazzo C, Jiang SIB, Kanitakis J, Khan A, Kim JYS, Kuzel TM, Lawrence N, Leitao MM Jr, MacLean AB, Maher IA, Mittal BB, Nehal KS, Ozog DM, Pettaway CA, Ross JS, Rossi AM, Servaes S, Solomon MJ, Thomas VD, Tolia M, Voelzke BB, Waldman A, Wong MK, Zhou Y, Arai N, Brackett A, Ibrahim SA, Kang BY, Poon E, Alam M
JAMA Oncol 2022 Apr 1;8(4):618-628. doi: 10.1001/jamaoncol.2021.7148. PMID: 35050310

Diagnosis and Treatment of Metastatic Colorectal Cancer: A Review.

Biller LH, Schrag D
JAMA 2021 Feb 16;325(7):669-685. doi: 10.1001/jama.2021.0106. PMID: 33591350

See all (3311)

Recent clinical studies

Etiology

Using Circulating Tumor DNA in Colorectal Cancer: Current and Evolving Practices.

Malla M, Loree JM, Kasi PM, Parikh AR
J Clin Oncol 2022 Aug 20;40(24):2846-2857. Epub 2022 Jul 15 doi: 10.1200/JCO.21.02615. PMID: 35839443 Free PMC Article

Nivolumab for the treatment of colorectal cancer.

Smith KM, Desai J
Expert Rev Anticancer Ther 2018 Jul;18(7):611-618. Epub 2018 Jun 11 doi: 10.1080/14737140.2018.1480942. PMID: 29792730

Pseudoadjuvant chemotherapy in resectable metastatic colorectal cancer.

Polastro L, El Hachem G, Hendlisz A
Curr Opin Oncol 2018 Jul;30(4):269-275. doi: 10.1097/CCO.0000000000000455. PMID: 29762149

Liver Transplant for Nonhepatocellular Carcinoma Malignancy.

Haberal Reyhan N
Exp Clin Transplant 2017 Mar;15(Suppl 2):69-73. doi: 10.6002/ect.TOND16.L18. PMID: 28302003

Liver transplantation for nonresectable liver metastases from colorectal cancer.

Hagness M, Foss A, Line PD, Scholz T, Jørgensen PF, Fosby B, Boberg KM, Mathisen O, Gladhaug IP, Egge TS, Solberg S, Hausken J, Dueland S
Ann Surg 2013 May;257(5):800-6. doi: 10.1097/SLA.0b013e3182823957. PMID: 23360920

See all (19026)

Diagnosis

Using Circulating Tumor DNA in Colorectal Cancer: Current and Evolving Practices.

Malla M, Loree JM, Kasi PM, Parikh AR
J Clin Oncol 2022 Aug 20;40(24):2846-2857. Epub 2022 Jul 15 doi: 10.1200/JCO.21.02615. PMID: 35839443 Free PMC Article

Cancers Metastatic to the Liver.

Rashidian N, Alseidi A, Kirks RC
Surg Clin North Am 2020 Jun;100(3):551-563. Epub 2020 Apr 3 doi: 10.1016/j.suc.2020.02.005. PMID: 32402300

Pulmonary enteric adenocarcinoma: an overview.

Palmirotta R, Lovero D, D'Oronzo S, Todisco A, Internò V, Mele F, Stucci LS, Silvestris F
Expert Rev Mol Med 2020 Apr 28;22:e1. doi: 10.1017/erm.2020.2. PMID: 32340641

Colorectal Cancer:: Imaging Conundrums.

Hall NC, Ruutiainen AT
Surg Oncol Clin N Am 2018 Apr;27(2):289-302. Epub 2018 Jan 20 doi: 10.1016/j.soc.2017.11.004. PMID: 29496090

Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: analysis of 1001 consecutive cases.

Fong Y, Fortner J, Sun RL, Brennan MF, Blumgart LH
Ann Surg 1999 Sep;230(3):309-18; discussion 318-21. doi: 10.1097/00000658-199909000-00004. PMID: 10493478 Free PMC Article

See all (13143)

Therapy

Organ-specific cholesterol metabolic aberration fuels liver metastasis of colorectal cancer.

Zhang KL, Zhu WW, Wang SH, Gao C, Pan JJ, Du ZG, Lu L, Jia HL, Dong QZ, Chen JH, Lu M, Qin LX
Theranostics 2021;11(13):6560-6572. Epub 2021 Apr 27 doi: 10.7150/thno.55609. PMID: 33995676 Free PMC Article

Trifluridine/tipiracil plus bevacizumab for third-line management of metastatic colorectal cancer: SUNLIGHT study design.

Tabernero J, Taieb J, Prager GW, Ciardiello F, Fakih M, Leger C, Fougeray R, Amellal N, van Cutsem E
Future Oncol 2021 Jun;17(16):1977-1985. Epub 2021 Feb 11 doi: 10.2217/fon-2020-1238. PMID: 33569986

Chemotherapy Maintenance.

Kasi PM, Grothey A
Cancer J 2016 May-Jun;22(3):199-204. doi: 10.1097/PPO.0000000000000195. PMID: 27341599

Role of surgery in colorectal cancer liver metastases.

Akgül Ö, Çetinkaya E, Ersöz Ş, Tez M
World J Gastroenterol 2014 May 28;20(20):6113-22. doi: 10.3748/wjg.v20.i20.6113. PMID: 24876733 Free PMC Article

Liver transplantation for nonresectable liver metastases from colorectal cancer.

See all (17843)

Prognosis

Stathmin expression in metastatic colorectal cancer.

Leiphrakpam PD, Lazenby AJ, Smith LM, Brattain MG, Are C
J Surg Oncol 2021 May;123(8):1764-1772. Epub 2021 Mar 25 doi: 10.1002/jso.26464. PMID: 33765336

Cancers Metastatic to the Liver.

Rashidian N, Alseidi A, Kirks RC
Surg Clin North Am 2020 Jun;100(3):551-563. Epub 2020 Apr 3 doi: 10.1016/j.suc.2020.02.005. PMID: 32402300

Contemporary surgical options for metastatic colorectal cancer.

Sun Z, Thacker JM
Curr Oncol Rep 2015 Apr;17(4):13. doi: 10.1007/s11912-015-0437-1. PMID: 25708798

Colorectal cancer.

Brenner H, Kloor M, Pox CP
Lancet 2014 Apr 26;383(9927):1490-1502. Epub 2013 Nov 11 doi: 10.1016/S0140-6736(13)61649-9. PMID: 24225001

Colorectal cancer in young adults.

Zbuk K, Sidebotham EL, Bleyer A, La Quaglia MP
Semin Oncol 2009 Oct;36(5):439-50. doi: 10.1053/j.seminoncol.2009.07.008. PMID: 19835739

See all (18201)

Clinical prediction guides

Disseminated epithelial cancers-An autopsy analysis.

Vaideeswar P, Patil S, Chaudhari J
Indian J Pathol Microbiol 2022 Jan-Mar;65(1):76-86. doi: 10.4103/IJPM.IJPM_1048_20. PMID: 35074969

Chemotherapy for colorectal cancer in the elderly.

Kim JH
World J Gastroenterol 2015 May 7;21(17):5158-66. doi: 10.3748/wjg.v21.i17.5158. PMID: 25954089 Free PMC Article

Targeting BRAF mutant metastatic colorectal cancer: clinical implications and emerging therapeutic strategies.

Tie J, Desai J
Target Oncol 2015 Jun;10(2):179-88. Epub 2014 Aug 15 doi: 10.1007/s11523-014-0330-0. PMID: 25119972

Colorectal cancer: all hands on deck.

Venook AP, Weiser MR, Tepper JE
Am Soc Clin Oncol Educ Book 2014:83-9. doi: 10.14694/EdBook_AM.2014.34.83. PMID: 24857064

Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: analysis of 1001 consecutive cases.

Fong Y, Fortner J, Sun RL, Brennan MF, Blumgart LH
Ann Surg 1999 Sep;230(3):309-18; discussion 318-21. doi: 10.1097/00000658-199909000-00004. PMID: 10493478 Free PMC Article

See all (14137)

Recent systematic reviews

Meta-analysis of neoadjuvant immunotherapy for non-metastatic colorectal cancer.

Zhou L, Yang XQ, Zhao GY, Wang FJ, Liu X
Front Immunol 2023;14:1044353. Epub 2023 Jan 27 doi: 10.3389/fimmu.2023.1044353. PMID: 36776899 Free PMC Article

Treatment of Metastatic Colorectal Cancer: ASCO Guideline.

Morris VK, Kennedy EB, Baxter NN, Benson AB 3rd, Cercek A, Cho M, Ciombor KK, Cremolini C, Davis A, Deming DA, Fakih MG, Gholami S, Hong TS, Jaiyesimi I, Klute K, Lieu C, Sanoff H, Strickler JH, White S, Willis JA, Eng C
J Clin Oncol 2023 Jan 20;41(3):678-700. Epub 2022 Oct 17 doi: 10.1200/JCO.22.01690. PMID: 36252154 Free PMC Article

KRAS and BRAF Mutations in Stage II and III Colon Cancer: A Systematic Review and Meta-Analysis.

Formica V, Sera F, Cremolini C, Riondino S, Morelli C, Arkenau HT, Roselli M
J Natl Cancer Inst 2022 Apr 11;114(4):517-527. doi: 10.1093/jnci/djab190. PMID: 34542636 Free PMC Article

Risk Factors for Early-Onset Colorectal Cancer: A Systematic Review and Meta-analysis.

O'Sullivan DE, Sutherland RL, Town S, Chow K, Fan J, Forbes N, Heitman SJ, Hilsden RJ, Brenner DR
Clin Gastroenterol Hepatol 2022 Jun;20(6):1229-1240.e5. Epub 2021 Jan 29 doi: 10.1016/j.cgh.2021.01.037. PMID: 33524598

The Role of Maintenance Strategies in Metastatic Colorectal Cancer: A Systematic Review and Network Meta-analysis of Randomized Clinical Trials.

Sonbol MB, Mountjoy LJ, Firwana B, Liu AJ, Almader-Douglas D, Mody K, Hubbard J, Borad M, Ahn DH, Murad MH, Bekaii-Saab T
JAMA Oncol 2020 Mar 1;6(3):e194489. Epub 2020 Mar 12 doi: 10.1001/jamaoncol.2019.4489. PMID: 31855256 Free PMC Article

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