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ALK-positive anaplastic large cell lymphoma

MedGen UID:
233117
Concept ID:
C1332079
Neoplastic Process
Synonyms: ALCL, ALK+; ALK+ ALCL; ALK+ anaplastic large cell lymphoma; ALK-Positive Anaplastic Large Cell Lymphoma; ALKoma; Anaplastic Large Cell Lymphoma, ALK-Positive; anaplastic large cell lymphoma, ALK-positive
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0017602
Orphanet: ORPHA300895

Definition

A type of ALCL, a rare and aggressive peripheral T-cell non-Hodgkin lymphoma affecting lymph nodes and extranodal sites, which is characterized by the expression of a protein called anaplastic lymphoma kinase (ALK). [from ORDO]

Professional guidelines

PubMed

Rigaud C, Knörr F, Brugières L, Woessmann W
Best Pract Res Clin Haematol 2023 Mar;36(1):101444. Epub 2023 Feb 2 doi: 10.1016/j.beha.2023.101444. PMID: 36907641
Rigaud C, Abbas R, Grand D, Minard-Colin V, Aladjidi N, Buchbinder N, Garnier N, Plat G, Couec ML, Duplan M, Lambilliotte A, Schmitt C, Leblanc T, Lamant L, Brugières L
Pediatr Blood Cancer 2021 Jun;68(6):e28982. Epub 2021 Mar 9 doi: 10.1002/pbc.28982. PMID: 33687135
Gooptu M, Rhoades R, Pro B
Cancer Treat Res 2015;165:289-303. doi: 10.1007/978-3-319-13150-4_12. PMID: 25655615

Recent clinical studies

Etiology

Chiattone C, Civallero M, Fischer T, Miranda E, Manni M, Zing NPC, Pileri SA, Montoto S, Horwitz SM, Cabrera ME, De Souza CA, Nagler A, Luminari S, Ferreri AJM, Carson KR, Re A, Rigacci L, Nassi L, Stepanishyna Y, Federico M, Inghirami G
Hematol Oncol 2022 Dec;40(5):953-961. Epub 2022 Sep 15 doi: 10.1002/hon.3074. PMID: 36083035
Subbiah V, Kuravi S, Ganguly S, Welch DR, Vivian CJ, Mushtaq MU, Hegde A, Iyer S, Behrang A, Ali SM, Madison RW, Venstrom JM, Jensen RA, McGuirk JP, Amin HM, Balusu R
ESMO Open 2021 Aug;6(4):100172. Epub 2021 Jul 7 doi: 10.1016/j.esmoop.2021.100172. PMID: 34242968Free PMC Article
Bonzheim I, Steinhilber J, Fend F, Lamant L, Quintanilla-Martinez L
Front Biosci (Schol Ed) 2015 Jun 1;7(2):248-59. doi: 10.2741/S438. PMID: 25961700
Damm-Welk C, Pillon M, Woessmann W, Mussolin L
Front Biosci (Schol Ed) 2015 Jun 1;7(2):205-16. doi: 10.2741/S434. PMID: 25961696
Schmitz N, Wu HS, Glass B
Semin Hematol 2014 Jan;51(1):67-72. Epub 2013 Nov 28 doi: 10.1053/j.seminhematol.2013.11.010. PMID: 24468318

Diagnosis

Mu W, Zhang M, Hu G, Han Y, Mao X, Chen C, Shen K, Dai Z, Zhu X, Zhou X, Huang L, Ao Q, Xiao M
Front Immunol 2023;14:1280007. Epub 2023 Dec 8 doi: 10.3389/fimmu.2023.1280007. PMID: 38143760Free PMC Article
Rigaud C, Knörr F, Brugières L, Woessmann W
Best Pract Res Clin Haematol 2023 Mar;36(1):101444. Epub 2023 Feb 2 doi: 10.1016/j.beha.2023.101444. PMID: 36907641
Brivio E, Baruchel A, Beishuizen A, Bourquin JP, Brown PA, Cooper T, Gore L, Kolb EA, Locatelli F, Maude SL, Mussai FJ, Vormoor-Bürger B, Vormoor J, von Stackelberg A, Zwaan CM
Eur J Cancer 2022 Mar;164:1-17. Epub 2022 Feb 1 doi: 10.1016/j.ejca.2021.12.029. PMID: 35121370
Bonzheim I, Steinhilber J, Fend F, Lamant L, Quintanilla-Martinez L
Front Biosci (Schol Ed) 2015 Jun 1;7(2):248-59. doi: 10.2741/S438. PMID: 25961700
Damm-Welk C, Pillon M, Woessmann W, Mussolin L
Front Biosci (Schol Ed) 2015 Jun 1;7(2):205-16. doi: 10.2741/S434. PMID: 25961696

Therapy

Brugières L, Cozic N, Houot R, Rigaud C, Sibon D, Arfi-Rouche J, Bories P, Cottereau AS, Delmer A, Ducassou S, Garnier N, Lamant L, Leruste A, Millot F, Moalla S, Morschhauser F, Nolla M, Pagnier A, Reguerre Y, Renaud L, Schmitt A, Simonin M, Verschuur A, Hoog Labouret N, Mahier Ait Oukhatar C, Vassal G
Eur J Cancer 2023 Sep;191:112984. Epub 2023 Jul 17 doi: 10.1016/j.ejca.2023.112984. PMID: 37549532
Rigaud C, Knörr F, Brugières L, Woessmann W
Best Pract Res Clin Haematol 2023 Mar;36(1):101444. Epub 2023 Feb 2 doi: 10.1016/j.beha.2023.101444. PMID: 36907641
Subbiah V, Kuravi S, Ganguly S, Welch DR, Vivian CJ, Mushtaq MU, Hegde A, Iyer S, Behrang A, Ali SM, Madison RW, Venstrom JM, Jensen RA, McGuirk JP, Amin HM, Balusu R
ESMO Open 2021 Aug;6(4):100172. Epub 2021 Jul 7 doi: 10.1016/j.esmoop.2021.100172. PMID: 34242968Free PMC Article
Hwang J, Song I, Lee K, Kim HR, Hong EH, Hwang JS, Ahn SH, Lee J
Invest New Drugs 2020 Oct;38(5):1282-1291. Epub 2020 Jan 20 doi: 10.1007/s10637-020-00896-4. PMID: 31956933
Zhang Y, Xu W, Liu H, Li J
J Hematol Oncol 2016 Apr 12;9:37. doi: 10.1186/s13045-016-0267-0. PMID: 27071634Free PMC Article

Prognosis

Rigaud C, Knörr F, Brugières L, Woessmann W
Best Pract Res Clin Haematol 2023 Mar;36(1):101444. Epub 2023 Feb 2 doi: 10.1016/j.beha.2023.101444. PMID: 36907641
Brivio E, Baruchel A, Beishuizen A, Bourquin JP, Brown PA, Cooper T, Gore L, Kolb EA, Locatelli F, Maude SL, Mussai FJ, Vormoor-Bürger B, Vormoor J, von Stackelberg A, Zwaan CM
Eur J Cancer 2022 Mar;164:1-17. Epub 2022 Feb 1 doi: 10.1016/j.ejca.2021.12.029. PMID: 35121370
Choi JW, Lee Y, Kim H, Cho HY, Min SK, Kim YS
Am J Surg Pathol 2022 Feb 1;46(2):241-248. doi: 10.1097/PAS.0000000000001820. PMID: 34619707
Damm-Welk C, Pillon M, Woessmann W, Mussolin L
Front Biosci (Schol Ed) 2015 Jun 1;7(2):205-16. doi: 10.2741/S434. PMID: 25961696
Schmitz N, Wu HS, Glass B
Semin Hematol 2014 Jan;51(1):67-72. Epub 2013 Nov 28 doi: 10.1053/j.seminhematol.2013.11.010. PMID: 24468318

Clinical prediction guides

Mu W, Zhang M, Hu G, Han Y, Mao X, Chen C, Shen K, Dai Z, Zhu X, Zhou X, Huang L, Ao Q, Xiao M
Front Immunol 2023;14:1280007. Epub 2023 Dec 8 doi: 10.3389/fimmu.2023.1280007. PMID: 38143760Free PMC Article
Chiattone C, Civallero M, Fischer T, Miranda E, Manni M, Zing NPC, Pileri SA, Montoto S, Horwitz SM, Cabrera ME, De Souza CA, Nagler A, Luminari S, Ferreri AJM, Carson KR, Re A, Rigacci L, Nassi L, Stepanishyna Y, Federico M, Inghirami G
Hematol Oncol 2022 Dec;40(5):953-961. Epub 2022 Sep 15 doi: 10.1002/hon.3074. PMID: 36083035
Choi JW, Lee Y, Kim H, Cho HY, Min SK, Kim YS
Am J Surg Pathol 2022 Feb 1;46(2):241-248. doi: 10.1097/PAS.0000000000001820. PMID: 34619707
Bonzheim I, Steinhilber J, Fend F, Lamant L, Quintanilla-Martinez L
Front Biosci (Schol Ed) 2015 Jun 1;7(2):248-59. doi: 10.2741/S438. PMID: 25961700
de Leval L, Bisig B, Thielen C, Boniver J, Gaulard P
Crit Rev Oncol Hematol 2009 Nov;72(2):125-43. Epub 2009 Feb 23 doi: 10.1016/j.critrevonc.2009.01.002. PMID: 19233683

Recent systematic reviews

Song F, Yu S, Jia M, Gao H, Sun PL
Int J Surg Pathol 2021 Sep;29(6):658-666. Epub 2021 Jan 11 doi: 10.1177/1066896920986967. PMID: 33427000

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