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Metastatic Malignant Neoplasm in the Retina

MedGen UID:
146904
•Concept ID:
C0686477
•
Neoplastic Process
Synonyms: Metastasis to the Retina; Metastatic malignant neoplasm of retina; Metastatic malignant neoplasm to retina; Metastatic Malignant Neoplasm to the Retina; Metastatic Neoplasm to the Retina; Metastatic Tumor to the Retina; Secondary malignant neoplasm of retina
SNOMED CT: Secondary malignant neoplasm of retina (94516003); Metastatic malignant neoplasm to retina (94516003); Metastatic malignant neoplasm of retina (94516003)

Definition

A malignant neoplasm that has spread to the retina from another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Malignant Neoplasm in the Retina

Professional guidelines

PubMed

Vitreous metastasis from cutaneous melanoma: diagnosis and management.
Ashkenazy N, Harbour JW, Dubovy SR, Albini TA, Sridhar J, Patel N, Hansen ED, Uchiyama E, Rubsamen PE, Correa ZM
Arq Bras Oftalmol 2023;87(5):e20220215. Epub 2023 Apr 17 doi: 10.5935/0004-2749.2022-0215. PMID: 39298731Free PMC Article
Vasoproliferative retinal tumors: Clinical presentation and treatment outcome.
Kiri H, Raval V, Ali H, Das AV, Kaliki S
Eur J Ophthalmol 2023 Jul;33(4):1596-1603. Epub 2022 Dec 27 doi: 10.1177/11206721221149075. PMID: 36575603
Treatment of metastatic uveal melanoma in 2022: improved treatment regimens and improved prognosis.
Reichstein D, Brock A, Lietman C, McKean M
Curr Opin Ophthalmol 2022 Nov 1;33(6):585-590. Epub 2022 Sep 8 doi: 10.1097/ICU.0000000000000905. PMID: 36094043

Recent clinical studies

Etiology

Epiretinal membrane: A review.
Fung AT, Galvin J, Tran T
Clin Exp Ophthalmol 2021 Apr;49(3):289-308. Epub 2021 Mar 24 doi: 10.1111/ceo.13914. PMID: 33656784
Conditional Survival in Uveal Melanoma.
Zabor EC, Radivoyevitch T, Singh AD, Kilic E, de Klein JEMM, Kalirai H, Coupland SE
Ophthalmol Retina 2021 Jun;5(6):536-542. Epub 2020 Sep 23 doi: 10.1016/j.oret.2020.09.015. PMID: 32979556
Retinoblastoma: An update.
Delhiwala KS, Vadakkal IP, Mulay K, Khetan V, Wick MR
Semin Diagn Pathol 2016 May;33(3):133-40. Epub 2015 Oct 23 doi: 10.1053/j.semdp.2015.10.007. PMID: 26969537
Understanding intraocular lymphomas.
Coupland SE, Damato B
Clin Exp Ophthalmol 2008 Aug;36(6):564-78. doi: 10.1111/j.1442-9071.2008.01843.x. PMID: 18954321
Retinoblastoma.
Aerts I, Lumbroso-Le Rouic L, Gauthier-Villars M, Brisse H, Doz F, Desjardins L
Orphanet J Rare Dis 2006 Aug 25;1:31. doi: 10.1186/1750-1172-1-31. PMID: 16934146Free PMC Article

Diagnosis

Epiretinal membrane: A review.
Fung AT, Galvin J, Tran T
Clin Exp Ophthalmol 2021 Apr;49(3):289-308. Epub 2021 Mar 24 doi: 10.1111/ceo.13914. PMID: 33656784
Retinal meteor.
Venkatesh R, Gurav P, Dave PA, Roy S
Indian J Ophthalmol 2017 Sep;65(9):879-881. doi: 10.4103/ijo.IJO_68_17. PMID: 28905838Free PMC Article
Retinoblastoma.
Rao R, Honavar SG
Indian J Pediatr 2017 Dec;84(12):937-944. Epub 2017 Jun 16 doi: 10.1007/s12098-017-2395-0. PMID: 28620731
Ipilimumab-Associated Retinopathy.
Crews J, Agarwal A, Jack L, Xu D, Do DV, Nguyen QD
Ophthalmic Surg Lasers Imaging Retina 2015 Jun;46(6):658-60. doi: 10.3928/23258160-20150610-10. PMID: 26114847
Retinoblastoma.
Aerts I, Lumbroso-Le Rouic L, Gauthier-Villars M, Brisse H, Doz F, Desjardins L
Orphanet J Rare Dis 2006 Aug 25;1:31. doi: 10.1186/1750-1172-1-31. PMID: 16934146Free PMC Article

Therapy

VITREOUS SEEDING OF CHOROIDAL MELANOMA.
Raval V, Bowen RC, Soto H, Biscotti C, Yeaney G, Sears J, Singh A
Retina 2021 Apr 1;41(4):890-894. doi: 10.1097/IAE.0000000000002989. PMID: 33009220
Pimasertib-associated ophthalmological adverse events.
van Dijk EHC, Kruit WHJ, Jager MJ, Luyten GPM, Vingerling JR, Boon CJF
Acta Ophthalmol 2018 Nov;96(7):712-718. Epub 2018 Jan 16 doi: 10.1111/aos.13677. PMID: 29338133
Ophthalmic manifestations of leukemia.
Talcott KE, Garg RJ, Garg SJ
Curr Opin Ophthalmol 2016 Nov;27(6):545-551. doi: 10.1097/ICU.0000000000000309. PMID: 27585213
Ipilimumab-Associated Retinopathy.
Crews J, Agarwal A, Jack L, Xu D, Do DV, Nguyen QD
Ophthalmic Surg Lasers Imaging Retina 2015 Jun;46(6):658-60. doi: 10.3928/23258160-20150610-10. PMID: 26114847
Intraocular lymphoma: a clinical perspective.
Davis JL
Eye (Lond) 2013 Feb;27(2):153-62. Epub 2012 Nov 30 doi: 10.1038/eye.2012.250. PMID: 23196650Free PMC Article

Prognosis

Exploring the FGF/FGFR System in Ocular Tumors: New Insights and Perspectives.
Loda A, Turati M, Semeraro F, Rezzola S, Ronca R
Int J Mol Sci 2022 Mar 30;23(7) doi: 10.3390/ijms23073835. PMID: 35409195Free PMC Article
Epiretinal membrane: A review.
Fung AT, Galvin J, Tran T
Clin Exp Ophthalmol 2021 Apr;49(3):289-308. Epub 2021 Mar 24 doi: 10.1111/ceo.13914. PMID: 33656784
Orbital metastases.
Ng E, Ilsen PF
Optometry 2010 Dec;81(12):647-57. doi: 10.1016/j.optm.2010.07.026. PMID: 21111373
Understanding intraocular lymphomas.
Coupland SE, Damato B
Clin Exp Ophthalmol 2008 Aug;36(6):564-78. doi: 10.1111/j.1442-9071.2008.01843.x. PMID: 18954321
Retinoblastoma.
Aerts I, Lumbroso-Le Rouic L, Gauthier-Villars M, Brisse H, Doz F, Desjardins L
Orphanet J Rare Dis 2006 Aug 25;1:31. doi: 10.1186/1750-1172-1-31. PMID: 16934146Free PMC Article

Clinical prediction guides

Detection of metastases using circulating tumour DNA in uveal melanoma.
Beasley AB, de Bruyn DP, Calapre L, Al-Ogaili Z, Isaacs TW, Bentel J, Reid AL, Dwarkasing RS, Pereira MR, Khattak MA, Meniawy TM, Millward M, Brosens E, de Klein A, Chen FK, Kiliҫ E, Gray ES
J Cancer Res Clin Oncol 2023 Nov;149(16):14953-14963. Epub 2023 Aug 22 doi: 10.1007/s00432-023-05271-3. PMID: 37608028Free PMC Article
Epiretinal membrane: A review.
Fung AT, Galvin J, Tran T
Clin Exp Ophthalmol 2021 Apr;49(3):289-308. Epub 2021 Mar 24 doi: 10.1111/ceo.13914. PMID: 33656784
Conditional Survival in Uveal Melanoma.
Zabor EC, Radivoyevitch T, Singh AD, Kilic E, de Klein JEMM, Kalirai H, Coupland SE
Ophthalmol Retina 2021 Jun;5(6):536-542. Epub 2020 Sep 23 doi: 10.1016/j.oret.2020.09.015. PMID: 32979556
Ipilimumab-Associated Retinopathy.
Crews J, Agarwal A, Jack L, Xu D, Do DV, Nguyen QD
Ophthalmic Surg Lasers Imaging Retina 2015 Jun;46(6):658-60. doi: 10.3928/23258160-20150610-10. PMID: 26114847
Retinoblastoma.
Aerts I, Lumbroso-Le Rouic L, Gauthier-Villars M, Brisse H, Doz F, Desjardins L
Orphanet J Rare Dis 2006 Aug 25;1:31. doi: 10.1186/1750-1172-1-31. PMID: 16934146Free PMC Article

Recent systematic reviews

Eye involvement in primary central nervous system lymphoma.
Farrall AL, Smith JR
Surv Ophthalmol 2020 Sep-Oct;65(5):548-561. Epub 2020 Feb 11 doi: 10.1016/j.survophthal.2020.02.001. PMID: 32057762
Retinal infiltrates secondary to metastatic squamous cell carcinoma masquerading as infectious retinitis.
Singh RP, Steinle NC, Bedi R, Kaiser P, Lowder CY
Retin Cases Brief Rep 2014 Fall;8(4):333-5. doi: 10.1097/ICB.0000000000000062. PMID: 25372541
Evaluating the risk of extraocular tumour spread following intravitreal injection therapy for retinoblastoma: a systematic review.
Smith SJ, Smith BD
Br J Ophthalmol 2013 Oct;97(10):1231-6. Epub 2013 Jun 5 doi: 10.1136/bjophthalmol-2013-303188. PMID: 23740960
Cutaneous malignant melanoma metastatic to the eye, lids, and orbit.
Rosenberg C, Finger PT
Surv Ophthalmol 2008 May-Jun;53(3):187-202. doi: 10.1016/j.survophthal.2008.02.003. PMID: 18501266

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