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Major salivary gland cancer

MedGen UID:
96919
•Concept ID:
C0496763
•
Neoplastic Process
Synonyms: cancer of major salivary gland; major salivary gland cancer; Malignant Major Salivary Gland Neoplasm; malignant major salivary gland neoplasm; Malignant Major Salivary Gland Tumor; malignant major salivary gland tumor; malignant major salivary gland tumour; Malignant Neoplasm of Major Salivary Gland; malignant neoplasm of major salivary gland; Malignant neoplasm of major salivary glands; malignant neoplasm of major salivary glands; Malignant Neoplasm of the Major Salivary Gland; malignant neoplasm of the major salivary gland; Malignant tumor of major salivary gland; Malignant Tumor of Major Salivary Gland; malignant tumor of major salivary gland; Malignant Tumor of the Major Salivary Gland; malignant tumor of the major salivary gland; malignant tumour of major salivary gland; malignant tumour of the major salivary gland
SNOMED CT: Malignant neoplasm of major salivary glands (363378008); Malignant tumor of major salivary gland (363378008)
 
Monarch Initiative: MONDO:0044743

Definition

A primary or metastatic malignant neoplasm affecting the major salivary glands. Representative examples include carcinoma, lymphoma, and sarcoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMajor salivary gland cancer

Professional guidelines

PubMed

Surgery of major salivary gland cancers: REFCOR recommendations by the formal consensus method.
Barry B, Verillaud B, Jegoux F, Pham Dang N, Baujat B, Chabrillac E, Vergez S, Fakhry N
Eur Ann Otorhinolaryngol Head Neck Dis 2024 May;141(3):153-160. Epub 2023 Nov 30 doi: 10.1016/j.anorl.2023.11.005. PMID: 38040591
Outcomes and prognostic factors in modern era management of major salivary gland cancer.
Jegadeesh N, Liu Y, Prabhu RS, Magliocca KR, Marcus DM, Higgins KA, Vainshtein JM, Trad Wadsworth J, Beitler JJ
Oral Oncol 2015 Aug;51(8):770-7. Epub 2015 May 29 doi: 10.1016/j.oraloncology.2015.05.005. PMID: 26033470Free PMC Article
Observations on the natural history and treatment of recurrent major salivary gland cancer.
Armstrong JG, Harrison LB, Spiro RH, Fass DE, Strong EW, Fuks ZY
J Surg Oncol 1990 Jul;44(3):138-41. doi: 10.1002/jso.2930440303. PMID: 2370797

Recent clinical studies

Etiology

Patterns and Trends in Adjuvant Therapy for Major Salivary Gland Cancer.
Patel AM, Haleem A, Choudhry HS, Povolotskiy R, Roden DF
Otolaryngol Head Neck Surg 2024 Jul;171(1):155-171. Epub 2024 Mar 14 doi: 10.1002/ohn.715. PMID: 38482915
Surgery of major salivary gland cancers: REFCOR recommendations by the formal consensus method.
Barry B, Verillaud B, Jegoux F, Pham Dang N, Baujat B, Chabrillac E, Vergez S, Fakhry N
Eur Ann Otorhinolaryngol Head Neck Dis 2024 May;141(3):153-160. Epub 2023 Nov 30 doi: 10.1016/j.anorl.2023.11.005. PMID: 38040591
Evaluation of Surgical Margin Status in Patients With Salivary Gland Cancer.
Hanson M, McGill M, Mimica X, Eagan A, Hay A, Wu J, Cohen MA, Patel SG, Ganly I
JAMA Otolaryngol Head Neck Surg 2022 Feb 1;148(2):128-138. doi: 10.1001/jamaoto.2021.3459. PMID: 34854898Free PMC Article
Major Salivary Gland Cancer With Distant Metastasis Upon Presentation: Patterns, Outcomes, and Imaging Implications.
Benchetrit L, Mehra S, Mahajan A, Rahmati RW, Judson BL, Edwards HA
Otolaryngol Head Neck Surg 2022 Aug;167(2):305-315. Epub 2021 Nov 16 doi: 10.1177/01945998211058354. PMID: 34784258
Insurance Status and Survival of Patients with Salivary Gland Cancer.
Saraswathula A, Megwalu UC
Otolaryngol Head Neck Surg 2018 Dec;159(6):998-1005. Epub 2018 Oct 16 doi: 10.1177/0194599818791798. PMID: 30324868

Diagnosis

Surgery of major salivary gland cancers: REFCOR recommendations by the formal consensus method.
Barry B, Verillaud B, Jegoux F, Pham Dang N, Baujat B, Chabrillac E, Vergez S, Fakhry N
Eur Ann Otorhinolaryngol Head Neck Dis 2024 May;141(3):153-160. Epub 2023 Nov 30 doi: 10.1016/j.anorl.2023.11.005. PMID: 38040591
Major Salivary Gland Cancer With Distant Metastasis Upon Presentation: Patterns, Outcomes, and Imaging Implications.
Benchetrit L, Mehra S, Mahajan A, Rahmati RW, Judson BL, Edwards HA
Otolaryngol Head Neck Surg 2022 Aug;167(2):305-315. Epub 2021 Nov 16 doi: 10.1177/01945998211058354. PMID: 34784258
Insurance Status and Survival of Patients with Salivary Gland Cancer.
Saraswathula A, Megwalu UC
Otolaryngol Head Neck Surg 2018 Dec;159(6):998-1005. Epub 2018 Oct 16 doi: 10.1177/0194599818791798. PMID: 30324868
Overview of major salivary gland cancer surgery in Ontario (2003-2010).
Eskander A, Irish J, Freeman J, Gullane P, Gilbert R, Groome PA, Hall SF, Urbach DR, Goldstein DP
J Otolaryngol Head Neck Surg 2014;43(1):50. Epub 2014 Dec 10 doi: 10.1186/s40463-014-0050-6. PMID: 25492404Free PMC Article
Major salivary gland cancer.
Witt RL
Surg Oncol Clin N Am 2004 Jan;13(1):113-27. doi: 10.1016/S1055-3207(03)00126-1. PMID: 15062365

Therapy

Surgical Resection Improves Overall Survival in cT4b Major Salivary Gland Cancer.
Patel AM, Haleem A, Choudhry HS, Brant JA, Brody RM, Carey RM
Otolaryngol Head Neck Surg 2024 May;170(5):1349-1363. Epub 2024 Mar 1 doi: 10.1002/ohn.686. PMID: 38426575
Development of machine learning models to predict lymph node metastases in major salivary gland cancers.
Costantino A, Canali L, Festa BM, Kim SH, Spriano G, De Virgilio A
Eur J Surg Oncol 2023 Sep;49(9):106965. Epub 2023 Jun 27 doi: 10.1016/j.ejso.2023.06.017. PMID: 37393130
The prognostic value of machine learning techniques versus cox regression model for head and neck cancer.
Peng J, Lu Y, Chen L, Qiu K, Chen F, Liu J, Xu W, Zhang W, Zhao Y, Yu Z, Ren J
Methods 2022 Sep;205:123-132. Epub 2022 Jul 4 doi: 10.1016/j.ymeth.2022.07.001. PMID: 35798257
Minimal acute toxicity from proton beam therapy for major salivary gland cancer.
Chuong M, Bryant J, Hartsell W, Larson G, Badiyan S, Laramore GE, Katz S, Tsai H, Vargas C
Acta Oncol 2020 Feb;59(2):196-200. Epub 2019 Dec 5 doi: 10.1080/0284186X.2019.1698764. PMID: 31805791
Complications of radio- and radiochemotherapy in patients undergoing major salivary gland cancer surgery.
Kordzińska-Cisek I, Grzybowska-Szatkowska L
Otolaryngol Pol 2019 Apr 5;73(3):26-31. doi: 10.5604/01.3001.0013.0508. PMID: 31249150

Prognosis

Patterns and Trends in Adjuvant Therapy for Major Salivary Gland Cancer.
Patel AM, Haleem A, Choudhry HS, Povolotskiy R, Roden DF
Otolaryngol Head Neck Surg 2024 Jul;171(1):155-171. Epub 2024 Mar 14 doi: 10.1002/ohn.715. PMID: 38482915
Epidemiology of major salivary gland cancer in Brazil: Incidence, morbidity, and mortality.
Cohen Goldemberg D, Alves LDB, Antunes HS, Thuler LCS, de Melo AC
Oral Dis 2023 Mar;29(2):707-713. Epub 2021 Jun 2 doi: 10.1111/odi.13896. PMID: 33930235
Major Salivary Gland Cancer With Distant Metastasis Upon Presentation: Patterns, Outcomes, and Imaging Implications.
Benchetrit L, Mehra S, Mahajan A, Rahmati RW, Judson BL, Edwards HA
Otolaryngol Head Neck Surg 2022 Aug;167(2):305-315. Epub 2021 Nov 16 doi: 10.1177/01945998211058354. PMID: 34784258
Insurance Status and Survival of Patients with Salivary Gland Cancer.
Saraswathula A, Megwalu UC
Otolaryngol Head Neck Surg 2018 Dec;159(6):998-1005. Epub 2018 Oct 16 doi: 10.1177/0194599818791798. PMID: 30324868
Overview of major salivary gland cancer surgery in Ontario (2003-2010).
Eskander A, Irish J, Freeman J, Gullane P, Gilbert R, Groome PA, Hall SF, Urbach DR, Goldstein DP
J Otolaryngol Head Neck Surg 2014;43(1):50. Epub 2014 Dec 10 doi: 10.1186/s40463-014-0050-6. PMID: 25492404Free PMC Article

Clinical prediction guides

Development of machine learning models to predict lymph node metastases in major salivary gland cancers.
Costantino A, Canali L, Festa BM, Kim SH, Spriano G, De Virgilio A
Eur J Surg Oncol 2023 Sep;49(9):106965. Epub 2023 Jun 27 doi: 10.1016/j.ejso.2023.06.017. PMID: 37393130
Major Salivary Gland Cancer With Distant Metastasis Upon Presentation: Patterns, Outcomes, and Imaging Implications.
Benchetrit L, Mehra S, Mahajan A, Rahmati RW, Judson BL, Edwards HA
Otolaryngol Head Neck Surg 2022 Aug;167(2):305-315. Epub 2021 Nov 16 doi: 10.1177/01945998211058354. PMID: 34784258
Mucoepidermoid carcinoma: Evaluating the prognostic impact of primary tumor site.
Mimica X, Yuan A, Hay A, Katabi N, Zanoni DK, Valero C, Shah JP, Wong RJ, Cohen MA, Patel SG, Ganly I
Oral Oncol 2021 Dec;123:105602. Epub 2021 Nov 9 doi: 10.1016/j.oraloncology.2021.105602. PMID: 34768210Free PMC Article
Impact of treating facilities' type and volume in patients with major salivary gland cancer.
Bollig CA, Zitsch RP 3rd
Laryngoscope 2019 Oct;129(10):2321-2327. Epub 2019 Jan 30 doi: 10.1002/lary.27844. PMID: 30698823
Overview of major salivary gland cancer surgery in Ontario (2003-2010).
Eskander A, Irish J, Freeman J, Gullane P, Gilbert R, Groome PA, Hall SF, Urbach DR, Goldstein DP
J Otolaryngol Head Neck Surg 2014;43(1):50. Epub 2014 Dec 10 doi: 10.1186/s40463-014-0050-6. PMID: 25492404Free PMC Article

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